RU2166849C1 - Method of sanitation of cattle farms with dictyocaulosis - Google Patents

Abstract

FIELD: agriculture, veterinary science. SUBSTANCE: invention relates to methods of treatment and prophylaxis against pulmonary helminthiasis in cattle. Method involves the use of the following anthelmintic preparations: dectomax, valbazen, duotin, cidectin, ivomec, levamisol, nilverm by developed schedules of use in threefold in the first pasturing year, twofold in the second pasturing year accounting for calves infection and persistence of anthemintic effect of preparations. Method ensures to eliminate dictyocaulosis infection from cattle young-stock and protect animals from infection. EFFECT: enhanced effectiveness of method. 4 cl, 5 tbl, 1 ex

Description

 The method relates to veterinary medicine, in particular to methods of treatment and prophylactic measures against pulmonary helminthiases of cattle.

 At present, dictyocaulosis of cattle is treated with helminthic preparations approved for use. The range of application of anthelmintic drugs is wide enough. Often, practical veterinarians have difficulty in choosing an effective and safe drug. The effectiveness of health-improving measures for dictation of cattle depends not only on the activity of drugs, but also on the timing of their use. In this regard, the author studied the optimal patterns of the use of anthelmintics in dictation of cattle, taking into account the persistence of anthelmintic action and the timing of infection of calves.

In veterinary medicine with dictation of cattle, it is customary to use:
- from the group of pyrimidines nilverm (1).

Химическое название - 2,3,5,5-тетрагидро-6-фениламидазол-2,1-в-тиазол;
- из группы макроциклических лактонов:
дектомакс (2). Действующее вещество препарата - дорамектин - новый представитель группы авермектинов.Molecular Formula - H ₁₂ C ₁₁ N ₂ S • HCl
Structural Formula -

The chemical name is 2,3,5,5-tetrahydro-6-phenylamidazole-2,1-b-thiazole;
- from the group of macrocyclic lactones:
dectomax (2). The active substance of the drug - doramectin - a new representative of the group of avermectins.

Предложен способ оздоровления хозяйств от диктиокаулеза крупного рогатого скота антгельминтиком локсураном 2-4 преимагинальными дегельминтизациями с интервалом в 20 суток, в пастбищный сезон; химиопрофилактики ежедневным вольным скармливанием 3-4 г фенотиазина телятам в смеси с комбикормом; а молодняку 1-2 лет в смеси с солью, дегельминтизацией весной и осенью животных - диктиокаулоносителей (12).The molecular formula of doramectin is C ₅₀ H ₇₄ O ₁₄
Chemical name - 25 cyclohexyl-5-0-dimethyl-25-di (1-methylpropyl) Avermectin Ala;
ivomek (3) according to the active substance 1% solution of ivermectin (10 mg / ml). It is a mixture of hydrogenated components B1a and B1b based on the Streptomyces avermitilis MA 4680 culture (NRRL 8165);
duotin (4) according to the active substance is an abamectin solution, which consists of 80% avermectin B1a (C ₄₈ H ₇₂ O ₁₄ ) and 20% avermectin B1b (C ₄₇ H ₇₀ O ₁₄ ). This is a fermentation product of the fungus Streptomyces avermitilis;
cidectin (5) according to the active substance is a 1% solution of moxidectin;
- from the group of benzimidazoles:
valbazene (6) according to the active substance is a 10% suspension of albendazole (benzimidazole derivative);
- anthelmintic levamisole (7) - chemical name (-) 2,3,5,6-tetrahydro-6-phenylimidazo-2,1-b-thiazole hydrochloride. Structural Formula -

A method for improving farms from dictation of cattle by the helminthic antioxidant loxuran 2-4 preimaginal deworming with an interval of 20 days, in the grazing season; chemoprophylaxis with daily free feeding of 3-4 g of phenothiazine to calves mixed with animal feed; and young animals 1-2 years old in a mixture with salt, deworming in spring and autumn of animals - dictyoca carriers (12).

 The claimed method includes a set of economic-restrictive and livestock measures, and is quite time-consuming.

 In accordance with the Manual on the use of dectomax (Pfizer USA) for the control of this and endoparasites of cattle, sheep and pigs approved by the Department of Veterinary of the Ministry of Agriculture and Food of the Russian Federation on April 12, 1996, it is recommended to introduce dectomax subcutaneously in the neck or shoulder of the animal, and intramuscularly in the neck, following aseptic rules at a dose of 0.2 mg per 1 kilogram of live weight, which corresponds to 1 ml of dextomax solution per 50 kg of body weight. A single injection of the drug reliably protects animals from dictiocaulosis - 28 days.

 The inventive method does not prevent the infection of animals with Dictyocaulus viviparus after 28 days and taking into account the period of preimaginal development of dictyocaulus in the cattle organism of 21-28 days, it does not prevent pasture contamination by D. viviparus larvae, i.e. calves are likely sources of invasion, which does not allow to heal the economy from this disease.

 The closest in technical essence of the claimed invention is a method of combating dicticocaulosis of cattle by injection of ivomec (company "MSD AGVET"). Ivomek is used three times in 3, 8 and 13 weeks after pasturing animals on a pasture. It was noted that ivomek completely protects animals from pulmonary helminths, the development cycle of parasites is interrupted, and the pasture is also cleared of them (8). This claimed method does not take into account the aspect of the biotic potential of the D. viviparus nematode, namely that sexually mature larvae overwinter and in the early spring are a source of invasion for cattle (9), and triple use of ivomek in the first year of grazing of animals prevents their infection until the end first decade of October.

 All drugs belonging to the group of macrocyclic lactones are highly effective for nematodoses in cattle. However, when it comes to the timing of the use of these anthelmintics, they are, as a rule, not defined or recommended vaguely, and sometimes contradictory (10).

 Based on the foregoing, the author set himself the task of finding a new method that would allow for the rehabilitation of farms unsuccessful in dictation of cattle.

 To solve this problem, the author is in connection with the impossibility of constant implementation of recreational measures against dictation of cattle in agricultural enterprises by pasture prevention (changing pasture plots, transferring animals to stall or stall-keeping facilities), rehabilitation of farms unsuccessful for dictation of young cattle , proposed based on the method of application of anthelmintic regimens: doramectin, valbazene, nilverm, levamisole, duotin, cydecti on and Ivomeka.

 Before the recovery begins, as well as during its implementation, it is necessary to take feces samples from 20% of young cattle and examine them by the quantitative coprolarvoscopic flotation method using the VIGIS counting chamber (K.I. Scriabin All-Russian Scientific Research Institute of Helminthology).

 In dysfunctional farms, young cattle of the first and second year of grazing should be assigned nilverm or valbazen in a dose of 15, respectively; 3.8 mg / kg; administer duotin or cidectin, ivomec, dectomax at a dose of 0.2 mg / kg; levamisole at a dose of 7.5 mg / kg.

 In calves of the first year of grazing, larvae of diktiocaulus are first detected in feces 3-4 weeks after pasture on a pasture (11). Consequently, the first deworming of calves is recommended 3 weeks after the start of grazing. The expediency of earlier deworming of calves is indicated by the absence of dictiocaulus larvae in their feces.

 Taking into account the timing of calf infection, the preimaginal development of dictyocaulus in the body of cattle, which is 21-28 days (11) and the persistence of anthelmintic action (table 1; 2), dectomax can be used in the pasture period for the treatment, prevention of dictyocaulosis and prevention of pasture contamination with an interval of 7.5 weeks (persistence of the anthelmintic effect of the drug 52 days); ivomek, cidectin and duotin with an interval of 6 weeks (persistence of anthelmintic action of drugs is 42 days); nilverm, valbazen, levamisole with an interval of 4 weeks (persistence of anthelmintic action of drugs is 28 days).

 Calf deworming schemes depend on the persistence of anthelmintic action of drugs, which may differ in different anthelmintics.

 The author carried out work on the study and dynamics of the timing of the detection of Dictyocaulus viviparus larvae in the feces of calves after using various drugs, namely levamisole, nilverm, valbazene, duotin, cidectin, ivomec and dectomax.

 The experiments were carried out in farms unsuccessful for dictation of cattle on black-motley calves with an average body weight of 102-128 kg, spontaneously infested with D. viviparus. Before the experiment, calves were numbered, weighed and divided into experimental (10-17 goals) and control (9 goals) groups.

 The calves of the experimental group were given orally once individually, taking into account the body, nilverm at a dose of 15 m / kg, valbazene at a dose of 3.8 mg / kg, subcutaneously administered once taking into account the body weight, duotin, cidectin, ivomec, dectomax at a dose of 0.2 mg / kg , levamisole at a dose of 7.5 mg / kg.

 Animals of the control group did not receive the drug and grazed together, where the invaded D. viviparus young cattle had previously grazed.

 Before giving and administering drugs, and also after 10, 20, 27, 35, 42 and 52 for after deworming, calves of all groups were taken fecal samples from the rectum after deworming and studied by flotation using a VIGIS counting chamber to record the number of D. viviparus g feces, the results were processed statistically with the calculation of average values and their errors. The effectiveness of the drugs was calculated 10, 20, 27, 35, 42 and 52 days after giving and administering the drugs separately according to the type of “control test” and “critical test”.

 The results are presented in table 1 and indicate a high anthelmintic efficacy of drugs in therapeutic doses according to coprolaroscopic studies.

 After deworming of young cattle by the indicated anthelmintics, dictyocaulus larvae in calves feces are first detected 4 weeks after the use of levamisole, nilverm and valbazene, 6 weeks after the administration of ivomec, duotin and cidectin and 7.5 weeks after the administration of dectomax.

 The invasion of calves of the experimental and control groups before the experiment did not differ significantly (P> 0.005). The number of D. viviparus larvae in g feces of untreated animals after 52 days increased by 6.7%. In this regard, for greater credibility, the effectiveness of the drugs was calculated both by the type of “control test” and by the type of “critical test”. The effectiveness of the drugs in these tests differed by 0.1-5.3% (table 2).

Deworming schemes:
- dectomax is introduced 3 weeks after the animals are pastured into the pasture (the beginning of the detection of D. viviparus larvae in animal feces) and again after 7.5 weeks (the beginning of the detection of dictiocaulus larvae after the introduction of the dectomax), i.e. by 3; 10.5; 18 week grazing;
- ivomek or cidectin, or duotin is introduced 3 weeks after the animals are pastured into the pasture (the beginning of the detection of D. viviparus larvae in animal feces) and again after 6 weeks (the beginning of the detection of dictyocaulus larvae after the introduction of ivomek, cidectin and duotin), i.e. by 3; 9th and 15th week of grazing;
- nilverm or valbazene is given or injected with levamisole 3 weeks after the animals are pasted into the pasture (the beginning of detection of D. viviparus larvae in animal feces) and again 4 weeks later (the beginning of detection of dictyocaulus larvae after giving nilverm or valbazene or the administration of levamisole), t. e. by 3; 7; 11th and 15th week of grazing.

 In the first year of the grazing season, the rehabilitation of farms unsuccessful for dictation of cattle is carried out according to three-time schemes for the use of one of the anthelmintics: dectomax, ivomek, cidectin, duotin, nilverm, valbazene, levamisole.

 Three-time administration of dectomax in the pasture period completely prevents infection of Dictuocaulus viviparus calves.

 Three-time use of ivomek or duotin or cidectin 3, 9, 15 weeks after pasture on the pasture prevents infection of calves D. viviparus until the end of the first decade of October.

 Three-time use of levamisole, or nilverm, or valbazene 3, 7, 11 weeks after pasture on the pasture prevents infection of calves D. viviparus until the end of the second decade of September.

The second year of the pasture season, the recovery of farms that are dysfunctional in dictation of cattle should be carried out twice using the method of using anthelmintic preparations:
- dectomax is introduced 3 weeks after the animals are pastured into the pasture (the beginning of the detection of D. viviparus larvae in animal feces) and again after 7.5 weeks (the beginning of the detection of dictiocaulus larvae after the introduction of the dectomax), i.e. by 3; 10.5 week grazing.

 - ivomek or cidectin or duotin is introduced 3 weeks after the animals are pastured into the pasture (the beginning of the detection of D. viviparus larvae in animal feces) and again after 6 weeks (the beginning of the detection of dictyocaulus larvae after administration of ivomek or cidectin or duotin), i.e. by 3; 9 week grazing.

 - nilverm or valbazen are asked whether levamisole is administered 3 weeks after the animals are pasted into the pasture (the beginning of the detection of D. viviparus larvae in animal feces) and again after 4 weeks (the beginning of the detection of dictiocaulus larvae after giving nilverm or valbazene or the introduction of levamisole), i.e. . by 3; 7 week grazing.

 An example of testing different patterns of use of anthelmintic drugs nilverm, dectomax, valbazene are shown in table 3.

 The studies were carried out on a farm that is permanently dysfunctional in dictation of cattle. For testing, the author selected nilverm, dectomax, and valbazene drugs that are effective against dictiocaulus.

 According to the author, the larvae of dictiocaulus begin to be detected in the feces of calves of the first year of grazing in the 2-3 days of June, i.e. 3-4 weeks after pasture of animals on pasture (11). Based on this, it can be assumed that calves begin to become infected with larvae of dictiocaulus in May, since it is known that the period of development of dictiocaulus to a mature stage from the moment the calves swallow the invasive larva until the laying of eggs by females ends in 21-28 days.

The interval between calves deworming, equal to 4 weeks for nilverm and valbazen, 7, 5 weeks for dectomax, was established by the author when studying the timing of the beginning of the isolation of dictiocaulus larvae with calves feces after giving nilverm, valbazen and the introduction of dectomax. In this regard, the author has taken the most acceptable and reasonable, from the point of view of the author, two schemes of preventive deworming, namely:
- according to the first scheme, deworming of calves with nilverm and valbazene was carried out 3 weeks after pasture on the pasture and again after 4 weeks. Conventionally, the 1st scheme was designated as (3; 4);
- according to the first scheme, dectomax deworming was carried out 3 weeks after pasture on the pasture and again after 7.5 weeks. Conventionally, the 1st scheme was designated as (3; 7.5).

 According to the second scheme, calves were dewormed three times: the first time - 3 weeks after pasturing on the pasture, the second time - 4 weeks after the first deworming and the third time 4 weeks after the second giving of nilverm and valbazene. Conventionally, this scheme was designated as (3; 4; 4).

 According to the second scheme, for dectomax, calves were dewormed three times: the 1st time - 3 weeks after pasturing in the pasture, the second time 7.5 weeks after the 1st deworming and the 3rd - 7.5 weeks after the 2nd deworming. Conventionally, the scheme was designated as (3; 7.5; 7.5).

 The indicated calf deworming schemes for dictyocaulosis were tested in farms permanently unfavorable for this disease on 36 calves of the first year of birth in the grazing period. The calves were numbered by ear tags, weighed and divided into three equivalent groups of 11-13 goals each. From May 18 to October 8, 1997, calves of all groups grazed together in the same herd on a pasture, where young cattle, infested with diktiocaulus, were previously grazed.

 Nilverm and valbazen were administered to 11–12 calves of the first groups, respectively, up to 15 and 3.8 mg / kg orally individually on June 9 (1st time), July 7 (2nd time), and August 4 (3rd time).

 To 12 calves of the first group, dectomax was administered at a dose of 0.2 mg / kg subcutaneously once taking into account body weight on June 9 (1st time), August 4 (2nd time) and September 29 (3rd time).

 Animals of the second groups nilverm and valbazen in a dose of 15 and 3.8 mg / kg, respectively, were given orally individually on June 9 (1st time) and July 7 (2nd time).

 For the animals of the second group (13 animals), dectomax was administered subcutaneously once at a dose of 0.2 mg / kg taking into account body weight on June 9 (1st time) and August 4 (2nd time).

 Group 3 calves (12 animals) did not receive the drug and served as a control.

 Feces from the rectum were taken from animals of all groups, examined by flotation on June 9, July 7, August 4, 24, September 18, October 8, and November 8, 1997. In this case, a VIGIS counting chamber was used to account for the number of larvae in g animal feces.

 The results showed that triple use of dectomax completely prevents the infection of calves with dictiocaulus in the pasture period until mid-September (table 3).

 In fecal samples of animals that received nilverm and valbazene three times 3, 7, and 11 weeks after pasture on the pasture, for the first time, single dictyocaulus larvae were found in two of 11-12 animals in mid-September. The remaining animals were free of dictiocaulus during the entire pasture and subsequent periods.

 In calves of the second experimental group, which were injected with dectomax twice, i.e., 3 and 10.5 weeks after pasturing in the pasture, larvae of dictyocaulus were detected in a single amount (6.3 specimens per g of feces) in the first decade of October. In animals of the second experimental groups, which received nilverm and valbazene twice, i.e., 3 and 7 weeks after pasture on the pasture, dictyocaulus larvae were found in late August (6.3 specimens per gram of feces), September and October (12.7 copies in grams of feces).

 Thus, the double use of nilverm and valbazene at the 3rd and 7th week of grazing calves prevents their infection with dictyocaulus and the clinical manifestation of the disease during June, July and the first two decades of August. However, subsequently, larvae of dictiocaulus were found in feces of 2-3 animals from 11-12 animals of these groups, i.e. calves at the end of the grazing season were contaminated by larvae and were likely sources of invasion in the subsequent period.

 In calves of the control group, dictiocaulus larvae were found in feces at all stages of the study, except at the beginning of the experiment and 3 weeks after pasture on the pasture.

 The average number of dictiocaulus larvae in g feces of control calves was July 7 - 47.4 ± 7.2 specimens, on August 4 106.8 ± 12.1 specimens, on August 24 92.3 ± 8.5 specimens, and September 18 45 , 9 ± 5.6) ind., October 8, 32.7 ± 5.6 ind. and November 8, 25.7 ± 5.4 ind.

 The author set himself the goal of conducting an economic assessment of the effect of nilverm, dectomax, and valbazen administration schemes on the growth of the body of young cattle.

 An example of evaluating the economic efficiency of the results of trials of triple and double use of dectomax, valbazene, nilverma are shown in table 4.

 Estimating the three-time use of nilverma in cattle dictation during cattle grazing in the pasture period, young cattle of the experimental group were weighed before the experiment and at the end of it, the average weight of one animal before the experiment was 107.2 ± 8.4 kg, and at the end of the experiment 164, 2 ± 12.9 kg. With a three-time use of nilverm against dictation of young cattle in the grazing period, 57.0 kg of live weight gain was obtained.

 Evaluating the two-time regimen of using nilverm against dictyocaulosis of young cattle in the grazing period, the average body weight of an animal of this group was 114.5 ± 10.8 kg at the beginning of the experiment and 160.1 ± 11.6 kg at the end of the experiment, i.e. 45.6 kg of gain in live weight was obtained.

 In the control group of animals, the average body weight before the experiment was 117.3 ± 9.5 kg, and at the end it was 156.3 ± 13.3, i.e. the amount of increase in live weight averaged 39.0 (table 4).

 The difference between the obtained growths in the control group of animals and the experimental group with three times the use of nilverm in the grazing period was 18.0 kg. And between the control group and the experimental with a double use of nilverm was 11.4 kg

 Thus, evaluating economically the deworming schemes of young cattle using nilverm with its triple use in the grazing period, an average of 18.0 kg more weight gain was obtained in comparison with the untreated livestock in case of dictyocauliasis, and with double use of nilverm body weight was on average 11.4 kg higher.

 Assessing the three-time administration of dectomax during dictation of young cattle in the pasture period, the animals of the experimental and control groups were weighed before the experiment and at the end of it. The average weight of one animal before the experiment was 109.4 ± 11.2 kg, and after applying three times the dextomax at the end of the experiment, it was 170.0 ± 13.5 kg, i.e. 60.6 kg of growth was obtained.

 With a double administration regimen for dectomax administration during cattle dictation in the grazing period, the average body weight of the animal before the experiment was 112.0 ± 10.3 kg and at the end of the experiment 164.8 ± 15.2 kg, i.e. the increase was 52.8 kg (table 4).

 The difference between the gain in animals of the control and experimental groups (three times the use of dectomax in the pasture period) was 21.6 kg, and between the control and experimental groups (two times the use of dectomax) was 7.8 kg.

 Thus, evaluating economically the deworming schemes of young cattle against dictiocauliasis using dectomax with its triple and double application in the pasture period, an average of 21.6 and 7.8 kg increase in animal body weight was obtained, compared to untreated livestock.

 Evaluating the three-time regimen of using valbazene for cattle dictation in the grazing period, the animals of the experimental and control groups were weighed before and at the end of the experiment. The average weight of the animals of the experimental groups before the experiment was 117.5 ± 12.2 kg, and at the end of the experiment 171.5 ± 14.1 kg. Therefore, during the pasture period with a three-time regimen of using valbazene, 54.0 kg of live weight gain was obtained.

 A two-time regimen for the use of valbazene against cattle dictation was also evaluated in the grazing period. The average body weight of the animals of the experimental group was 105.8 ± 9.8 kg before the experiment and 154.0 ± 10.3 kg at the end of the experiment, i.e. 48.2 kg of body weight gain were obtained (table 4).

 In the control group of animals, the average body weight before the experiment was 117.3 ± 9.5 kg, and at the end 156.3 ± 13.3 kg, i.e. weight gain was an average of 39.0 kg.

 The difference between the obtained increase in animals of the control and experimental groups (triple use of valbazene) was 15.0 kg, and compared to double use of valbazene - 10.2 kg.

 Thus, evaluating economically the deworming schemes of young cattle against diktiocaulosis using valbazene when applied three times in the pasture period, an average of 15.0 kg more weight gain was obtained compared to the group of untreated animals. And with the double use of valbazene in the pasture period, the increase in body weight of the treated animals for a period of 4 months was on average 10.2 kg higher.

 The use of anthelmintics: dectomax or nilverm, levamisole, valbazene, duotin, cidectin, ivomek allows you to free young cattle from dictiocaulus and prevent animals from becoming infected.

 Improvement of cattle farms dictated by dictation of cattle is achieved by using dectomax nilverm, levamisole, valbazen, duotin, cidectin, ivomec according to the developed schemes for their use, taking into account the timing of calf infection and persistence of the anthelmintic effect of the preparations.

 The method is illustrated by the following example.

 Example 1

 The author tested the use of anthelmintic drugs in farms unsuccessful in dictation of cattle, the Central region of the Non-Chernozem zone and the Central Chernozem region of the Russian Federation (table 5).

 At Pamyat Oktyabrya CJSC, young cattle of the first and second year of grazing (148 animals) received oral valbazene once individually at a dose of 3.8 mg / kg, taking into account body weight, in 1995 three times, i.e. 3, 7 and 11 weeks after pasture in the pasture and in 1996 twice, that is, on the 3rd and 7th week of grazing.

 In the All-Russian Union of Artists' Union of Motherland, "Rodina", young cattle (210 animals) were treated with dectomax once subcutaneously at a dose of 0.2 mg / kg taking into account body weight, in 1995 three times, i.e. after 3; 10.5 and 18 weeks after pasture in the pasture and in 1996 twice, i.e. on the 3rd and 10.5th week of grazing.

 At VN Tsvetkov’s Plemzavod LLP, young cattle (38 animals) were given oral nilver at a dose of 15 mg / kg, taking into account body weight, in 1995 three times, i.e. 3, 7 and 11 weeks after the pasture in the pasture and in 1996 twice, i.e. on the 3rd and 7th week of grazing.

 The prevalence of invasion in young cattle of the second year of grazing before the start of farm rehabilitation was 28.3; 39.0 and 23.6% when detected on average 84.3 - 106.8 ind. larvae in g feces.

 At the end of the pasture season of 1995, the intensity of invasion (EI) of young cattle after three times the use of valbazene (AOZT "Pamyat Oktyabrya"), dectomax (VSHP MO RF "Rodina") and nilverma (Plemzavod named after VN Tsvetkov LLP) ) amounted to 8.8, respectively; 0 and 13.1% when detected on average 12.7; 0 and 12.7 copies. dictyocaulus larvae in grams of feces. In the spring of 1996 (the second year of the experiment), the EI of animals in the farm where valbazen, dectomax and nilverm were used was 9.4, respectively; 0 and 13.1% in the presence of feces in g 17.4; 0 and 25.3 ind. larvae. In the fall of 1996 and the spring of 1997, young cattle of all these farms were practically free of D. viviparus.

 The experiments showed that as a result of inventive activity, the author proposed a new method for the treatment and prophylactic measures in farms unsuccessful in cattle dictation.

Sources of information
1. Maltsev K.L., Arkhipov I.A., Shumakovich I.E. The effectiveness of new dosage forms of nilverma in dictation of young cattle // Transactions of the All-Russian Institute of Helminthology, Moscow, 1997. - V. 33. - P. 107.

 2. Arkhipov I.A., Maltsev K.L., Durdusov S.D., Lazarev G.M., Sadykov R.S. Evaluation of the antiparasitic effectiveness of dectomax // Veterinary medicine. - 1997. - N 2. - S. 34.

 3. Lemekhov P.A. Efficiency of Ivomec in cattle dictation in production conditions // Bulletin of Vses. Institute of helminthol. - 1987. Issue. 48. - S. 53.

 4. Arkhipov I.A., Aksenova I.N., Zemskov V.A. The effectiveness of duotin against endo- and ectoparasites of cattle // Veterinary medicine, 1995. - N 2. - P. 38.

 5. Lazarev G. M., Ponomarev I. A., Durdusov S. D., Onishchuk M. S., Basanov E. R., Badmaev N. B., Larionov Yu. N. The effectiveness of cidectin in parasitic diseases of ruminants in the arid zone of southern Russia // Veterinary Medicine, 1994. - N 2. - P. 29.

 6. Arkhipov I. A., Basaev E.R., Aksenova I.N. The effectiveness of valbazene against the main sheep helminthiases // Veterinary medicine, 1996. - N 4. - P. 35.

 7. Akbaev M.Sh. Parasitology and invasive animal diseases // Moscow, Kolos, 1998. - P. 192.

 8. According to the materials of "Livestock Farming" Prevention of diktiokauleza // Veterinary newspaper, 1995. - N 10. - P. 8.

 9. Staroverova N. A. Survival of Dictyocaulus viviparus larvae on pastures of the Non-Black Earth Region of the Russian Federation // Ecological parasitology. - Ivanovo, 1998 .-- S. 42.

 10. Koreshkov M.N. Comparative effectiveness of drugs of the group of macrocyclic lactones in animal nematodoses // Abstract ... of a candidate veterinarian. sciences. Tyumen, 1996 .-- S. 12.

 11. Maltsev K.L. Duration of infection of calves Dictyocaulus viviparus in the Central zone of Russia // Mater. doc. scientific conf. "Theory and practice of controlling parasitic diseases." Moscow. 1999 .-- S. 146.

 12. Strelchik V. A. The study of some issues of the pathogenesis and epizootology of dictyocaulosis of calves in the Middle Irtysh Region and measures to combat invasion // Abstract. thesis. ... cand. vet. sciences. Omsk, 1969 .-- S. 14.

Claims (4)

 1. A method for improving the well-being of dictated cattle dictation, including triple administration of an anthelmintic in the first year of grazing, characterized in that the anthelmintic is additionally introduced twice in the second year of grazing.  2. The method according to claim 1, characterized in that as an anthelmintic, dectomax is used, which is administered subcutaneously or intramuscularly in the first year of grazing by 3; 10.5; 18 weeks, and in the second year of grazing at 3 and 10.5 weeks.  3. The method according to claim 1, characterized in that as an anthelmintic use duotin or cidectin, or ivomek, which is administered intramuscularly or subcutaneously in the first year of grazing by 3; 9; 15 weeks, and in the second year of grazing at 3 and 9 weeks.  4. The method according to claim 1, characterized in that as an anthelmintic use nilverm or valbazene, which are given orally, or administered subcutaneously or intramuscularly, levamisole in the first year of grazing by 3; 7; 11 weeks, and in the second year of grazing at 3 and 7 weeks.

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