RU2565402C2 - Способы получения радиоиммуноконъюгатов - Google Patents

Способы получения радиоиммуноконъюгатов Download PDF

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Publication number
RU2565402C2
RU2565402C2 RU2012106301/15A RU2012106301A RU2565402C2 RU 2565402 C2 RU2565402 C2 RU 2565402C2 RU 2012106301/15 A RU2012106301/15 A RU 2012106301/15A RU 2012106301 A RU2012106301 A RU 2012106301A RU 2565402 C2 RU2565402 C2 RU 2565402C2
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Russia
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reaction mixture
scn
chelating
hum195
dota
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RU2012106301/15A
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English (en)
Russian (ru)
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RU2012106301A (ru
Inventor
Джейми САЙМОН
А. Гэйлорд КИНГ
БЕРМУДЕС Хосуэ Мануэль МОРЕНО
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Актиниум Фармасьютикалз Инк.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
RU2012106301/15A 2009-07-22 2010-07-22 Способы получения радиоиммуноконъюгатов RU2565402C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22771009P 2009-07-22 2009-07-22
US61/227,710 2009-07-22
PCT/US2010/042885 WO2011011592A1 (en) 2009-07-22 2010-07-22 Methods for generating radioimmunoconjugates

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2015137512A Division RU2704802C2 (ru) 2009-07-22 2010-07-22 Способы получения радиоиммуноконъюгатов

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RU2012106301A RU2012106301A (ru) 2013-08-27
RU2565402C2 true RU2565402C2 (ru) 2015-10-20

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RU2012106301/15A RU2565402C2 (ru) 2009-07-22 2010-07-22 Способы получения радиоиммуноконъюгатов
RU2015137512A RU2704802C2 (ru) 2009-07-22 2010-07-22 Способы получения радиоиммуноконъюгатов

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US (1) US9603954B2 (enExample)
EP (1) EP2456472B1 (enExample)
JP (2) JP5985392B2 (enExample)
CN (2) CN104710504B (enExample)
CA (1) CA2768658C (enExample)
IN (1) IN2012DN00551A (enExample)
RU (2) RU2565402C2 (enExample)
WO (1) WO2011011592A1 (enExample)

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CN114814055B (zh) * 2015-09-08 2025-03-18 沃特世科技公司 用于分析抗体-药物缀合物的多维色谱方法
CN110290816B (zh) * 2016-12-16 2022-09-30 澳大利亚国立大学 用于靶向施用的放射性标记材料
SI3568205T1 (sl) 2017-01-12 2023-12-29 Radiomedix Inc. Zdravljenje rakastih celic, ki prekomerno izražajo receptorje za somatostatin, z uporabo derivatov okreotida, kelatiranih v radioizotope
ES3049118T3 (en) * 2017-07-31 2025-12-15 Actinium Pharmaceuticals Inc Treatments for a hematological malignancy
CN109550061A (zh) * 2017-09-26 2019-04-02 南京江原安迪科正电子研究发展有限公司 一种用于放射性核素标记抗体的试剂盒及应用
WO2022056354A1 (en) * 2020-09-11 2022-03-17 Actinium Pharmaceuticals, Inc. Trophoblast glycoprotein radioimmunotherapy for the treatment of solid cancers
US12447218B1 (en) * 2021-02-09 2025-10-21 Actinium Pharmaceuticals, Inc. Radioconjugates directed to MHC-complexed antigens in cancer
CN119256014A (zh) 2022-03-24 2025-01-03 锕医药有限责任公司 人源化抗cd45抗体
JPWO2023190402A1 (enExample) 2022-03-30 2023-10-05
WO2023240135A2 (en) 2022-06-07 2023-12-14 Actinium Pharmaceuticals, Inc. Bifunctional chelators and conjugates
CA3265385A1 (en) 2022-08-22 2024-02-29 Abdera Therapeutics Inc. DLL3 BINDING MOLECULES AND THEIR USES
WO2025213061A2 (en) 2024-04-04 2025-10-09 Ethyreal Bio, Inc. Anti-tshr antibodies and uses thereof

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Also Published As

Publication number Publication date
CN102596258A (zh) 2012-07-18
RU2015137512A (ru) 2018-12-25
EP2456472B1 (en) 2024-03-27
RU2012106301A (ru) 2013-08-27
JP5985392B2 (ja) 2016-09-06
JP2016199583A (ja) 2016-12-01
CN102596258B (zh) 2015-01-28
EP2456472C0 (en) 2024-03-27
RU2704802C2 (ru) 2019-10-31
JP2013500258A (ja) 2013-01-07
RU2015137512A3 (enExample) 2019-04-02
WO2011011592A1 (en) 2011-01-27
EP2456472A4 (en) 2014-08-27
CN104710504A (zh) 2015-06-17
CA2768658C (en) 2018-04-03
IN2012DN00551A (enExample) 2015-06-12
US9603954B2 (en) 2017-03-28
CN104710504B (zh) 2019-09-13
HK1211304A1 (en) 2016-05-20
EP2456472A1 (en) 2012-05-30
CA2768658A1 (en) 2011-01-27
US20120220754A1 (en) 2012-08-30

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