MX371417B - Composiciones de profarmacos de aripiprazol. - Google Patents

Composiciones de profarmacos de aripiprazol.

Info

Publication number
MX371417B
MX371417B MX2017002029A MX2017002029A MX371417B MX 371417 B MX371417 B MX 371417B MX 2017002029 A MX2017002029 A MX 2017002029A MX 2017002029 A MX2017002029 A MX 2017002029A MX 371417 B MX371417 B MX 371417B
Authority
MX
Mexico
Prior art keywords
aripiprazole prodrug
prodrug
surface stabilizer
aripiprazole
particles
Prior art date
Application number
MX2017002029A
Other languages
English (en)
Other versions
MX2017002029A (es
Inventor
Elaine Liversidge
Cresswell Philip
Hickey Magali
Manser David
Jr Palmieri Michael
Montminy PAQUETTE Sara
PERKIN Kristopher
Smith Greg
Steinberg Brian
Turncliff Ryan
ZEIDAN Tarek
P Cash Ethan
L Hard Marjie
Original Assignee
Alkermes Pharma Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51352472&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX371417(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alkermes Pharma Ireland Ltd filed Critical Alkermes Pharma Ireland Ltd
Publication of MX2017002029A publication Critical patent/MX2017002029A/es
Publication of MX371417B publication Critical patent/MX371417B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Abstract

Se describe una composición que comprende (a) una población de partículas de un profármaco de aripiprazol que tiene un tamaño de partícula basado en el volumen (Dv50) de menos de 1000 nm y (b) por lo menos un estabilizador de superficie que comprende un componente adsorbido que se adsorbe en la superficie de las partículas del profármaco de aripiprazol y un componente libre disponible para la solubilización del profármaco de aripiprazol; la proporción del estabilizador de superficie con el profármaco proporciona la cantidad óptima de estabilizador de superficie libre con la finalidad de producir una formulación inicial de estudio; también se describen los métodos de tratamiento que utilizan la composición antes mencionada.
MX2017002029A 2014-08-18 2015-08-17 Composiciones de profarmacos de aripiprazol. MX371417B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462038665P 2014-08-18 2014-08-18
EP14181328 2014-08-18
PCT/EP2015/068872 WO2016026822A1 (en) 2014-08-18 2015-08-17 Aripiprazole prodrug compositions

Publications (2)

Publication Number Publication Date
MX2017002029A MX2017002029A (es) 2017-08-14
MX371417B true MX371417B (es) 2020-01-29

Family

ID=51352472

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017002029A MX371417B (es) 2014-08-18 2015-08-17 Composiciones de profarmacos de aripiprazol.

Country Status (21)

Country Link
US (1) US20220079939A1 (es)
EP (2) EP3182958B2 (es)
JP (1) JP6571166B2 (es)
CN (3) CN112494492B (es)
AU (1) AU2015306198B2 (es)
BR (1) BR112017002926A2 (es)
CA (1) CA2957762A1 (es)
CY (1) CY1124625T1 (es)
DK (1) DK3508196T3 (es)
ES (1) ES2884849T3 (es)
HR (1) HRP20211271T1 (es)
HU (1) HUE055711T2 (es)
IL (2) IL292079B1 (es)
MX (1) MX371417B (es)
NZ (2) NZ767204A (es)
PL (2) PL3182958T5 (es)
PT (1) PT3508196T (es)
RS (2) RS62232B1 (es)
RU (1) RU2705376C2 (es)
SI (2) SI3508196T1 (es)
WO (1) WO2016026822A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3182958T4 (da) * 2014-08-18 2022-07-04 Alkermes Pharma Ireland Ltd Aripiprazol-prodrugsammensætninger
US10016415B2 (en) 2014-08-18 2018-07-10 Alkermes Pharma Ireland Limited Aripiprazole prodrug compositions
CA3014788A1 (en) * 2016-02-17 2017-08-24 Alkermes Pharma Ireland Limited Compositions of multiple aripiprazole prodrugs
CN110025572A (zh) * 2018-01-11 2019-07-19 四川科伦药物研究院有限公司 月桂酰阿立哌唑混悬剂及其制备方法
EP3761983A1 (en) * 2018-03-05 2021-01-13 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy
CN110327296B (zh) * 2019-08-06 2021-10-22 深圳市泛谷药业股份有限公司 一种阿立哌唑长效注射制剂及其制备方法
AU2022288895A1 (en) 2021-06-08 2024-01-18 Chugai Seiyaku Kabushiki Kaisha Formulation containing dihydropyridazine-3,5-dione derivative

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US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
AU660852B2 (en) 1992-11-25 1995-07-06 Elan Pharma International Limited Method of grinding pharmaceutical substances
US5336507A (en) 1992-12-11 1994-08-09 Sterling Winthrop Inc. Use of charged phospholipids to reduce nanoparticle aggregation
TW384224B (en) 1994-05-25 2000-03-11 Nano Sys Llc Method of preparing submicron particles of a therapeutic or diagnostic agent
US5718388A (en) 1994-05-25 1998-02-17 Eastman Kodak Continuous method of grinding pharmaceutical substances
US5560932A (en) 1995-01-10 1996-10-01 Nano Systems L.L.C. Microprecipitation of nanoparticulate pharmaceutical agents
US5665331A (en) 1995-01-10 1997-09-09 Nanosystems L.L.C. Co-microprecipitation of nanoparticulate pharmaceutical agents with crystal growth modifiers
US5662883A (en) 1995-01-10 1997-09-02 Nanosystems L.L.C. Microprecipitation of micro-nanoparticulate pharmaceutical agents
US5534270A (en) 1995-02-09 1996-07-09 Nanosystems Llc Method of preparing stable drug nanoparticles
US5510118A (en) 1995-02-14 1996-04-23 Nanosystems Llc Process for preparing therapeutic compositions containing nanoparticles
US5543133A (en) 1995-02-14 1996-08-06 Nanosystems L.L.C. Process of preparing x-ray contrast compositions containing nanoparticles
DE69637441T2 (de) 1995-10-17 2009-03-05 Jagotec Ag Verabreichung unlöslicher arzneistoffe
GB9622173D0 (en) 1996-10-24 1996-12-18 Glaxo Group Ltd Particulate Products
DE60222160T2 (de) * 2001-10-12 2008-06-12 Elan Pharma International Ltd., Athlone Zusammensetzungen mit einer kombination aus eigenschaften sofortiger freisetzung und kontrollierter freisetzung
US20050032811A1 (en) * 2003-08-06 2005-02-10 Josiah Brown Methods for administering aripiprazole
PT1675573E (pt) * 2003-10-23 2008-12-30 Otsuka Pharma Co Ltd Formulação de iripiprazole injectável estéril de libertação controlada e um processo para a sua preparação
EP2279727A3 (en) * 2005-09-15 2011-10-05 Elan Pharma International Limited Nanoparticulate aripiprazole formulations
LT2445502T (lt) 2009-06-25 2017-09-25 Alkermes Pharma Ireland Limited Heterocikliniai junginiai, skirti neurologinių ir fiziologinių susirgimų gydymui
CA2830511C (en) * 2011-03-18 2021-09-14 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising aripiprazole lauroxil and sorbitan laurate
CA2867121C (en) * 2012-03-19 2021-05-25 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising fatty acid esters
US9999670B2 (en) * 2012-03-19 2018-06-19 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising benzyl alcohol
EP3718536A1 (en) * 2012-09-19 2020-10-07 Alkermes Pharma Ireland Limited Pharmaceutical compositions having improved storage stability

Also Published As

Publication number Publication date
CN112641785A (zh) 2021-04-13
WO2016026822A1 (en) 2016-02-25
CA2957762A1 (en) 2016-02-25
EP3182958B1 (en) 2019-02-27
AU2015306198B2 (en) 2021-02-25
AU2015306198A1 (en) 2017-03-02
HRP20211271T1 (hr) 2022-01-07
NZ728914A (en) 2023-11-24
SI3182958T2 (sl) 2022-07-29
SI3182958T1 (sl) 2019-05-31
RU2017108204A (ru) 2018-09-21
EP3182958B2 (en) 2022-05-18
NZ767204A (en) 2024-02-23
EP3508196B1 (en) 2021-07-14
IL292079B1 (en) 2024-03-01
IL250607A0 (en) 2017-04-30
CN112494492A (zh) 2021-03-16
JP2017524021A (ja) 2017-08-24
HUE055711T2 (hu) 2021-12-28
CY1124625T1 (el) 2022-07-22
RS62232B1 (sr) 2021-09-30
IL250607B (en) 2022-05-01
RS58746B2 (sr) 2022-07-29
EP3182958A1 (en) 2017-06-28
RU2017108204A3 (es) 2019-04-04
RU2705376C2 (ru) 2019-11-07
PL3508196T3 (pl) 2021-12-20
EP3508196A1 (en) 2019-07-10
JP6571166B2 (ja) 2019-09-04
PT3508196T (pt) 2021-08-25
CN112494492B (zh) 2023-08-25
SI3508196T1 (sl) 2021-12-31
BR112017002926A2 (pt) 2017-12-12
IL292079A (en) 2022-06-01
CN106794251B (zh) 2020-12-29
US20220079939A1 (en) 2022-03-17
DK3508196T3 (da) 2021-08-16
RS58746B1 (sr) 2019-06-28
ES2884849T3 (es) 2021-12-13
PL3182958T5 (pl) 2022-09-12
CN106794251A (zh) 2017-05-31
MX2017002029A (es) 2017-08-14
PL3182958T3 (pl) 2019-07-31

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