RU2674995C2 - Фармацевтические комбинации - Google Patents

Фармацевтические комбинации Download PDF

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Publication number
RU2674995C2
RU2674995C2 RU2015124954A RU2015124954A RU2674995C2 RU 2674995 C2 RU2674995 C2 RU 2674995C2 RU 2015124954 A RU2015124954 A RU 2015124954A RU 2015124954 A RU2015124954 A RU 2015124954A RU 2674995 C2 RU2674995 C2 RU 2674995C2
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RU
Russia
Prior art keywords
compound
melanoma
inhibitor compound
pharmaceutically acceptable
combination
Prior art date
Application number
RU2015124954A
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English (en)
Russian (ru)
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RU2015124954A (ru
Inventor
Дейл ПОРТЕР
Кэролайн Эмери
Луцзянь ТАНЬ
Падмаджа ЙЕРРАМИЛЛИ-РАО
Original Assignee
Новартис Аг
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Application filed by Новартис Аг filed Critical Новартис Аг
Publication of RU2015124954A publication Critical patent/RU2015124954A/ru
Application granted granted Critical
Publication of RU2674995C2 publication Critical patent/RU2674995C2/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2015124954A 2012-11-29 2013-11-26 Фармацевтические комбинации RU2674995C2 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261731174P 2012-11-29 2012-11-29
US61/731,174 2012-11-29
US201261731555P 2012-11-30 2012-11-30
US61/731,555 2012-11-30
US201361755520P 2013-01-23 2013-01-23
US61/755,520 2013-01-23
PCT/US2013/071852 WO2014085381A1 (en) 2012-11-29 2013-11-26 Pharmaceutical combinations

Publications (2)

Publication Number Publication Date
RU2015124954A RU2015124954A (ru) 2017-01-11
RU2674995C2 true RU2674995C2 (ru) 2018-12-14

Family

ID=49753513

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2015124954A RU2674995C2 (ru) 2012-11-29 2013-11-26 Фармацевтические комбинации

Country Status (16)

Country Link
US (1) US9446043B2 (enExample)
EP (1) EP2925366B1 (enExample)
JP (1) JP6437444B2 (enExample)
CN (1) CN104812415A (enExample)
AU (1) AU2013352379B2 (enExample)
BR (1) BR112015012497B1 (enExample)
CA (1) CA2892578C (enExample)
DK (1) DK2925366T3 (enExample)
ES (1) ES2669248T3 (enExample)
HU (1) HUE037618T2 (enExample)
NZ (1) NZ708802A (enExample)
PL (1) PL2925366T3 (enExample)
RU (1) RU2674995C2 (enExample)
TR (1) TR201806682T4 (enExample)
UA (1) UA115250C2 (enExample)
WO (1) WO2014085381A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201904851D0 (en) 2019-04-05 2019-05-22 Katholieke Univ Leven Melanoma treatment
US11086278B2 (en) 2019-08-29 2021-08-10 Inventus Holdings, Llc Adaptive system monitoring using incremental regression model development
WO2022221586A1 (en) * 2021-04-15 2022-10-20 Ideaya Biosciences, Inc. Combination therapy comprising a pkc inhibitor and a mek inhibitor
US20260083731A1 (en) * 2022-08-26 2026-03-26 Ideaya Biosciences, Inc. Methods of treating uveal melanoma with a pkc inhibitor
GB202408599D0 (en) * 2024-06-14 2024-07-31 Vasopharma Ab Combination treatments
GB202408598D0 (en) * 2024-06-14 2024-07-31 Edvince Ab Combination treatments

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002038561A1 (en) * 2000-11-07 2002-05-16 Novartis Ag Indolylmaleimide derivatives as protein kinase c inhibitors
WO2003077914A1 (en) * 2002-03-13 2003-09-25 Array Biopharma, Inc N3 alkylated benzimidazole derivatives as mek inhibitors
US20050009767A1 (en) * 2003-07-10 2005-01-13 Icn Pharmaceuticals Switzerland Ag Use of ribofuranose derivatives against inflammatory bowel diseases

Family Cites Families (12)

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US5489608A (en) 1989-12-21 1996-02-06 Goedecke Aktiengesellschaft Indolocarbazole derivatives and the use thereof
US5475085A (en) 1991-02-07 1995-12-12 Molecumetics, Ltd. Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same
PL182124B1 (pl) 1993-12-07 2001-11-30 Lilly Co Eli Nowe zwiazki oraz srodek farmaceutyczny przeznaczony do leczenia powiklan cukrzycowych lub do leczenia nowotworów PL PL PL PL PL PL PL PL
US5545636A (en) 1993-12-23 1996-08-13 Eli Lilly And Company Protein kinase C inhibitors
DK0817627T3 (da) 1993-12-23 2005-06-06 Lilly Co Eli Inhibitorer af proteinkinase C
CA2237221C (en) 1995-11-20 2003-03-25 Eli Lilly And Company Protein kinase c inhibitor
WO2002006213A2 (en) 2000-07-19 2002-01-24 Warner-Lambert Company Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids
US6645970B2 (en) 2000-11-07 2003-11-11 Novartis Ag Indolylmaleimide derivatives
PE20040079A1 (es) 2002-04-03 2004-04-19 Novartis Ag Derivados de indolilmaleimida
PT2298768E (pt) 2004-06-11 2012-12-05 Japan Tobacco Inc Derivados de 5-amino-2,4,7-trioxo-3,4,7,8-tetra-hidro-2hpirido[ 2,3-d]pirimidina e compostos relacionados para o tratamento do cancro
CN102898364A (zh) 2005-05-18 2013-01-30 阵列生物制药公司 Mek的杂环抑制剂及其使用方法
PL1904482T3 (pl) 2005-07-11 2011-06-30 Novartis Ag Pochodne indolilomaleimidowe

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002038561A1 (en) * 2000-11-07 2002-05-16 Novartis Ag Indolylmaleimide derivatives as protein kinase c inhibitors
WO2003077914A1 (en) * 2002-03-13 2003-09-25 Array Biopharma, Inc N3 alkylated benzimidazole derivatives as mek inhibitors
US20050009767A1 (en) * 2003-07-10 2005-01-13 Icn Pharmaceuticals Switzerland Ag Use of ribofuranose derivatives against inflammatory bowel diseases

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CAMPILLO N.E. In silico ADME Approaches // Frontiers in Drug Design & Discovery 4, 2009, стр. 320. PHENEGER J. et al. Characterization of ARRY-438162, a potent MEK inhibitor in combination with Methotreaxate or Ibuprofen in vivo modls of arthritis // American College of Rheumatology, Annual Scientific Meeting, 2006. U0126 Bis[amino[(2-aminophenyl)thio]methylene] butanedinitrile // Life Technolodies, 09.09.2011. Приказ 82 Министерства Здравоохранения Российской Федерации, 29.02.2000, стр. 4. *
WU X. et al. The protein kinase C inhibitor Enzastaurin exhibits antitumor activity against uveal melanoma // PLoS *
WU X. et al. The protein kinase C inhibitor Enzastaurin exhibits antitumor activity against uveal melanoma // PLoS ONE 12.01.2012 *

Also Published As

Publication number Publication date
RU2015124954A (ru) 2017-01-11
BR112015012497A8 (pt) 2019-10-01
PL2925366T3 (pl) 2018-08-31
CA2892578C (en) 2021-01-12
US20150306101A1 (en) 2015-10-29
JP6437444B2 (ja) 2018-12-12
NZ708802A (en) 2019-09-27
WO2014085381A1 (en) 2014-06-05
AU2013352379B2 (en) 2018-09-06
DK2925366T3 (en) 2018-06-06
EP2925366A1 (en) 2015-10-07
CA2892578A1 (en) 2014-06-05
BR112015012497A2 (pt) 2017-07-11
UA115250C2 (uk) 2017-10-10
JP2016501222A (ja) 2016-01-18
CN104812415A (zh) 2015-07-29
BR112015012497B1 (pt) 2022-05-17
AU2013352379A1 (en) 2015-06-11
TR201806682T4 (tr) 2018-06-21
ES2669248T3 (es) 2018-05-24
EP2925366B1 (en) 2018-02-21
HK1215789A1 (en) 2016-09-15
US9446043B2 (en) 2016-09-20
HUE037618T2 (hu) 2018-09-28

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