RU2650598C2 - Мультифокусные соникации для гипертермических лечебных воздействий с использованием ультразвука, сфокусированного под контролем магнитно-резонансной томографии - Google Patents
Мультифокусные соникации для гипертермических лечебных воздействий с использованием ультразвука, сфокусированного под контролем магнитно-резонансной томографии Download PDFInfo
- Publication number
- RU2650598C2 RU2650598C2 RU2015117609A RU2015117609A RU2650598C2 RU 2650598 C2 RU2650598 C2 RU 2650598C2 RU 2015117609 A RU2015117609 A RU 2015117609A RU 2015117609 A RU2015117609 A RU 2015117609A RU 2650598 C2 RU2650598 C2 RU 2650598C2
- Authority
- RU
- Russia
- Prior art keywords
- target
- acoustic pressure
- sonication
- powers
- temperature profile
- Prior art date
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
- A61B5/015—By temperature mapping of body part
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
- A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7271—Specific aspects of physiological measurement analysis
- A61B5/7278—Artificial waveform generation or derivation, e.g. synthesizing signals from measured signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/74—Details of notification to user or communication with user or patient; User input means
- A61B5/742—Details of notification to user or communication with user or patient; User input means using visual displays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/74—Details of notification to user or communication with user or patient; User input means
- A61B5/7475—User input or interface means, e.g. keyboard, pointing device, joystick
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00084—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
- A61B2034/101—Computer-aided simulation of surgical operations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/37—Surgical systems with images on a monitor during operation
- A61B2090/374—NMR or MRI
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2576/00—Medical imaging apparatus involving image processing or analysis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0078—Ultrasound therapy with multiple treatment transducers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
- A61N2007/027—Localised ultrasound hyperthermia with multiple foci created simultaneously
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Artificial Intelligence (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Physiology (AREA)
- Psychiatry (AREA)
- Signal Processing (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Surgical Instruments (AREA)
- High Energy & Nuclear Physics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261713132P | 2012-10-12 | 2012-10-12 | |
| US61/713,132 | 2012-10-12 | ||
| PCT/IB2013/059001 WO2014057388A1 (en) | 2012-10-12 | 2013-09-30 | Multi-foci sonications for hyperthermia treatments using magnetic resonance-guided focussed ultrasound. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015117609A RU2015117609A (ru) | 2016-12-10 |
| RU2650598C2 true RU2650598C2 (ru) | 2018-04-16 |
Family
ID=49885310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015117609A RU2650598C2 (ru) | 2012-10-12 | 2013-09-30 | Мультифокусные соникации для гипертермических лечебных воздействий с использованием ультразвука, сфокусированного под контролем магнитно-резонансной томографии |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20150258353A1 (https=) |
| EP (1) | EP2906291B1 (https=) |
| JP (1) | JP6496662B2 (https=) |
| CN (1) | CN104884127B (https=) |
| BR (1) | BR112015007848A8 (https=) |
| ES (1) | ES2732575T3 (https=) |
| RU (1) | RU2650598C2 (https=) |
| WO (1) | WO2014057388A1 (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8444562B2 (en) | 2004-10-06 | 2013-05-21 | Guided Therapy Systems, Llc | System and method for treating muscle, tendon, ligament and cartilage tissue |
| US8535228B2 (en) | 2004-10-06 | 2013-09-17 | Guided Therapy Systems, Llc | Method and system for noninvasive face lifts and deep tissue tightening |
| US10864385B2 (en) | 2004-09-24 | 2020-12-15 | Guided Therapy Systems, Llc | Rejuvenating skin by heating tissue for cosmetic treatment of the face and body |
| US8690778B2 (en) | 2004-10-06 | 2014-04-08 | Guided Therapy Systems, Llc | Energy-based tissue tightening |
| US8133180B2 (en) | 2004-10-06 | 2012-03-13 | Guided Therapy Systems, L.L.C. | Method and system for treating cellulite |
| US9694212B2 (en) | 2004-10-06 | 2017-07-04 | Guided Therapy Systems, Llc | Method and system for ultrasound treatment of skin |
| US11883688B2 (en) | 2004-10-06 | 2024-01-30 | Guided Therapy Systems, Llc | Energy based fat reduction |
| KR20240113495A (ko) | 2004-10-06 | 2024-07-22 | 가이디드 테라피 시스템스, 엘.엘.씨. | 초음파 치료 시스템 |
| US20060111744A1 (en) | 2004-10-13 | 2006-05-25 | Guided Therapy Systems, L.L.C. | Method and system for treatment of sweat glands |
| US9827449B2 (en) | 2004-10-06 | 2017-11-28 | Guided Therapy Systems, L.L.C. | Systems for treating skin laxity |
| US11235179B2 (en) | 2004-10-06 | 2022-02-01 | Guided Therapy Systems, Llc | Energy based skin gland treatment |
| EP2279699B1 (en) | 2004-10-06 | 2019-07-24 | Guided Therapy Systems, L.L.C. | Method for non-invasive cosmetic enhancement of cellulite |
| US11207548B2 (en) | 2004-10-07 | 2021-12-28 | Guided Therapy Systems, L.L.C. | Ultrasound probe for treating skin laxity |
| US11724133B2 (en) | 2004-10-07 | 2023-08-15 | Guided Therapy Systems, Llc | Ultrasound probe for treatment of skin |
| KR102087909B1 (ko) | 2008-06-06 | 2020-03-12 | 얼테라, 인크 | 코스메틱 치료 시스템 |
| US12102473B2 (en) | 2008-06-06 | 2024-10-01 | Ulthera, Inc. | Systems for ultrasound treatment |
| JP2012513837A (ja) | 2008-12-24 | 2012-06-21 | ガイデッド セラピー システムズ, エルエルシー | 脂肪減少および/またはセルライト処置のための方法およびシステム |
| US9510802B2 (en) | 2012-09-21 | 2016-12-06 | Guided Therapy Systems, Llc | Reflective ultrasound technology for dermatological treatments |
| US11376074B2 (en) | 2013-01-25 | 2022-07-05 | Yoav Levy | Simulation-based focused-ultrasound treatment planning |
| JP6403689B2 (ja) | 2013-01-29 | 2018-10-10 | インサイテック・リミテッド | シミュレーションベース集束超音波治療計画 |
| CN204017181U (zh) | 2013-03-08 | 2014-12-17 | 奥赛拉公司 | 美学成像与处理系统、多焦点处理系统和执行美容过程的系统 |
| SG11201608691YA (en) | 2014-04-18 | 2016-11-29 | Ulthera Inc | Band transducer ultrasound therapy |
| JP2016019586A (ja) * | 2014-07-14 | 2016-02-04 | 株式会社日立メディコ | 凍結治療システム |
| US11185720B2 (en) * | 2014-10-17 | 2021-11-30 | Koninklijke Philips N.V. | Ultrasound patch for ultrasound hyperthermia and imaging |
| CA3007665A1 (en) | 2016-01-18 | 2017-07-27 | Ulthera, Inc. | Compact ultrasound device having annular ultrasound array peripherally electrically connected to flexible printed circuit board and method of assembly thereof |
| IL264440B (en) | 2016-08-16 | 2022-07-01 | Ulthera Inc | Systems and methods for cosmetic treatment of the skin using ultrasound |
| CN111032157B (zh) * | 2017-06-29 | 2023-04-21 | 医视特有限公司 | 基于模拟的药物治疗计划 |
| EP3459596A1 (en) | 2017-09-26 | 2019-03-27 | Koninklijke Philips N.V. | Power adjustment in magnetic resonance guided high intensity focused ultrasound |
| JP2021500126A (ja) * | 2017-10-19 | 2021-01-07 | プロファウンド メディカル インク | 熱治療のための処理システムおよびダイナミック補正方法 |
| US11191444B2 (en) | 2017-10-19 | 2021-12-07 | Profound Medical Inc. | Processing system and dynamic correction method for thermal therapy |
| CN111712301B (zh) * | 2017-12-11 | 2022-07-22 | 医视特有限公司 | 适应性闭环超声治疗 |
| TW202529848A (zh) | 2018-01-26 | 2025-08-01 | 美商奧賽拉公司 | 用於多個維度中的同時多聚焦超音治療的系統和方法 |
| WO2019164836A1 (en) | 2018-02-20 | 2019-08-29 | Ulthera, Inc. | Systems and methods for combined cosmetic treatment of cellulite with ultrasound |
| JP2022513577A (ja) | 2018-11-30 | 2022-02-09 | ウルセラ インコーポレイテッド | 超音波処置の効能を増強させるためのシステムおよび方法 |
| US11684807B2 (en) | 2018-12-27 | 2023-06-27 | Insightec Ltd. | Optimization of transducer configurations in ultrasound procedures |
| CA3137928A1 (en) | 2019-07-15 | 2021-01-21 | Ulthera, Inc. | Systems and methods for measuring elasticity with imaging of ultrasound multi-focus shearwaves in multiple dimensions |
| ES2793798B2 (es) * | 2020-02-13 | 2022-04-29 | Julia Jose Manuel Saenz | Aparato emisor de ultrasonidos para aplicacion de tratamientos selectivos sobre tejido adiposo en procesos de remodelacion / rejuvenecimiento corporal |
| CN111494817B (zh) * | 2020-02-26 | 2022-03-04 | 南北兄弟药业投资有限公司 | 一种hifu设备大焦域形成系统及其焦域形成方法 |
| CN111529974B (zh) * | 2020-06-01 | 2021-09-24 | 南京大学 | 一种基于环形阵列的超声定向定温加热方法 |
| US20220252550A1 (en) * | 2021-01-26 | 2022-08-11 | Ultraleap Limited | Ultrasound Acoustic Field Manipulation Techniques |
| CN112704822B (zh) * | 2021-02-07 | 2022-05-31 | 河南省中医院(河南中医药大学第二附属医院) | 一种用于妇科的超声热疗设备 |
| CN113133826B (zh) * | 2021-04-23 | 2023-04-07 | 四川大学华西医院 | 一种hifu低温聚焦方法、设备和系统 |
| NO20221061A1 (en) * | 2022-10-05 | 2024-04-08 | Exact Therapeutics As | Act enhanced ablation therapy |
| CN117018483B (zh) * | 2023-10-08 | 2023-12-22 | 北京小超科技有限公司 | 一种温度增强的微分多焦点超声空化装置 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2210409C2 (ru) * | 1998-01-25 | 2003-08-20 | Чун Цин Хифу Текнолоджи Ко., Лтд. | Система фокусированного воздействия ультразвуком высокой интенсивности для сканирования и лечения опухолей |
| US20100030076A1 (en) * | 2006-08-01 | 2010-02-04 | Kobi Vortman | Systems and Methods for Simultaneously Treating Multiple Target Sites |
| WO2011156624A2 (en) * | 2010-06-09 | 2011-12-15 | Regents Of The University Of Minnesota | Dual mode ultrasound transducer (dmut) system and method for controlling delivery of ultrasound therapy |
| US20120191020A1 (en) * | 2011-01-25 | 2012-07-26 | Shuki Vitek | Uniform thermal treatment of tissue interfaces |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4893624A (en) * | 1988-06-21 | 1990-01-16 | Massachusetts Institute Of Technology | Diffuse focus ultrasound hyperthermia system |
| JP3386488B2 (ja) * | 1992-03-10 | 2003-03-17 | 株式会社東芝 | 超音波治療装置 |
| JPH1014967A (ja) * | 1996-06-30 | 1998-01-20 | Shimadzu Corp | 超音波ハイパーサーミア装置 |
| JP4460691B2 (ja) * | 1998-09-30 | 2010-05-12 | 株式会社東芝 | 超音波治療装置 |
| FR2823678B1 (fr) * | 2001-04-20 | 2004-01-09 | Centre Nat Rech Scient | Ensemble de traitement thermique de tissus biologiques |
| JP4088126B2 (ja) * | 2002-09-09 | 2008-05-21 | 株式会社東芝 | 超音波治療装置 |
| WO2010052596A1 (en) * | 2008-11-04 | 2010-05-14 | Koninklijke Philips Electronics, N.V. | Method and system for ultrasound therapy |
| RU2011147045A (ru) * | 2009-04-20 | 2013-05-27 | Конинклейке Филипс Электроникс Н.В. | Устройство управления для управления терапевтическим устройством |
-
2013
- 2013-09-30 ES ES13814610T patent/ES2732575T3/es active Active
- 2013-09-30 EP EP13814610.5A patent/EP2906291B1/en not_active Not-in-force
- 2013-09-30 BR BR112015007848A patent/BR112015007848A8/pt not_active Application Discontinuation
- 2013-09-30 JP JP2015536248A patent/JP6496662B2/ja not_active Expired - Fee Related
- 2013-09-30 RU RU2015117609A patent/RU2650598C2/ru not_active IP Right Cessation
- 2013-09-30 CN CN201380053265.1A patent/CN104884127B/zh not_active Expired - Fee Related
- 2013-09-30 WO PCT/IB2013/059001 patent/WO2014057388A1/en not_active Ceased
- 2013-09-30 US US14/433,468 patent/US20150258353A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2210409C2 (ru) * | 1998-01-25 | 2003-08-20 | Чун Цин Хифу Текнолоджи Ко., Лтд. | Система фокусированного воздействия ультразвуком высокой интенсивности для сканирования и лечения опухолей |
| US20100030076A1 (en) * | 2006-08-01 | 2010-02-04 | Kobi Vortman | Systems and Methods for Simultaneously Treating Multiple Target Sites |
| WO2011156624A2 (en) * | 2010-06-09 | 2011-12-15 | Regents Of The University Of Minnesota | Dual mode ultrasound transducer (dmut) system and method for controlling delivery of ultrasound therapy |
| US20120191020A1 (en) * | 2011-01-25 | 2012-07-26 | Shuki Vitek | Uniform thermal treatment of tissue interfaces |
Non-Patent Citations (1)
| Title |
|---|
| Ronald J. Lalonde et al.Optimizing Ultrasound Focus Distributions for Hyperthermia, IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 42, NO. 10, OCTOBER 1995, pp.981-990. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104884127B (zh) | 2018-11-02 |
| US20150258353A1 (en) | 2015-09-17 |
| JP2015531290A (ja) | 2015-11-02 |
| WO2014057388A1 (en) | 2014-04-17 |
| JP6496662B2 (ja) | 2019-04-03 |
| EP2906291A1 (en) | 2015-08-19 |
| CN104884127A (zh) | 2015-09-02 |
| RU2015117609A (ru) | 2016-12-10 |
| BR112015007848A8 (pt) | 2018-02-06 |
| BR112015007848A2 (pt) | 2017-08-08 |
| ES2732575T3 (es) | 2019-11-25 |
| EP2906291B1 (en) | 2019-05-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2650598C2 (ru) | Мультифокусные соникации для гипертермических лечебных воздействий с использованием ультразвука, сфокусированного под контролем магнитно-резонансной томографии | |
| US11806496B2 (en) | Adaptive, closed-loop ultrasound therapy | |
| US20260000919A1 (en) | Aberration corrections for dynamically changing media during ultrasound therapy | |
| Bobkova et al. | Focusing of high-intensity ultrasound through the rib cage using a therapeutic random phased array | |
| US10694974B2 (en) | Method and system for MRI-based targeting, monitoring, and quantification of thermal and mechanical bioeffects in tissue induced by high intensity focused ultrasound | |
| US10806952B2 (en) | Therapeutic ultrasound apparatus and method | |
| US12246195B2 (en) | Pre-treatment tissue sensitization for focused ultrasound procedures | |
| Partanen et al. | Reduction of peak acoustic pressure and shaping of heated region by use of multifoci sonications in MR‐guided high‐intensity focused ultrasound mediated mild hyperthermia | |
| CN101888876A (zh) | 运动补偿的影像引导聚焦超声治疗系统 | |
| JPH07184907A (ja) | 超音波治療装置 | |
| Zhou | Generation of uniform lesions in high intensity focused ultrasound ablation | |
| Ding et al. | Modulation of transcranial focusing thermal deposition in nonlinear HIFU brain surgery by numerical simulation | |
| Ellens et al. | Frequency considerations for deep ablation with high‐intensity focused ultrasound: a simulation study | |
| Lu et al. | Enhanced-cavitation heating protocols in focused ultrasound surgery with broadband split-focus approach | |
| Sasaki et al. | Effect of split-focus approach on producing larger coagulation in swine liver | |
| Hutchinson et al. | Intracavitary ultrasound phased arrays for prostate thermal therapies: MRI compatibility and in vivo testing | |
| Chang et al. | Treatable focal region modulated by double excitation signal superimposition to realize platform temperature distribution during transcranial brain tumor therapy with high-intensity focused ultrasound | |
| Fan et al. | Comparative study of lesions created by high-intensity focused ultrasound using sequential discrete and continuous scanning strategies | |
| Ji et al. | A method of introducing cooling time between multiple sonications in focused ultrasound surgery | |
| US20200330114A1 (en) | Therapeutic ultrasonic device and the use thereof | |
| Staruch et al. | MRI-controlled ultrasound thermal therapy | |
| Sokka et al. | Gas-bubble enhanced heating in rabbit thigh in vivo | |
| Wang | Focused Ultrasound for Enhancement of Drug Delivery into Malignant Tissues |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HZ9A | Changing address for correspondence with an applicant | ||
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20201001 |