RU2705376C2 - Композиции пролекарства арипипразола - Google Patents

Композиции пролекарства арипипразола Download PDF

Info

Publication number
RU2705376C2
RU2705376C2 RU2017108204A RU2017108204A RU2705376C2 RU 2705376 C2 RU2705376 C2 RU 2705376C2 RU 2017108204 A RU2017108204 A RU 2017108204A RU 2017108204 A RU2017108204 A RU 2017108204A RU 2705376 C2 RU2705376 C2 RU 2705376C2
Authority
RU
Russia
Prior art keywords
composition
aripiprazole
less
prodrug
particles
Prior art date
Application number
RU2017108204A
Other languages
English (en)
Russian (ru)
Other versions
RU2017108204A (ru
RU2017108204A3 (cg-RX-API-DMAC10.html
Inventor
Филип КРЕССУЭЛЛ
Магали ХИКИ
Элейн Ливерсидж
Дэвид Мансер
Майкл Мл. ПАЛМЬЕРИ
Сара Монтмини ПАКЕТТ
Кристофер ПЕРКИН
Грег СМИТ
Брайан СТЕЙНБЕРГ
Райан ТЁРНКЛИФФ
Тарек ЗЕЙДАН
Этан П. КЭШ
Марджи Л. ХАРД
Original Assignee
Алкермес Фарма Айэленд Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51352472&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2705376(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Алкермес Фарма Айэленд Лимитед filed Critical Алкермес Фарма Айэленд Лимитед
Publication of RU2017108204A publication Critical patent/RU2017108204A/ru
Publication of RU2017108204A3 publication Critical patent/RU2017108204A3/ru
Application granted granted Critical
Publication of RU2705376C2 publication Critical patent/RU2705376C2/ru

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2017108204A 2014-08-18 2015-08-17 Композиции пролекарства арипипразола RU2705376C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462038665P 2014-08-18 2014-08-18
EP14181328.7 2014-08-18
EP14181328 2014-08-18
US62/038,665 2014-08-18
PCT/EP2015/068872 WO2016026822A1 (en) 2014-08-18 2015-08-17 Aripiprazole prodrug compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2019134055A Division RU2817019C2 (ru) 2014-08-18 2015-08-17 Композиции пролекарства арипипразола

Publications (3)

Publication Number Publication Date
RU2017108204A RU2017108204A (ru) 2018-09-21
RU2017108204A3 RU2017108204A3 (cg-RX-API-DMAC10.html) 2019-04-04
RU2705376C2 true RU2705376C2 (ru) 2019-11-07

Family

ID=51352472

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2017108204A RU2705376C2 (ru) 2014-08-18 2015-08-17 Композиции пролекарства арипипразола

Country Status (20)

Country Link
US (1) US12642798B2 (cg-RX-API-DMAC10.html)
EP (2) EP3508196B1 (cg-RX-API-DMAC10.html)
JP (1) JP6571166B2 (cg-RX-API-DMAC10.html)
CN (3) CN112494492B (cg-RX-API-DMAC10.html)
AU (1) AU2015306198B2 (cg-RX-API-DMAC10.html)
BR (1) BR112017002926A2 (cg-RX-API-DMAC10.html)
CY (1) CY1124625T1 (cg-RX-API-DMAC10.html)
DK (1) DK3508196T3 (cg-RX-API-DMAC10.html)
ES (1) ES2884849T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20211271T1 (cg-RX-API-DMAC10.html)
HU (1) HUE055711T2 (cg-RX-API-DMAC10.html)
IL (2) IL292079B2 (cg-RX-API-DMAC10.html)
MX (1) MX371417B (cg-RX-API-DMAC10.html)
PL (2) PL3508196T3 (cg-RX-API-DMAC10.html)
PT (1) PT3508196T (cg-RX-API-DMAC10.html)
RS (2) RS58746B2 (cg-RX-API-DMAC10.html)
RU (1) RU2705376C2 (cg-RX-API-DMAC10.html)
SI (2) SI3508196T1 (cg-RX-API-DMAC10.html)
SM (2) SMT202100481T1 (cg-RX-API-DMAC10.html)
WO (1) WO2016026822A1 (cg-RX-API-DMAC10.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10016415B2 (en) 2014-08-18 2018-07-10 Alkermes Pharma Ireland Limited Aripiprazole prodrug compositions
TR201905694T4 (tr) * 2014-08-18 2019-05-21 Alkermes Pharma Ireland Ltd Aripiprazol ön ilaç bileşimleri.
SMT202100481T1 (it) 2014-08-18 2021-09-14 Alkermes Pharma Ireland Ltd Composizioni per profarmaci di aripiprazolo
CA3014788A1 (en) 2016-02-17 2017-08-24 Alkermes Pharma Ireland Limited Compositions of multiple aripiprazole prodrugs
CN110025572A (zh) * 2018-01-11 2019-07-19 四川科伦药物研究院有限公司 月桂酰阿立哌唑混悬剂及其制备方法
AU2019230014B2 (en) * 2018-03-05 2024-11-28 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy
CN110327296B (zh) * 2019-08-06 2021-10-22 深圳市泛谷药业股份有限公司 一种阿立哌唑长效注射制剂及其制备方法
WO2022260064A1 (ja) 2021-06-08 2022-12-15 中外製薬株式会社 ジヒドロピリダジン－３，５－ジオン誘導体を含有する製剤

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003030872A2 (en) * 2001-10-12 2003-04-17 Elan Pharma International Ltd. Compositions having a combination of particles for immediate release and for controlled release
US7807680B2 (en) * 2003-10-23 2010-10-05 Otsuka Pharmaceutical Co., Ltd. Controlled release sterile injectable aripiprazole formulation and method
US20120238552A1 (en) * 2011-03-18 2012-09-20 Alkermes, Inc. Pharmaceutical compositions comprising sorbitan esters
US8338427B2 (en) * 2003-08-06 2012-12-25 Alkermes, Inc. Methods for administering aripiprazole
CA2885196A1 (en) * 2012-09-19 2013-09-19 Alkermes Pharma Ireland Limited Pharmaceutical compositions having improved storage stability
WO2013142205A1 (en) * 2012-03-19 2013-09-26 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising benzyl alcohol
US20130267503A1 (en) * 2012-03-19 2013-10-10 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising fatty acid esters

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
NZ248813A (en) 1992-11-25 1995-06-27 Eastman Kodak Co Polymeric grinding media used in grinding pharmaceutical substances
US5336507A (en) 1992-12-11 1994-08-09 Sterling Winthrop Inc. Use of charged phospholipids to reduce nanoparticle aggregation
US5718388A (en) 1994-05-25 1998-02-17 Eastman Kodak Continuous method of grinding pharmaceutical substances
TW384224B (en) 1994-05-25 2000-03-11 Nano Sys Llc Method of preparing submicron particles of a therapeutic or diagnostic agent
US5662883A (en) 1995-01-10 1997-09-02 Nanosystems L.L.C. Microprecipitation of micro-nanoparticulate pharmaceutical agents
US5665331A (en) 1995-01-10 1997-09-09 Nanosystems L.L.C. Co-microprecipitation of nanoparticulate pharmaceutical agents with crystal growth modifiers
US5560932A (en) 1995-01-10 1996-10-01 Nano Systems L.L.C. Microprecipitation of nanoparticulate pharmaceutical agents
US5534270A (en) 1995-02-09 1996-07-09 Nanosystems Llc Method of preparing stable drug nanoparticles
US5543133A (en) 1995-02-14 1996-08-06 Nanosystems L.L.C. Process of preparing x-ray contrast compositions containing nanoparticles
US5510118A (en) 1995-02-14 1996-04-23 Nanosystems Llc Process for preparing therapeutic compositions containing nanoparticles
ES2306452T3 (es) 1995-10-17 2008-11-01 Jagotec Ag Aporte de farmacos insolubles.
GB9622173D0 (en) 1996-10-24 1996-12-18 Glaxo Group Ltd Particulate Products
DE10350717A1 (de) * 2003-10-30 2005-06-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse
EP1679065A1 (en) 2005-01-07 2006-07-12 OctoPlus Sciences B.V. Controlled release compositions for interferon based on PEGT/PBT block copolymers
WO2007035348A2 (en) * 2005-09-15 2007-03-29 Elan Pharma International, Limited Nanoparticulate aripiprazole formulations
US20120238553A1 (en) 2009-01-27 2012-09-20 Neurosearch A/S Novel benzodioxolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use
JP5732453B2 (ja) 2009-06-25 2015-06-10 アルカーメス ファーマ アイルランド リミテッド Ｎｈ酸性化合物のプロドラッグ
PT2445502T (pt) 2009-06-25 2017-09-22 Alkermes Pharma Ireland Ltd Compostos heterocíclicos para o tratamento de distúrbios neurológicos e psicológicos
CA3035442C (en) * 2009-06-25 2022-07-19 Alkermes Pharma Ireland Limited Prodrugs of nh-acidic compounds
WO2013142202A1 (en) 2012-03-19 2013-09-26 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising glycerol esters
CN103393594A (zh) * 2013-08-22 2013-11-20 万特制药(海南)有限公司 一种新的阿立哌唑的制剂组合物
AU2015231278B2 (en) 2014-03-20 2020-01-23 Alkermes Pharma Ireland Limited Aripiprazole formulations having increased injection speeds
US10016415B2 (en) 2014-08-18 2018-07-10 Alkermes Pharma Ireland Limited Aripiprazole prodrug compositions
SMT202100481T1 (it) 2014-08-18 2021-09-14 Alkermes Pharma Ireland Ltd Composizioni per profarmaci di aripiprazolo
SMT202100212T1 (it) 2014-08-25 2021-07-12 Alkermes Pharma Ireland Ltd Processo di cristallizzazione di derivati di aripiprazolo in formulazioni a rilascio prolungato per il trattamento di schizofrenia
CN105012236A (zh) 2015-08-10 2015-11-04 深圳市泛谷药业有限公司 一种长效非水载体注射液及其制备方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003030872A2 (en) * 2001-10-12 2003-04-17 Elan Pharma International Ltd. Compositions having a combination of particles for immediate release and for controlled release
US8338427B2 (en) * 2003-08-06 2012-12-25 Alkermes, Inc. Methods for administering aripiprazole
US7807680B2 (en) * 2003-10-23 2010-10-05 Otsuka Pharmaceutical Co., Ltd. Controlled release sterile injectable aripiprazole formulation and method
US20120238552A1 (en) * 2011-03-18 2012-09-20 Alkermes, Inc. Pharmaceutical compositions comprising sorbitan esters
WO2013142205A1 (en) * 2012-03-19 2013-09-26 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising benzyl alcohol
US20130267503A1 (en) * 2012-03-19 2013-10-10 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising fatty acid esters
CA2885196A1 (en) * 2012-09-19 2013-09-19 Alkermes Pharma Ireland Limited Pharmaceutical compositions having improved storage stability

Also Published As

Publication number Publication date
CA2957762A1 (en) 2016-02-25
RS58746B1 (sr) 2019-06-28
MX2017002029A (es) 2017-08-14
ES2884849T3 (es) 2021-12-13
RS62232B1 (sr) 2021-09-30
EP3182958B1 (en) 2019-02-27
CN112494492A (zh) 2021-03-16
AU2015306198B2 (en) 2021-02-25
RU2017108204A (ru) 2018-09-21
HRP20211271T1 (hr) 2022-01-07
PL3508196T3 (pl) 2021-12-20
CN112494492B (zh) 2023-08-25
DK3508196T3 (da) 2021-08-16
IL292079B2 (en) 2024-07-01
NZ767204A (en) 2024-02-23
CY1124625T1 (el) 2022-07-22
EP3182958A1 (en) 2017-06-28
CN106794251B (zh) 2020-12-29
JP2017524021A (ja) 2017-08-24
PL3182958T5 (pl) 2022-09-12
RS58746B2 (sr) 2022-07-29
PT3508196T (pt) 2021-08-25
JP6571166B2 (ja) 2019-09-04
EP3508196A1 (en) 2019-07-10
SMT202100481T1 (it) 2021-09-14
SI3182958T1 (sl) 2019-05-31
CN106794251A (zh) 2017-05-31
IL292079B1 (en) 2024-03-01
EP3182958B2 (en) 2022-05-18
SI3182958T2 (sl) 2022-07-29
HUE055711T2 (hu) 2021-12-28
MX371417B (es) 2020-01-29
BR112017002926A2 (pt) 2017-12-12
PL3182958T3 (pl) 2019-07-31
US12642798B2 (en) 2026-06-02
AU2015306198A1 (en) 2017-03-02
NZ728914A (en) 2023-11-24
EP3508196B1 (en) 2021-07-14
RU2017108204A3 (cg-RX-API-DMAC10.html) 2019-04-04
WO2016026822A1 (en) 2016-02-25
SMT201900236T1 (it) 2019-07-11
IL292079A (en) 2022-06-01
IL250607A0 (en) 2017-04-30
SI3508196T1 (sl) 2021-12-31
CN112641785A (zh) 2021-04-13
IL250607B (en) 2022-05-01
US20220079939A1 (en) 2022-03-17

Similar Documents

Publication Publication Date Title
US11154552B2 (en) Aripiprazole prodrug composition
US20220079939A1 (en) Aripiprazole prodrug composition
JP7157830B2 (ja) アリピプラゾールプロドラッグ組成物
US10159671B2 (en) Compositions of multiple aripiprazole prodrugs
RU2817019C2 (ru) Композиции пролекарства арипипразола
CA2957762C (en) Aripiprazole prodrug compositions
HK40049829A (en) Aripiprazole prodrug compositions
HK40049829B (en) Aripiprazole prodrug compositions
HK1235285B (en) Aripiprazole prodrug compositions
HK1235285A1 (en) Aripiprazole prodrug compositions
Ohashi et al. Novel Approach to Pre-Exposure Prophylaxis (PrEP) of COVID-19: Development of S-892216 Long-Acting Injectable Suspension