RU2656181C1 - Анти-pd-1-антитела, способ их получения и способ применения - Google Patents

Анти-pd-1-антитела, способ их получения и способ применения Download PDF

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Publication number
RU2656181C1
RU2656181C1 RU2016128487A RU2016128487A RU2656181C1 RU 2656181 C1 RU2656181 C1 RU 2656181C1 RU 2016128487 A RU2016128487 A RU 2016128487A RU 2016128487 A RU2016128487 A RU 2016128487A RU 2656181 C1 RU2656181 C1 RU 2656181C1
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Russia
Prior art keywords
antibody
binding
antibodies
human
antigen
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RU2016128487A
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English (en)
Russian (ru)
Inventor
Виктория Михайловна Екимова
Дмитрий Валерьевич Коржавин
Юлия Сергеевна Черных
Тимофей Александрович Неманкин
Валерий Владимирович Соловьев
Анна Константиновна Владимирова
Ирина Андреевна Буланкина
Сергей Васильевич Дидук
Ольга Владимировна Гончарова
Анна Владимировна Ерошова
Яков Юрьевич Устюгов
Марина Владимировна Артюхова
Андрей Борисович Улитин
Роман Алексеевич Иванов
Дмитрий Валентинович Морозов
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Закрытое Акционерное Общество "Биокад"
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Application filed by Закрытое Акционерное Общество "Биокад" filed Critical Закрытое Акционерное Общество "Биокад"
Priority to RU2016128487A priority Critical patent/RU2656181C1/ru
Priority to JOP/2019/0002A priority patent/JOP20190002A1/ar
Priority to PCT/RU2017/050056 priority patent/WO2018013017A1/ru
Priority to PE2019000027A priority patent/PE20190450A1/es
Priority to CR20190009A priority patent/CR20190009A/es
Priority to BR112019000436A priority patent/BR112019000436A2/pt
Priority to AU2017297138A priority patent/AU2017297138B2/en
Priority to US16/095,800 priority patent/US11136408B2/en
Priority to KR1020197003862A priority patent/KR102482710B1/ko
Priority to CN201780055794.3A priority patent/CN110023335B/zh
Priority to MX2018014937A priority patent/MX2018014937A/es
Priority to JP2018567611A priority patent/JP6993992B2/ja
Priority to MA44547A priority patent/MA44547B1/fr
Priority to CA3021372A priority patent/CA3021372A1/en
Priority to NZ750221A priority patent/NZ750221A/en
Priority to EP17828049.1A priority patent/EP3486257A4/en
Application granted granted Critical
Publication of RU2656181C1 publication Critical patent/RU2656181C1/ru
Priority to PH12018550179A priority patent/PH12018550179A1/en
Priority to CL2018003407A priority patent/CL2018003407A1/es
Priority to NI201900002A priority patent/NI201900002A/es
Priority to ZA2019/00792A priority patent/ZA201900792B/en
Priority to CONC2019/0001246A priority patent/CO2019001246A2/es
Priority to ECSENADI201910852A priority patent/ECSP19010852A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
RU2016128487A 2016-07-13 2016-07-13 Анти-pd-1-антитела, способ их получения и способ применения RU2656181C1 (ru)

Priority Applications (22)

Application Number Priority Date Filing Date Title
RU2016128487A RU2656181C1 (ru) 2016-07-13 2016-07-13 Анти-pd-1-антитела, способ их получения и способ применения
JOP/2019/0002A JOP20190002A1 (ar) 2016-07-13 2017-06-16 أجسام مضادة (أنتي – بي دي – 1) وطريقة الإنتاج وطريقة استخدام كل منهم
CA3021372A CA3021372A1 (en) 2016-07-13 2017-07-04 Anti-pd-1 antibodies, a method of production and a method of use thereof
CR20190009A CR20190009A (es) 2016-07-13 2017-07-04 Anticuerpos anti-pd-1, un método de producción y un método para su uso.
BR112019000436A BR112019000436A2 (pt) 2016-07-13 2017-07-04 anticorpos anti-pd-1, método de produção e método de uso dos mesmos
AU2017297138A AU2017297138B2 (en) 2016-07-13 2017-07-04 Anti-PD-1 antibodies, method for producing same and method for using same
US16/095,800 US11136408B2 (en) 2016-07-13 2017-07-04 Anti-PD-1 antibodies, method for producing same and method for using same
KR1020197003862A KR102482710B1 (ko) 2016-07-13 2017-07-04 항-pd-1 항체, 이의 생산 방법 및 사용 방법
CN201780055794.3A CN110023335B (zh) 2016-07-13 2017-07-04 抗-pd-1抗体、其生产方法及其使用方法
MX2018014937A MX2018014937A (es) 2016-07-13 2017-07-04 Anticuerpos anti-pd-1, un metodo de produccion y un metodo para su uso.
PCT/RU2017/050056 WO2018013017A1 (ru) 2016-07-13 2017-07-04 Анти-pd-1-антитела, способ их получения и способ применения
MA44547A MA44547B1 (fr) 2016-07-13 2017-07-04 Anticorps anti-pd-1,procédé de leur production et de leur utilisation
PE2019000027A PE20190450A1 (es) 2016-07-13 2017-07-04 Anticuerpos anti-pd-1, un metodo de produccion y un metodo para su uso
NZ750221A NZ750221A (en) 2016-07-13 2017-07-04 Anti-pd-1 antibodies, method for producing same and method for using same
EP17828049.1A EP3486257A4 (en) 2016-07-13 2017-07-04 ANTI-PD-1 ANTIBODY, METHOD FOR PRODUCING THE SAME AND METHOD FOR USE THEREOF
JP2018567611A JP6993992B2 (ja) 2016-07-13 2017-07-04 抗ｐｄ－１抗体、その産生方法及びその使用方法
PH12018550179A PH12018550179A1 (en) 2016-07-13 2018-10-26 Anti-pd-1 antibodies, method for producing same and method for using same
CL2018003407A CL2018003407A1 (es) 2016-07-13 2018-11-29 Anticuerdos anti-pd-1, método para producir el mismo y método para usar el mismo.
NI201900002A NI201900002A (es) 2016-07-13 2019-01-08 Anticuerpos anti-pd-1, un método de producción y un método para su uso
ZA2019/00792A ZA201900792B (en) 2016-07-13 2019-02-07 Anti-pd-1 antibodies, method for producing same and method for using same
CONC2019/0001246A CO2019001246A2 (es) 2016-07-13 2019-02-12 Anticuerpos anti-pd-1, un método de producción y un método para su uso
ECSENADI201910852A ECSP19010852A (es) 2016-07-13 2019-02-13 Anticuerpos anti-pd-1, un método de producción y un método para su uso

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2016128487A RU2656181C1 (ru) 2016-07-13 2016-07-13 Анти-pd-1-антитела, способ их получения и способ применения

Publications (1)

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RU2656181C1 true RU2656181C1 (ru) 2018-05-31

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US (1) US11136408B2 (https=)
EP (1) EP3486257A4 (https=)
JP (1) JP6993992B2 (https=)
KR (1) KR102482710B1 (https=)
CN (1) CN110023335B (https=)
BR (1) BR112019000436A2 (https=)
CA (1) CA3021372A1 (https=)
CL (1) CL2018003407A1 (https=)
CO (1) CO2019001246A2 (https=)
CR (1) CR20190009A (https=)
EC (1) ECSP19010852A (https=)
JO (1) JOP20190002A1 (https=)
MA (1) MA44547B1 (https=)
MX (1) MX2018014937A (https=)
NI (1) NI201900002A (https=)
NZ (1) NZ750221A (https=)
PE (1) PE20190450A1 (https=)
PH (1) PH12018550179A1 (https=)
RU (1) RU2656181C1 (https=)
WO (1) WO2018013017A1 (https=)
ZA (1) ZA201900792B (https=)

Cited By (2)

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RU2788095C2 (ru) * 2018-02-01 2023-01-16 МЕРК ШАРП И ДОУМ ЭлЭлСи Анти-pd-1 антитела
US12122834B2 (en) 2018-02-01 2024-10-22 Merck Sharp & Dohme Llc Anti-PD-1 antibodies

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IL300122A (en) 2015-11-18 2023-03-01 Merck Sharp ַ& Dohme Llc Substances that bind to PD1 and/or LAG3
JP7275030B2 (ja) 2017-01-20 2023-05-17 タユー ファシャ バイオテック メディカル グループ カンパニー， リミテッド 抗ｐｄ－１抗体およびその使用
MX2019012295A (es) 2017-04-14 2020-02-07 Tollnine Inc Polinucleotidos inmunomoduladores, conjugados de anticuerpos de los mismos y metodos para su uso.
CR20190550A (es) 2017-06-05 2020-04-05 Janssen Biotech Inc Anticuerpos que se unen específicamente a pd-1 y métodos de uso
EP4029877B1 (en) 2017-08-03 2024-01-17 Amgen Inc. Interleukin-21 muteins and methods of treatment
TW201930344A (zh) 2018-01-12 2019-08-01 美商安進公司 抗ｐｄ-１抗體及治療方法
US12258407B2 (en) 2018-07-19 2025-03-25 Tayu Huaxia Biotech Medical Group Co., Ltd. Anti-PD-1 antibodies, dosages and uses thereof
CN109652453B (zh) * 2018-12-29 2021-04-06 杭州科兴生物科技有限公司 一种基于pd-1/pdl-1阻断功能及生物效应的抗癌药物快速筛选方法
WO2020239558A1 (en) 2019-05-24 2020-12-03 Pfizer Inc. Combination therapies using cdk inhibitors
WO2020252471A1 (en) * 2019-06-14 2020-12-17 Dana-Farber Cancer Institute, Inc. Antibodies against pd-1 and methods of use thereof
CN111420049A (zh) * 2019-08-22 2020-07-17 Biocad股份公司 抗-pd1抗体prolgolimab的水性药物组合物及其应用
RU2753282C2 (ru) 2019-09-19 2021-08-12 Закрытое Акционерное Общество "Биокад" ИММУНОЦИТОКИН, ВКЛЮЧАЮЩИЙ ГЕТЕРОДИМЕРНЫЙ БЕЛКОВЫЙ КОМПЛЕКС НА ОСНОВЕ IL-15/IL-15Rα, И ЕГО ПРИМЕНЕНИЕ
CA3169523A1 (en) 2020-02-28 2021-09-02 Jaume Pons Transglutaminase-mediated conjugation
CR20220596A (es) 2020-05-26 2023-01-23 Boehringer Ingelheim Int Anticuerpos anti-pd-1
US20220168293A1 (en) 2020-12-02 2022-06-02 Pfizer Inc. Time to resolution of axitinib-related adverse events
KR20220082775A (ko) * 2020-12-10 2022-06-17 주식회사 유틸렉스 항-pd-1 항체 및 이의 용도
KR20230163503A (ko) 2021-03-31 2023-11-30 메뤼스 엔.페. 신규한 pd-1 결합 도메인
PY2227428A (es) 2021-04-08 2022-11-24 Biocad Joint Stock Co Método para tratar una neoplasia maligna mediante la combinación de un anticuerpo contra pd-1 y un agente quimioterapéutico
TW202327595A (zh) 2021-10-05 2023-07-16 美商輝瑞大藥廠 用於治療癌症之氮雜內醯胺化合物的組合
WO2023079428A1 (en) 2021-11-03 2023-05-11 Pfizer Inc. Combination therapies using tlr7/8 agonist
WO2024077069A1 (en) * 2022-10-05 2024-04-11 Chulalongkorn University Monoclonal antibodies against human programmed cell death protein 1 (pd-1)

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