RU2667072C2 - Производство молибдена-99 с использованием электронных пучков - Google Patents
Производство молибдена-99 с использованием электронных пучков Download PDFInfo
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- RU2667072C2 RU2667072C2 RU2015155247A RU2015155247A RU2667072C2 RU 2667072 C2 RU2667072 C2 RU 2667072C2 RU 2015155247 A RU2015155247 A RU 2015155247A RU 2015155247 A RU2015155247 A RU 2015155247A RU 2667072 C2 RU2667072 C2 RU 2667072C2
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 18
- ZOKXTWBITQBERF-AKLPVKDBSA-N Molybdenum Mo-99 Chemical compound [99Mo] ZOKXTWBITQBERF-AKLPVKDBSA-N 0.000 title claims abstract description 8
- 229950009740 molybdenum mo-99 Drugs 0.000 title claims abstract description 8
- 238000010894 electron beam technology Methods 0.000 title claims description 44
- 238000006243 chemical reaction Methods 0.000 claims abstract description 16
- 238000012546 transfer Methods 0.000 claims abstract description 15
- 230000004907 flux Effects 0.000 claims abstract description 8
- 238000001816 cooling Methods 0.000 claims description 53
- 230000005461 Bremsstrahlung Effects 0.000 claims description 23
- 229910052715 tantalum Inorganic materials 0.000 claims description 13
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims description 13
- 229910052751 metal Inorganic materials 0.000 claims description 12
- 239000002184 metal Substances 0.000 claims description 12
- 230000001681 protective effect Effects 0.000 claims description 12
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 7
- 229910052802 copper Inorganic materials 0.000 claims description 7
- 239000010949 copper Substances 0.000 claims description 7
- 238000009434 installation Methods 0.000 claims description 7
- 230000001678 irradiating effect Effects 0.000 claims description 6
- ZOKXTWBITQBERF-RNFDNDRNSA-N molybdenum-100 Chemical compound [100Mo] ZOKXTWBITQBERF-RNFDNDRNSA-N 0.000 claims description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 4
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 150000002739 metals Chemical class 0.000 claims description 3
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims description 3
- 229910052721 tungsten Inorganic materials 0.000 claims description 3
- 239000010937 tungsten Substances 0.000 claims description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 2
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- 229910017052 cobalt Inorganic materials 0.000 claims description 2
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- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 2
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- 229910052763 palladium Inorganic materials 0.000 claims description 2
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- 239000010948 rhodium Substances 0.000 claims description 2
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 claims description 2
- 238000012384 transportation and delivery Methods 0.000 claims description 2
- 229910052725 zinc Inorganic materials 0.000 claims description 2
- 239000011701 zinc Substances 0.000 claims description 2
- 239000012809 cooling fluid Substances 0.000 claims 4
- 229910052713 technetium Inorganic materials 0.000 claims 2
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 12
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- 239000000126 substance Substances 0.000 abstract 1
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- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 30
- 229910052750 molybdenum Inorganic materials 0.000 description 29
- 239000011733 molybdenum Substances 0.000 description 28
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- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 6
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 3
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- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 229910052790 beryllium Inorganic materials 0.000 description 2
- ATBAMAFKBVZNFJ-UHFFFAOYSA-N beryllium atom Chemical compound [Be] ATBAMAFKBVZNFJ-UHFFFAOYSA-N 0.000 description 2
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- 229910052709 silver Inorganic materials 0.000 description 2
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- 238000001228 spectrum Methods 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- FRWYFWZENXDZMU-UHFFFAOYSA-N 2-iodoquinoline Chemical compound C1=CC=CC2=NC(I)=CC=C21 FRWYFWZENXDZMU-UHFFFAOYSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 229910001080 W alloy Inorganic materials 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000000908 ammonium hydroxide Substances 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- LTPBRCUWZOMYOC-UHFFFAOYSA-N beryllium oxide Inorganic materials O=[Be] LTPBRCUWZOMYOC-UHFFFAOYSA-N 0.000 description 1
- 230000037182 bone density Effects 0.000 description 1
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- 229940056501 technetium 99m Drugs 0.000 description 1
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- 229910052719 titanium Inorganic materials 0.000 description 1
- JFALSRSLKYAFGM-OIOBTWANSA-N uranium-235 Chemical compound [235U] JFALSRSLKYAFGM-OIOBTWANSA-N 0.000 description 1
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Images
Classifications
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
- G21K1/00—Arrangements for handling particles or ionising radiation, e.g. focusing or moderating
- G21K1/10—Scattering devices; Absorbing devices; Ionising radiation filters
- G21K1/12—Resonant absorbers or driving arrangements therefor, e.g. for Moessbauer-effect devices
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
- G21G1/12—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by electromagnetic irradiation, e.g. with gamma or X-rays
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H6/00—Targets for producing nuclear reactions
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H9/00—Linear accelerators
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
- G21G2001/0036—Molybdenum
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
- G21K5/00—Irradiation devices
- G21K5/08—Holders for targets or for other objects to be irradiated
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- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- High Energy & Nuclear Physics (AREA)
- Plasma & Fusion (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Optics & Photonics (AREA)
- General Chemical & Material Sciences (AREA)
- Particle Accelerators (AREA)
- Physical Vapour Deposition (AREA)
- Manufacture And Refinement Of Metals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2816453 | 2013-05-23 | ||
| CA2816453A CA2816453C (fr) | 2013-05-23 | 2013-05-23 | Production de molybdene 99 au moyen de faisceaux d'electrons |
| PCT/CA2014/050479 WO2014186898A1 (fr) | 2013-05-23 | 2014-05-23 | Production de molybdène-99 à l'aide de faisceaux d'électrons |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015155247A RU2015155247A (ru) | 2017-06-28 |
| RU2667072C2 true RU2667072C2 (ru) | 2018-09-14 |
Family
ID=51932678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015155247A RU2667072C2 (ru) | 2013-05-23 | 2014-05-23 | Производство молибдена-99 с использованием электронных пучков |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP3000114B1 (fr) |
| JP (1) | JP6426716B2 (fr) |
| CN (1) | CN105453187B (fr) |
| AU (1) | AU2014271174B2 (fr) |
| BR (1) | BR112015029336A2 (fr) |
| CA (1) | CA2816453C (fr) |
| HK (1) | HK1222944A1 (fr) |
| IL (1) | IL242695B (fr) |
| RU (1) | RU2667072C2 (fr) |
| WO (1) | WO2014186898A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2692729C2 (ru) * | 2012-04-27 | 2019-06-26 | Триумф | Способы, системы и устройство для циклотронного получения технеция-99m |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9837176B2 (en) | 2013-05-23 | 2017-12-05 | Canadian Light Source Inc. | Production of molybdenum-99 using electron beams |
| US9892808B2 (en) | 2013-05-23 | 2018-02-13 | Canadian Light Source Inc. | Production of molybdenum-99 using electron beams |
| CA2892495C (fr) * | 2014-05-23 | 2023-03-21 | Canadian Light Source Inc. | Production de molybdene 99 a l'aide de faisceaux d'electrons |
| NL2016110A (en) * | 2015-03-03 | 2016-09-30 | Asml Netherlands Bv | Radioisotope Production. |
| JP6339034B2 (ja) * | 2015-03-09 | 2018-06-06 | 住友重機械工業株式会社 | 放射性同位元素精製装置 |
| CN105355254B (zh) * | 2015-10-19 | 2017-12-19 | 中国科学院近代物理研究所 | 加速器运行在线连续可调圆孔限束光阑 |
| JP6752590B2 (ja) * | 2016-02-29 | 2020-09-09 | 日本メジフィジックス株式会社 | ターゲット装置および放射性核種製造装置 |
| WO2018137042A1 (fr) * | 2017-01-26 | 2018-08-02 | Canadian Light Source Inc. | Fenêtre de sortie de faisceau d'électrons pour la production d'isotopes |
| US11286172B2 (en) | 2017-02-24 | 2022-03-29 | BWXT Isotope Technology Group, Inc. | Metal-molybdate and method for making the same |
| EP3474637B1 (fr) * | 2017-10-20 | 2020-07-15 | Soletanche Freyssinet | Système de rechargement et de transport automatique pour cibles solides |
| KR20210064214A (ko) * | 2018-08-27 | 2021-06-02 | 비더블유엑스티 아이소토프 테크놀로지 그룹, 인크. | 방사성 동위원소를 생산하기 위한 표적 조사 시스템 |
| TWI684184B (zh) * | 2019-01-23 | 2020-02-01 | 日商住友重機械工業股份有限公司 | 自屏蔽迴旋加速器系統 |
| CN110473645B (zh) * | 2019-08-20 | 2024-03-01 | 西安迈斯拓扑科技有限公司 | 基于韧致辐射和光核反应双功能靶的99Mo生产方法及设备 |
| CN110706840B (zh) * | 2019-10-18 | 2021-01-05 | 中国科学院合肥物质科学研究院 | 一种基于加速器驱动的99Mo次临界生产装置及方法 |
| RU2716818C1 (ru) * | 2019-10-18 | 2020-03-17 | Акционерное общество "Государственный научный центр Российской Федерации - Физико-энергетический институт имени А.И. Лейпунского" | Устройство для производства радионуклидов |
| RU2716824C1 (ru) * | 2019-10-18 | 2020-03-17 | Акционерное общество "Государственный научный центр Российской Федерации - Физико-энергетический институт имени А.И. Лейпунского" | Мишенный узел ускорителя электронов |
| CN110853792B (zh) * | 2019-11-11 | 2021-07-23 | 西安迈斯拓扑科技有限公司 | 基于高功率电子加速器生产医用同位素的方法和设备 |
| CN112289574A (zh) * | 2020-10-22 | 2021-01-29 | 叶振磊 | 一种隔爆型变压器制造加工系统 |
| CN113351017B (zh) * | 2021-06-23 | 2022-04-08 | 中国核动力研究设计院 | 一种用于生产碘-125的回路中气态碘的提取装置 |
| US20230040941A1 (en) * | 2021-08-03 | 2023-02-09 | Uchicago Argonne, Llc | Efficient bremsstrahlung converter |
| CN114121331B (zh) * | 2021-11-26 | 2023-02-28 | 中山大学 | 强流电子直线加速器核素制备系统 |
| CN114334206A (zh) * | 2021-12-23 | 2022-04-12 | 中国核电工程有限公司 | 一种移动式屏蔽体以及手套箱 |
| CN116847530B (zh) * | 2023-07-25 | 2024-02-20 | 中广核辐照技术有限公司 | 一种电子直线加速器的调节装置及其调节方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5784423A (en) * | 1995-09-08 | 1998-07-21 | Massachusetts Institute Of Technology | Method of producing molybdenum-99 |
| RU2001100541A (ru) * | 2001-01-10 | 2003-01-20 | РНЦ "Курчатовский институт" | Способ получения радиоизотопа молибден-99 |
| US20100028234A1 (en) * | 2008-07-30 | 2010-02-04 | Uchicago Argonne, Llc. | Methods for making and processing metal targets for producing Cu-67 radioisotope for medical applications |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2327824A1 (fr) * | 1998-04-10 | 1999-10-21 | Duke University | Procedes et systemes pour la production en serie de materiaux radioactifs |
| US6907106B1 (en) * | 1998-08-24 | 2005-06-14 | Varian Medical Systems, Inc. | Method and apparatus for producing radioactive materials for medical treatment using x-rays produced by an electron accelerator |
| RU2200997C2 (ru) * | 2001-01-10 | 2003-03-20 | Российский научный центр "Курчатовский институт" | Способ получения радиоизотопа молибден-99 |
| JP4392280B2 (ja) * | 2004-03-26 | 2009-12-24 | 株式会社日立製作所 | 放射性同位元素製造装置および放射性薬剤製造装置 |
| EP2152165A1 (fr) * | 2007-05-24 | 2010-02-17 | P-cure Ltd. | Appareil et methode de traitement par irradiation |
| DE102008007309A1 (de) * | 2008-02-02 | 2009-08-06 | Alfons Roschel | Elektronenabsauger |
| WO2009100063A2 (fr) * | 2008-02-05 | 2009-08-13 | The Curators Of The University Of Missouri | Production de radio-isotopes et traitement d’une solution d’un matériau cible |
| JP5158981B2 (ja) * | 2010-01-25 | 2013-03-06 | 独立行政法人放射線医学総合研究所 | 放射性核種製造装置 |
| US9693443B2 (en) * | 2010-04-19 | 2017-06-27 | General Electric Company | Self-shielding target for isotope production systems |
| US20120281799A1 (en) * | 2011-05-04 | 2012-11-08 | Wells Douglas P | Irradiation Device and Method for Preparing High Specific Activity Radioisotopes |
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2013
- 2013-05-23 CA CA2816453A patent/CA2816453C/fr active Active
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2014
- 2014-05-23 WO PCT/CA2014/050479 patent/WO2014186898A1/fr active Application Filing
- 2014-05-23 RU RU2015155247A patent/RU2667072C2/ru active
- 2014-05-23 JP JP2016514229A patent/JP6426716B2/ja active Active
- 2014-05-23 EP EP14801507.6A patent/EP3000114B1/fr active Active
- 2014-05-23 CN CN201480041163.2A patent/CN105453187B/zh active Active
- 2014-05-23 AU AU2014271174A patent/AU2014271174B2/en active Active
- 2014-05-23 BR BR112015029336A patent/BR112015029336A2/pt active Search and Examination
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2015
- 2015-11-19 IL IL242695A patent/IL242695B/en active IP Right Grant
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2016
- 2016-09-22 HK HK16111158.7A patent/HK1222944A1/zh unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5784423A (en) * | 1995-09-08 | 1998-07-21 | Massachusetts Institute Of Technology | Method of producing molybdenum-99 |
| RU2001100541A (ru) * | 2001-01-10 | 2003-01-20 | РНЦ "Курчатовский институт" | Способ получения радиоизотопа молибден-99 |
| US20100028234A1 (en) * | 2008-07-30 | 2010-02-04 | Uchicago Argonne, Llc. | Methods for making and processing metal targets for producing Cu-67 radioisotope for medical applications |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2692729C2 (ru) * | 2012-04-27 | 2019-06-26 | Триумф | Способы, системы и устройство для циклотронного получения технеция-99m |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105453187A (zh) | 2016-03-30 |
| CN105453187B (zh) | 2019-01-11 |
| CA2816453C (fr) | 2019-09-17 |
| AU2014271174A1 (en) | 2015-12-10 |
| BR112015029336A2 (pt) | 2017-07-25 |
| EP3000114A4 (fr) | 2017-01-25 |
| JP6426716B2 (ja) | 2018-12-05 |
| IL242695B (en) | 2019-08-29 |
| RU2015155247A (ru) | 2017-06-28 |
| EP3000114B1 (fr) | 2018-05-02 |
| EP3000114A1 (fr) | 2016-03-30 |
| JP2016520194A (ja) | 2016-07-11 |
| CA2816453A1 (fr) | 2014-11-23 |
| WO2014186898A1 (fr) | 2014-11-27 |
| AU2014271174B2 (en) | 2018-01-18 |
| HK1222944A1 (zh) | 2017-07-14 |
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