RU2704802C2 - Способы получения радиоиммуноконъюгатов - Google Patents

Способы получения радиоиммуноконъюгатов Download PDF

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Publication number
RU2704802C2
RU2704802C2 RU2015137512A RU2015137512A RU2704802C2 RU 2704802 C2 RU2704802 C2 RU 2704802C2 RU 2015137512 A RU2015137512 A RU 2015137512A RU 2015137512 A RU2015137512 A RU 2015137512A RU 2704802 C2 RU2704802 C2 RU 2704802C2
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Russia
Prior art keywords
reaction mixture
chelating
hum195
acid
scn
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RU2015137512A
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English (en)
Russian (ru)
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RU2015137512A (ru
RU2015137512A3 (enExample
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Джейми САЙМОН
А. Гэйлорд КИНГ
БЕРМУДЕС Хосуэ Мануэль МОРЕНО
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Актиниум Фармасьютикалз Инк.
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Publication of RU2015137512A3 publication Critical patent/RU2015137512A3/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
RU2015137512A 2009-07-22 2010-07-22 Способы получения радиоиммуноконъюгатов RU2704802C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22771009P 2009-07-22 2009-07-22
US61/227,710 2009-07-22

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU2012106301/15A Division RU2565402C2 (ru) 2009-07-22 2010-07-22 Способы получения радиоиммуноконъюгатов

Publications (3)

Publication Number Publication Date
RU2015137512A RU2015137512A (ru) 2018-12-25
RU2015137512A3 RU2015137512A3 (enExample) 2019-04-02
RU2704802C2 true RU2704802C2 (ru) 2019-10-31

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Family Applications (2)

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RU2015137512A RU2704802C2 (ru) 2009-07-22 2010-07-22 Способы получения радиоиммуноконъюгатов
RU2012106301/15A RU2565402C2 (ru) 2009-07-22 2010-07-22 Способы получения радиоиммуноконъюгатов

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RU2012106301/15A RU2565402C2 (ru) 2009-07-22 2010-07-22 Способы получения радиоиммуноконъюгатов

Country Status (8)

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US (1) US9603954B2 (enExample)
EP (1) EP2456472B1 (enExample)
JP (2) JP5985392B2 (enExample)
CN (2) CN104710504B (enExample)
CA (1) CA2768658C (enExample)
IN (1) IN2012DN00551A (enExample)
RU (2) RU2704802C2 (enExample)
WO (1) WO2011011592A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2846977C1 (ru) * 2020-04-29 2025-09-22 Новартис Аг Способы мечения радиоактивными изотопами psma-связывающих лигандов и наборы для их осуществления

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CN114814055B (zh) * 2015-09-08 2025-03-18 沃特世科技公司 用于分析抗体-药物缀合物的多维色谱方法
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EP3568205B1 (en) 2017-01-12 2023-08-16 Radiomedix Inc. Treatment of cancer cells overexpressing somatostatin receptors using ocreotide derivatives chelated to radioisotopes
ES3049118T3 (en) * 2017-07-31 2025-12-15 Actinium Pharmaceuticals Inc Treatments for a hematological malignancy
CN109550061A (zh) * 2017-09-26 2019-04-02 南京江原安迪科正电子研究发展有限公司 一种用于放射性核素标记抗体的试剂盒及应用
CA3192391A1 (en) * 2020-09-11 2022-03-17 Actinium Pharmaceuticals, Inc. Trophoblast glycoprotein radioimmunotherapy for the treatment of solid cancers
US12447218B1 (en) * 2021-02-09 2025-10-21 Actinium Pharmaceuticals, Inc. Radioconjugates directed to MHC-complexed antigens in cancer
JP2025510189A (ja) 2022-03-24 2025-04-14 アクティニウム ファーマシューティカルズ インコーポレイテッド ヒト化抗ｃｄ４５抗体
WO2023190402A1 (ja) 2022-03-30 2023-10-05 日本メジフィジックス株式会社 複合体の製造方法
WO2023240135A2 (en) 2022-06-07 2023-12-14 Actinium Pharmaceuticals, Inc. Bifunctional chelators and conjugates
AU2023330110A1 (en) 2022-08-22 2025-03-06 Abdera Therapeutics Inc. Dll3 binding molecules and uses thereof
WO2025213061A2 (en) 2024-04-04 2025-10-09 Ethyreal Bio, Inc. Anti-tshr antibodies and uses thereof

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US20030086868A1 (en) * 2002-08-12 2003-05-08 Dangshe Ma Actinium-225 complexes and conjugates for radioimmunotherapy

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2846977C1 (ru) * 2020-04-29 2025-09-22 Новартис Аг Способы мечения радиоактивными изотопами psma-связывающих лигандов и наборы для их осуществления

Also Published As

Publication number Publication date
RU2015137512A (ru) 2018-12-25
CA2768658C (en) 2018-04-03
CN104710504A (zh) 2015-06-17
CN104710504B (zh) 2019-09-13
EP2456472A4 (en) 2014-08-27
RU2012106301A (ru) 2013-08-27
CN102596258B (zh) 2015-01-28
CA2768658A1 (en) 2011-01-27
EP2456472B1 (en) 2024-03-27
RU2565402C2 (ru) 2015-10-20
JP5985392B2 (ja) 2016-09-06
US9603954B2 (en) 2017-03-28
HK1211304A1 (en) 2016-05-20
CN102596258A (zh) 2012-07-18
JP2013500258A (ja) 2013-01-07
US20120220754A1 (en) 2012-08-30
EP2456472A1 (en) 2012-05-30
WO2011011592A1 (en) 2011-01-27
JP2016199583A (ja) 2016-12-01
EP2456472C0 (en) 2024-03-27
RU2015137512A3 (enExample) 2019-04-02
IN2012DN00551A (enExample) 2015-06-12

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