RU2592236C1 - Method of sheep nematodosis treating and preventing - Google Patents

Abstract

FIELD: veterinary science.

SUBSTANCE: invention refers to veterinary science and aims at sheep strongylatoses treating and preventing. Method involves using antiparasitic preparation “Praziver” orally individually in dosage 0.4 ml per 10 kg of animal body weight, together with triple (every 72 hours) intramuscular introduction of “Ajsidivit” immunomodulator in a dose of 3 ml per animal.

EFFECT: method provides 100 % efficiency of the declared method of treating sheep strongylatoses, as well as allows to accelerate therapeutic effect antiparasitic preparation.

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Description

The invention relates to the field of veterinary medicine, in particular to methods for the prevention and treatment of strictilatoses of the gastrointestinal tract (GIT) of sheep, and can be used in the field of veterinary medicine and animal husbandry.

Nematodoses are an animal disease caused by numerous species of round helminths of the Nematoda class. The intestinal nematodes of sheep include the Strongylata suborder, which combines four families: Strongylidae, Trichostrongylidae, Trichonematidae, and Ancylostomatidae. All of them are hematophagous, secrete nematode toxins - hemolysin, develop without an intermediate host (ovipositing), have a different size. Infection of sheep with strongilatoses of the gastrointestinal tract occurs alimentary.

Nematodes are localized in various parts of the digestive canal. Strongilatoses of the digestive canal of sheep are caused by parasitization of both adult helminths and their larvae (bunostoma, cooperation, trichostrongilus, gemonchus, etc.) [1].

The pathogenic effect of strong gastrointestinal tract on the body of sheep is multifaceted and consists of mechanical, toxic and allergic influences. In addition, with helminthiases, immunity is reduced and susceptibility to infectious diseases increases. The totality of these effects causes huge economic damage to livestock [2].

Currently, anthelmintics of a wide spectrum of action have been successfully introduced for the treatment of helminthiases: tetramisole (in a group way, mixed with food), albendazole (in a group way, mixed with food), fenbendazole (in a group way, mixed with food), ivermek (p / to, in / m). But the disadvantage of these drugs is their narrow spectrum of action. Tetramisole, ivermectins are ineffective with cestodoses. The drugs albendazole and fenbendazole have high doses of activity against moniesia, but do not act on scolex cestodes, which allows them to recover again. In addition, when using some anthelmintics, side effects are noted: salivation, embryotropic effect. To reduce these side effects, an “ANTIHELMINT AGENT” has been developed - which contains phenasal, fenbendazole and polyvinylpyrrolidone in the ratio of 7.2: 0.8: 2.0. This tool at a dose of 50 mg / kg has an extended spectrum of action against moniesia and nematodes in cattle and sheep (Patent RU 2452489) [3].

The Praziver veterinary drug with a broad antiparasitic spectrum of activity is intended for the treatment and prophylaxis of the imaginal and larval phases of the development of nematodes of the gastrointestinal tract and lungs, as well as cestodes, sarcoptoid mites, insects and larvae of gadflies parasitizing in farm animals [4]. Praziver contains, as active substances, praziquantel, ivermectin, knotweed extract and excipients. The drug is administered twice orally at a dose of 0.4-0.6 per 10 kg with an interval of 7-12 days. Praziver belongs to moderately hazardous substances (3 hazard classes according to GOSU 12.1.007-76), does not have an embryotoxic, teratogenic and sensitizing effect. Slaughter for meat of small cattle is allowed no earlier than 28 days after deworming.

Biologically active substances that are part of the drug Aidsidiv have an activating effect on the central, autonomic nervous system and metabolic processes, have antioxidant and membrane-protective properties, contributing to the improvement of all forms of immune reactivity, provide increased resistance of the animal's body to adverse environmental factors and diseases of various etiologies, stimulate motor activity of the digestive tract, secretion of digestive glands, increase the activity of nevyh enzymes contribute to the growth and development of young animals and increasing productivity of farm animals [5].

The well-known tool "METHOD OF TREATMENT OF RUMENTAL ANIMAL HELMINTOSIS AND MEDICINE FOR ITS IMPLEMENTATION" (Patent RU 2412698), used for the treatment and prevention of parasitic diseases of ruminants, which is a solution of praziquantel, ivermectin and the target additive: 1 g (1 g) , 25, ivermectin - 0.01, sodium selenite - 0.0036, target additive - 0.9364). However, the aforementioned agent does not prevent re-infection and has immunosuppressive activity [6].

The aim of the present invention is to stimulate the nonspecific resistance of the body of the sheep, necessary to enhance the therapeutic efficacy of anthelmintic.

The objective of the invention is solved due to the fact that for the treatment and prevention of strictiliasis of the gastrointestinal tract of sheep, the drug Praziver is administered orally at a dose of 0.4 ml per 10 kg of animal body weight, in conjunction with the immunosomulator Aysidivit, which is administered intramuscularly three times with an interval of 3 days, at a dose 3 ml per animal.

The technical result of the invention is that the drug improves the therapeutic effectiveness of praziver and increase the immune status of sheep.

The essence of the method is illustrated by examples:

Example 1. In 2013, trials of the drug Praziver with strong gastrointestinal infections of the gastrointestinal tract of sheep with the immunocorrector Aisidivit were conducted in a private farm in the village of Vinzili, Tyumen Region. To set up the experiment, the experimental and control groups of sheep, 10 animals each, of the same age and with the same live weight, were selected. All the sheep in the experiment were spontaneously invaded by the pathogens of strong gastrointestinal tract gastrointestinal tract (100% invasiveness). The diagnosis was made according to the results of the study of fecal samples by the methods of Fulleborn and ether - acetic sedimentation. The sheep of the experimental group were once orally individually injected with Praziver at a dose of 0.4 ml per 10 kg of the animal’s body weight, together with three times (with an interval of 72 hours) intramuscular administration of the Aizidivit immunomodulator at a dose of 3 ml per animal as a means to increase resistance in pathological conditions accompanied by a decrease in the immunoreactivity of the body. Aidisivit in therapeutic doses is non-toxic, does not have local irritating, hepatotoxic and sensitizing effects, is compatible with antiparasitic, antimicrobial and other chemotherapeutic drugs [5]. The effectiveness of the treatment of sheep with strong gastrointestinal tract was judged by the results of fecal samples after 7 and 14 days from the start of the experiment using the above methods. As can be seen from table 1, in all the sheep of the experimental group after 7 days the extensivity of the composition Praziver + Aisidivit was 90.0%, after 14 days - 100%, respectively.

Example 2. To assess the effectiveness of chemoprophylaxis of spontaneous infection with sheep gastrointestinal strictilases, three groups were formed. The sheep of the first group were once orally individually injected with Praziver at a dose of 0.4 ml per 10 kg of animal body weight, together with three times (with an interval of 72 hours) intramuscular administration of the immunodomulator Aisidivit at a dose of 3 ml per animal as a means to increase resistance in pathological conditions accompanied by a decrease in the immunoreactivity of the body [5]. Sheeps of the second group were administered only Praziver at a dose of 0.4 ml per 10 kg of animal body weight. Animals of the third group did not use the drug (control). Throughout the experiment, the sheep of the experimental and control groups were kept together. In each group, fecal samples were studied for the presence of pathogens of strong gastrointestinal tracts of the gastrointestinal tract of small cattle by the methods of Fulleborn and ether - acetic sedimentation after 7 and 14 days from the start of the experiment. Thus, as can be seen from table 2, the proposed method for the treatment and prevention of strong gastrointestinal infections of sheep gastrointestinal tract by the combined use of Prazivera and Isidivit is more effective than the method with one Prazivera preparation by 20%.

The result indicates a 100% effectiveness of the claimed method for the treatment and prevention of sheep gastrointestinal strictilitis infections, as well as the claimed method allows to accelerate the therapeutic effect of the drug.

Information sources

1. Akbaev M.Sh., Vodyanov A.A., Kosminkov N.E. Parasitology and invasive diseases of animals / M.Sh. Akbaev, A.A. Vodyanov, N.E. Kosminkov and others; under the editorship of M.Sh. Akbaeva. - M: Kolos, 1998 .-- 743 p.

2. Sidorkin V. A., Polutov D. B., Yakunin K. A., Samylkina L. M., Listratov A. V., Sapunov A. Ya., Antonov M. M. The effectiveness of alvet - suspension in animal helminthiasis // Veterinary medicine. 2006. No8. S. 31-32.

3. Patent RU 2452489 C1, 06/10/12

4. Instructions for use of the drug Praziver for the treatment of parasitic diseases of farm animals (registration number PVR-2-6.0 / 02581).

5. Instructions for use of the drug Aidsidivit (registration number PVR-2-6.8 / 02406).

6. Patent RU 2412698, 02.27.11.

Claims (1)

A method for the treatment and prevention of strictilitis of the gastrointestinal tract of sheep, including the use of the antiparasitic drug Praziver once orally at a dose of 0.4 ml per 10 kg of animal body weight and immunomodulator Isidivit three times (with an interval of 72 hours) intramuscularly at a dose of 3 ml per animal, which leads to stimulate the nonspecific resistance of the sheep organism; as a result, the therapeutic effectiveness of the anthelmintic is enhanced.