RU2640913C2 - Средства и способы лечения и/или предотвращения рака, зависимого от природного лиганда ahr - Google Patents

Средства и способы лечения и/или предотвращения рака, зависимого от природного лиганда ahr Download PDF

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RU2640913C2
RU2640913C2 RU2014104696A RU2014104696A RU2640913C2 RU 2640913 C2 RU2640913 C2 RU 2640913C2 RU 2014104696 A RU2014104696 A RU 2014104696A RU 2014104696 A RU2014104696 A RU 2014104696A RU 2640913 C2 RU2640913 C2 RU 2640913C2
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ahr
tdo
cells
kyn
inhibitor
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RU2014104696A
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RU2014104696A (ru
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Михаель ПЛАТТЕН
Кристиан ОПИТЦ
Вольфганг ВИК
Ульрике ЛИТЦЕНБУРГЕР
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Дойчес Кребсфоршунгсцентрум
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y113/00—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13)
    • C12Y113/11—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13) with incorporation of two atoms of oxygen (1.13.11)
    • C12Y113/11011—Tryptophan 2,3-dioxygenase (1.13.11.11), i.e. indolamine 2,3-dioxygenase 2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y113/00—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13)
    • C12Y113/11—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13) with incorporation of two atoms of oxygen (1.13.11)
    • C12Y113/11017—Indole 2,3-dioxygenase (1.13.11.17)

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  • Wood Science & Technology (AREA)
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  • Biochemistry (AREA)
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  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
RU2014104696A 2011-09-07 2012-09-07 Средства и способы лечения и/или предотвращения рака, зависимого от природного лиганда ahr RU2640913C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161531861P 2011-09-07 2011-09-07
US61/531,861 2011-09-07
PCT/EP2012/067504 WO2013034685A1 (en) 2011-09-07 2012-09-07 Means and methods for treating and/or preventing natural ahr ligand-dependent cancer

Publications (2)

Publication Number Publication Date
RU2014104696A RU2014104696A (ru) 2015-10-20
RU2640913C2 true RU2640913C2 (ru) 2018-01-12

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RU2014104696A RU2640913C2 (ru) 2011-09-07 2012-09-07 Средства и способы лечения и/или предотвращения рака, зависимого от природного лиганда ahr

Country Status (15)

Country Link
US (1) US9593062B2 (enExample)
EP (1) EP2753315B1 (enExample)
JP (1) JP6047160B2 (enExample)
KR (1) KR20140074330A (enExample)
CN (1) CN104023713A (enExample)
AU (1) AU2012306285B2 (enExample)
BR (1) BR112014004937A2 (enExample)
CA (1) CA2846275C (enExample)
ES (1) ES2626015T3 (enExample)
HK (1) HK1201471A1 (enExample)
IL (1) IL231107A (enExample)
MX (1) MX348941B (enExample)
RU (1) RU2640913C2 (enExample)
WO (1) WO2013034685A1 (enExample)
ZA (1) ZA201401011B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2826628C1 (ru) * 2020-03-27 2024-09-16 Тон-А Ст Ко., Лтд. Производные аминопиримидина и их применение в качестве модуляторов рецептора ароматических углеводородов

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JP2953065B2 (ja) 1990-12-28 1999-09-27 石川島播磨重工業株式会社 宇宙飛翔体
CA3173052A1 (en) 2013-08-30 2015-03-05 Board Of Regents, The University Of Texas System Administration of kynurenine depleting enzymes for tumor therapy
IL250833B (en) 2014-08-29 2022-09-01 Univ Texas Administration of kynurenine depleting enzymes for tumor therapy
EP3274053A4 (en) 2015-03-23 2018-12-05 The Brigham and Women's Hospital, Inc. Tolerogenic nanoparticles for treating diabetes mellitus
PT3370768T (pt) 2015-11-03 2022-04-21 Janssen Biotech Inc Anticorpos que se ligam especificamente ao pd-1 e seus usos
EP3423483B1 (en) 2016-03-02 2025-09-24 Board Of Regents Of the University Of Texas System Human kynureninase enzyme variants having improved pharmacological properties
CN107510694B (zh) * 2016-06-16 2022-03-29 中国科学院上海巴斯德研究所 激活潜伏感染的艾滋病病毒的化合物及其在艾滋病治疗中的应用
CN106214673A (zh) * 2016-08-31 2016-12-14 深圳市第二人民医院 表没食子儿茶素没食子酸酯在制备预防或治疗膀胱肿瘤的药物中的用途
WO2018085775A1 (en) * 2016-11-04 2018-05-11 Ohio State Innovation Foundation Methods and compositions for treating multiple myeloma and increasing antibody dependent cell cytotoxicity by targeting the aryl hydrocarbon receptor
CN111163766A (zh) 2017-08-17 2020-05-15 医肯纳肿瘤学公司 Ahr抑制剂和其用途
US12398209B2 (en) 2018-01-22 2025-08-26 Janssen Biotech, Inc. Methods of treating cancers with antagonistic anti-PD-1 antibodies
CA3096549A1 (en) 2018-04-16 2019-10-24 Board Of Regents, The University Of Texas System Human kynureninase enzymes and uses thereof
RU2699932C1 (ru) * 2018-11-14 2019-09-11 Федеральное государственное бюджетное образовательное учреждение высшего образования "Северо-Осетинская государственная медицинская академия" Министерства здравоохранения Российской Федерации Способ прогнозирования риска развития рака печени у экспериментальных животных
CN109813913B (zh) * 2019-01-31 2021-11-09 中国医学科学院肿瘤医院 芳烃受体(AhR)在预测免疫治疗效果中的应用
CN114828863A (zh) 2019-10-17 2022-07-29 医肯纳肿瘤学公司 聚乙二醇化犬尿氨酸酶以及其用于治疗癌症的用途
BR112022013673A2 (pt) * 2020-01-10 2022-09-13 Ikena Oncology Inc Inibidores de ahr e seus usos
CN114019164B (zh) * 2020-12-31 2023-11-21 中国科学院生态环境研究中心 筛选抗胶质瘤药物的方法和试剂盒
CN112807305A (zh) * 2020-12-31 2021-05-18 中国科学院生态环境研究中心 Ch223191在抑制肿瘤细胞迁移中的应用
CN114470238A (zh) * 2022-03-25 2022-05-13 华中科技大学同济医学院附属协和医院 AhR抑制剂CH223191在制备抑制肿瘤相关巨噬细胞药物中的应用
CN121378137A (zh) * 2025-11-05 2026-01-23 青岛大学 一种芳香烃受体ahr抑制剂ch223191的合成方法

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Patent Citations (2)

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WO2007128723A1 (en) * 2006-05-03 2007-11-15 Symrise Gmbh & Co. Kg Ah receptor antagonists
US20100183564A1 (en) * 2008-10-30 2010-07-22 Irm Llc Compounds that expand hematopoietic stem cells

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LYON DE et al. "Tryptophan degradation in women with brest cancer: a pilot study" BMC Res Notes 2011 May 26; 4:156. VELDHOEN M. et al. "Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells". J Exp Med. 2009 Jan 16;206(1):43-9. doi: 10.1084/jem.20081438. Epub 2008 Dec 29, реферат, найдено из PubMed PMID:19114668. *
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2826628C1 (ru) * 2020-03-27 2024-09-16 Тон-А Ст Ко., Лтд. Производные аминопиримидина и их применение в качестве модуляторов рецептора ароматических углеводородов

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MX348941B (es) 2017-07-04
US9593062B2 (en) 2017-03-14
BR112014004937A2 (pt) 2017-06-20
ZA201401011B (en) 2018-07-25
CN104023713A (zh) 2014-09-03
ES2626015T3 (es) 2017-07-21
CA2846275A1 (en) 2013-03-14
JP6047160B2 (ja) 2016-12-21
HK1201471A1 (en) 2015-09-04
EP2753315B1 (en) 2017-03-01
IL231107A (en) 2017-11-30
RU2014104696A (ru) 2015-10-20
MX2014002776A (es) 2014-11-25
WO2013034685A1 (en) 2013-03-14
AU2012306285A1 (en) 2014-02-27
JP2014526450A (ja) 2014-10-06
EP2753315A1 (en) 2014-07-16
IL231107A0 (en) 2014-04-30
AU2012306285B2 (en) 2017-05-18
US20140294860A1 (en) 2014-10-02
CA2846275C (en) 2019-07-16
KR20140074330A (ko) 2014-06-17

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