RU2663324C1 - Method of treatment rabbits with myxomatosis - Google Patents

Abstract

FIELD: veterinary science.SUBSTANCE: invention relates to veterinary medicine, namely to a method of treating rabbits with myxomatosis. Method provides for complex use Anandine 10 % in a dose of 0.2 ml/kg once a day for 10 days, Lozeval in a dose of 0.2 ml/kg and Pikhtoin.EFFECT: usage of this scheme allows to increase the effectiveness of rabbits with myxomatosis treatment by 30–40 %.1 cl, 1 tbl

Description

The invention relates to veterinary medicine, and in particular to a method for the treatment of rabbits with myxomatosis.

Myxomatosis is an infectious disease of rabbits, the causative agent of which is a DNA-containing virus from the Poxviridae family. The disease is characterized by serous-purulent conjunctivitis, inflammation of the mucous membranes of the digestive tract and the formation of nodules on the skin of the ears and nose (mix).

The death of rabbits with myxomatosis can reach up to 100%.

A known method of treating rabbit myxomatosis (RF patent 2259843 dated 05/10/2005 IPC A61K 39/12), comprising parenteral administration of a medicinal substance, where a vaccine against myxomatosis from strain "B-82" or a suspension of mix, which is administered to rabbits four times, is used as a medicinal substance with an interval of 24 hours in the amount of one immunizing dose.

The disadvantage of this method is the instability of the results, a large percentage of complications and rapid death with significant damage to animals. This method can be effective only in the early stages of the development of the disease.

A known method of treating rabbit myxomatosis (RF patent 2188001 dated 08.27.2002 IPC A61K 31/00, A61P 31/14 - prototype) comprising the administration of a drug substance intramuscularly, which is used 1-aminoadamantane hydrochloride (amantadine, midantane), which is administered at a dose of at least 20 mg per 1 kg of live weight twice a day, two days in a row.

The disadvantage of this method is the low therapeutic efficacy, since amantadine has an effect against an RNA-containing influenza virus type A.

The technical result of the invention is to increase the effectiveness of the treatment of rabbits with myxomatosis.

The technical result is achieved by the fact that in the method of treating rabbits with myxomatosis involving the use of drugs, according to the invention, anandine 10% 0.2 ml / kg of animal body weight intramuscularly, lozewal 0 are used once a day for 10 days , 2 ml / kg of animal body weight orally and fir to lubricate the affected skin 1 time per day.

The novelty of the proposed method lies in the fact that for the treatment of rabbits with myxomatosis with varying severity, drugs with antiviral, immunomodulatory and anti-inflammatory effects were used.

A method of treating rabbits with myxomatosis is as follows.

For the treatment of rabbits, anandine 10% 0.2 ml / kg of the animal’s intramuscularly, lozewal 0.2 ml / kg of the animal’s orally and pichtoin to lubricate the affected areas of the skin 1 time are used once a day for 10 days as medications. in a day.

Dosages of anandine and lozewal drugs were taken in optimal quantities according to the Instructions (instructions) for use (https://www.vidal.ru/veterinar/anandinum-27729; http://fb.ru/article/267506/preparat-lozeval- instruktsiya-po-primeneniyu-analogi-i-otzyivyi).

Anandine is used in veterinary medicine and belongs to the new highly active synthetic organic compounds. Glucaminopropylcarbacridone (anandine), which is part of the preparation, belongs to the group of low molecular weight cytokine inducers (interferons, TNF, interleukins), is effective against almost all classes of both DNA and RNA viruses, and has immunomodulating and anti-inflammatory activity. Anandin is recommended primarily as a specific antiviral drug for the treatment of severe viral infections of various localization (dermatropic, neurotropic, pneumotropic and pantropic viruses), as well as infections associated with immunodeficiency states (http://www.webapteka.ru/drugbase/name14209 .html; http://www.veterinarka.ru/vetmedicaments/anandin.html; https://www.vidal.ru/veterinar/anandinum-27729).

Lozeval is a complex drug and includes substances such as morpholonium; thiosemicarbazone; ammonium dichloride; polyethylene lenglycol-9; dimethyl sulfoxide. The drug blocks DNA and RNA viruses, inhibiting their virulence and reproduction. In addition, the lozewal has a detrimental effect on gram-positive and gram-negative bacteria, on mold and yeast-like fungi (http://fb.ru/article/267506/preparat-lozeval-instruktsiya-po-primeneniyu-analogi-i-otzyivyi; Onishchuk F. D. The effectiveness of the use of the new drug “Lozoval” in veterinary medicine // Basic research. - 2004. - No. 4. - P. 54-55: https://fundamental-research.ru/ru/article/view?id=5408) .

Pichtoin contains 100 g of pine resin as an active ingredient, 20 g, and as excipients: beeswax or wax - 8 g, chemically precipitated chalk - 10 g and industrial oil - up to 100 g. Pichtoin has a comprehensive anti-inflammatory, antimicrobial and regenerative effect. Pine gum, which is part of Pikhtoin, due to the presence of flavonoids and phytoncides, provides antiseptic properties of the drug. When applied to the skin, Pikhtoin penetrates the sebaceous glands and partially intercellular passages. In the glands and intercellular passages, the biologically active components of the resin are soluble and gradually absorbed, helping to expand the blood vessels, improve blood circulation, accelerate the resorption of products of inflammation and wound healing (http://www.veterinarka.ru/vetmedicaments/pihtoin.html).

The therapeutic effectiveness of the proposed method is presented in the following examples.

Example 1. The effectiveness of the proposed method in severe myxomatosis

For the experiment, 2 dwarf rabbits (male and female) belonging to citizen L. were selected, delivered to the veterinary clinic of the Pashkovsky agricultural college (Krasnodar), they had a generalized form of myxomatosis, which was characterized by high temperature (40.8 ° C) difficulty breathing, purulent conjunctivitis, the presence of multiple mixes on the ears, nose, genitals and eyelids, complete refusal of food. Previously, within a week, rabbits were treated in another veterinary clinic using roncoleukin in a dose of 10 thousand units. and Baytril 5% in a dose of 0.1 ml, which was administered 1 time per day intramuscularly.

Animals began to be treated according to a regimen including intramuscular administration of 10% anandine at a dose of 0.2 ml / kg body weight 1 time per day, Lozewal oral administration of 0.2 ml / kg body weight 1 time per day and treatment with a mix of Pikhtoin ointment 1 time per day.

After 3 days, they established a decrease in body temperature to normal (38.1 ° C), the animals developed an appetite, the previously formed myxomas were crusted, and the appearance of new mixes was not noted, and swelling of the eyelids subsided. The treatment is ongoing.

After 5 days, the disappearance of rabbits conjunctivitis and swelling on the genitals and ears was established. Some old mixes began to be rejected. Animals are mobile, appetite is well expressed. The treatment is ongoing.

After 7 days it was found that all myxomas are covered with dense crusts, no new ones have formed, swelling on the genitals, eyelids and ears are gone. Animals consume food and water well, are mobile, the temperature is normal. The treatment is ongoing.

After 10 days, the recovery of rabbits was recorded, which is characterized by a complete release of the skin from the mix and swelling, lack of discharge from the eyes, even and clean breathing, expressed appetite and mobility.

Example 2. The effectiveness of the proposed method in the treatment of rabbits in the conditions of personal subsidiary plots (LPH)

Of the total chinchilla rabbit stock (325 animals) in the private farms located on the territory of the Krasnodar Territory, 29 animals fell ill with myxomatosis. Sick animals were isolated from conditionally healthy animals by placing them in separate cells. Conditionally healthy animals were subjected to prophylactic immunization with a live culture vaccine against myxomatosis from strain B-82. Sick rabbits with varying degrees of disease severity were divided into 2 groups according to the principle of analogues and treated. The animals of the first group (15 animals) were treated according to a regimen comprising intramuscular administration of 10% anandine at a dose of 0.2 ml / kg body weight 1 time per day, Lozewal oral administration of 0.2 ml / kg body weight 1 time per day and mix treatment Pichtoin ointment 1 time per day. Animals of the second group (14 animals) were treated according to the prototype, namely, amantadine (PK-MERC trademark 0.4% solution) was intramuscularly administered at a dose of 20 mg / kg live weight twice a day, for two consecutive days. The treatment results are presented in the table, which shows that in the first group and in the second group there were recovered animals, however, the treatment efficiency was excellent.

As can be seen from the table, the efficiency of the proposed method was 93.3%, while the efficiency of the prototype circuit was 57.1%. In addition, animals in the first group recovered 1.9 days faster than animals in the second group. The cost-effectiveness of treatment in the first group amounted to 11,617.65 rubles, while the payback of 1 ruble of costs was 11.83 rubles. The cost-effectiveness of treatment in the second group was 6563.84 rubles, and the payback was 10.32 rubles.

Thus, the claimed method of treating rabbits with myxomatosis showed higher therapeutic and economic efficiency.

Claims (1)

A method of treating rabbits with myxomatosis, including the use of drugs, characterized in that the drugs used once a day for 10 days, Anandine 10% 0.2 ml / kg of animal body weight intramuscularly, lozewal 0.2 ml / kg body weight of the animal orally and fir to lubricate the affected areas of the skin 1 time per day.