KR102181365B1 - 단백질 키나아제 억제제로서 새로운 피롤로피리미딘 화합물 - Google Patents

단백질 키나아제 억제제로서 새로운 피롤로피리미딘 화합물 Download PDF

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KR102181365B1
KR102181365B1 KR1020157006007A KR20157006007A KR102181365B1 KR 102181365 B1 KR102181365 B1 KR 102181365B1 KR 1020157006007 A KR1020157006007 A KR 1020157006007A KR 20157006007 A KR20157006007 A KR 20157006007A KR 102181365 B1 KR102181365 B1 KR 102181365B1
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hydrogen
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halo
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KR20150068949A (ko
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시아오 수
시아오보 왕
롱 마오
리 자오
비아오 시
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에이시아 바이오사이언시스 인코포레이티드.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
KR1020157006007A 2012-08-06 2013-07-11 단백질 키나아제 억제제로서 새로운 피롤로피리미딘 화합물 Active KR102181365B1 (ko)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201261680231P 2012-08-06 2012-08-06
US61/680,231 2012-08-06
US13/843,554 US9034885B2 (en) 2012-01-13 2013-03-15 EGFR modulators and uses thereof
US13/843,554 2013-03-15
US201361814147P 2013-04-19 2013-04-19
US61/814,147 2013-04-19
US13/917,514 2013-06-13
US13/917,514 US8685988B2 (en) 2012-08-06 2013-06-13 EGFR modulators and uses thereof
PCT/US2013/050163 WO2014025486A1 (en) 2012-08-06 2013-07-11 Novel pyrrolopyrimidine compounds as inhibitors of protein kinases

Publications (2)

Publication Number Publication Date
KR20150068949A KR20150068949A (ko) 2015-06-22
KR102181365B1 true KR102181365B1 (ko) 2020-11-23

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ES (2) ES2733576T3 (enExample)
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HU (1) HUE031955T2 (enExample)
IN (1) IN2015DN00914A (enExample)
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EP2880035B9 (en) 2017-05-17
NZ629807A (en) 2017-04-28
SG11201500872SA (en) 2015-03-30
SMT201700136T1 (it) 2017-05-08
EP3170825A1 (en) 2017-05-24
HK1210471A1 (en) 2016-04-22
DK2880035T3 (en) 2017-03-06
KR20150068949A (ko) 2015-06-22
CA2881275C (en) 2020-10-20
BR112015002709A2 (pt) 2017-07-04
JP6215938B2 (ja) 2017-10-18
ES2618007T3 (es) 2017-06-20
AU2013300106B2 (en) 2017-11-30
EP2880035A1 (en) 2015-06-10
CN103748096B (zh) 2017-10-20
HRP20170311T1 (hr) 2017-04-21
JP2017061581A (ja) 2017-03-30
BR112015002709B1 (pt) 2022-09-20
CN103748096A (zh) 2014-04-23
IN2015DN00914A (enExample) 2015-06-12
LT2880035T (lt) 2017-03-27
EP2880035B1 (en) 2016-12-07
JP2015524468A (ja) 2015-08-24
ZA201500762B (en) 2021-09-29
WO2014025486A1 (en) 2014-02-13
AU2013300106A1 (en) 2015-02-19
PT2880035T (pt) 2017-03-10
HUE031955T2 (en) 2017-08-28
EP3170825B1 (en) 2019-04-10
MX2015001715A (es) 2015-07-06
CA2881275A1 (en) 2014-02-13
CN107266453B (zh) 2020-02-07
ES2733576T3 (es) 2019-12-02
RU2645672C2 (ru) 2018-02-27
RU2015107831A (ru) 2016-09-27
CN107266453A (zh) 2017-10-20
RU2018104702A (ru) 2019-02-22
CY1120844T1 (el) 2019-12-11
MX361992B (es) 2018-12-19
ZA201600648B (en) 2021-09-29

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