RU2659171C2 - Способ лечения лимфомы, применяя тиенотриазолодиазепиновые соединения - Google Patents
Способ лечения лимфомы, применяя тиенотриазолодиазепиновые соединения Download PDFInfo
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- RU2659171C2 RU2659171C2 RU2015101106A RU2015101106A RU2659171C2 RU 2659171 C2 RU2659171 C2 RU 2659171C2 RU 2015101106 A RU2015101106 A RU 2015101106A RU 2015101106 A RU2015101106 A RU 2015101106A RU 2659171 C2 RU2659171 C2 RU 2659171C2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261663885P | 2012-06-25 | 2012-06-25 | |
| US61/663,885 | 2012-06-25 | ||
| US201261670918P | 2012-07-12 | 2012-07-12 | |
| US61/670,918 | 2012-07-12 | ||
| PCT/EP2013/063313 WO2014001356A1 (en) | 2012-06-25 | 2013-06-25 | Method of treating lymphoma using thienotriazolodiazepine compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015101106A RU2015101106A (ru) | 2016-08-10 |
| RU2659171C2 true RU2659171C2 (ru) | 2018-06-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015101106A RU2659171C2 (ru) | 2012-06-25 | 2013-06-25 | Способ лечения лимфомы, применяя тиенотриазолодиазепиновые соединения |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20140018353A1 (https=) |
| EP (1) | EP2863923B1 (https=) |
| JP (1) | JP6265979B2 (https=) |
| KR (1) | KR20150045423A (https=) |
| CN (1) | CN105050605A (https=) |
| AU (1) | AU2013283378B2 (https=) |
| BR (1) | BR112014032105A2 (https=) |
| CA (1) | CA2877434A1 (https=) |
| IN (1) | IN2014DN11269A (https=) |
| MX (1) | MX2014015986A (https=) |
| RU (1) | RU2659171C2 (https=) |
| WO (1) | WO2014001356A1 (https=) |
Families Citing this family (35)
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| CA2861066C (en) | 2012-01-12 | 2024-01-02 | Yale University | Compounds and methods for the enhanced degradation of targeted proteins and other polypeptides by an e3 ubiquitin ligase |
| MX366703B (es) | 2013-03-15 | 2019-07-22 | Incyte Holdings Corp | Heterociclos tricíclicos como inhibidores de la proteína bet. |
| AR096837A1 (es) | 2013-07-08 | 2016-02-03 | Incyte Corp | Heterociclos tricíclicos como inhibidores de proteínas bet |
| WO2015014998A1 (en) * | 2013-08-01 | 2015-02-05 | Oncoethix Sa | Pharmaceutical formulation containing thienotriazolodiazepine compounds |
| KR20160037201A (ko) * | 2013-08-06 | 2016-04-05 | 온코에틱스 게엠베하 | Bet-브로모도메인 억제제를 사용한 미만성 거대 b-세포 림프종 (dlbcl)의 치료 방법 |
| WO2015018522A1 (en) * | 2013-08-06 | 2015-02-12 | Oncoethix Sa | Bet-bromodomain inhibitor shows synergism with several anti-cancer agents in pre-clinical models of diffuse large b-cell lymphoma (dlbcl) |
| WO2015018520A1 (en) * | 2013-08-06 | 2015-02-12 | Oncoethix Sa | A bet-brd inhibitor represents a novel agent for alk positive anaplastic large cell lymphoma |
| US9399640B2 (en) | 2013-11-26 | 2016-07-26 | Incyte Corporation | Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors |
| WO2015081189A1 (en) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2877434A1 (en) | 2014-01-03 |
| JP2015531747A (ja) | 2015-11-05 |
| MX2014015986A (es) | 2016-02-11 |
| BR112014032105A2 (pt) | 2017-08-01 |
| WO2014001356A1 (en) | 2014-01-03 |
| AU2013283378A1 (en) | 2015-01-29 |
| CN105050605A (zh) | 2015-11-11 |
| KR20150045423A (ko) | 2015-04-28 |
| RU2015101106A (ru) | 2016-08-10 |
| AU2013283378B2 (en) | 2017-07-13 |
| EP2863923B1 (en) | 2019-05-08 |
| IN2014DN11269A (https=) | 2015-10-09 |
| EP2863923A1 (en) | 2015-04-29 |
| JP6265979B2 (ja) | 2018-01-24 |
| US20140018353A1 (en) | 2014-01-16 |
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