RU2699278C2 - Устройство для инактивации бактерий - Google Patents
Устройство для инактивации бактерий Download PDFInfo
- Publication number
- RU2699278C2 RU2699278C2 RU2016147150A RU2016147150A RU2699278C2 RU 2699278 C2 RU2699278 C2 RU 2699278C2 RU 2016147150 A RU2016147150 A RU 2016147150A RU 2016147150 A RU2016147150 A RU 2016147150A RU 2699278 C2 RU2699278 C2 RU 2699278C2
- Authority
- RU
- Russia
- Prior art keywords
- electrodes
- electric field
- stratum corneum
- skin
- plane
- Prior art date
Links
- 230000001580 bacterial effect Effects 0.000 title claims abstract description 22
- 230000002779 inactivation Effects 0.000 title abstract description 14
- 230000005684 electric field Effects 0.000 claims abstract description 89
- 210000000434 stratum corneum Anatomy 0.000 claims abstract description 88
- 210000003491 skin Anatomy 0.000 claims abstract description 76
- 238000004520 electroporation Methods 0.000 claims abstract description 38
- 210000004027 cell Anatomy 0.000 claims abstract description 31
- 210000002615 epidermis Anatomy 0.000 claims abstract description 27
- 230000007423 decrease Effects 0.000 claims abstract description 16
- 230000035515 penetration Effects 0.000 claims abstract description 14
- 210000004927 skin cell Anatomy 0.000 claims abstract description 6
- 239000011159 matrix material Substances 0.000 claims description 15
- 230000005284 excitation Effects 0.000 claims description 6
- 210000005036 nerve Anatomy 0.000 claims description 6
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 abstract description 37
- 230000000694 effects Effects 0.000 abstract description 7
- 230000007794 irritation Effects 0.000 abstract description 5
- 239000000126 substance Substances 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 2
- 210000004087 cornea Anatomy 0.000 abstract 2
- 230000033228 biological regulation Effects 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
- 239000000523 sample Substances 0.000 description 10
- 210000004243 sweat Anatomy 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 239000011248 coating agent Substances 0.000 description 6
- 238000000576 coating method Methods 0.000 description 6
- 230000006378 damage Effects 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 208000035985 Body Odor Diseases 0.000 description 4
- 210000000170 cell membrane Anatomy 0.000 description 4
- 210000005260 human cell Anatomy 0.000 description 4
- 230000002427 irreversible effect Effects 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 206010040904 Skin odour abnormal Diseases 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000000415 inactivating effect Effects 0.000 description 3
- 238000013271 transdermal drug delivery Methods 0.000 description 3
- 241000446313 Lamella Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 230000005495 cold plasma Effects 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 210000004907 gland Anatomy 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 239000012212 insulator Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- 239000000232 Lipid Bilayer Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000008238 biochemical pathway Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 230000003833 cell viability Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 210000000736 corneocyte Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000005672 electromagnetic field Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000037323 metabolic rate Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 235000019645 odor Nutrition 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 230000008058 pain sensation Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000008823 permeabilization Effects 0.000 description 1
- 238000002428 photodynamic therapy Methods 0.000 description 1
- 238000001126 phototherapy Methods 0.000 description 1
- 230000003334 potential effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- -1 salt ions Chemical class 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 210000005127 stratified epithelium Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000008400 supply water Substances 0.000 description 1
- 230000003746 surface roughness Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000013460 sweaty Diseases 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/03—Electric current
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Electrotherapy Devices (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14166869.9 | 2014-05-02 | ||
| EP14166869 | 2014-05-02 | ||
| PCT/EP2015/059373 WO2015165986A1 (en) | 2014-05-02 | 2015-04-29 | A device for inactivating bacteria |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2016147150A RU2016147150A (ru) | 2018-06-05 |
| RU2016147150A3 RU2016147150A3 (enExample) | 2018-12-07 |
| RU2699278C2 true RU2699278C2 (ru) | 2019-09-04 |
Family
ID=50679877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016147150A RU2699278C2 (ru) | 2014-05-02 | 2015-04-29 | Устройство для инактивации бактерий |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10384051B2 (enExample) |
| EP (1) | EP3137160B1 (enExample) |
| JP (1) | JP6751351B2 (enExample) |
| CN (1) | CN106255525B (enExample) |
| RU (1) | RU2699278C2 (enExample) |
| WO (1) | WO2015165986A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2762988C1 (ru) * | 2020-06-01 | 2021-12-24 | Байосенс Вебстер (Изрэйл) Лтд. | Применение абляции путем необратимой электропорации (нэп) с использованием катетера с матрицей электродов |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180099140A1 (en) * | 2012-06-18 | 2018-04-12 | Michael Tavger | Method and system for triggering wound recovery by delivering solution into the pores of recipient |
| MX375691B (es) * | 2016-03-22 | 2025-03-06 | Koninklijke Philips Nv | Dispositivo de plasma frio para tratar la piel. |
| KR102497377B1 (ko) | 2017-03-27 | 2023-02-08 | 노보셀 리미티드 | 피내 용액 전달을 위한 시스템, 장치, 및 방법 |
| JP6708317B2 (ja) | 2018-03-05 | 2020-06-10 | 株式会社村田製作所 | 抗菌デバイス、及び電気機器 |
| KR102132370B1 (ko) * | 2018-03-13 | 2020-08-05 | 주식회사 지씨에스 | 피부관리장치, 피부관리장치의 구동방법 및 컴퓨터 판독가능 기록매체 |
| CA3183538A1 (en) * | 2020-07-02 | 2022-01-06 | Mary K. CANTY | Method for optimizing treatment of infected metallic implants by measuring charge transfer |
| CN115350400A (zh) * | 2022-09-06 | 2022-11-18 | 北京翌光科技有限公司 | 一种射频美容装置 |
| TWI847384B (zh) * | 2022-11-23 | 2024-07-01 | 國立清華大學 | 熱電驅動穿戴系統 |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5702359A (en) * | 1995-06-06 | 1997-12-30 | Genetronics, Inc. | Needle electrodes for mediated delivery of drugs and genes |
| US5968006A (en) * | 1997-11-04 | 1999-10-19 | Genetronics, Inc. | Method and apparatus for a combination of electroporation and iontophoresis for the delivery of drugs and genes |
| RU2141853C1 (ru) * | 1993-04-01 | 1999-11-27 | Дженетроникс, Инк. | Система для клинического применения электропорации с обратной связью, управляющей напряжением |
| US6711435B2 (en) * | 1998-11-09 | 2004-03-23 | Transpharma Ltd. | Transdermal drug delivery and analyte extraction |
| US20040230227A1 (en) * | 1998-11-09 | 2004-11-18 | Zohar Avrahami | Handheld apparatus and method for transdermal drug delivery and analyte extraction |
| RU2477155C2 (ru) * | 2011-04-27 | 2013-03-10 | Закрытое акционерное общество "Патент-Фарм" | Способ лечения андрогенетической алопеции |
| WO2013066427A1 (en) * | 2011-06-28 | 2013-05-10 | Inovio Pharmaceuticals, Inc. | A miniminally invasive dermal electroporation device |
| US20130260435A1 (en) * | 2010-12-15 | 2013-10-03 | Old Dominion University Research Foundation | Electroporation-induced electrosensitization |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989006555A1 (en) * | 1988-01-21 | 1989-07-27 | Massachusetts Institute Of Technology | Transport of molecules across tissue using electroporation |
| US5983131A (en) * | 1995-08-11 | 1999-11-09 | Massachusetts Institute Of Technology | Apparatus and method for electroporation of tissue |
| JP2002520101A (ja) * | 1998-07-13 | 2002-07-09 | ジェネトロニクス、インコーポレーテッド | 電気的に補助される化粧用薬剤の局部送達法および装置 |
| US7133717B2 (en) * | 1999-08-25 | 2006-11-07 | Johnson & Johnson Consumer Companies, Inc. | Tissue electroperforation for enhanced drug delivery and diagnostic sampling |
| CN1606461B (zh) | 2001-10-24 | 2011-03-23 | 纸型电池有限公司 | 一种用制剂作皮肤治疗的装置、一种成套器具及皮肤贴片 |
| US8734421B2 (en) | 2003-06-30 | 2014-05-27 | Johnson & Johnson Consumer Companies, Inc. | Methods of treating pores on the skin with electricity |
| EP1682217A4 (en) * | 2003-11-13 | 2008-04-30 | Alza Corp | SYSTEM UDN PROCEDURE FOR THE TRANSDERMAL LEVY |
| US20080063866A1 (en) * | 2006-05-26 | 2008-03-13 | Georgia Tech Research Corporation | Method for Making Electrically Conductive Three-Dimensional Structures |
| US20090048651A1 (en) | 2007-08-17 | 2009-02-19 | Biofisica Inc. | Medical electrode systems and methods |
| EP2156860A1 (en) * | 2008-08-20 | 2010-02-24 | Centre National De La Recherche Scientifique-CNRS | Method for producing insulated electrodes for applying electric fields into conductive material |
| US9895189B2 (en) * | 2009-06-19 | 2018-02-20 | Angiodynamics, Inc. | Methods of sterilization and treating infection using irreversible electroporation |
-
2015
- 2015-04-29 US US15/306,850 patent/US10384051B2/en active Active
- 2015-04-29 EP EP15720065.0A patent/EP3137160B1/en active Active
- 2015-04-29 WO PCT/EP2015/059373 patent/WO2015165986A1/en not_active Ceased
- 2015-04-29 JP JP2016565352A patent/JP6751351B2/ja active Active
- 2015-04-29 CN CN201580021888.XA patent/CN106255525B/zh active Active
- 2015-04-29 RU RU2016147150A patent/RU2699278C2/ru active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2141853C1 (ru) * | 1993-04-01 | 1999-11-27 | Дженетроникс, Инк. | Система для клинического применения электропорации с обратной связью, управляющей напряжением |
| US5702359A (en) * | 1995-06-06 | 1997-12-30 | Genetronics, Inc. | Needle electrodes for mediated delivery of drugs and genes |
| US5968006A (en) * | 1997-11-04 | 1999-10-19 | Genetronics, Inc. | Method and apparatus for a combination of electroporation and iontophoresis for the delivery of drugs and genes |
| US6711435B2 (en) * | 1998-11-09 | 2004-03-23 | Transpharma Ltd. | Transdermal drug delivery and analyte extraction |
| US20040230227A1 (en) * | 1998-11-09 | 2004-11-18 | Zohar Avrahami | Handheld apparatus and method for transdermal drug delivery and analyte extraction |
| US20130260435A1 (en) * | 2010-12-15 | 2013-10-03 | Old Dominion University Research Foundation | Electroporation-induced electrosensitization |
| RU2477155C2 (ru) * | 2011-04-27 | 2013-03-10 | Закрытое акционерное общество "Патент-Фарм" | Способ лечения андрогенетической алопеции |
| WO2013066427A1 (en) * | 2011-06-28 | 2013-05-10 | Inovio Pharmaceuticals, Inc. | A miniminally invasive dermal electroporation device |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2762988C1 (ru) * | 2020-06-01 | 2021-12-24 | Байосенс Вебстер (Изрэйл) Лтд. | Применение абляции путем необратимой электропорации (нэп) с использованием катетера с матрицей электродов |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106255525A (zh) | 2016-12-21 |
| EP3137160B1 (en) | 2023-04-19 |
| US20170043154A1 (en) | 2017-02-16 |
| CN106255525B (zh) | 2020-02-11 |
| RU2016147150A3 (enExample) | 2018-12-07 |
| US10384051B2 (en) | 2019-08-20 |
| JP2017520285A (ja) | 2017-07-27 |
| EP3137160A1 (en) | 2017-03-08 |
| JP6751351B2 (ja) | 2020-09-02 |
| RU2016147150A (ru) | 2018-06-05 |
| WO2015165986A1 (en) | 2015-11-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2699278C2 (ru) | Устройство для инактивации бактерий | |
| RU2323017C2 (ru) | Устройство и способ контролируемой доставки активных веществ в кожу | |
| JP5894678B2 (ja) | 患者の経胸的インピーダンスを減少させる器具及び方法 | |
| US6757560B1 (en) | Transdermal delivery system (TDS) with electrode network | |
| JP6118456B2 (ja) | 無線周波数電流を用いた皮膚のための処置装置 | |
| US8343147B2 (en) | Electrolytic tissue treatment | |
| US6795727B2 (en) | Devices and methods for promoting transcutaneous movement of substances | |
| CN105658200A (zh) | 跨组织层递送分子的方法和装置 | |
| JP2010075710A (ja) | 経皮パッチ | |
| JP2017520285A5 (enExample) | ||
| KR20200086695A (ko) | 활성 제제의 경피 전달 장치 및 방법 | |
| ES2800901T3 (es) | Dispositivo de iontoforesis con pieza de extremo multi-electrodo | |
| US20090125025A1 (en) | DC tissue treatment | |
| KR20200116569A (ko) | 경피 전달 촉진을 위한 복합 시술 장치 | |
| CN215135863U (zh) | 微电流纳米微针晶片装置 | |
| KR100899100B1 (ko) | 피부 관리기 | |
| CN112587791A (zh) | 微电流纳米微针晶片装置及导入外泌体的方法 | |
| KR20090090057A (ko) | 갈바닉 이온도입 기능을 갖는 화장품용기 |