RU2698049C2 - Ротавирусные частицы с химерными поверхностными белками - Google Patents

Ротавирусные частицы с химерными поверхностными белками Download PDF

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RU2698049C2
RU2698049C2 RU2016103770A RU2016103770A RU2698049C2 RU 2698049 C2 RU2698049 C2 RU 2698049C2 RU 2016103770 A RU2016103770 A RU 2016103770A RU 2016103770 A RU2016103770 A RU 2016103770A RU 2698049 C2 RU2698049 C2 RU 2698049C2
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protein
rotavirus
linker
adapter
heterologous
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RU2016103770A
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Russian (ru)
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RU2016103770A3 (enExample
RU2016103770A (ru
Inventor
Филип Р. ДОРМИТЦЕР
Николаус ГРИГОРИЕФФ
Стефен Харрисон
Цзюньхуа ПАН
Итан СЕТТЕМБРЕ
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Новартис Аг
Чилдрен'З Медикал Сентер Корпорейшн
Брэндис Юниверсити
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/20—Protein or domain folding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/14—Reoviridae, e.g. rotavirus, bluetongue virus, Colorado tick fever virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/42—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12311—Rotavirus, e.g. rotavirus A
    • C12N2720/12321—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12311—Rotavirus, e.g. rotavirus A
    • C12N2720/12323—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12311—Rotavirus, e.g. rotavirus A
    • C12N2720/12351—Methods of production or purification of viral material

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
RU2016103770A 2013-07-08 2014-07-08 Ротавирусные частицы с химерными поверхностными белками RU2698049C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13175637 2013-07-08
EP13175637.1 2013-07-08
PCT/EP2014/064652 WO2015004158A1 (en) 2013-07-08 2014-07-08 Rotavirus particles with chimeric surface proteins

Publications (3)

Publication Number Publication Date
RU2016103770A RU2016103770A (ru) 2017-08-11
RU2016103770A3 RU2016103770A3 (enExample) 2018-07-25
RU2698049C2 true RU2698049C2 (ru) 2019-08-21

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US (1) US10192025B2 (enExample)
EP (1) EP3019518B1 (enExample)
JP (1) JP6594306B2 (enExample)
CN (1) CN105518022B (enExample)
AU (1) AU2014289274B2 (enExample)
CA (1) CA2916827C (enExample)
ES (1) ES2733279T3 (enExample)
MX (1) MX367150B (enExample)
RU (1) RU2698049C2 (enExample)
WO (1) WO2015004158A1 (enExample)

Families Citing this family (11)

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Publication number Priority date Publication date Assignee Title
SMT202000101T1 (it) * 2008-10-10 2020-03-13 Childrens Medical Center Vaccino con trimero di env di hiv-1 stabilizzato biochimicamente
CN105263506B (zh) 2013-01-07 2018-03-09 贝丝以色列女执事医疗中心 稳定的人免疫缺陷病毒(HIV)包膜(EnV)三聚体疫苗及其使用方法
US10174292B2 (en) 2015-03-20 2019-01-08 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
US9931394B2 (en) 2015-03-23 2018-04-03 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
WO2017071713A1 (en) * 2015-10-30 2017-05-04 University Of Copenhagen Virus like particle with efficient epitope display
MA44418B1 (fr) * 2017-03-02 2021-11-30 Intelligent Virus Imaging Inc Procédé permettant la mesure quantitative de contenu particulaire à l'aide d'une imagerie à l'état hydraté
CN109627295B (zh) * 2018-12-29 2020-08-04 四川大学 一种通用型狂犬病相关病毒g蛋白胞外段的制备方法
CN110144334B (zh) * 2019-05-05 2021-03-16 中国水产科学研究院长江水产研究所 一种共表达草鱼呼肠孤病毒外衣壳蛋白vp4和vp35的重组杆状病毒的制备方法和应用
CN110408637B (zh) * 2019-08-08 2020-12-25 中国水产科学研究院长江水产研究所 一种草鱼出血病酵母口服疫苗及应用
CN114316009B (zh) * 2020-09-29 2023-04-25 上海交通大学 一种能够结合多种病毒的蛋白及其应用
CN115044597A (zh) * 2022-07-22 2022-09-13 态创生物科技(广州)有限公司 基于噬菌体展示和蛋白酶切割的寡肽表达和提纯方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001514A1 (en) * 1987-08-10 1989-02-23 The University Of Melbourne Molecular cloning of human rotavirus serotype 4 gene 9 encoding vp7, the major outer capsid neutralisation specific glycoprotein and expression of vp7 and fragments thereof for use in a vaccine
RU2215035C2 (ru) * 1991-12-06 2003-10-27 Уайтхэд институт фор биомедикл рисерч Рекомбинантный полиовирусный вектор (варианты), способ его получения (варианты), способ индукции иммунного ответа у индивидуума (варианты), способ получения белка (варианты), вакцинная композиция для терапии или профилактики инфекционных заболеваний (варианты)
US20080293039A1 (en) * 2007-03-29 2008-11-27 Msd Korea Co., Ltd. VP7 gene of human rotavirus and composition for diagnosis of human rotavirus infection comprising primer or probe specific to thereof

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EP0235754A2 (en) 1986-03-04 1987-09-09 Abbott Laboratories Composition and methods of use for a lacZ rotavirus fusion protein
WO2006007555A2 (en) * 2004-07-01 2006-01-19 Children's Medical Center Corporation ¨ Rotavirus antigens
US7655439B2 (en) 2005-09-09 2010-02-02 Zymogenetics, Inc. Trimerizing polypeptides
CN102465137B (zh) * 2010-11-05 2014-03-12 上海生物制品研究所有限责任公司 表达轮状病毒类表达颗粒的毕赤酵母、其制备方法及用途

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001514A1 (en) * 1987-08-10 1989-02-23 The University Of Melbourne Molecular cloning of human rotavirus serotype 4 gene 9 encoding vp7, the major outer capsid neutralisation specific glycoprotein and expression of vp7 and fragments thereof for use in a vaccine
RU2215035C2 (ru) * 1991-12-06 2003-10-27 Уайтхэд институт фор биомедикл рисерч Рекомбинантный полиовирусный вектор (варианты), способ его получения (варианты), способ индукции иммунного ответа у индивидуума (варианты), способ получения белка (варианты), вакцинная композиция для терапии или профилактики инфекционных заболеваний (варианты)
US20080293039A1 (en) * 2007-03-29 2008-11-27 Msd Korea Co., Ltd. VP7 gene of human rotavirus and composition for diagnosis of human rotavirus infection comprising primer or probe specific to thereof

Non-Patent Citations (1)

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Title
HUANG P. et al. Spike protein VP8* of human rotavirus recognizes histo-blood group antigens in a type-specific manner J Virol. 2012 May;86(9):4833-43. doi: 10.1128/JVI.05507-11. Epub 2012 Feb 15. *

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Publication number Publication date
WO2015004158A1 (en) 2015-01-15
JP6594306B2 (ja) 2019-10-23
US20160188790A1 (en) 2016-06-30
MX367150B (es) 2019-08-07
JP2016530236A (ja) 2016-09-29
CN105518022A (zh) 2016-04-20
RU2016103770A3 (enExample) 2018-07-25
MX2016000075A (es) 2016-07-19
RU2016103770A (ru) 2017-08-11
EP3019518A1 (en) 2016-05-18
US10192025B2 (en) 2019-01-29
EP3019518B1 (en) 2019-04-03
CN105518022B (zh) 2020-08-18
AU2014289274B2 (en) 2018-11-15
ES2733279T3 (es) 2019-11-28
CA2916827C (en) 2021-11-02
AU2014289274A1 (en) 2016-02-18
CA2916827A1 (en) 2015-01-15

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