RU2735257C1 - Method for treating postpartum endometritis of bovine animals - Google Patents

Abstract

FIELD: veterinary medicine.SUBSTANCE: invention refers to veterinary science and can be used in therapy of postnatal purulent-catarrhal endometritis of cows. Method involves an intrauterine introduction of an antibacterial preparation, as an antibacterial preparation, a complex of preparations Argovit and Dimexid in form of 10 % and 5 % aqueous solutions in dose of 0.3 ml/kg of live weight once in 48 hours for 6–7 days.EFFECT: use of the invention provides higher therapeutic effectiveness and reduced length of treatment.1 cl, 2 tbl, 2 ex

Description

The invention relates to veterinary medicine, in particular, can be used in the treatment of endometritis in cattle.

For the treatment of postpartum diseases in cows, antimicrobial drugs are used, including antibiotics, sulfanilamide, nitrofuran, quinoxaline drugs, fluoroquinolones and other agents. But not all of them give the expected effect. This is primarily due to a decrease in the sensitivity of the uterine microflora to drugs. In this connection, there is a need to create new complex drugs.

A known method of treating cows with purulent-catarrhal endometritis, including the intramuscular injection of 2 ml of 2% solution of sinestrol and 10 ml of trivit for 10 days and additionally on the 3.5 and 7th days, the introduction of intravenous jet infused 1000 ml of ozonized saline together with 20 IU of oxytocin, and intrauterinely with rectal fixation of the cervix, administration at intervals of 48 hours in a volume of 50-75 ml of ozonized refined vegetable oil. (I.G. Konopeltsev, abstract of the dissertation for the degree of dissertation for the degree of scholar in doctoral sciences, Voronezh, 2004, p. 14).

The disadvantage of this method is its multicomponent nature, laboriousness of the treatment process and the possibility of developing side diseases.

Known veterinary drug Diphurura for the treatment and prevention of postpartum endometritis in cows and metritis-mastitis-agalactia in sows. It is a complex preparation containing furakilin, dioxidine, dimethyl sulfoxide and distilled water. The drug is administered intrauterinely to cows using a Janet syringe for therapeutic purposes - 100-150 ml every 48 hours until clinical recovery, but no more than 5 times (Mikhalev, V.I. Use of Difur for the treatment and prevention of acute postpartum purulent-catarrhal endometritis in cows : Candidate of Science thesis / V.I. Mikhalev. - Voronezh, 2001. - 138 p.).

The main disadvantages of Difur are: insufficiently high therapeutic efficacy; high therapeutic dose; high cost of the drug due to the high concentration of dimethyl sulfoxide.

The closest solution adopted for the prototype is a method of treating cows with postpartum purulent-catarrhal endometritis (patent No. 2660579) based on the use of a catholyte saturated with silver ions and ozone. The drug is administered intrauterinely, 100 ml every other day until the closure of the cervix.

The disadvantages of this method are: inaccessibility, high cost of the drug associated with the method of its manufacture.

The problem solved by the claimed invention is to enhance the therapeutic effect of the applied components of the drug.

The task is achieved by the fact that in the method of therapy of postpartum purulent-catarrhal endometritis of cows, including intrauterine administration of an antibacterial drug, where a complex of drugs argovit, Dimexide is used as an antibacterial drug in the form of 10% and 5% aqueous solutions at a dose of 0.3 ml / kg live weight 1 time per 48 hours for 6-7 days.

The invention is illustrated by the following examples.

Argovit is a complex of highly dispersed particles of cluster silver, polyvinylpyrrolidone and an aqueous solution obtained by the electric beam method. The drug has a wide spectrum of antimicrobial action against gram-positive and gram-negative, aerobic and anaerobic, spore-forming and asporogenic bacteria in the form of monocultures and microbial associations. Manufacturer LLC SPC "Vector Vita", e-mail: vectot-vita@ngs.ru.

Dimexide is a solution of the active substance dimethyl sulfoxide, which has pronounced anti-inflammatory, analgesic and antiseptic properties.

Example 1.

To determine the most optimal therapeutic dose of a preparation containing highly dispersed particles of cluster silver, obtained by the electrobeam method in a complex with Dimexide, three groups of black-and-white cows with postpartum purulent-catarrhal endometritis were formed on the basis of analogs. The animals were injected with argovit in the form of 5%, 10% and 15% and dimexide in the form of 5% aqueous solutions intrauterinely in doses from 0.1 to 0.3 ml / kg of live weight once every 48 hours.

The use of a complex drug with a concentration of active substances (argovit 5% + 5% solution of Dimexide) intrauterinely in doses from 0.1 to 0.3 ml / kg of live weight 1 time in 48 hours, showed the least therapeutic effect in the treatment of postpartum purulent catarrhal endometritis of cows. Recovering occurred on average 8.7-10.2 days.

The use of a complex preparation with a concentration of active substances (argovit 10% + 5% solution of Dimexide) intrauterinely at a dose of 0.3 ml / kg of live weight once every 48 hours, showed the greatest therapeutic effect in the treatment of postpartum purulent-catarrhal endometritis of cows, with which recovery took place on the 6.9th day.

The use of the drug with the concentration of the active substance (argovit 15% + 5% solution of Dimexidum) intrauterinely in doses from 0.1 to 0.3 ml / kg of live weight 1 time in 48 hours, is characterized by similar indicators of the recovery time as the use of the drug (Argovit 10% + 5% solution of Dimexide) at a dose of 0.3 ml / kg of live weight (Table 1).

From the generalized results it follows that the greatest therapeutic effect in the treatment of postpartum purulent-catarrhal endometritis in cows was achieved when using the drug in group 2 (0.3 ml / kg of live weight). However, the use of the drug (argovit 15% + 5% solution of Dimexidum) intrauterinely at doses from 0.1 to 0.3 ml / kg did not reveal a significant increase in the therapeutic effect and led to an overrun of the active ingredients that make up the drug.

The research results showed that the most effective dose of the drug, which has a pronounced therapeutic effect and a shorter treatment period (6.9 ± 0.1 days), is a dose of 0.3 ml / kg.

Example 2.

Determination of the therapeutic efficacy of an antibacterial drug with a concentration of active substances (argovit 10% + 5% dimexide solution) in the treatment of postpartum purulent-catarrhal endometritis in cows.

To study the comparative effectiveness of therapy for postpartum purulent-catarrhal endometritis in cows, three groups of animals were formed according to the analogy principle: the first group (n = 20) was injected with fish oil intrauterinely (0.3 ml / kg of live weight) with oxytetracycline hydrochloride (40 mg / kg of live weight). mass), 1 time in 48 hours. Uteroton 0.02 ml / kg live weight, intramuscularly, once every 48 hours.

The second group (n = 20) was injected with the drug argumestin intrauterinely at a dose of 0.2 ml / kg of live weight once a day until recovery. Uteroton 0.02 ml / kg of live weight, intramuscularly, once every 48 hours.

The third group (n = 20) was injected intrauterinely with the drug, where the complex of drugs argovit, Dimexide in the form of 10% and 5% aqueous solutions at a dose of 0.3 ml / kg of live weight was used as an antibacterial drug once every 48 hours. Uteroton 0.02 ml / kg live weight, intramuscularly, once every 48 hours.

The therapeutic efficacy of the drug argovit was determined by the percentage of recovery. The average duration of treatment for postpartum purulent-catarrhal endometritis of cows in the first group was 14.1 ± 0.6 days, in the second group 8.6 ± 0.4, while in the third group the duration of therapy was 6.9 ± 0.1 days ...

Claims (1)

A method of therapy for postpartum purulent-catarrhal endometritis of cows, including intrauterine administration of an antibacterial drug, where a complex of drugs argovit, dimexide is used as an antibacterial drug in the form of 10% and 5% aqueous solutions at a dose of 0.3 ml / kg of live weight once every 48 hours within 6-7 days.