DK2925366T3 - PHARMACEUTICAL COMBINATIONS - Google Patents
PHARMACEUTICAL COMBINATIONS Download PDFInfo
- Publication number
- DK2925366T3 DK2925366T3 DK13802815.4T DK13802815T DK2925366T3 DK 2925366 T3 DK2925366 T3 DK 2925366T3 DK 13802815 T DK13802815 T DK 13802815T DK 2925366 T3 DK2925366 T3 DK 2925366T3
- Authority
- DK
- Denmark
- Prior art keywords
- compound
- combination
- pharmaceutically acceptable
- inhibitor compound
- aeb071
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- HSZCJVZRHXPCIA-UHFFFAOYSA-N n-benzyl-n-ethylaniline Chemical compound C=1C=CC=CC=1N(CC)CC1=CC=CC=C1 HSZCJVZRHXPCIA-UHFFFAOYSA-N 0.000 description 1
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- 239000008279 sol Substances 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US201261731174P | 2012-11-29 | 2012-11-29 | |
| US201261731555P | 2012-11-30 | 2012-11-30 | |
| US201361755520P | 2013-01-23 | 2013-01-23 | |
| PCT/US2013/071852 WO2014085381A1 (en) | 2012-11-29 | 2013-11-26 | Pharmaceutical combinations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2925366T3 true DK2925366T3 (en) | 2018-06-06 |
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| US (1) | US9446043B2 (enExample) |
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| JP (1) | JP6437444B2 (enExample) |
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| BR (1) | BR112015012497B1 (enExample) |
| CA (1) | CA2892578C (enExample) |
| DK (1) | DK2925366T3 (enExample) |
| ES (1) | ES2669248T3 (enExample) |
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| TR (1) | TR201806682T4 (enExample) |
| UA (1) | UA115250C2 (enExample) |
| WO (1) | WO2014085381A1 (enExample) |
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| GB201904851D0 (en) | 2019-04-05 | 2019-05-22 | Katholieke Univ Leven | Melanoma treatment |
| US11086278B2 (en) | 2019-08-29 | 2021-08-10 | Inventus Holdings, Llc | Adaptive system monitoring using incremental regression model development |
| WO2022221586A1 (en) * | 2021-04-15 | 2022-10-20 | Ideaya Biosciences, Inc. | Combination therapy comprising a pkc inhibitor and a mek inhibitor |
| US20260083731A1 (en) * | 2022-08-26 | 2026-03-26 | Ideaya Biosciences, Inc. | Methods of treating uveal melanoma with a pkc inhibitor |
| GB202408599D0 (en) * | 2024-06-14 | 2024-07-31 | Vasopharma Ab | Combination treatments |
| GB202408598D0 (en) * | 2024-06-14 | 2024-07-31 | Edvince Ab | Combination treatments |
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| US5489608A (en) | 1989-12-21 | 1996-02-06 | Goedecke Aktiengesellschaft | Indolocarbazole derivatives and the use thereof |
| US5475085A (en) | 1991-02-07 | 1995-12-12 | Molecumetics, Ltd. | Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same |
| PL182124B1 (pl) | 1993-12-07 | 2001-11-30 | Lilly Co Eli | Nowe zwiazki oraz srodek farmaceutyczny przeznaczony do leczenia powiklan cukrzycowych lub do leczenia nowotworów PL PL PL PL PL PL PL PL |
| US5545636A (en) | 1993-12-23 | 1996-08-13 | Eli Lilly And Company | Protein kinase C inhibitors |
| DK0817627T3 (da) | 1993-12-23 | 2005-06-06 | Lilly Co Eli | Inhibitorer af proteinkinase C |
| CA2237221C (en) | 1995-11-20 | 2003-03-25 | Eli Lilly And Company | Protein kinase c inhibitor |
| WO2002006213A2 (en) | 2000-07-19 | 2002-01-24 | Warner-Lambert Company | Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids |
| SG159378A1 (en) | 2000-11-07 | 2010-03-30 | Novartis Ag | Indolylmaleimide derivatives as protein kinase c inhibitors |
| US6645970B2 (en) | 2000-11-07 | 2003-11-11 | Novartis Ag | Indolylmaleimide derivatives |
| TWI343377B (en) | 2002-03-13 | 2011-06-11 | Array Biopharma Inc | N3 alkylated benzimidazole derivatives as mek inhibitors |
| PE20040079A1 (es) | 2002-04-03 | 2004-04-19 | Novartis Ag | Derivados de indolilmaleimida |
| US6930093B2 (en) * | 2003-07-10 | 2005-08-16 | Valeant Research & Development | Use of ribofuranose derivatives against inflammatory bowel diseases |
| PT2298768E (pt) | 2004-06-11 | 2012-12-05 | Japan Tobacco Inc | Derivados de 5-amino-2,4,7-trioxo-3,4,7,8-tetra-hidro-2hpirido[ 2,3-d]pirimidina e compostos relacionados para o tratamento do cancro |
| CN102898364A (zh) | 2005-05-18 | 2013-01-30 | 阵列生物制药公司 | Mek的杂环抑制剂及其使用方法 |
| PL1904482T3 (pl) | 2005-07-11 | 2011-06-30 | Novartis Ag | Pochodne indolilomaleimidowe |
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- 2013-11-26 RU RU2015124954A patent/RU2674995C2/ru active
- 2013-11-26 HU HUE13802815A patent/HUE037618T2/hu unknown
- 2013-11-26 TR TR2018/06682T patent/TR201806682T4/tr unknown
- 2013-11-26 UA UAA201505167A patent/UA115250C2/uk unknown
- 2013-11-26 WO PCT/US2013/071852 patent/WO2014085381A1/en not_active Ceased
- 2013-11-26 PL PL13802815T patent/PL2925366T3/pl unknown
- 2013-11-26 NZ NZ70880213A patent/NZ708802A/en unknown
- 2013-11-26 DK DK13802815.4T patent/DK2925366T3/en active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2015124954A (ru) | 2017-01-11 |
| BR112015012497A8 (pt) | 2019-10-01 |
| PL2925366T3 (pl) | 2018-08-31 |
| CA2892578C (en) | 2021-01-12 |
| US20150306101A1 (en) | 2015-10-29 |
| JP6437444B2 (ja) | 2018-12-12 |
| NZ708802A (en) | 2019-09-27 |
| WO2014085381A1 (en) | 2014-06-05 |
| AU2013352379B2 (en) | 2018-09-06 |
| EP2925366A1 (en) | 2015-10-07 |
| CA2892578A1 (en) | 2014-06-05 |
| BR112015012497A2 (pt) | 2017-07-11 |
| UA115250C2 (uk) | 2017-10-10 |
| JP2016501222A (ja) | 2016-01-18 |
| CN104812415A (zh) | 2015-07-29 |
| BR112015012497B1 (pt) | 2022-05-17 |
| AU2013352379A1 (en) | 2015-06-11 |
| TR201806682T4 (tr) | 2018-06-21 |
| ES2669248T3 (es) | 2018-05-24 |
| EP2925366B1 (en) | 2018-02-21 |
| HK1215789A1 (en) | 2016-09-15 |
| US9446043B2 (en) | 2016-09-20 |
| RU2674995C2 (ru) | 2018-12-14 |
| HUE037618T2 (hu) | 2018-09-28 |
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