RU2675928C2 - Композиции клеток, полученные из дедифференцированных перепрограммированных клеток - Google Patents

Композиции клеток, полученные из дедифференцированных перепрограммированных клеток Download PDF

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RU2675928C2
RU2675928C2 RU2015131279A RU2015131279A RU2675928C2 RU 2675928 C2 RU2675928 C2 RU 2675928C2 RU 2015131279 A RU2015131279 A RU 2015131279A RU 2015131279 A RU2015131279 A RU 2015131279A RU 2675928 C2 RU2675928 C2 RU 2675928C2
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cells
cell
endoderm
pancreatic
pdx1
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RU2015131279A
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Russian (ru)
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RU2015131279A (ru
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Алан Д. Агулник
Оливия КЕЛЛИ
Юки ОХИ
Аллан РОБИНС
Томас ШУЛЬЦ
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Виасайт, Инк.
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Priority claimed from US13/761,078 external-priority patent/US9109245B2/en
Application filed by Виасайт, Инк. filed Critical Виасайт, Инк.
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
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  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
RU2015131279A 2013-02-06 2014-02-06 Композиции клеток, полученные из дедифференцированных перепрограммированных клеток RU2675928C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/761,078 2013-02-06
US13/761,078 US9109245B2 (en) 2009-04-22 2013-02-06 Cell compositions derived from dedifferentiated reprogrammed cells
PCT/US2014/015156 WO2014124172A1 (en) 2013-02-06 2014-02-06 Cell compositions derived from dedifferentiated reprogrammed cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2018144412A Division RU2754089C2 (ru) 2013-02-06 2014-02-06 Композиции клеток, полученные из дедифференцированных перепрограммированных клеток

Publications (2)

Publication Number Publication Date
RU2015131279A RU2015131279A (ru) 2017-03-13
RU2675928C2 true RU2675928C2 (ru) 2018-12-25

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RU2015131279A RU2675928C2 (ru) 2013-02-06 2014-02-06 Композиции клеток, полученные из дедифференцированных перепрограммированных клеток
RU2018144412A RU2754089C2 (ru) 2013-02-06 2014-02-06 Композиции клеток, полученные из дедифференцированных перепрограммированных клеток

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RU2018144412A RU2754089C2 (ru) 2013-02-06 2014-02-06 Композиции клеток, полученные из дедифференцированных перепрограммированных клеток

Country Status (8)

Country Link
EP (1) EP2954045A1 (enExample)
JP (5) JP6517702B2 (enExample)
AU (4) AU2014214879A1 (enExample)
CA (2) CA2898431C (enExample)
HK (1) HK1218139A1 (enExample)
IL (5) IL321825A (enExample)
RU (2) RU2675928C2 (enExample)
WO (1) WO2014124172A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9109245B2 (en) 2009-04-22 2015-08-18 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
SG11201700874SA (en) 2014-08-04 2017-03-30 Takeda Pharmaceuticals Co Method for proliferation of pancreatic progenitor cells
MA45479A (fr) * 2016-04-14 2019-02-20 Janssen Biotech Inc Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
EP3690022A1 (en) * 2016-05-18 2020-08-05 Keio University Cell culture medium for culturing organoid, culture method, and organoid
EP3587560A4 (en) 2017-01-27 2020-12-16 Kaneka Corporation Endodermal cell mass, and method for producing any one of three primary germ layer cell mass from pluripotent cells
NZ800904A (en) 2017-06-14 2025-08-29 Vertex Pharma Devices and methods for delivering therapeutics
EP3654996A4 (en) * 2017-07-21 2021-03-24 Semma Therapeutics, Inc. REAGGREGATION OF PANCREATIC BETA CELLS DERIVED FROM STEM CELLS
CN112912490B (zh) * 2018-08-03 2023-12-26 千纸鹤治疗公司 细胞制造方法
EP3854869A4 (en) * 2018-09-19 2022-09-07 Takeda Pharmaceutical Company Limited INSULIN-PRODUCING CELLS
EP3976236A1 (en) 2019-05-31 2022-04-06 W.L. Gore & Associates Inc. A biocompatible membrane composite
CA3257300A1 (en) 2019-05-31 2025-06-12 W. L. Gore & Associates, Inc. Cell encapsulation devices with controlled oxygen diffusion distances
EP3975926A1 (en) 2019-05-31 2022-04-06 W.L. Gore & Associates, Inc. A biocompatible membrane composite
CN114173837A (zh) 2019-05-31 2022-03-11 W.L.戈尔及同仁股份有限公司 生物相容性膜复合材料
IL300105A (en) 2020-07-31 2023-03-01 Vertex Pharma Pancreatic endocrine cell differentiation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000059525A2 (en) * 1999-04-06 2000-10-12 Genentech, Inc. USE OF ErbB RECEPTOR LIGANDS IN TREATING DIABETES
US20100272695A1 (en) * 2009-04-22 2010-10-28 Alan Agulnick Cell compositions derived from dedifferentiated reprogrammed cells

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6759039B2 (en) * 2000-06-30 2004-07-06 Amcyte, Inc. Culturing pancreatic stem cells having a specified, intermediate stage of development
WO2002059278A2 (en) * 2001-01-24 2002-08-01 The Government Of The United States Of America, As Represented By The Secretary Of Department Of Health & Human Services Differentiation of stem cells to pancreatic endocrine cells
SG169324A1 (en) * 2005-10-14 2011-03-30 Univ Minnesota Differentiation of non-embryonic stem cells to cells having a pancreatic phenotype
WO2007143193A1 (en) * 2006-06-02 2007-12-13 University Of Georgia Research Foundation, Inc. Pancreatic and liver endoderm cells and tissue by differentiation of definitive endoderm cells obtained from human embryonic stems
JP2012508584A (ja) * 2008-11-14 2012-04-12 ヴィアサイト，インコーポレイテッド ヒト多能性幹細胞由来膵臓細胞のカプセル化
US9109245B2 (en) * 2009-04-22 2015-08-18 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
US8685726B2 (en) * 2009-04-27 2014-04-01 Viacyte, Inc. Small molecules supporting pluripotent cell growth and methods thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000059525A2 (en) * 1999-04-06 2000-10-12 Genentech, Inc. USE OF ErbB RECEPTOR LIGANDS IN TREATING DIABETES
US20100272695A1 (en) * 2009-04-22 2010-10-28 Alan Agulnick Cell compositions derived from dedifferentiated reprogrammed cells

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HUOTARI MA, et al. "ErbB signaling regulates lineage determination of developing pancreatic islet cells in embryonic organ culture", Endocrinology. 2002; 143(11): 4437-4446. *
HUOTARI MA, et al. "ErbB signaling regulates lineage determination of developing pancreatic islet cells in embryonic organ culture", Endocrinology. 2002; 143(11): 4437-4446. KILSOO J, et al. "Differentiation and Transplantation of Functional Pancreatic Beta Cells Generated from Induced Pluripotent Stem Cells Derived from a Type 1 Diabetes Mouse Model", Stem Cell Dev. 2012; 21(14): 2642-2655. ZHU FF, et al. "Generation of pancreatic insulin-producing cells from rhesus monkey induced pluripotent stem cells", Diabetologia. 2011; 54: 2325. *
KILSOO J, et al. "Differentiation and Transplantation of Functional Pancreatic Beta Cells Generated from Induced Pluripotent Stem Cells Derived from a Type 1 Diabetes Mouse Model", Stem Cell Dev. 2012; 21(14): 2642-2655. *
ZHU FF, et al. "Generation of pancreatic insulin-producing cells from rhesus monkey induced pluripotent stem cells", Diabetologia. 2011; 54: 2325. *
ПОЛЯHОВСКИЙ О.Л. и др. "ERBB-онкогены-мишени моноклональных антител", Биохимия. 2012; 77(3): 289-311. *

Also Published As

Publication number Publication date
RU2018144412A3 (enExample) 2020-02-14
IL239953A0 (en) 2015-08-31
AU2022200075C1 (en) 2023-07-06
EP2954045A1 (en) 2015-12-16
JP6721752B2 (ja) 2020-07-15
WO2014124172A1 (en) 2014-08-14
IL290717B1 (en) 2024-06-01
IL290717A (en) 2022-04-01
JP2025000625A (ja) 2025-01-07
IL311689B1 (en) 2025-08-01
CA2898431C (en) 2023-10-17
CA3212301A1 (en) 2014-08-14
RU2015131279A (ru) 2017-03-13
JP7550830B2 (ja) 2024-09-13
AU2019201314A1 (en) 2019-03-14
AU2019201314B2 (en) 2021-10-14
RU2754089C2 (ru) 2021-08-26
IL311689B2 (en) 2025-12-01
AU2023202507A1 (en) 2023-05-11
AU2014214879A1 (en) 2015-07-30
JP2016506736A (ja) 2016-03-07
JP7250731B2 (ja) 2023-04-03
RU2018144412A (ru) 2019-03-25
IL239953B (en) 2021-05-31
IL290717B2 (en) 2024-10-01
CA2898431A1 (en) 2014-08-14
IL283088B (en) 2022-04-01
IL311689A (en) 2024-05-01
AU2022200075A1 (en) 2022-02-03
JP2023017838A (ja) 2023-02-07
JP2019146578A (ja) 2019-09-05
IL321825A (en) 2025-08-01
JP2020178694A (ja) 2020-11-05
JP6517702B2 (ja) 2019-05-22
AU2023202507B2 (en) 2025-12-04
AU2022200075B2 (en) 2023-02-02
HK1218139A1 (zh) 2017-02-03
IL283088A (en) 2021-06-30

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