RU2645672C2 - Новые соединения пирролопиримидина в качестве ингибиторов протеинкиназ - Google Patents

Новые соединения пирролопиримидина в качестве ингибиторов протеинкиназ Download PDF

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RU2645672C2
RU2645672C2 RU2015107831A RU2015107831A RU2645672C2 RU 2645672 C2 RU2645672 C2 RU 2645672C2 RU 2015107831 A RU2015107831 A RU 2015107831A RU 2015107831 A RU2015107831 A RU 2015107831A RU 2645672 C2 RU2645672 C2 RU 2645672C2
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alkyl
hydrogen
certain embodiments
phenyl
compound
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RU2015107831A
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RU2015107831A (ru
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Сяо СЮЙ
Сяобо ВАН
Лун МАО
Ли ЧЖАО
Бяо СИ
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Ацея Байосайенсиз Инк.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
RU2015107831A 2012-08-06 2013-07-11 Новые соединения пирролопиримидина в качестве ингибиторов протеинкиназ RU2645672C2 (ru)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201261680231P 2012-08-06 2012-08-06
US61/680,231 2012-08-06
US13/843,554 US9034885B2 (en) 2012-01-13 2013-03-15 EGFR modulators and uses thereof
US13/843,554 2013-03-15
US201361814147P 2013-04-19 2013-04-19
US61/814,147 2013-04-19
US13/917,514 2013-06-13
US13/917,514 US8685988B2 (en) 2012-08-06 2013-06-13 EGFR modulators and uses thereof
PCT/US2013/050163 WO2014025486A1 (en) 2012-08-06 2013-07-11 Novel pyrrolopyrimidine compounds as inhibitors of protein kinases

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RU2677653C2 (ru) * 2013-07-11 2019-01-18 Ацея Байосайенсиз Инк. Производные пиримидина в качестве ингибиторов киназы
US10449196B2 (en) 2012-08-06 2019-10-22 ACEA Therapeutics, Inc. EGFR modulators and uses thereof
US10533011B2 (en) 2015-10-09 2020-01-14 ACEA Therapeutics, Inc. Pharmaceutical salts, physical forms, and compositions of pyrrolopyrimidine kinase inhibitors, and methods of making same
US10596174B2 (en) 2012-01-13 2020-03-24 ACEA Therapeutics, Inc. Pyrrolopyrimidine compounds as inhibitors of protein kinases
US11498922B2 (en) 2017-04-07 2022-11-15 ACEA Therapeutics, Inc. Pharmaceutical composition comprising N-(3-((2-((3-fluoro-4-(4-methylpiperazin-1-yl phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenylacrylamide

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CN106749266B (zh) * 2016-11-14 2019-01-22 山东大学 吡咯并[2,3-d]嘧啶类化合物的高效制备方法
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10596174B2 (en) 2012-01-13 2020-03-24 ACEA Therapeutics, Inc. Pyrrolopyrimidine compounds as inhibitors of protein kinases
US10449196B2 (en) 2012-08-06 2019-10-22 ACEA Therapeutics, Inc. EGFR modulators and uses thereof
US11007197B2 (en) 2012-08-06 2021-05-18 ACEA Therapeutics, Inc. EGFR modulators and uses thereof
RU2677653C2 (ru) * 2013-07-11 2019-01-18 Ацея Байосайенсиз Инк. Производные пиримидина в качестве ингибиторов киназы
US10562918B2 (en) 2013-07-11 2020-02-18 ACEA Therapeutics, Inc. Heterocyclic compounds and uses thereof
US10533011B2 (en) 2015-10-09 2020-01-14 ACEA Therapeutics, Inc. Pharmaceutical salts, physical forms, and compositions of pyrrolopyrimidine kinase inhibitors, and methods of making same
US11498922B2 (en) 2017-04-07 2022-11-15 ACEA Therapeutics, Inc. Pharmaceutical composition comprising N-(3-((2-((3-fluoro-4-(4-methylpiperazin-1-yl phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenylacrylamide

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SG11201500872SA (en) 2015-03-30
SMT201700136T1 (it) 2017-05-08
KR102181365B1 (ko) 2020-11-23
EP3170825A1 (en) 2017-05-24
HK1210471A1 (en) 2016-04-22
DK2880035T3 (en) 2017-03-06
KR20150068949A (ko) 2015-06-22
CA2881275C (en) 2020-10-20
BR112015002709A2 (pt) 2017-07-04
JP6215938B2 (ja) 2017-10-18
ES2618007T3 (es) 2017-06-20
AU2013300106B2 (en) 2017-11-30
EP2880035A1 (en) 2015-06-10
CN103748096B (zh) 2017-10-20
HRP20170311T1 (hr) 2017-04-21
JP2017061581A (ja) 2017-03-30
BR112015002709B1 (pt) 2022-09-20
CN103748096A (zh) 2014-04-23
IN2015DN00914A (enExample) 2015-06-12
LT2880035T (lt) 2017-03-27
EP2880035B1 (en) 2016-12-07
JP2015524468A (ja) 2015-08-24
ZA201500762B (en) 2021-09-29
WO2014025486A1 (en) 2014-02-13
AU2013300106A1 (en) 2015-02-19
PT2880035T (pt) 2017-03-10
HUE031955T2 (en) 2017-08-28
EP3170825B1 (en) 2019-04-10
MX2015001715A (es) 2015-07-06
CA2881275A1 (en) 2014-02-13
CN107266453B (zh) 2020-02-07
ES2733576T3 (es) 2019-12-02
RU2015107831A (ru) 2016-09-27
CN107266453A (zh) 2017-10-20
RU2018104702A (ru) 2019-02-22
CY1120844T1 (el) 2019-12-11
MX361992B (es) 2018-12-19
ZA201600648B (en) 2021-09-29

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