NZ708802A - Pharmaceutical combinations comprising a protein kinase c inhibitor compound and a mitogen activated protein kinase inhibitor compound - Google Patents
Pharmaceutical combinations comprising a protein kinase c inhibitor compound and a mitogen activated protein kinase inhibitor compoundInfo
- Publication number
- NZ708802A NZ708802A NZ70880213A NZ70880213A NZ708802A NZ 708802 A NZ708802 A NZ 708802A NZ 70880213 A NZ70880213 A NZ 70880213A NZ 70880213 A NZ70880213 A NZ 70880213A NZ 708802 A NZ708802 A NZ 708802A
- Authority
- NZ
- New Zealand
- Prior art keywords
- inhibitor compound
- protein kinase
- pharmaceutically acceptable
- mitogen activated
- combination
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261731174P | 2012-11-29 | 2012-11-29 | |
| US201261731555P | 2012-11-30 | 2012-11-30 | |
| US201361755520P | 2013-01-23 | 2013-01-23 | |
| PCT/US2013/071852 WO2014085381A1 (en) | 2012-11-29 | 2013-11-26 | Pharmaceutical combinations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ708802A true NZ708802A (en) | 2019-09-27 |
Family
ID=49753513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ70880213A NZ708802A (en) | 2012-11-29 | 2013-11-26 | Pharmaceutical combinations comprising a protein kinase c inhibitor compound and a mitogen activated protein kinase inhibitor compound |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9446043B2 (enExample) |
| EP (1) | EP2925366B1 (enExample) |
| JP (1) | JP6437444B2 (enExample) |
| CN (1) | CN104812415A (enExample) |
| AU (1) | AU2013352379B2 (enExample) |
| BR (1) | BR112015012497B1 (enExample) |
| CA (1) | CA2892578C (enExample) |
| DK (1) | DK2925366T3 (enExample) |
| ES (1) | ES2669248T3 (enExample) |
| HU (1) | HUE037618T2 (enExample) |
| NZ (1) | NZ708802A (enExample) |
| PL (1) | PL2925366T3 (enExample) |
| RU (1) | RU2674995C2 (enExample) |
| TR (1) | TR201806682T4 (enExample) |
| UA (1) | UA115250C2 (enExample) |
| WO (1) | WO2014085381A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201904851D0 (en) | 2019-04-05 | 2019-05-22 | Katholieke Univ Leven | Melanoma treatment |
| US11086278B2 (en) | 2019-08-29 | 2021-08-10 | Inventus Holdings, Llc | Adaptive system monitoring using incremental regression model development |
| WO2022221586A1 (en) * | 2021-04-15 | 2022-10-20 | Ideaya Biosciences, Inc. | Combination therapy comprising a pkc inhibitor and a mek inhibitor |
| EP4577309A2 (en) * | 2022-08-26 | 2025-07-02 | Ideaya Biosciences, Inc. | Methods of treating uveal melanoma with a pkc inhibitor |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5489608A (en) | 1989-12-21 | 1996-02-06 | Goedecke Aktiengesellschaft | Indolocarbazole derivatives and the use thereof |
| US5475085A (en) | 1991-02-07 | 1995-12-12 | Molecumetics, Ltd. | Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same |
| NO308798B1 (no) | 1993-12-07 | 2000-10-30 | Lilly Co Eli | Proteinkinase-C-hemmere, anvendelse av samme for fremstilling av farmasøytika samt farmasøytisk formulering omfattende samme |
| US5545636A (en) | 1993-12-23 | 1996-08-13 | Eli Lilly And Company | Protein kinase C inhibitors |
| ATE456367T1 (de) | 1993-12-23 | 2010-02-15 | Lilly Co Eli | Proteinkinase c inhibitoren |
| ZA969646B (en) | 1995-11-20 | 1998-05-18 | Lilly Co Eli | Protein kinase C inhibitor. |
| IL153817A0 (en) | 2000-07-19 | 2003-07-31 | Warner Lambert Co | Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids |
| US6645970B2 (en) | 2000-11-07 | 2003-11-11 | Novartis Ag | Indolylmaleimide derivatives |
| PE20020544A1 (es) | 2000-11-07 | 2002-07-30 | Novartis Ag | Derivados de indolilmaleimida |
| CA2478374C (en) | 2002-03-13 | 2009-01-06 | Eli M. Wallace | N3 alkylated benzimidazole derivatives as mek inhibitors |
| AR039209A1 (es) | 2002-04-03 | 2005-02-09 | Novartis Ag | Derivados de indolilmaleimida |
| US6930093B2 (en) * | 2003-07-10 | 2005-08-16 | Valeant Research & Development | Use of ribofuranose derivatives against inflammatory bowel diseases |
| PT1761528E (pt) | 2004-06-11 | 2008-04-15 | Japan Tobacco Inc | Derivados de 5-amino-2,4,7-trioxo-3,4,7,8-tetra-hidro-2hpirido[ 2,3-d]pirimidina e compostos relacionados para o tratamento do cancro |
| RU2500673C2 (ru) | 2005-05-18 | 2013-12-10 | Астразенека Аб | Гетероциклические ингибиторы мек и способы их применения |
| US7781438B2 (en) | 2005-07-11 | 2010-08-24 | Novartis Ag | Indolylmaleimide derivatives |
-
2013
- 2013-11-26 PL PL13802815T patent/PL2925366T3/pl unknown
- 2013-11-26 US US14/647,939 patent/US9446043B2/en active Active
- 2013-11-26 JP JP2015545170A patent/JP6437444B2/ja active Active
- 2013-11-26 CN CN201380061889.8A patent/CN104812415A/zh active Pending
- 2013-11-26 BR BR112015012497-6A patent/BR112015012497B1/pt active IP Right Grant
- 2013-11-26 DK DK13802815.4T patent/DK2925366T3/en active
- 2013-11-26 AU AU2013352379A patent/AU2013352379B2/en active Active
- 2013-11-26 TR TR2018/06682T patent/TR201806682T4/tr unknown
- 2013-11-26 RU RU2015124954A patent/RU2674995C2/ru active
- 2013-11-26 EP EP13802815.4A patent/EP2925366B1/en active Active
- 2013-11-26 WO PCT/US2013/071852 patent/WO2014085381A1/en not_active Ceased
- 2013-11-26 NZ NZ70880213A patent/NZ708802A/en unknown
- 2013-11-26 CA CA2892578A patent/CA2892578C/en active Active
- 2013-11-26 ES ES13802815.4T patent/ES2669248T3/es active Active
- 2013-11-26 HU HUE13802815A patent/HUE037618T2/hu unknown
- 2013-11-26 UA UAA201505167A patent/UA115250C2/uk unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1215789A1 (en) | 2016-09-15 |
| AU2013352379B2 (en) | 2018-09-06 |
| US9446043B2 (en) | 2016-09-20 |
| PL2925366T3 (pl) | 2018-08-31 |
| RU2015124954A (ru) | 2017-01-11 |
| BR112015012497A8 (pt) | 2019-10-01 |
| BR112015012497A2 (pt) | 2017-07-11 |
| UA115250C2 (uk) | 2017-10-10 |
| HUE037618T2 (hu) | 2018-09-28 |
| RU2674995C2 (ru) | 2018-12-14 |
| BR112015012497B1 (pt) | 2022-05-17 |
| AU2013352379A1 (en) | 2015-06-11 |
| CN104812415A (zh) | 2015-07-29 |
| EP2925366A1 (en) | 2015-10-07 |
| CA2892578A1 (en) | 2014-06-05 |
| EP2925366B1 (en) | 2018-02-21 |
| WO2014085381A1 (en) | 2014-06-05 |
| JP6437444B2 (ja) | 2018-12-12 |
| JP2016501222A (ja) | 2016-01-18 |
| CA2892578C (en) | 2021-01-12 |
| TR201806682T4 (tr) | 2018-06-21 |
| DK2925366T3 (en) | 2018-06-06 |
| ES2669248T3 (es) | 2018-05-24 |
| US20150306101A1 (en) | 2015-10-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NZ703940A (en) | Pharmaceutical combinations comprising a b-raf inhibitor, an egfr inhibitor and optionally a pi3k-alpha inhibitor | |
| MX2015001122A (es) | Combinaciones farmaceuticas de un inhibidor de cdk4/6 y un inhibidor de b-raf. | |
| MX2014010590A (es) | Terapia de combinacion para trastornos proliferativos. | |
| MX2016008362A (es) | Combinaciones farmaceuticas. | |
| MX2021004639A (es) | Combinaciones de inhibidores de desmetilasa-1 especifica de lisina (lsd1) para uso en el tratamiento de tumores solidos. | |
| EA201070167A1 (ru) | Замещенные производные индазола, активные как ингибиторы киназы | |
| MX393855B (es) | Terapia de combinación que comprende un inhibidor de raf y trametinib | |
| MX346186B (es) | Inhibidores de proteina cinasas. | |
| PH12016501394A1 (en) | Compounds for treating patients with ros1 mutant cancer cells | |
| EA201101507A1 (ru) | Способы лечения солидных опухолей | |
| ATE557015T1 (de) | 3,4-diarylpyrazole als proteinkinaseinhibitoren | |
| WO2015054619A8 (en) | Use of a pcsk9 inhibitor to treat hyperlipidemia | |
| UA94097C2 (ru) | Пиридил- и пиримидинилзамещенные производной пиррола, тиофена и фурана как ингибиторы киназ | |
| MX2014002471A (es) | Combinaciones sinergicas de los inhibidores de p13k y mek. | |
| BR112013032122A2 (pt) | liberação modificada de 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)fenil] benzamida solubilizada usando ácidos orgânicos | |
| TN2013000414A1 (en) | 4-amino-5-fluoro-3- [6- (4 -methylpiperazin- 1 - yl) - 1h - benzimidazol - 2 - yl] - 1h - quinoli n-2-one for use in the treatment of adenoid cystic carcinoma | |
| NZ714963A (en) | Compositions and methods for treating anemia | |
| MX2015002005A (es) | Combinacion de inhibidor de p13k e inhibidor de c-met. | |
| WO2013142182A3 (en) | Combination therapy of a mek inhibitor and igf1r inhibitor | |
| NZ708802A (en) | Pharmaceutical combinations comprising a protein kinase c inhibitor compound and a mitogen activated protein kinase inhibitor compound | |
| NZ602807A (en) | 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one and an mtor inhibitor | |
| MX2016010482A (es) | Combinaciones farmaceuticas que comprenden un inhibidor de pi3k para el tratamiento de cancer. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 26 NOV 2021 BY THOMSON REUTERS Effective date: 20200926 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 26 NOV 2022 BY THOMSON REUTERS Effective date: 20211002 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 26 NOV 2023 BY THOMSON REUTERS Effective date: 20221003 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 26 NOV 2024 BY THOMSON REUTERS Effective date: 20231002 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 26 NOV 2025 BY THOMSON REUTERS Effective date: 20241002 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 26 NOV 2026 BY THOMSON REUTERS Effective date: 20251001 |