ES2053196T3 - Metodo para la produccion de un radioinmunoconjugado. - Google Patents
Metodo para la produccion de un radioinmunoconjugado.Info
- Publication number
- ES2053196T3 ES2053196T3 ES90909718T ES90909718T ES2053196T3 ES 2053196 T3 ES2053196 T3 ES 2053196T3 ES 90909718 T ES90909718 T ES 90909718T ES 90909718 T ES90909718 T ES 90909718T ES 2053196 T3 ES2053196 T3 ES 2053196T3
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- production
- radio
- treatment
- well
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Abstract
LA INVENCION ACTUAL SE REFIERE A LA UTILIZACION DEL ACTINIO O DE UNO DE SUS FILIALES EN LA RADIOINMUNOTERAPIA. TAMBIEN SE PROPORCIONAN OTROS INMUNODERIVADOS QUE COMPRENDEN UN ISOTOPO, UN AGENTE SERVIDOR Y UN ANTICUERPO DE CONCENTRACION LENTA. LA INVENCION INCLUYE TAMBIEN, COMPUESTOS FARMACEUTICOS QUE COMPRENDEN DICHOS INMUNODERIVADOS, ASI COMO, OTROS COMPUESTOS QUE COMPRENDEN UNO O MAS AGENTES EXPULSORES. ESTOS COMPUESTOS EN CONSONANCIA CON LA INVENCION SON, PARTICULARMENTE, UTILES PARA EL TRATAMIENTO DE MICROMETASTASIS EN TERAPIAS COADYUVANTES, ASI COMO, PARA EL TRATAMIENTO DE TUMORES LOCALIZADOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP89201591 | 1989-06-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2053196T3 true ES2053196T3 (es) | 1994-07-16 |
Family
ID=8202415
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90909718T Expired - Lifetime ES2053196T3 (es) | 1989-06-19 | 1990-06-19 | Metodo para la produccion de un radioinmunoconjugado. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5246691C1 (es) |
EP (1) | EP0429624B1 (es) |
JP (1) | JPH089553B2 (es) |
KR (1) | KR0179645B1 (es) |
AU (1) | AU629367B2 (es) |
CA (1) | CA2034484C (es) |
DE (1) | DE69007430T2 (es) |
DK (1) | DK0429624T3 (es) |
ES (1) | ES2053196T3 (es) |
FI (1) | FI98707C (es) |
WO (1) | WO1990015625A1 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6403771B1 (en) * | 1991-02-19 | 2002-06-11 | Actinium Pharmaceuticals, Limited | Method and means for site directed therapy |
CA2100709C (en) * | 1992-07-27 | 2004-03-16 | Maurits W. Geerlings | Method and means for site directed therapy |
EP0746761A4 (en) * | 1993-03-12 | 1997-02-26 | Akzo America Inc | PROCESS FOR EXTRACTING RADON 220 FROM A MIXTURE OF RADIOACTIVE ISOTOPES |
LU88636A1 (de) * | 1995-07-03 | 1997-01-03 | Euratom | Verfahren zur Erzeugung von Actinium-225 |
LU88637A1 (de) * | 1995-07-03 | 1997-01-03 | Euratom | Verfahren zur Erzeugung von Actinium-225 und Wismut-213 durch Bestrahlung von Radium-226 mit hochenergetischen Gammaquanten |
EP0842668B1 (en) * | 1996-11-15 | 2002-09-04 | European Atomic Energy Community (Euratom) | Ex-corpore method for treating human blood cells |
US5809394A (en) * | 1996-12-13 | 1998-09-15 | Battelle Memorial Institute | Methods of separating short half-life radionuclides from a mixture of radionuclides |
US6117413A (en) * | 1997-11-12 | 2000-09-12 | Battelle Memorial Institute | Radionuclide-binding compound, a radionuclide delivery system, a method of making a radium complexing compound, a method of extracting a radionuclide, and a method of delivering a radionuclide |
JP2002509122A (ja) * | 1998-01-16 | 2002-03-26 | エムセーアー ディベロップメント ベー.フェー. | 癌および自己免疫疾患のための治療における放射性標識化モノクローナルIgMの使用 |
DE19911329A1 (de) * | 1998-03-27 | 2000-09-21 | Benes Ivan Friedrich | Humantherapeutisch anwendbares Radioimmunkonjugat und Verfahren zu seiner Herstellung |
US6696551B1 (en) * | 1999-03-23 | 2004-02-24 | The United States Of America As Represented By The Department Of Health And Human Services | 225Ac-HEHA and related compounds, methods of synthesis and methods of use |
AU7548901A (en) * | 2000-06-16 | 2002-01-02 | Sloan Kettering Inst Cancer | Liposomal encapsulation of chelated actinium-225 and uses thereof |
US6852296B2 (en) * | 2001-06-22 | 2005-02-08 | Pg Research Foundation | Production of ultrapure bismuth-213 for use in therapeutic nuclear medicine |
US7087206B2 (en) * | 2002-04-12 | 2006-08-08 | Pg Research Foundation | Multicolumn selectivity inversion generator for production of high purity actinium for use in therapeutic nuclear medicine |
US20030086868A1 (en) * | 2002-08-12 | 2003-05-08 | Dangshe Ma | Actinium-225 complexes and conjugates for radioimmunotherapy |
WO2004062722A2 (en) * | 2003-01-08 | 2004-07-29 | Sloan Kettering Institute For Cancer Research | Prevention of systemic toxicity during radioimmunotherapy for intravascularly disseminated cancers |
EA008195B1 (ru) * | 2003-04-15 | 2007-04-27 | Алгета Ас | Применение тория-227 в лучевой терапии заболеваний мягких тканей |
DE102004022200B4 (de) * | 2004-05-05 | 2006-07-20 | Actinium Pharmaceuticals, Inc. | Radium-Target sowie Verfahren zu seiner Herstellung |
US7618627B2 (en) | 2004-06-03 | 2009-11-17 | The Regents Of The University Of California | Method of increasing radiation sensitivity by inhibition of beta one integrin |
US7736610B2 (en) * | 2004-09-24 | 2010-06-15 | Battelle Energy Alliance, Llc | Actinium radioisotope products of enhanced purity |
US7157061B2 (en) * | 2004-09-24 | 2007-01-02 | Battelle Energy Alliance, Llc | Process for radioisotope recovery and system for implementing same |
DE102006008023B4 (de) * | 2006-02-21 | 2008-05-29 | Actinium Pharmaceuticals, Inc. | Verfahren zum Reinigen von 225Ac aus bestrahlten 226Ra-Targets |
EP2082071B1 (en) * | 2006-09-08 | 2014-06-25 | Actinium Pharmaceuticals Inc. | Method for the purification of radium from different sources |
RU2565402C2 (ru) | 2009-07-22 | 2015-10-20 | Актиниум Фармасьютикалз Инк. | Способы получения радиоиммуноконъюгатов |
GB201002508D0 (en) | 2010-02-12 | 2010-03-31 | Algeta As | Product |
US20150157742A1 (en) * | 2013-12-11 | 2015-06-11 | The European Atomic Energy Community (Euratom), Represented By The European Commission | SYNTHESIS OF BIOLOGICAL COMPOUNDS LABELED WITH THE ALPHA EMITTER Ac-225 |
EP3409297A1 (en) | 2017-05-30 | 2018-12-05 | AlfaRim Medial Holding B.V. | The optimal 225actinium--213bismuth generator for alpha-particle radioimmunotherapy |
US20200230266A1 (en) | 2017-09-20 | 2020-07-23 | Alfarim Medical Holding B.V. | The optimal 225actinium--213bismuth generator for alpha-particle radioimmunotherapy |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4454106A (en) * | 1982-06-07 | 1984-06-12 | Gansow Otto A | Use of metal chelate conjugated monoclonal antibodies |
US4472509A (en) * | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
GB8308235D0 (en) * | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4828991A (en) * | 1984-01-31 | 1989-05-09 | Akzo N.V. | Tumor specific monoclonal antibodies |
NZ210867A (en) * | 1984-01-31 | 1989-01-06 | Litton Bionetics Inc | Tumour-specific monoclonal antibodies, production thereof and use |
NO881077L (no) * | 1987-03-11 | 1988-09-12 | Univ Michigan | Kjemo-radio-immuno-konjugater. |
US4923985A (en) * | 1988-05-25 | 1990-05-08 | The United States Of America As Represented By The Department Of Health & Human Services | Process for synthesizing macrocyclic chelates |
-
1990
- 1990-06-19 AU AU58574/90A patent/AU629367B2/en not_active Expired
- 1990-06-19 ES ES90909718T patent/ES2053196T3/es not_active Expired - Lifetime
- 1990-06-19 JP JP2509181A patent/JPH089553B2/ja not_active Expired - Lifetime
- 1990-06-19 WO PCT/EP1990/000990 patent/WO1990015625A1/en active IP Right Grant
- 1990-06-19 DK DK90909718.0T patent/DK0429624T3/da active
- 1990-06-19 EP EP90909718A patent/EP0429624B1/en not_active Expired - Lifetime
- 1990-06-19 CA CA002034484A patent/CA2034484C/en not_active Expired - Lifetime
- 1990-06-19 DE DE69007430T patent/DE69007430T2/de not_active Expired - Lifetime
-
1991
- 1991-02-18 FI FI910772A patent/FI98707C/fi active
- 1991-02-18 KR KR1019910700189A patent/KR0179645B1/ko not_active IP Right Cessation
- 1991-02-19 US US07657580 patent/US5246691C1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69007430T2 (de) | 1994-07-07 |
AU629367B2 (en) | 1992-10-01 |
DE69007430D1 (de) | 1994-04-21 |
JPH089553B2 (ja) | 1996-01-31 |
KR0179645B1 (en) | 1999-03-20 |
FI910772A0 (fi) | 1991-02-18 |
EP0429624A1 (en) | 1991-06-05 |
JPH04500366A (ja) | 1992-01-23 |
EP0429624B1 (en) | 1994-03-16 |
DK0429624T3 (da) | 1994-05-30 |
AU5857490A (en) | 1991-01-08 |
US5246691A (en) | 1993-09-21 |
US5246691C1 (en) | 2001-10-09 |
FI98707C (fi) | 1997-08-11 |
CA2034484A1 (en) | 1990-12-20 |
WO1990015625A1 (en) | 1990-12-27 |
KR920700690A (ko) | 1992-08-10 |
FI98707B (fi) | 1997-04-30 |
CA2034484C (en) | 2000-08-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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