TR201905694T4 - Aripiprazol ön ilaç bileşimleri. - Google Patents

Aripiprazol ön ilaç bileşimleri. Download PDF

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Publication number
TR201905694T4
TR201905694T4 TR2019/05694T TR201905694T TR201905694T4 TR 201905694 T4 TR201905694 T4 TR 201905694T4 TR 2019/05694 T TR2019/05694 T TR 2019/05694T TR 201905694 T TR201905694 T TR 201905694T TR 201905694 T4 TR201905694 T4 TR 201905694T4
Authority
TR
Turkey
Prior art keywords
aripiprazole prodrug
surface stabilizer
prodrug
aripiprazole
particles
Prior art date
Application number
TR2019/05694T
Other languages
English (en)
Inventor
Cresswell Philip
Hickey Magali
Liversidge Elaine
Manser David
Jr Palmieri Michael
Montminy PAQUETTE Sara
PERKIN Kristopher
Smith Greg
Steinberg Brian
Turncliff Ryan
ZEIDAN Tarek
P Cash Ethan
L Hard Marjie
Original Assignee
Alkermes Pharma Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Pharma Ireland Ltd filed Critical Alkermes Pharma Ireland Ltd
Publication of TR201905694T4 publication Critical patent/TR201905694T4/tr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)

Abstract

(a) 1000 nm'den daha az bir hacme dayalı partikül boyutuna (Dv50) sahip bir aripiprazol ön ilacına ait bir partikül popülasyonunu ve (b) aripiprazol ön ilacı partiküllerinin yüzeyinde adsorbe edilen bir adsorbe bileşen ve aripiprazol ön ilacın çözünmesi için mevcut bir serbest bileşen içeren en az bir yüzey stabilizatörünü içeren bir bileşim açıklanmaktadır. Yüzey stabilizatörünün ön ilaca oranı, bir giriş formülasyonu üretilmesi amaçlarıyla serbest yüzey stabilizatörünün optimal niceliğini sağlamaktadır. Ayrıca yukarıda bahsedilen bileşimi kullanan tedavi yöntemleri açıklanmaktadır.
TR2019/05694T 2014-08-18 2015-08-17 Aripiprazol ön ilaç bileşimleri. TR201905694T4 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462038665P 2014-08-18 2014-08-18
EP14181328 2014-08-18

Publications (1)

Publication Number Publication Date
TR201905694T4 true TR201905694T4 (tr) 2019-05-21

Family

ID=53872058

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/05694T TR201905694T4 (tr) 2014-08-18 2015-08-17 Aripiprazol ön ilaç bileşimleri.

Country Status (9)

Country Link
JP (2) JP6826167B2 (tr)
CY (1) CY1121594T1 (tr)
DK (1) DK3182958T4 (tr)
ES (1) ES2721270T5 (tr)
HR (1) HRP20190642T2 (tr)
HU (1) HUE043169T2 (tr)
LT (2) LT3508196T (tr)
PT (1) PT3182958T (tr)
TR (1) TR201905694T4 (tr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3508196T (lt) * 2014-08-18 2021-09-10 Alkermes Pharma Ireland Limited Aripiprazolo provaisto kompozicijos

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3508196B1 (en) * 2014-08-18 2021-07-14 Alkermes Pharma Ireland Limited Aripiprazole prodrug compositions
LT3508196T (lt) * 2014-08-18 2021-09-10 Alkermes Pharma Ireland Limited Aripiprazolo provaisto kompozicijos

Also Published As

Publication number Publication date
DK3182958T4 (da) 2022-07-04
HRP20190642T1 (hr) 2019-05-31
JP7157830B2 (ja) 2022-10-20
ES2721270T3 (es) 2019-07-30
RU2019134055A (ru) 2020-02-03
HRP20190642T2 (hr) 2022-07-08
LT3182958T (lt) 2019-06-25
ES2721270T5 (es) 2022-07-21
JP2020007316A (ja) 2020-01-16
PT3182958T (pt) 2019-05-23
CY1121594T1 (el) 2020-05-29
HUE043169T2 (hu) 2019-08-28
JP6826167B2 (ja) 2021-02-03
LT3508196T (lt) 2021-09-10
JP2021059604A (ja) 2021-04-15
HRP20190642T4 (hr) 2022-06-24
DK3182958T3 (da) 2019-05-06

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TR201905694T4 (tr) Aripiprazol ön ilaç bileşimleri.