RU2646486C2 - Композиции для медицинского устройства, содержащие бактериальные штаммы, которые продуцируют экзополисахариды совместно с камедями и/или желатинами - Google Patents
Композиции для медицинского устройства, содержащие бактериальные штаммы, которые продуцируют экзополисахариды совместно с камедями и/или желатинами Download PDFInfo
- Publication number
- RU2646486C2 RU2646486C2 RU2015104728A RU2015104728A RU2646486C2 RU 2646486 C2 RU2646486 C2 RU 2646486C2 RU 2015104728 A RU2015104728 A RU 2015104728A RU 2015104728 A RU2015104728 A RU 2015104728A RU 2646486 C2 RU2646486 C2 RU 2646486C2
- Authority
- RU
- Russia
- Prior art keywords
- streptococcus thermophilus
- thermophilus dsm
- dsm
- gum
- composition
- Prior art date
Links
- 230000001580 bacterial effect Effects 0.000 title claims abstract description 49
- 239000000203 mixture Substances 0.000 title claims abstract description 47
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- 235000019322 gelatine Nutrition 0.000 title description 20
- 235000011852 gelatine desserts Nutrition 0.000 title description 20
- 241000194020 Streptococcus thermophilus Species 0.000 claims abstract description 65
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- 229920001938 Vegetable gum Polymers 0.000 description 11
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- 239000000546 pharmaceutical excipient Substances 0.000 description 8
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Classifications
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- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
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- A—HUMAN NECESSITIES
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- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A23L29/275—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of animal origin, e.g. chitin
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A61K35/66—Microorganisms or materials therefrom
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/02—Algae
- A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
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- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
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- Natural Medicines & Medicinal Plants (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Inorganic Chemistry (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2012A001328 | 2012-07-30 | ||
| IT001328A ITMI20121328A1 (it) | 2012-07-30 | 2012-07-30 | Composizione per dispositivo medico comprendente ceppi di batteri produttori di esopolisaccaridi in associazione con gomme e/o gelatine. |
| PCT/IB2013/001668 WO2014020408A1 (en) | 2012-07-30 | 2013-07-30 | Compositions for a medical device comprising exopolysaccharide-producing bacterial strains in association with gums and/or gelatines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015104728A RU2015104728A (ru) | 2016-09-20 |
| RU2646486C2 true RU2646486C2 (ru) | 2018-03-05 |
Family
ID=46982688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015104728A RU2646486C2 (ru) | 2012-07-30 | 2013-07-30 | Композиции для медицинского устройства, содержащие бактериальные штаммы, которые продуцируют экзополисахариды совместно с камедями и/или желатинами |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9889166B2 (pl) |
| EP (1) | EP2879685B1 (pl) |
| KR (1) | KR20150038435A (pl) |
| CN (1) | CN104540512A (pl) |
| BR (1) | BR112015002054A2 (pl) |
| CA (1) | CA2879014A1 (pl) |
| DK (1) | DK2879685T3 (pl) |
| ES (1) | ES2650455T3 (pl) |
| IN (1) | IN2015MN00094A (pl) |
| IT (1) | ITMI20121328A1 (pl) |
| PL (1) | PL2879685T3 (pl) |
| PT (1) | PT2879685T (pl) |
| RU (1) | RU2646486C2 (pl) |
| WO (1) | WO2014020408A1 (pl) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20121328A1 (it) | 2012-07-30 | 2014-01-31 | Probiotical Spa | Composizione per dispositivo medico comprendente ceppi di batteri produttori di esopolisaccaridi in associazione con gomme e/o gelatine. |
| CA2945631C (en) * | 2014-04-15 | 2023-04-11 | Novintethical Pharma Sa | Compositions based on xyloglucan and proteins for the treatment of intestinal disorders |
| EP3145518B1 (en) | 2014-05-05 | 2021-02-17 | Probiotical S.p.A. | A composition comprising l. reuteri ler03 and l. salivarius ls06 for use in antiviral and antibacterial treating in a subject undergoing anti-tumor chemotherapy, leukemia treatment or aids therapy |
| CA2967219A1 (en) * | 2014-11-26 | 2016-06-02 | Probiotical S.P.A. | Strains of lactobacillus or bifidobacterium for maintaining homeostasis |
| ITUB20155700A1 (it) * | 2015-11-18 | 2017-05-18 | Probiotical Spa | Composizioni con azione sinergica tra un complesso gelificante muco-aderente contro il passaggio degli antigeni, e batteri immunomodulanti anti-IL17 per uso nel trattamento delle malattie autoimmuni e neurodegenerative IL17 dipendenti. |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002204669A (ja) * | 2001-01-11 | 2002-07-23 | Toyo Shinyaku:Kk | ケール加工物を含む便秘改善食品 |
| CN101773221A (zh) * | 2010-01-21 | 2010-07-14 | 蜡笔小新(天津)有限公司 | 合生元果冻及其制作方法 |
| RU2410423C2 (ru) * | 2005-10-11 | 2011-01-27 | Анидрал С.Р.Л. | Способ получения по меньшей мере одной неаллергенной пробиотической бактериальной культуры для изготовления пищевого продукта или фармацевтической композиции, предназначенных для лиц, пораженных целиакией и особенно чувствительных к аллергенным веществам глютенового и/или молочного типа (варианты) |
| WO2011018547A1 (en) * | 2009-08-12 | 2011-02-17 | Vetcare Oy | Probiotic preparation for the prevention or treatment of canine gastrointestinal disorders |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005060937A1 (en) * | 2003-12-23 | 2005-07-07 | Chr. Hansen A/S | Compressed tablets comprising viable probiotic microorganisms |
| EP2046352A4 (en) * | 2006-06-06 | 2012-03-21 | Univ Mcgill | FERMENTED MILK PRODUCT AND ITS USE |
| CN101611738A (zh) * | 2008-06-26 | 2009-12-30 | 遵义市乳制品有限公司 | 双歧多益生菌多功能酸奶 |
| CN102100252A (zh) * | 2009-12-18 | 2011-06-22 | 光明乳业股份有限公司 | 发酵乳制品及其制备方法和原料组合物，植物乳杆菌应用 |
| MY149012A (en) * | 2010-03-29 | 2013-06-28 | Univ Putra Malaysia | Bioencapsule and method thereof |
| ES2350436B1 (es) * | 2010-07-21 | 2011-11-28 | Fundacion Leia, C.D.T. | Material simbiotico microencapsulado |
| ITMI20110934A1 (it) | 2011-05-24 | 2012-11-25 | Cohen Miguel Angel Alonso | Tannato di gelatina e sue associazioni per uso nel trattamento di malattie infiammatorie gastrointestinali |
| CN102283334A (zh) * | 2011-08-31 | 2011-12-21 | 西华大学 | 可改善小型犬肠道微生态的复合益生菌微胶囊 |
| ITRM20110477A1 (it) | 2011-09-09 | 2013-03-10 | Giovanni Mogna | Composizione comprendente n-acetilcisteina e/o lisozima microincapsulato gastroprotetto in associazione con batteri probiotici in grado di ripristinare l'effetto barriera proprio dello stomaco che viene perso durante il trattamento farmacologico dell |
| ITMI20121328A1 (it) | 2012-07-30 | 2014-01-31 | Probiotical Spa | Composizione per dispositivo medico comprendente ceppi di batteri produttori di esopolisaccaridi in associazione con gomme e/o gelatine. |
-
2012
- 2012-07-30 IT IT001328A patent/ITMI20121328A1/it unknown
-
2013
- 2013-07-30 KR KR1020157005091A patent/KR20150038435A/ko not_active Application Discontinuation
- 2013-07-30 CN CN201380040172.5A patent/CN104540512A/zh active Pending
- 2013-07-30 EP EP13777111.9A patent/EP2879685B1/en active Active
- 2013-07-30 CA CA2879014A patent/CA2879014A1/en not_active Abandoned
- 2013-07-30 DK DK13777111.9T patent/DK2879685T3/en active
- 2013-07-30 BR BR112015002054A patent/BR112015002054A2/pt not_active IP Right Cessation
- 2013-07-30 US US14/417,768 patent/US9889166B2/en not_active Expired - Fee Related
- 2013-07-30 WO PCT/IB2013/001668 patent/WO2014020408A1/en active Application Filing
- 2013-07-30 PT PT137771119T patent/PT2879685T/pt unknown
- 2013-07-30 PL PL13777111T patent/PL2879685T3/pl unknown
- 2013-07-30 RU RU2015104728A patent/RU2646486C2/ru active
- 2013-07-30 ES ES13777111.9T patent/ES2650455T3/es active Active
-
2015
- 2015-01-13 IN IN94MUN2015 patent/IN2015MN00094A/en unknown
-
2017
- 2017-12-20 US US15/848,812 patent/US20180133268A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002204669A (ja) * | 2001-01-11 | 2002-07-23 | Toyo Shinyaku:Kk | ケール加工物を含む便秘改善食品 |
| RU2410423C2 (ru) * | 2005-10-11 | 2011-01-27 | Анидрал С.Р.Л. | Способ получения по меньшей мере одной неаллергенной пробиотической бактериальной культуры для изготовления пищевого продукта или фармацевтической композиции, предназначенных для лиц, пораженных целиакией и особенно чувствительных к аллергенным веществам глютенового и/или молочного типа (варианты) |
| WO2011018547A1 (en) * | 2009-08-12 | 2011-02-17 | Vetcare Oy | Probiotic preparation for the prevention or treatment of canine gastrointestinal disorders |
| CN101773221A (zh) * | 2010-01-21 | 2010-07-14 | 蜡笔小新(天津)有限公司 | 合生元果冻及其制作方法 |
Non-Patent Citations (1)
| Title |
|---|
| Guzganu IL "Severe diarrhea in a 4-month-old baby girl with acute gastroenteritis: a case report and review of the literature", Case Rep Gastrointest Med. 2012; 2012:920375. doi: 10.1155/2012/920375. Epub 2012 Mar 25. стр.1-4. * |
Also Published As
| Publication number | Publication date |
|---|---|
| PT2879685T (pt) | 2017-12-12 |
| CN104540512A (zh) | 2015-04-22 |
| EP2879685A1 (en) | 2015-06-10 |
| ES2650455T3 (es) | 2018-01-18 |
| EP2879685B1 (en) | 2017-09-20 |
| DK2879685T3 (en) | 2017-12-11 |
| US20180133268A1 (en) | 2018-05-17 |
| US20150202239A1 (en) | 2015-07-23 |
| CA2879014A1 (en) | 2014-02-06 |
| WO2014020408A1 (en) | 2014-02-06 |
| RU2015104728A (ru) | 2016-09-20 |
| US9889166B2 (en) | 2018-02-13 |
| IN2015MN00094A (pl) | 2015-10-16 |
| KR20150038435A (ko) | 2015-04-08 |
| PL2879685T3 (pl) | 2018-03-30 |
| ITMI20121328A1 (it) | 2014-01-31 |
| BR112015002054A2 (pt) | 2017-07-04 |
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