JP6047160B2 - 天然ahrリガンド依存性癌を治療および/または予防するための手段および方法 - Google Patents

天然ahrリガンド依存性癌を治療および/または予防するための手段および方法 Download PDF

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JP6047160B2
JP6047160B2 JP2014528990A JP2014528990A JP6047160B2 JP 6047160 B2 JP6047160 B2 JP 6047160B2 JP 2014528990 A JP2014528990 A JP 2014528990A JP 2014528990 A JP2014528990 A JP 2014528990A JP 6047160 B2 JP6047160 B2 JP 6047160B2
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cancer
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プラッテン,ミヒャエル
オピッツ,クリスティアーネ
ヴィック,ヴォルフガング
リッツェンブルガー,ウルリケ
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ドイチェス クレブスフォルシュンクスツェントルム
ドイチェス クレブスフォルシュンクスツェントルム
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12Y113/11011Tryptophan 2,3-dioxygenase (1.13.11.11), i.e. indolamine 2,3-dioxygenase 2
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    • C12Y113/00Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13)
    • C12Y113/11Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13) with incorporation of two atoms of oxygen (1.13.11)
    • C12Y113/11017Indole 2,3-dioxygenase (1.13.11.17)

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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JP2014528990A 2011-09-07 2012-09-07 天然ahrリガンド依存性癌を治療および/または予防するための手段および方法 Active JP6047160B2 (ja)

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Application Number Priority Date Filing Date Title
US201161531861P 2011-09-07 2011-09-07
US61/531,861 2011-09-07
PCT/EP2012/067504 WO2013034685A1 (en) 2011-09-07 2012-09-07 Means and methods for treating and/or preventing natural ahr ligand-dependent cancer

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JP2014526450A JP2014526450A (ja) 2014-10-06
JP2014526450A5 JP2014526450A5 (enExample) 2015-08-06
JP6047160B2 true JP6047160B2 (ja) 2016-12-21

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US (1) US9593062B2 (enExample)
EP (1) EP2753315B1 (enExample)
JP (1) JP6047160B2 (enExample)
KR (1) KR20140074330A (enExample)
CN (1) CN104023713A (enExample)
AU (1) AU2012306285B2 (enExample)
BR (1) BR112014004937A2 (enExample)
CA (1) CA2846275C (enExample)
ES (1) ES2626015T3 (enExample)
HK (1) HK1201471A1 (enExample)
IL (1) IL231107A (enExample)
MX (1) MX348941B (enExample)
RU (1) RU2640913C2 (enExample)
WO (1) WO2013034685A1 (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2953065B2 (ja) 1990-12-28 1999-09-27 石川島播磨重工業株式会社 宇宙飛翔体

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EP3492094A1 (en) 2013-08-30 2019-06-05 Board of Regents, The University of Texas System Administration of kynurenine depleting enzymes for tumor therapy
EP3186371B1 (en) 2014-08-29 2024-08-14 Board of Regents, The University of Texas System Administration of kynurenine depleting enzymes for tumor therapy
US20180071376A1 (en) 2015-03-23 2018-03-15 The Brigham And Women`S Hospital, Inc. Tolerogenic nanoparticles for treating diabetes mellitus
SI3370768T1 (sl) 2015-11-03 2022-04-29 Janssen Biotech, Inc. Protitelesa, ki se specifično vežejo na PD-1, in njihove uporabe
WO2017151860A1 (en) 2016-03-02 2017-09-08 Broard Of Regents, The University Of Texas System Human kynureninase enzyme variants having improved pharmacological properties
CN107510694B (zh) * 2016-06-16 2022-03-29 中国科学院上海巴斯德研究所 激活潜伏感染的艾滋病病毒的化合物及其在艾滋病治疗中的应用
CN106214673A (zh) * 2016-08-31 2016-12-14 深圳市第二人民医院 表没食子儿茶素没食子酸酯在制备预防或治疗膀胱肿瘤的药物中的用途
WO2018085775A1 (en) * 2016-11-04 2018-05-11 Ohio State Innovation Foundation Methods and compositions for treating multiple myeloma and increasing antibody dependent cell cytotoxicity by targeting the aryl hydrocarbon receptor
JP7269917B2 (ja) * 2017-08-17 2023-05-09 イケナ オンコロジー, インコーポレイテッド Ahr阻害剤およびその使用
US12398209B2 (en) 2018-01-22 2025-08-26 Janssen Biotech, Inc. Methods of treating cancers with antagonistic anti-PD-1 antibodies
JP7432851B2 (ja) 2018-04-16 2024-02-19 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム ヒトキヌレニナーゼ酵素及びその使用
RU2699932C1 (ru) * 2018-11-14 2019-09-11 Федеральное государственное бюджетное образовательное учреждение высшего образования "Северо-Осетинская государственная медицинская академия" Министерства здравоохранения Российской Федерации Способ прогнозирования риска развития рака печени у экспериментальных животных
CN109813913B (zh) * 2019-01-31 2021-11-09 中国医学科学院肿瘤医院 芳烃受体(AhR)在预测免疫治疗效果中的应用
JP2023510797A (ja) * 2020-01-10 2023-03-15 イケナ オンコロジー, インコーポレイテッド Ahr阻害剤及びその使用
CN114019164B (zh) * 2020-12-31 2023-11-21 中国科学院生态环境研究中心 筛选抗胶质瘤药物的方法和试剂盒
CN112807305A (zh) * 2020-12-31 2021-05-18 中国科学院生态环境研究中心 Ch223191在抑制肿瘤细胞迁移中的应用
CN114470238A (zh) * 2022-03-25 2022-05-13 华中科技大学同济医学院附属协和医院 AhR抑制剂CH223191在制备抑制肿瘤相关巨噬细胞药物中的应用

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US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
HK1047109A1 (zh) 1999-10-15 2003-02-07 University Of Massachusetts 作为指定基因干预工具的rna干预轨迹基因
JP4587652B2 (ja) * 2002-09-09 2010-11-24 株式会社フラバミン 新規フラボノイド化合物及びその利用
CN1744887A (zh) * 2003-02-04 2006-03-08 株式会社益力多本社 乳癌耐性蛋白抑制剂
WO2007128723A1 (en) * 2006-05-03 2007-11-15 Symrise Gmbh & Co. Kg Ah receptor antagonists
WO2010008427A1 (en) 2008-04-11 2010-01-21 Ludwig Institute For Cancer Research Ltd. Tryptophan catabolism in cancer treatment and diagnosis
PE20100362A1 (es) * 2008-10-30 2010-05-27 Irm Llc Derivados de purina que expanden las celulas madre hematopoyeticas

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2953065B2 (ja) 1990-12-28 1999-09-27 石川島播磨重工業株式会社 宇宙飛翔体

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CA2846275C (en) 2019-07-16
CA2846275A1 (en) 2013-03-14
RU2014104696A (ru) 2015-10-20
ZA201401011B (en) 2018-07-25
IL231107A (en) 2017-11-30
US20140294860A1 (en) 2014-10-02
EP2753315B1 (en) 2017-03-01
ES2626015T3 (es) 2017-07-21
EP2753315A1 (en) 2014-07-16
AU2012306285B2 (en) 2017-05-18
WO2013034685A1 (en) 2013-03-14
BR112014004937A2 (pt) 2017-06-20
MX2014002776A (es) 2014-11-25
CN104023713A (zh) 2014-09-03
IL231107A0 (en) 2014-04-30
RU2640913C2 (ru) 2018-01-12
HK1201471A1 (zh) 2015-09-04
JP2014526450A (ja) 2014-10-06
KR20140074330A (ko) 2014-06-17
MX348941B (es) 2017-07-04
US9593062B2 (en) 2017-03-14
AU2012306285A1 (en) 2014-02-27

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