RU2663448C2 - Способ ингибирования экспрессии ил-22 активированными т-клетками - Google Patents

Способ ингибирования экспрессии ил-22 активированными т-клетками Download PDF

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RU2663448C2
RU2663448C2 RU2015125680A RU2015125680A RU2663448C2 RU 2663448 C2 RU2663448 C2 RU 2663448C2 RU 2015125680 A RU2015125680 A RU 2015125680A RU 2015125680 A RU2015125680 A RU 2015125680A RU 2663448 C2 RU2663448 C2 RU 2663448C2
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compound
cells
vitamin
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pharmaceutical composition
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RU2015125680A (ru
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Паола ЛОВАТО
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Лео Фарма А/С
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/5939,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • AHUMAN NECESSITIES
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    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
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    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2015125680A 2012-11-30 2013-11-28 Способ ингибирования экспрессии ил-22 активированными т-клетками RU2663448C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261731867P 2012-11-30 2012-11-30
US61/731,867 2012-11-30
PCT/EP2013/074958 WO2014083099A1 (en) 2012-11-30 2013-11-28 A method of inhibiting the expression of il-22 in activated t-cells

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RU2015125680A RU2015125680A (ru) 2017-01-10
RU2663448C2 true RU2663448C2 (ru) 2018-08-06

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US (1) US9855285B2 (enExample)
EP (1) EP2925364A1 (enExample)
JP (1) JP6367819B2 (enExample)
CN (1) CN104822392B (enExample)
RU (1) RU2663448C2 (enExample)
WO (1) WO2014083099A1 (enExample)

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Publication number Priority date Publication date Assignee Title
GB201701583D0 (en) * 2017-01-31 2017-03-15 Drug Delivery Solutions Ltd Topical composition
FR3071508B1 (fr) * 2017-09-26 2022-07-29 Genoskin Modele ex vivo de peau humaine inflammee et ses utilisations pour le criblage de composes anti-inflammatoires
EP3853204A4 (en) * 2018-09-21 2022-06-22 Apramitha Innovations Private Limited IMPROVED AND STABLE APREMILAST PHARMACEUTICAL COMPOSITIONS
JP2022518292A (ja) * 2019-01-23 2022-03-14 パス セラピューティクス,インク. ホスホジエステラーゼ4(pde4)阻害によるてんかんの治療方法
US20210212962A1 (en) * 2020-01-13 2021-07-15 Sol-Gel Technologies Ltd. Methods and compositions for the treatment of granuloma annulare or subcutaneous inflammation and non-infection granulomatous diseases
CN116919958A (zh) * 2023-07-05 2023-10-24 南方医科大学口腔医院 罗氟司特在骨缺损修复治疗中的应用
WO2025221488A1 (en) * 2024-04-16 2025-10-23 Alto Neuroscience, Inc. Transdermal administration of pde4 inhibitors for reduction in adverse events

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WO2008104175A2 (en) * 2007-02-28 2008-09-04 Leo Pharma A/S Novel phosphodiesterase inhibitors
WO2011076207A2 (en) * 2009-12-22 2011-06-30 Leo Pharma A/S Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants

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Publication number Priority date Publication date Assignee Title
WO2006123726A1 (ja) * 2005-05-18 2006-11-23 Kyowa Hakko Kogyo Co., Ltd. 医薬組成物
AU2007336538B2 (en) * 2006-12-22 2012-04-05 Leo Pharma A/S Substituted acetophenones useful as PDE4 inhibitors
CA2688670A1 (en) * 2007-04-19 2008-10-30 Leo Pharma A/S Src family kinase inhibitors
SG172206A1 (en) * 2008-12-19 2011-07-28 Leo Pharma As Triazolopyridines as phosphodiesterase inhibitors for treatment of dermal diseases
NZ603895A (en) * 2010-06-24 2014-10-31 Leo Pharma As Novel phosphodiesterase inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008104175A2 (en) * 2007-02-28 2008-09-04 Leo Pharma A/S Novel phosphodiesterase inhibitors
WO2011076207A2 (en) * 2009-12-22 2011-06-30 Leo Pharma A/S Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
KERSTIN WOLK et al. IL-22 Increases the Innate Immunity of Tissues// Volume 21, Issue 2, August 2004, Pages 241-254. *
LAURA A. TESMER et al. Th17 cells in human disease // Immunol Rev. 2008 Jun; 223: 87-113. *
MITRA A.et al. Topical delivery for the treatment of psoriasis // Expert Opin Drug Deliv., 2010, Aug;7(8):977-92. *
MITRA A.et al. Topical delivery for the treatment of psoriasis // Expert Opin Drug Deliv., 2010, Aug;7(8):977-92. KERSTIN WOLK et al. IL-22 Increases the Innate Immunity of Tissues// Volume 21, Issue 2, August 2004, Pages 241-254. КОЛОГРИВОВА И.В. и др. Молекулярные аспекты функционирования T-хелперов 17-го типа // Бюллетень Сибирской медицины, 2011, 4, стр.96, [он-лайн], [найдено 18.10.2017]. Найдено из Интернет: < URL: http://old.ssmu.ru/bull/11/04/18.pdf. LAURA A. TESMER et al. Th17 cells in human disease // Immunol Rev. 2008 Jun; 223: 87-113. *
КОЛОГРИВОВА И.В. и др. Молекулярные аспекты функционирования T-хелперов 17-го типа // Бюллетень Сибирской медицины, 2011, 4, стр.96, [он-лайн], [найдено 18.10.2017]. Найдено из Интернет: < URL: http://old.ssmu.ru/bull/11/04/18.pdf. *

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Publication number Publication date
US20150297616A1 (en) 2015-10-22
WO2014083099A1 (en) 2014-06-05
CN104822392A (zh) 2015-08-05
EP2925364A1 (en) 2015-10-07
JP6367819B2 (ja) 2018-08-01
JP2016501209A (ja) 2016-01-18
US9855285B2 (en) 2018-01-02
CN104822392B (zh) 2017-09-08
RU2015125680A (ru) 2017-01-10
HK1212894A1 (zh) 2016-06-24

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