RU2557955C1 - Method of treatment of urinogenital mycoplasmosis of dogs - Google Patents

Abstract

FIELD: veterinary medicine.

SUBSTANCE: method comprises subcutaneous administration of antibiotic preparation enroxyl 5% at a dose of 0.1 ml/kg daily one time a day for 7 days and intramuscular administration of homeopathic preparation ovarinin at a dose of 1 ml/kg one time for 4 days, 4-fold.

EFFECT: use of the invention enables to increase the efficiency of treatment, to reduce treatment time and to restore reproductive function of dogs.

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Description

The invention relates to veterinary medicine, and in particular to a method for the treatment of urogenital mycoplasmosis of dogs.

Mycoplasmas are widespread in nature, their individual species can be pathogenic both for plants and for humans or warm-blooded animals [Kovalenko, Ya.R. Mycoplasmosis animals / Ya.R. Kovalenko. M .: Kolos, 1976. - P.14].

Mycoplasmosis of animals is a group of infectious diseases caused by microorganisms from the Mollicutes class.

Dogs are often diagnosed with urogenital diseases caused by representatives of Mycoplasma and Ureaplasma, which are normally found in the urogenital system of healthy animals.

The transmission of the pathogen occurs, as a rule, through sexual contact, but an airborne transmission route is also possible. With dog mycoplasmosis, embryo resorption, abortion are possible, puppies are born underdeveloped, high neonatal mortality is observed in the first days of life. In females, obstetric and gynecological diseases that are difficult to treat are recorded, in males - balanoposthitis, urethritis, prostatitis, orchoepididymitis, scrotal edema, decreased fertility [Sochnev V.V. Mixed carnivorous infections in urban areas / V.V. Sochnev, E.V. Medova, Yu.V. Pashkina, E.A. Gracheva and others // Veterinary pathology, 2006. - No. 3. - S. 72-74].

Since small domestic animals are in the closest contact with humans, there is a real threat of transmission of the pathogen from animal to human. Similar lesions of the genitourinary tract are also observed in humans, while the specific causative agent is mycoplasmas and ureaplasmas [Novikova N.N. Express methods for the diagnosis of associative urogenital mycoplasmosis of carnivores: author. dis. for a job. scientist step. Cand. Breathes Science / N.N. Novikov. - Novosibirsk, 2002. - C.3].

Known drug for the treatment of bacterial infections of animals and birds complicated by mycoplasmosis. The preparation contains tylosin and chloramphenicol, as well as solvents or fillers, stabilizers and preservatives in the following ratio of components, wt.%: Tylosin 0.25-50.0, chloramphenicol 2.5-90.0, solvents or fillers, stabilizers, preservatives - up to 100. The combined use of tylosin and chloramphenicol can increase therapeutic efficacy by 2.13% and 2.64%, respectively, in comparison with the separate use of tylosin and chloramphenicol, as well as reduce the content of tylosin by 5 times (Patent 2162690 RU).

A known method of treating animal mycoplasmosis with the use of an antibiotic tetracycline series (levotetrasulfine) and an immunomodulator westin or alnorine according to the following scheme: intramuscularly levotetrasulfin 0.4 ml / kg and alnorin 400 IU / kg once every 15 days, or levotetrasulfin 0.4 ml / kg and vestin 0.06 mg / kg once every 15 days. The method improves the efficiency of treatment of animals by reducing the treatment time (Patent 2219915 RU).

The closest solution adopted for the prototype is a well-known drug that promotes the elimination of mycoplasmas. Among antibiotics in veterinary medicine, tylosin is most widely used [Leshchinsky II. Macrolides - drugs of choice for the fight against animal mycoplasmosis / I.I. Leshchinsky // RVZH SHGZH, 2009. - No. 1. - S. 44-45]. Homeopathic medicines are also used: mastometrine, liarsin, the action of which stimulates the immune system and enhances the reproductive function of carnivores. After the use of mastometrin, the output of puppies in the main female was significantly higher in female foxes of the experimental groups than in the control group by an average of 23.91-23.78%, and the young stock was significantly lower before registration on average 4.49-6.29% against 20.44% in the control group (Kochueva N.A. Homeopathic methods for the correction of the reproductive function of female Arctic foxes / N.A. Kochueva, V.N. Bochkarev, N.V. Garntseva // Veterinary pathology, 2007. - No. 3. - S.204-207).

The disadvantage of using antibiotics is the relatively low effectiveness due to the emergence of resistant forms of mycoplasmas as a result of prolonged use of antibiotics in doses below their therapeutic level.

A method of treating dogs urogenital mycoplasmosis is characterized in that an antibiotic of the fluoroquinolone series and a homeopathic preparation are used as an etiotropic substance.

The essence of the invention lies in the fact that as an etiotropic substance, an antibiotic enroxil 5% is used, as well as a homeopathic preparation ovarinin. Enroxil 5% is administered subcutaneously to dogs at a dose of 0.1 ml / kg daily 1 time per day for 7 days and intramuscularly ovarinin at a dose of 1 ml / kg once every 4 days, 4 times.

Enroxil 5% belongs to the group of fluoroquinolones and has a wide spectrum of bactericidal action, based on the suppression of bacterial DNA replication. Enrofloxacin is active against gram-positive and gram-negative microorganisms.

Ovarinin contains homeopathic substances as active substances: Apis mellifelica - C12; Pulsatilla pratensis - C30; Sulfur - C200; Sepia - C30; Creazotum - C30; Lachesis - C12. Ovarinin restores metabolism, affects the immune and central nervous system, which leads to a cascade of biological reactions at the molecular and submolecular levels in the cells of the body, leading to reparative, anti-inflammatory, restorative processes and a change in hormonal status.

An example of the method

When developing the optimal treatment regimen for dogs with urogenital syndrome caused by mycoplasmas and chlamydia, dogs aged 2 to 6 years were used, divided by the principle of analogues into three groups: 2 experimental and 1 control, 10 animals each. The criteria for inclusion in the study groups were: taking into account the general condition and severity of the disease, positive laboratory tests for mycoplasma and chlamydial infection, the animals being in the same conditions of feeding and feeding.

As a result of various treatment regimens, the clinical therapeutic effect was evaluated. Evaluation of effectiveness was carried out by the disappearance of the clinical symptoms of the disease (table 1).

In recovered animals, the sexual cycle and reproductive function were restored (Table 2).

Thus, the clinical and therapeutic effect of the treatment regimen using the antibacterial drug Enroksil 5% and the homeopathic preparation ovarinin at a dose of 1 ml / kg in the treatment of the urogenital syndrome caused by mycoplasmas and chlamydia, consisted in increasing the treatment efficiency by 40%, reducing the duration of treatment by 2 days compared with monotherapy with an antibacterial drug, as well as in 85.7% restoration of the reproductive function of recovered animals and the possibility of avoiding surgery.

Claims (1)

A method of treating urogenital mycoplasmosis of dogs, comprising administering an antibiotic, characterized in that enroxil 5% is administered subcutaneously as a antibiotic at a dose of 0.1 ml / kg daily 1 time per day for 7 days and intramuscularly ovarinin at a dose of 1 ml / kg 1 time in 4 days, 4 times.