RU2688919C1 - Изоксазолиновые композиции и их применение в провилактике или лечении паразитарных инвазий животных - Google Patents
Изоксазолиновые композиции и их применение в провилактике или лечении паразитарных инвазий животных Download PDFInfo
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- RU2688919C1 RU2688919C1 RU2016129474A RU2016129474A RU2688919C1 RU 2688919 C1 RU2688919 C1 RU 2688919C1 RU 2016129474 A RU2016129474 A RU 2016129474A RU 2016129474 A RU2016129474 A RU 2016129474A RU 2688919 C1 RU2688919 C1 RU 2688919C1
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- Russia
- Prior art keywords
- drinking water
- polysorbate
- polysorbate surfactant
- surfactant
- fluralaner
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- BYKRNSHANADUFY-UHFFFAOYSA-M sodium octanoate Chemical compound [Na+].CCCCCCCC([O-])=O BYKRNSHANADUFY-UHFFFAOYSA-M 0.000 description 1
- OGBHACNFHJJTQT-UHFFFAOYSA-M sodium;4-butoxycarbonylphenolate Chemical compound [Na+].CCCCOC(=O)C1=CC=C([O-])C=C1 OGBHACNFHJJTQT-UHFFFAOYSA-M 0.000 description 1
- PESXGULMKCKJCC-UHFFFAOYSA-M sodium;4-methoxycarbonylphenolate Chemical class [Na+].COC(=O)C1=CC=C([O-])C=C1 PESXGULMKCKJCC-UHFFFAOYSA-M 0.000 description 1
- IXMINYBUNCWGER-UHFFFAOYSA-M sodium;4-propoxycarbonylphenolate Chemical class [Na+].CCCOC(=O)C1=CC=C([O-])C=C1 IXMINYBUNCWGER-UHFFFAOYSA-M 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
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Classifications
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- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
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- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Animal Husbandry (AREA)
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- Birds (AREA)
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- Organic Chemistry (AREA)
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- Biochemistry (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (3)
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| EP13199006.1 | 2013-12-20 | ||
| EP13199006 | 2013-12-20 | ||
| PCT/EP2014/078634 WO2015091898A1 (en) | 2013-12-20 | 2014-12-19 | Isoxazoline compositions and use thereof in the prevention or treatment of parasite infestations in animals |
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| RU2019114223A Division RU2791637C2 (ru) | 2013-12-20 | 2014-12-19 | Изоксазолиновые композиции и их применение в профилактике или лечении паразитарных инвазий животных |
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| RU2016129474A RU2016129474A (ru) | 2018-01-25 |
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| RU2688919C1 (ru) * | 2013-12-20 | 2019-05-23 | Интервет Интернэшнл Б.В. | Изоксазолиновые композиции и их применение в провилактике или лечении паразитарных инвазий животных |
| US20170232024A1 (en) | 2014-08-04 | 2017-08-17 | Jerry Tan Eye Surgery Pte Ltd | Pharmaceutical compositions for demodex related blepharitis and eyelid crusting |
| EP4599830A2 (en) * | 2014-12-22 | 2025-08-13 | Intervet International B.V. | Isoxazoline compounds for use in treating demodicosis |
| PL3313400T3 (pl) * | 2015-06-23 | 2022-07-25 | Intervet International B.V. | Roztwór izoksazoliny zawierający witaminę e do stosowania z odkażoną wodą pitną |
| WO2018039508A1 (en) * | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| KR20190091268A (ko) * | 2016-10-31 | 2019-08-05 | 더 스크립스 리서치 인스티튜트 | 매개체 전파 질환의 전염을 예방하기 위한 방법 및 조성물 |
| KR102694519B1 (ko) | 2017-11-07 | 2024-08-13 | 인터벳 인터내셔널 비.브이. | 큰 크기의 이속사졸린 입자를 제조하는 방법 |
| US20210177808A1 (en) * | 2017-11-07 | 2021-06-17 | Intervet Inc. | Injectable isoxazoline pharmaceutical compositions and their use against parasite infestation |
| CA3085787A1 (en) | 2017-12-15 | 2019-06-20 | Tarsus Pharmaceuticals, Inc. | Isoxazoline parasiticide formulations and methods for treating blepharitis |
| EP3726972A1 (en) | 2017-12-20 | 2020-10-28 | Intervet International B.V. | Method and system for external fish parasite monitoring in aquaculture |
| CA3084300A1 (en) | 2017-12-20 | 2019-06-27 | Intervet International B.V. | Method and system for external fish parasite monitoring in aquaculture |
| WO2019121844A1 (en) * | 2017-12-20 | 2019-06-27 | Intervet International B.V. | System for external fish parasite monitoring in aquaculture |
| CN111511202A (zh) * | 2017-12-20 | 2020-08-07 | 英特维特国际股份有限公司 | 用于水产养殖中的鱼外部寄生虫监测的系统 |
| EP3726971A1 (en) | 2017-12-20 | 2020-10-28 | Intervet International B.V. | System for external fish parasite monitoring in aquaculture |
| KR102142916B1 (ko) * | 2018-08-17 | 2020-08-10 | 부산대학교 산학협력단 | 상향식 방법을 통한 난용성 약물을 포함하는 나노현탁액의 제조방법 및 이로 제조된 나노현탁액 |
| EP3986377A4 (en) * | 2019-06-19 | 2023-07-19 | Tarsus Pharmaceuticals, Inc. | Isoxazoline parasiticide formulations and methods for treating blepharitis |
| US20220249445A1 (en) * | 2019-06-19 | 2022-08-11 | Tarsus Pharmaceuticals, Inc. | Isoxazoline parasiticide formulations and methods for treating blepharitis |
| CN116194450A (zh) | 2020-07-24 | 2023-05-30 | 礼蓝美国公司 | 用于制备异噁唑啉化合物及其中间体的工艺 |
| CN114306231B (zh) * | 2021-12-29 | 2023-03-24 | 天津市中升挑战生物科技有限公司 | 一种氟雷拉纳杀虫剂及其制备方法和应用 |
| CN117064851A (zh) * | 2023-09-20 | 2023-11-17 | 中国农业大学 | 一种异噁唑啉类驱虫药制剂的制备方法 |
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-
2014
- 2014-12-19 RU RU2016129474A patent/RU2688919C1/ru active
- 2014-12-19 HU HUE14815365A patent/HUE066811T2/hu unknown
- 2014-12-19 PL PL14815365.3T patent/PL3082867T3/pl unknown
- 2014-12-19 US US15/102,414 patent/US10456358B2/en active Active
- 2014-12-19 PT PT232069062T patent/PT4306168T/pt unknown
- 2014-12-19 JP JP2016540677A patent/JP6581586B2/ja active Active
- 2014-12-19 CN CN201910734505.3A patent/CN110327468B/zh active Active
- 2014-12-19 ES ES14815365T patent/ES2971061T3/es active Active
- 2014-12-19 EP EP14815365.3A patent/EP3082867B1/en active Active
- 2014-12-19 EP EP23206906.2A patent/EP4306168B1/en active Active
- 2014-12-19 CN CN201480068585.9A patent/CN105813651B/zh active Active
- 2014-12-19 WO PCT/EP2014/078634 patent/WO2015091898A1/en active Application Filing
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2021
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2023
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Patent Citations (4)
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| WO2007053902A1 (en) * | 2005-11-10 | 2007-05-18 | Bomac Animal Health Pty Limited | Method of treating parasites |
| WO2009024541A2 (en) * | 2007-08-17 | 2009-02-26 | Intervet International B.V. | Isoxazoline compositions and their use as antiparasitics |
| WO2012089622A2 (en) * | 2010-12-27 | 2012-07-05 | Intervet International B.V. | Topical localized isoxazoline formulation |
| US20130065846A1 (en) * | 2011-09-12 | 2013-03-14 | Mark D. Soll | Parasiticidal compositions comprising an isoxazoline active agent, methods and uses thereof |
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| US11883530B2 (en) | 2024-01-30 |
| JP6581586B2 (ja) | 2019-09-25 |
| ES2971061T3 (es) | 2024-06-03 |
| PT4306168T (pt) | 2025-07-24 |
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| EP3082867B1 (en) | 2024-01-17 |
| CN105813651B (zh) | 2021-11-23 |
| US10456358B2 (en) | 2019-10-29 |
| US20160317439A1 (en) | 2016-11-03 |
| CN110327468B (zh) | 2023-04-28 |
| US20200000720A1 (en) | 2020-01-02 |
| CN110327468A (zh) | 2019-10-15 |
| JP2016540809A (ja) | 2016-12-28 |
| MX373872B (es) | 2020-03-26 |
| RU2016129474A (ru) | 2018-01-25 |
| EP3082867A1 (en) | 2016-10-26 |
| HUE066811T2 (hu) | 2024-09-28 |
| US20240122849A1 (en) | 2024-04-18 |
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| RU2019114223A (ru) | 2019-06-28 |
| US20210353537A1 (en) | 2021-11-18 |
| MX2016008118A (es) | 2016-09-16 |
| WO2015091898A1 (en) | 2015-06-25 |
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