RU2295962C1 - Method for stimulating reparative processes in bony tissue after osteosynthesis - Google Patents

Abstract

FIELD: veterinary science.

SUBSTANCE: the present innovation deals with stimulating reparative processes in bony tissue in postsurgical period after osteosynthesis. For this purpose it is necessary to introduce additionally selplex at the dosage of 5 mg/kg body weight once daily. Therapy course lasts for 14 d. The innovation enables to considerably shorten the terms for reconstructing motor function in dogs.

EFFECT: higher efficiency of stimulation.

3 ex, 1 tbl

Description

The invention relates to veterinary therapy, namely to the treatment of animals in the postoperative period. Most effective is its use after osteosynthesis.

Known postoperative therapy, including the minimum number of drugs necessary for the rehabilitation of the animal organism after osteosynthesis. All drugs are used intramuscularly: 1% diphenhydramine solution (3.0 mg / kg weight 1 time per day for 4 days); 50% solution of dipyrone (0.03 g / kg weight 1 time per day for 4 days); 30% solution of lincomycin hydrochloride (10.0 mg / kg weight 1 time per day for 10 days); 5% solution of ascorbic acid (2.0 mg / kg weight 1 time per day for 7 days); tetravita (0.05 ml / kg weight 1 time per day after 5 days 5 injections); 10% solution of calcium glucanate (2-5 ml per animal 1 time per day for 7 days) [Sakhno N.V. Improving the intramedullary osteosynthesis of the tubular bones of cats in the age aspect // Diss. ... Candidate of Science. - Voronezh, 2003. - P.46].

The main disadvantage of such therapy is that it includes an insufficient number of drugs necessary for the rehabilitation of the animal organism after osteosynthesis. To stimulate osteoreparation and the formation of bone marrow in a shorter time, additional use of drugs is needed that would facilitate the early removal of intramedullary and osseous fixatives, the inclusion of limbs in the function of support and movement.

Esobel is also a biologically active, anti-inflammatory drug, a water-soluble dry extract of silt sulfide mud. The drug has antioxidant properties mainly due to the content of highly polar lipids. The main trace elements of Esobela are Cu, Mn, Ag, Co, P, Zn. Currently, as an additional therapy, electrophoresis of Esobela has been tested in people with injuries of the musculoskeletal system, including fractures [Saratikov A.S. et al. New hepatoprotective and anti-inflammatory drugs of peloids. - Tomsk: Publishing house Tom. University, 2004. - S.15, 123, 150].

The main disadvantage of this method is that it requires extensive hydration of the skin at the site of bone fracture during electrophoresis. This is unacceptable, especially in the first time after surgery, for the regeneration of soft tissues connected by skin sutures. Extensive tactile action at the fracture site causes pain with the manifestation of animal anxiety. In addition, a significant number of components are included in the composition of Esobela, which in certain conditions may limit its use.

The objective of the invention is to reduce the timing of bone repair after osteosynthesis.

The problem is achieved due to the fact that in the known method of stimulating reparative processes in bone tissue after osteosynthesis in veterinary medicine, according to the invention, in the postoperative period, an additional 5 mg per 1 kg of live weight is additionally injected into the postoperative period 1 time per day for 14 days .

Sel-plex is obtained by microbiological method from yeast cells and released in the form of a powder of light brown color with no noticeable odor. Sel-Plex contains 1000 mg / kg of selenium mainly in amino acids and is an indispensable antioxidant that plays an important role in ensuring the health, high productivity and reproductive qualities of farm animals. Sel-plex is used inside with food for the prevention of impaired reproductive function, in particular in cattle at a dose of 4 g per head per day during the dry period and 3 g per head per day after calving until fruitful insemination. The amount of selenium added to the feed should not exceed 0.3 g / t for pigs, poultry and cattle and 0.1 g / t for horses [Temporary instruction on the use of sel-plex preparation manufactured by Alltech, Ireland in poultry diets , pigs and cattle. Approved by the Ministry of Agriculture and Food of the Russian Federation, the Department of Veterinary Medicine No. 11840-2-2.1-1364 of 07.10.01].

The experiments were carried out on 3 groups of dogs, 5 animals each. Dogs of the first group were treated according to the known method, dogs of the second group were treated in addition to the known method, using individually inside Plex in a dose of 0.01 g per 1 kg The formation of the third group of dogs was needed after statistical processing of the obtained blood test results. So, in dogs of the second group, against the background of increased reparative processes, an increase in the number of eosinophils was revealed - up to 5.2 ± 1.52% (by 0.2%). Such a change in the leukocyte formula is explained by an allergy to sellex or its intolerance in the amount used, although this condition has not been clinically manifested in animals. To eliminate the latent allergic state of the body on the use of SEL-Plex, the applied dose of the drug was reduced.

Example 1. Dogs of the first group immediately after the operation was prescribed a course of drugs according to the known method, used intramuscularly: 1% solution of diphenhydramine (3.0 mg / kg of weight 1 time per day for 4 days); 50% solution of dipyrone (0.03 g / kg of weight 1 time per day for 4 days); 30% solution of lincomycin hydrochloride (10.0 mg / kg weight 1 time per day for 10 days); 5% r-ra of ascorbic acid (2.0 mg / kg weight 1 time per day for 7 days); tetravita (0.05 ml / kg weight 1 time per day after 5 days 5 injections); 10% solution of calcium glucanate (2-5 ml per animal 1 time per day for 7 days).

Example 2. Dogs of the second group were treated according to the same scheme, but 24 hours after the operation, pelplex was additionally applied at a dose of 0.01 g per 1 kg of live weight, individually assigned to each animal orally with food 1 time per day for 14 days.

Example 3. Dogs of the third group were treated according to the same scheme, but 24 hours after the operation, pelplex was additionally applied at a lower dose of 5 mg per 1 kg of live weight, given individually to each animal orally with food 1 time per day 14 days.

The results of treatment of these groups of dogs are presented in table 1.

Table 1. Partial Full Stimulation load recovery osteoreparative Allergy to sel-plex damaged supporting quantity or him limbs the functions animals intolerance (day) (day) According to the well-known - fourteen 24-27 method, (n = 5) (the drug was not used) Content increase Additionally, SEL-Plex in eosinophils up to 5.2 ± 1.52 dose of 0.01 g / kg % (0.2%), 10 20-22 (n = 5) clinically in animals this condition did not manifest Additionally, SEL-Plex in None, content dose of 5 mg / kg, eosinophils are not 10 20-22 (n = 5) exceeded 5.0%

As you can see, the therapeutic effectiveness of the additional use of SELPLEX after osteosynthesis is much higher than from the treatment of dogs by a known method. In addition, sel-plex at a dose of 5 mg / kg does not even cause a latent allergic state of the body to its use, which can manifest itself in changes in the leukocyte formula - an increased content of eosinophils.

The use of SELPLEX in a dose of 5 mg / kg allows you to restore support function in dogs after osteosynthesis on average 5 days earlier compared to the known method. It should also be noted that long-term results after osteosynthesis were tracked, which made it possible to verify the high therapeutic effect of SELPLEX, there were no postoperative complications.

The results obtained indicate the need for widespread implementation of the proposed method in practice.

Claims (1)

A method of stimulating reparative processes in bone tissue after osteosynthesis in veterinary medicine, characterized in that in the postoperative period an additional 5 mg per 1 kg of live weight is injected inside once a day for 14 days.