CN104710504B - 用于制备放射性免疫缀合物的方法 - Google Patents
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Immunology (AREA)
- Optics & Photonics (AREA)
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- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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| CN104710504A CN104710504A (zh) | 2015-06-17 |
| CN104710504B true CN104710504B (zh) | 2019-09-13 |
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| IN (1) | IN2012DN00551A (enExample) |
| RU (2) | RU2565402C2 (enExample) |
| WO (1) | WO2011011592A1 (enExample) |
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| GB201208309D0 (en) * | 2012-05-11 | 2012-06-27 | Algeta As | Complexes |
| US20150157742A1 (en) * | 2013-12-11 | 2015-06-11 | The European Atomic Energy Community (Euratom), Represented By The European Commission | SYNTHESIS OF BIOLOGICAL COMPOUNDS LABELED WITH THE ALPHA EMITTER Ac-225 |
| CA2949365A1 (en) * | 2014-05-16 | 2015-11-19 | Memorial Sloan Kettering Cancer Center | One-step labeling of antibodies to high specific activity with actinium-225 |
| CN114814055B (zh) * | 2015-09-08 | 2025-03-18 | 沃特世科技公司 | 用于分析抗体-药物缀合物的多维色谱方法 |
| CN110290816B (zh) * | 2016-12-16 | 2022-09-30 | 澳大利亚国立大学 | 用于靶向施用的放射性标记材料 |
| SI3568205T1 (sl) | 2017-01-12 | 2023-12-29 | Radiomedix Inc. | Zdravljenje rakastih celic, ki prekomerno izražajo receptorje za somatostatin, z uporabo derivatov okreotida, kelatiranih v radioizotope |
| ES3049118T3 (en) * | 2017-07-31 | 2025-12-15 | Actinium Pharmaceuticals Inc | Treatments for a hematological malignancy |
| CN109550061A (zh) * | 2017-09-26 | 2019-04-02 | 南京江原安迪科正电子研究发展有限公司 | 一种用于放射性核素标记抗体的试剂盒及应用 |
| WO2022056354A1 (en) * | 2020-09-11 | 2022-03-17 | Actinium Pharmaceuticals, Inc. | Trophoblast glycoprotein radioimmunotherapy for the treatment of solid cancers |
| US12447218B1 (en) * | 2021-02-09 | 2025-10-21 | Actinium Pharmaceuticals, Inc. | Radioconjugates directed to MHC-complexed antigens in cancer |
| CN119256014A (zh) | 2022-03-24 | 2025-01-03 | 锕医药有限责任公司 | 人源化抗cd45抗体 |
| JPWO2023190402A1 (enExample) | 2022-03-30 | 2023-10-05 | ||
| WO2023240135A2 (en) | 2022-06-07 | 2023-12-14 | Actinium Pharmaceuticals, Inc. | Bifunctional chelators and conjugates |
| CA3265385A1 (en) | 2022-08-22 | 2024-02-29 | Abdera Therapeutics Inc. | DLL3 BINDING MOLECULES AND THEIR USES |
| WO2025213061A2 (en) | 2024-04-04 | 2025-10-09 | Ethyreal Bio, Inc. | Anti-tshr antibodies and uses thereof |
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| US6670456B2 (en) * | 2001-02-28 | 2003-12-30 | Dow Global Technologies Inc. | Actinium-225 complexes and conjugates for targeted radiotherapy |
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-
2010
- 2010-07-22 WO PCT/US2010/042885 patent/WO2011011592A1/en not_active Ceased
- 2010-07-22 RU RU2012106301/15A patent/RU2565402C2/ru active
- 2010-07-22 EP EP10802893.7A patent/EP2456472B1/en active Active
- 2010-07-22 IN IN551DEN2012 patent/IN2012DN00551A/en unknown
- 2010-07-22 RU RU2015137512A patent/RU2704802C2/ru active
- 2010-07-22 JP JP2012521780A patent/JP5985392B2/ja active Active
- 2010-07-22 CN CN201510083376.8A patent/CN104710504B/zh active Active
- 2010-07-22 US US13/386,316 patent/US9603954B2/en active Active
- 2010-07-22 CA CA2768658A patent/CA2768658C/en active Active
- 2010-07-22 CN CN201080036704.4A patent/CN102596258B/zh active Active
-
2016
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5612016A (en) * | 1988-04-01 | 1997-03-18 | Immunomedics, Inc. | Conjugates of antibodies and bifunctional ligands |
| US6670456B2 (en) * | 2001-02-28 | 2003-12-30 | Dow Global Technologies Inc. | Actinium-225 complexes and conjugates for targeted radiotherapy |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102596258A (zh) | 2012-07-18 |
| RU2015137512A (ru) | 2018-12-25 |
| EP2456472B1 (en) | 2024-03-27 |
| RU2012106301A (ru) | 2013-08-27 |
| JP5985392B2 (ja) | 2016-09-06 |
| JP2016199583A (ja) | 2016-12-01 |
| CN102596258B (zh) | 2015-01-28 |
| EP2456472C0 (en) | 2024-03-27 |
| RU2704802C2 (ru) | 2019-10-31 |
| JP2013500258A (ja) | 2013-01-07 |
| RU2015137512A3 (enExample) | 2019-04-02 |
| WO2011011592A1 (en) | 2011-01-27 |
| EP2456472A4 (en) | 2014-08-27 |
| CN104710504A (zh) | 2015-06-17 |
| CA2768658C (en) | 2018-04-03 |
| IN2012DN00551A (enExample) | 2015-06-12 |
| RU2565402C2 (ru) | 2015-10-20 |
| US9603954B2 (en) | 2017-03-28 |
| HK1211304A1 (en) | 2016-05-20 |
| EP2456472A1 (en) | 2012-05-30 |
| CA2768658A1 (en) | 2011-01-27 |
| US20120220754A1 (en) | 2012-08-30 |
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