CA2768658C - Methods for generating radioimmunoconjugates - Google Patents
Methods for generating radioimmunoconjugates Download PDFInfo
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- CA2768658C CA2768658C CA2768658A CA2768658A CA2768658C CA 2768658 C CA2768658 C CA 2768658C CA 2768658 A CA2768658 A CA 2768658A CA 2768658 A CA2768658 A CA 2768658A CA 2768658 C CA2768658 C CA 2768658C
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- 235000020357 syrup Nutrition 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229940056501 technetium 99m Drugs 0.000 description 1
- PORWMNRCUJJQNO-NOHWODKXSA-N tellurium-121 Chemical compound [121Te] PORWMNRCUJJQNO-NOHWODKXSA-N 0.000 description 1
- GZCRRIHWUXGPOV-NJFSPNSNSA-N terbium-161 Chemical compound [161Tb] GZCRRIHWUXGPOV-NJFSPNSNSA-N 0.000 description 1
- BKVIYDNLLOSFOA-OIOBTWANSA-N thallium-201 Chemical compound [201Tl] BKVIYDNLLOSFOA-OIOBTWANSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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| US61/227,710 | 2009-07-22 | ||
| PCT/US2010/042885 WO2011011592A1 (en) | 2009-07-22 | 2010-07-22 | Methods for generating radioimmunoconjugates |
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| CA2768658A1 CA2768658A1 (en) | 2011-01-27 |
| CA2768658C true CA2768658C (en) | 2018-04-03 |
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| RU (2) | RU2704802C2 (enExample) |
| WO (1) | WO2011011592A1 (enExample) |
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| GB201208309D0 (en) * | 2012-05-11 | 2012-06-27 | Algeta As | Complexes |
| US20150157742A1 (en) * | 2013-12-11 | 2015-06-11 | The European Atomic Energy Community (Euratom), Represented By The European Commission | SYNTHESIS OF BIOLOGICAL COMPOUNDS LABELED WITH THE ALPHA EMITTER Ac-225 |
| EP3142710A4 (en) * | 2014-05-16 | 2018-04-25 | Memorial Sloan Kettering Cancer Center | One-step labeling of antibodies to high specific activity with actinium-225 |
| CN114814055B (zh) * | 2015-09-08 | 2025-03-18 | 沃特世科技公司 | 用于分析抗体-药物缀合物的多维色谱方法 |
| WO2018107205A1 (en) | 2016-12-16 | 2018-06-21 | The Australian National University | Radiolabelled material for targeted administration |
| EP3568205B1 (en) | 2017-01-12 | 2023-08-16 | Radiomedix Inc. | Treatment of cancer cells overexpressing somatostatin receptors using ocreotide derivatives chelated to radioisotopes |
| ES3049118T3 (en) * | 2017-07-31 | 2025-12-15 | Actinium Pharmaceuticals Inc | Treatments for a hematological malignancy |
| CN109550061A (zh) * | 2017-09-26 | 2019-04-02 | 南京江原安迪科正电子研究发展有限公司 | 一种用于放射性核素标记抗体的试剂盒及应用 |
| CA3192391A1 (en) * | 2020-09-11 | 2022-03-17 | Actinium Pharmaceuticals, Inc. | Trophoblast glycoprotein radioimmunotherapy for the treatment of solid cancers |
| US12447218B1 (en) * | 2021-02-09 | 2025-10-21 | Actinium Pharmaceuticals, Inc. | Radioconjugates directed to MHC-complexed antigens in cancer |
| JP2025510189A (ja) | 2022-03-24 | 2025-04-14 | アクティニウム ファーマシューティカルズ インコーポレイテッド | ヒト化抗ｃｄ４５抗体 |
| WO2023190402A1 (ja) | 2022-03-30 | 2023-10-05 | 日本メジフィジックス株式会社 | 複合体の製造方法 |
| WO2023240135A2 (en) | 2022-06-07 | 2023-12-14 | Actinium Pharmaceuticals, Inc. | Bifunctional chelators and conjugates |
| AU2023330110A1 (en) | 2022-08-22 | 2025-03-06 | Abdera Therapeutics Inc. | Dll3 binding molecules and uses thereof |
| WO2025213061A2 (en) | 2024-04-04 | 2025-10-09 | Ethyreal Bio, Inc. | Anti-tshr antibodies and uses thereof |
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| US4001387A (en) | 1973-07-30 | 1977-01-04 | Medi-Physics, Inc. | Process for preparing radiopharmaceuticals |
| US4305922A (en) | 1978-10-04 | 1981-12-15 | University Patents, Inc. | Labeling proteins with 99m-Tc by ligand exchange |
| US4296785A (en) | 1979-07-09 | 1981-10-27 | Mallinckrodt, Inc. | System for generating and containerizing radioisotopes |
| US4472509A (en) | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
| US4454106A (en) | 1982-06-07 | 1984-06-12 | Gansow Otto A | Use of metal chelate conjugated monoclonal antibodies |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4732864A (en) | 1983-10-06 | 1988-03-22 | E. I. Du Pont De Nemours And Company | Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules |
| US4894364A (en) | 1983-10-26 | 1990-01-16 | Greer Sheldon B | Method and materials for sensitizing neoplastic tissue to radiation |
| US4828991A (en) | 1984-01-31 | 1989-05-09 | Akzo N.V. | Tumor specific monoclonal antibodies |
| US4663129A (en) | 1985-01-30 | 1987-05-05 | The United States Of America As Represented By The United States Department Of Energy | Isotopic generator for bismuth-212 and lead-212 from radium |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5306509A (en) | 1987-03-17 | 1994-04-26 | Turner Robert E | Prevention and treatment of oral lesions |
| IL87405A0 (en) | 1987-08-12 | 1989-01-31 | Immunomedics Inc | Radiolabeled agents and methods and kits for the production thereof |
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| US5612016A (en) * | 1988-04-01 | 1997-03-18 | Immunomedics, Inc. | Conjugates of antibodies and bifunctional ligands |
| JPH0720989B2 (ja) | 1988-05-25 | 1995-03-08 | アメリカ合衆国 | 大環状キレート化合物の抱合体と診断的テスト方法 |
| US4923985A (en) | 1988-05-25 | 1990-05-08 | The United States Of America As Represented By The Department Of Health & Human Services | Process for synthesizing macrocyclic chelates |
| US5292868A (en) | 1989-05-26 | 1994-03-08 | Akzo N.V. | Chelating agents for attaching metal ions to proteins |
| ES2053196T3 (es) | 1989-06-19 | 1994-07-16 | Akzo Nv | Metodo para la produccion de un radioinmunoconjugado. |
| ATE133290T1 (de) | 1989-07-12 | 1996-02-15 | Mallinckrodt Medical Inc | Verfahren und gerät zur herstellung eines radiodiagnostischen gasförmigen radionukleids |
| US5443816A (en) | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
| LU87684A1 (de) | 1990-02-23 | 1991-10-08 | Euratom | Verfahren zur erzeugung von aktinium-225 und wismut-213 |
| US5038046A (en) | 1990-07-10 | 1991-08-06 | Biotechnetics | Method and generator for producing radioactive lead-212 |
| US6403771B1 (en) | 1991-02-19 | 2002-06-11 | Actinium Pharmaceuticals, Limited | Method and means for site directed therapy |
| CA2100709C (en) | 1992-07-27 | 2004-03-16 | Maurits W. Geerlings | Method and means for site directed therapy |
| IL113610A0 (en) * | 1994-06-03 | 1995-08-31 | Immunomedics Inc | A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same |
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| WO2002022000A2 (en) | 2000-09-15 | 2002-03-21 | Sloan Kettering Institute For Cancer Research | Targeted alpha particle therapy using actinium-225 conjugates |
| US6670456B2 (en) | 2001-02-28 | 2003-12-30 | Dow Global Technologies Inc. | Actinium-225 complexes and conjugates for targeted radiotherapy |
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| US7666414B2 (en) * | 2001-06-01 | 2010-02-23 | Cornell Research Foundation, Inc. | Methods for treating prostate cancer using modified antibodies to prostate-specific membrane antigen |
| RU2352582C2 (ru) | 2002-01-03 | 2009-04-20 | Шеринг Акциенгезельшафт | Конъюгаты, содержащие антитело, специфическое для ed-в-домена фибронектина, и их применение для обнаружения и лечения опухолей |
| US20040022726A1 (en) | 2002-06-03 | 2004-02-05 | Goldenberg David M. | Methods and compositions for intravesical therapy of bladder cancer |
| US20030086868A1 (en) * | 2002-08-12 | 2003-05-08 | Dangshe Ma | Actinium-225 complexes and conjugates for radioimmunotherapy |
| US20060058218A1 (en) * | 2004-09-10 | 2006-03-16 | General Electric Company | Solid phase conjugation of complexing agents and targeting moieties |
| US7736647B2 (en) | 2005-06-15 | 2010-06-15 | Monoclonal Antibodies Therapeutics | Anti-CD71 monoclonal antibodies and uses thereof for treating malignant tumor cells |
| CA2650953A1 (en) | 2006-05-03 | 2007-11-15 | Bayer Schering Pharma Aktiengesellschaft | Combination of an anti edb fibronectin domain antibody l19-sip and an anti-egfr antibody |
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- 2010-07-22 WO PCT/US2010/042885 patent/WO2011011592A1/en not_active Ceased
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- 2010-07-22 CN CN201080036704.4A patent/CN102596258B/zh active Active
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2016
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Also Published As
| Publication number | Publication date |
|---|---|
| RU2015137512A (ru) | 2018-12-25 |
| CN104710504A (zh) | 2015-06-17 |
| CN104710504B (zh) | 2019-09-13 |
| RU2704802C2 (ru) | 2019-10-31 |
| EP2456472A4 (en) | 2014-08-27 |
| RU2012106301A (ru) | 2013-08-27 |
| CN102596258B (zh) | 2015-01-28 |
| CA2768658A1 (en) | 2011-01-27 |
| EP2456472B1 (en) | 2024-03-27 |
| RU2565402C2 (ru) | 2015-10-20 |
| JP5985392B2 (ja) | 2016-09-06 |
| US9603954B2 (en) | 2017-03-28 |
| HK1211304A1 (en) | 2016-05-20 |
| CN102596258A (zh) | 2012-07-18 |
| JP2013500258A (ja) | 2013-01-07 |
| US20120220754A1 (en) | 2012-08-30 |
| EP2456472A1 (en) | 2012-05-30 |
| WO2011011592A1 (en) | 2011-01-27 |
| JP2016199583A (ja) | 2016-12-01 |
| EP2456472C0 (en) | 2024-03-27 |
| RU2015137512A3 (enExample) | 2019-04-02 |
| IN2012DN00551A (enExample) | 2015-06-12 |
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| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20150721 |