RU2650598C2 - Мультифокусные соникации для гипертермических лечебных воздействий с использованием ультразвука, сфокусированного под контролем магнитно-резонансной томографии - Google Patents

Мультифокусные соникации для гипертермических лечебных воздействий с использованием ультразвука, сфокусированного под контролем магнитно-резонансной томографии Download PDF

Info

Publication number
RU2650598C2
RU2650598C2 RU2015117609A RU2015117609A RU2650598C2 RU 2650598 C2 RU2650598 C2 RU 2650598C2 RU 2015117609 A RU2015117609 A RU 2015117609A RU 2015117609 A RU2015117609 A RU 2015117609A RU 2650598 C2 RU2650598 C2 RU 2650598C2
Authority
RU
Russia
Prior art keywords
target
acoustic pressure
sonication
powers
temperature profile
Prior art date
Application number
RU2015117609A
Other languages
English (en)
Russian (ru)
Other versions
RU2015117609A (ru
Inventor
Ари Илкка Микаэль ПАРТАНЕН
Матти Оскари ТИЛЛАНДЕР
Мэттью ДРЕЕР
Макс КОЛЕР
Original Assignee
Профаунд Медикал Инк.
Дзе Говермент Оф Дзе Юнайтед Стейтс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Профаунд Медикал Инк., Дзе Говермент Оф Дзе Юнайтед Стейтс filed Critical Профаунд Медикал Инк.
Publication of RU2015117609A publication Critical patent/RU2015117609A/ru
Application granted granted Critical
Publication of RU2650598C2 publication Critical patent/RU2650598C2/ru

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • A61B5/015—By temperature mapping of body part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271—Specific aspects of physiological measurement analysis
    • A61B5/7278—Artificial waveform generation or derivation, e.g. synthesizing signals from measured signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient; User input means
    • A61B5/742—Details of notification to user or communication with user or patient; User input means using visual displays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient; User input means
    • A61B5/7475—User input or interface means, e.g. keyboard, pointing device, joystick
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A61B2017/00084—Temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
    • A61B2034/101—Computer-aided simulation of surgical operations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/374—NMR or MRI
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2576/00—Medical imaging apparatus involving image processing or analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0078—Ultrasound therapy with multiple treatment transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A61N2007/027—Localised ultrasound hyperthermia with multiple foci created simultaneously

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physiology (AREA)
  • Signal Processing (AREA)
  • Hematology (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Surgical Instruments (AREA)
  • High Energy & Nuclear Physics (AREA)
RU2015117609A 2012-10-12 2013-09-30 Мультифокусные соникации для гипертермических лечебных воздействий с использованием ультразвука, сфокусированного под контролем магнитно-резонансной томографии RU2650598C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261713132P 2012-10-12 2012-10-12
US61/713,132 2012-10-12
PCT/IB2013/059001 WO2014057388A1 (en) 2012-10-12 2013-09-30 Multi-foci sonications for hyperthermia treatments using magnetic resonance-guided focussed ultrasound.

Publications (2)

Publication Number Publication Date
RU2015117609A RU2015117609A (ru) 2016-12-10
RU2650598C2 true RU2650598C2 (ru) 2018-04-16

Family

ID=49885310

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2015117609A RU2650598C2 (ru) 2012-10-12 2013-09-30 Мультифокусные соникации для гипертермических лечебных воздействий с использованием ультразвука, сфокусированного под контролем магнитно-резонансной томографии

Country Status (8)

Country Link
US (1) US20150258353A1 (https=)
EP (1) EP2906291B1 (https=)
JP (1) JP6496662B2 (https=)
CN (1) CN104884127B (https=)
BR (1) BR112015007848A8 (https=)
ES (1) ES2732575T3 (https=)
RU (1) RU2650598C2 (https=)
WO (1) WO2014057388A1 (https=)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8535228B2 (en) 2004-10-06 2013-09-17 Guided Therapy Systems, Llc Method and system for noninvasive face lifts and deep tissue tightening
US10864385B2 (en) 2004-09-24 2020-12-15 Guided Therapy Systems, Llc Rejuvenating skin by heating tissue for cosmetic treatment of the face and body
US8444562B2 (en) 2004-10-06 2013-05-21 Guided Therapy Systems, Llc System and method for treating muscle, tendon, ligament and cartilage tissue
US9827449B2 (en) 2004-10-06 2017-11-28 Guided Therapy Systems, L.L.C. Systems for treating skin laxity
US11883688B2 (en) 2004-10-06 2024-01-30 Guided Therapy Systems, Llc Energy based fat reduction
US8133180B2 (en) 2004-10-06 2012-03-13 Guided Therapy Systems, L.L.C. Method and system for treating cellulite
US11235179B2 (en) 2004-10-06 2022-02-01 Guided Therapy Systems, Llc Energy based skin gland treatment
WO2006042163A2 (en) 2004-10-06 2006-04-20 Guided Therapy Systems, L.L.C. Method and system for cosmetic enhancement
US9694212B2 (en) 2004-10-06 2017-07-04 Guided Therapy Systems, Llc Method and system for ultrasound treatment of skin
US20060111744A1 (en) 2004-10-13 2006-05-25 Guided Therapy Systems, L.L.C. Method and system for treatment of sweat glands
KR20170117205A (ko) 2004-10-06 2017-10-20 가이디드 테라피 시스템스, 엘.엘.씨. 초음파 치료 시스템
US8690779B2 (en) 2004-10-06 2014-04-08 Guided Therapy Systems, Llc Noninvasive aesthetic treatment for tightening tissue
US11207548B2 (en) 2004-10-07 2021-12-28 Guided Therapy Systems, L.L.C. Ultrasound probe for treating skin laxity
US11724133B2 (en) 2004-10-07 2023-08-15 Guided Therapy Systems, Llc Ultrasound probe for treatment of skin
KR102746886B1 (ko) 2008-06-06 2024-12-27 얼테라, 인크 초음파 치료 시스템
US12102473B2 (en) 2008-06-06 2024-10-01 Ulthera, Inc. Systems for ultrasound treatment
EP2382010A4 (en) 2008-12-24 2014-05-14 Guided Therapy Systems Llc METHOD AND SYSTEMS FOR FAT REDUCTION AND / OR TREATMENT OF CELLULITE
US9510802B2 (en) 2012-09-21 2016-12-06 Guided Therapy Systems, Llc Reflective ultrasound technology for dermatological treatments
US11376074B2 (en) 2013-01-25 2022-07-05 Yoav Levy Simulation-based focused-ultrasound treatment planning
EP2950737B1 (en) 2013-01-29 2023-01-11 Insightec Ltd. Simulation-based focused-ultrasound treatment planning
CN204017181U (zh) 2013-03-08 2014-12-17 奥赛拉公司 美学成像与处理系统、多焦点处理系统和执行美容过程的系统
AU2015247951A1 (en) 2014-04-18 2016-11-17 Ulthera, Inc. Band transducer ultrasound therapy
JP2016019586A (ja) * 2014-07-14 2016-02-04 株式会社日立メディコ 凍結治療システム
EP3206748B1 (en) * 2014-10-17 2024-04-17 Koninklijke Philips N.V. An ultrasound patch for ultrasound hyperthermia and ablation therapy
CN108367317B (zh) 2016-01-18 2020-10-09 奥赛拉公司 具有外围电连接到柔性印刷电路板的环形超声波阵列的紧凑型超声波装置及其组装方法
CA3022003A1 (en) 2016-08-16 2018-02-22 Ulthera, Inc. Systems and methods for cosmetic ultrasound treatment of skin
CN111032157B (zh) * 2017-06-29 2023-04-21 医视特有限公司 基于模拟的药物治疗计划
EP3459596A1 (en) 2017-09-26 2019-03-27 Koninklijke Philips N.V. Power adjustment in magnetic resonance guided high intensity focused ultrasound
US11191444B2 (en) 2017-10-19 2021-12-07 Profound Medical Inc. Processing system and dynamic correction method for thermal therapy
CN111225609B (zh) * 2017-10-19 2024-02-02 博放医疗有限公司 用于热疗法的处理系统和动态校正方法
WO2019116107A1 (en) * 2017-12-11 2019-06-20 Insightec, Ltd. Adaptive, closed- loop ultrasound therapy
TWI797235B (zh) 2018-01-26 2023-04-01 美商奧賽拉公司 用於多個維度中的同時多聚焦超音治療的系統和方法
WO2019164836A1 (en) 2018-02-20 2019-08-29 Ulthera, Inc. Systems and methods for combined cosmetic treatment of cellulite with ultrasound
BR112021006999A2 (pt) 2018-11-30 2021-07-20 Ulthera, Inc. sistemas e métodos para melhorar a eficácia de tratamento com ultrassom
US11684807B2 (en) 2018-12-27 2023-06-27 Insightec Ltd. Optimization of transducer configurations in ultrasound procedures
KR20220035151A (ko) 2019-07-15 2022-03-21 얼테라, 인크 초음파 다초점 전단파의 다차원 이미징으로 탄력을 측정하는 시스템 및 장치
ES2793798B2 (es) * 2020-02-13 2022-04-29 Julia Jose Manuel Saenz Aparato emisor de ultrasonidos para aplicacion de tratamientos selectivos sobre tejido adiposo en procesos de remodelacion / rejuvenecimiento corporal
CN111494817B (zh) * 2020-02-26 2022-03-04 南北兄弟药业投资有限公司 一种hifu设备大焦域形成系统及其焦域形成方法
CN111529974B (zh) * 2020-06-01 2021-09-24 南京大学 一种基于环形阵列的超声定向定温加热方法
US20220252550A1 (en) * 2021-01-26 2022-08-11 Ultraleap Limited Ultrasound Acoustic Field Manipulation Techniques
CN112704822B (zh) * 2021-02-07 2022-05-31 河南省中医院（河南中医药大学第二附属医院） 一种用于妇科的超声热疗设备
CN113133826B (zh) * 2021-04-23 2023-04-07 四川大学华西医院 一种hifu低温聚焦方法、设备和系统
NO20221061A1 (en) * 2022-10-05 2024-04-08 Exact Therapeutics As Act enhanced ablation therapy
CN117018483B (zh) * 2023-10-08 2023-12-22 北京小超科技有限公司 一种温度增强的微分多焦点超声空化装置

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2210409C2 (ru) * 1998-01-25 2003-08-20 Чун Цин Хифу Текнолоджи Ко., Лтд. Система фокусированного воздействия ультразвуком высокой интенсивности для сканирования и лечения опухолей
US20100030076A1 (en) * 2006-08-01 2010-02-04 Kobi Vortman Systems and Methods for Simultaneously Treating Multiple Target Sites
WO2011156624A2 (en) * 2010-06-09 2011-12-15 Regents Of The University Of Minnesota Dual mode ultrasound transducer (dmut) system and method for controlling delivery of ultrasound therapy
US20120191020A1 (en) * 2011-01-25 2012-07-26 Shuki Vitek Uniform thermal treatment of tissue interfaces

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4893624A (en) * 1988-06-21 1990-01-16 Massachusetts Institute Of Technology Diffuse focus ultrasound hyperthermia system
JP3386488B2 (ja) * 1992-03-10 2003-03-17 株式会社東芝 超音波治療装置
JPH1014967A (ja) * 1996-06-30 1998-01-20 Shimadzu Corp 超音波ハイパーサーミア装置
JP4460691B2 (ja) * 1998-09-30 2010-05-12 株式会社東芝 超音波治療装置
FR2823678B1 (fr) * 2001-04-20 2004-01-09 Centre Nat Rech Scient Ensemble de traitement thermique de tissus biologiques
JP4088126B2 (ja) * 2002-09-09 2008-05-21 株式会社東芝 超音波治療装置
BRPI0914520A2 (pt) * 2008-11-04 2015-12-15 Koninkl Philips Electronics Nv meio de armazenamento legível em computador, e, sistema de ablação por ultrassom
RU2011147045A (ru) * 2009-04-20 2013-05-27 Конинклейке Филипс Электроникс Н.В. Устройство управления для управления терапевтическим устройством

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2210409C2 (ru) * 1998-01-25 2003-08-20 Чун Цин Хифу Текнолоджи Ко., Лтд. Система фокусированного воздействия ультразвуком высокой интенсивности для сканирования и лечения опухолей
US20100030076A1 (en) * 2006-08-01 2010-02-04 Kobi Vortman Systems and Methods for Simultaneously Treating Multiple Target Sites
WO2011156624A2 (en) * 2010-06-09 2011-12-15 Regents Of The University Of Minnesota Dual mode ultrasound transducer (dmut) system and method for controlling delivery of ultrasound therapy
US20120191020A1 (en) * 2011-01-25 2012-07-26 Shuki Vitek Uniform thermal treatment of tissue interfaces

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Ronald J. Lalonde et al.Optimizing Ultrasound Focus Distributions for Hyperthermia, IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 42, NO. 10, OCTOBER 1995, pp.981-990. *

Also Published As

Publication number Publication date
US20150258353A1 (en) 2015-09-17
WO2014057388A1 (en) 2014-04-17
BR112015007848A2 (pt) 2017-08-08
RU2015117609A (ru) 2016-12-10
JP6496662B2 (ja) 2019-04-03
EP2906291B1 (en) 2019-05-15
ES2732575T3 (es) 2019-11-25
CN104884127B (zh) 2018-11-02
EP2906291A1 (en) 2015-08-19
CN104884127A (zh) 2015-09-02
JP2015531290A (ja) 2015-11-02
BR112015007848A8 (pt) 2018-02-06

Similar Documents

Publication Publication Date Title
RU2650598C2 (ru) Мультифокусные соникации для гипертермических лечебных воздействий с использованием ультразвука, сфокусированного под контролем магнитно-резонансной томографии
US11806496B2 (en) Adaptive, closed-loop ultrasound therapy
US20260000919A1 (en) Aberration corrections for dynamically changing media during ultrasound therapy
Bobkova et al. Focusing of high-intensity ultrasound through the rib cage using a therapeutic random phased array
US10694974B2 (en) Method and system for MRI-based targeting, monitoring, and quantification of thermal and mechanical bioeffects in tissue induced by high intensity focused ultrasound
US10806952B2 (en) Therapeutic ultrasound apparatus and method
CN101888876B (zh) 运动补偿的影像引导聚焦超声治疗系统
US12246195B2 (en) Pre-treatment tissue sensitization for focused ultrasound procedures
Partanen et al. Reduction of peak acoustic pressure and shaping of heated region by use of multifoci sonications in MR‐guided high‐intensity focused ultrasound mediated mild hyperthermia
JPH07184907A (ja) 超音波治療装置
Zhou Generation of uniform lesions in high intensity focused ultrasound ablation
Ding et al. Modulation of transcranial focusing thermal deposition in nonlinear HIFU brain surgery by numerical simulation
Ellens et al. Frequency considerations for deep ablation with high‐intensity focused ultrasound: a simulation study
Sasaki et al. Effect of split-focus approach on producing larger coagulation in swine liver
Hutchinson et al. Intracavitary ultrasound phased arrays for prostate thermal therapies: MRI compatibility and in vivo testing
Chang et al. Treatable focal region modulated by double excitation signal superimposition to realize platform temperature distribution during transcranial brain tumor therapy with high-intensity focused ultrasound
Fan et al. Comparative study of lesions created by high-intensity focused ultrasound using sequential discrete and continuous scanning strategies
Ji et al. A method of introducing cooling time between multiple sonications in focused ultrasound surgery
US20200330114A1 (en) Therapeutic ultrasonic device and the use thereof
Staruch et al. MRI-controlled ultrasound thermal therapy
Sokka et al. Gas-bubble enhanced heating in rabbit thigh in vivo
Wang Focused Ultrasound for Enhancement of Drug Delivery into Malignant Tissues

Legal Events

Date Code Title Description
HZ9A Changing address for correspondence with an applicant
MM4A The patent is invalid due to non-payment of fees

Effective date: 20201001