RU2637934C2 - Способ получения оксиморфона - Google Patents

Способ получения оксиморфона Download PDF

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Publication number
RU2637934C2
RU2637934C2 RU2016107369A RU2016107369A RU2637934C2 RU 2637934 C2 RU2637934 C2 RU 2637934C2 RU 2016107369 A RU2016107369 A RU 2016107369A RU 2016107369 A RU2016107369 A RU 2016107369A RU 2637934 C2 RU2637934 C2 RU 2637934C2
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RU
Russia
Prior art keywords
oxymorphone
acid
hydrogenation
approximately
solution
Prior art date
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RU2016107369A
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English (en)
Russian (ru)
Other versions
RU2016107369A (ru
Inventor
Николас АРЧЕР
Юарт ГРАНТ
Брайан ХАЙНРИХ
Саруп МАТХАРУ
Original Assignee
Джонсон Мэтти Паблик Лимитед Компани
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Application filed by Джонсон Мэтти Паблик Лимитед Компани filed Critical Джонсон Мэтти Паблик Лимитед Компани
Publication of RU2016107369A publication Critical patent/RU2016107369A/ru
Application granted granted Critical
Publication of RU2637934C2 publication Critical patent/RU2637934C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
RU2016107369A 2013-08-02 2014-02-05 Способ получения оксиморфона RU2637934C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361861777P 2013-08-02 2013-08-02
US61/861,777 2013-08-02
PCT/GB2014/050317 WO2015015146A1 (en) 2013-08-02 2014-02-05 Process for the preparation of oxymorphone

Publications (2)

Publication Number Publication Date
RU2016107369A RU2016107369A (ru) 2017-09-05
RU2637934C2 true RU2637934C2 (ru) 2017-12-08

Family

ID=50114388

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2016107369A RU2637934C2 (ru) 2013-08-02 2014-02-05 Способ получения оксиморфона

Country Status (9)

Country Link
US (3) US9120800B2 (de)
EP (1) EP3027622B8 (de)
CN (2) CN105452253A (de)
AU (1) AU2014298257B2 (de)
BR (1) BR112016002079A2 (de)
CA (1) CA2919602C (de)
GB (1) GB2517000B (de)
RU (1) RU2637934C2 (de)
WO (1) WO2015015146A1 (de)

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* Cited by examiner, † Cited by third party
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GB201313915D0 (en) * 2013-08-02 2013-09-18 Johnson Matthey Plc Process
GB2517000B (en) * 2013-08-02 2018-05-09 Johnson Matthey Plc Process for the synthesis of oxymorphone alkaloid and oxymorphone salts
US9918979B2 (en) * 2015-01-29 2018-03-20 Johnson Matthey Public Limited Company Process of preparing low ABUK oxymorphone hydrochloride
US20160340362A1 (en) * 2015-05-20 2016-11-24 Noramco, Inc. Process For The Preparation Of Oxymorphone Freebase

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WO2008072018A1 (en) * 2006-12-14 2008-06-19 Johnson Matthey Public Limited Company Improved method for making analgesics
WO2008118654A1 (en) * 2007-03-23 2008-10-02 Mallinckrodt Inc. Improved preparation of oxymorphone from oripavine
EP2377866A1 (de) * 2010-03-23 2011-10-19 Siegfried Ltd. Herstellung von Opiaten hoher Reinheit in einem Durchflussreaktor
WO2013102784A1 (en) * 2012-01-05 2013-07-11 American Power Conversion Corporation Calibration of current sensors in paralled power converters

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GB1478759A (en) 1974-11-18 1977-07-06 Alza Corp Process for forming outlet passageways in pills using a laser
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FR2636330B1 (fr) 1988-09-13 1990-11-30 Sanofi Sa Procede de preparation de derives de morphinane
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GB2517000B (en) * 2013-08-02 2018-05-09 Johnson Matthey Plc Process for the synthesis of oxymorphone alkaloid and oxymorphone salts

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2297419C2 (ru) * 2001-08-23 2007-04-20 Акцо Нобель Н.В. Производное 14-гидроксинорморфинона, производное морфинона, производное морфина, способы получения производного 14-гидроксинорморфинона, производное морфинона, нороксиморфона
WO2008072018A1 (en) * 2006-12-14 2008-06-19 Johnson Matthey Public Limited Company Improved method for making analgesics
WO2008118654A1 (en) * 2007-03-23 2008-10-02 Mallinckrodt Inc. Improved preparation of oxymorphone from oripavine
EP2377866A1 (de) * 2010-03-23 2011-10-19 Siegfried Ltd. Herstellung von Opiaten hoher Reinheit in einem Durchflussreaktor
WO2013102784A1 (en) * 2012-01-05 2013-07-11 American Power Conversion Corporation Calibration of current sensors in paralled power converters

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* Cited by examiner, † Cited by third party
Title
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Also Published As

Publication number Publication date
EP3027622B1 (de) 2019-04-03
US20190225622A1 (en) 2019-07-25
AU2014298257A1 (en) 2016-02-25
RU2016107369A (ru) 2017-09-05
US20150038715A1 (en) 2015-02-05
BR112016002079A2 (pt) 2017-09-05
GB2517000A (en) 2015-02-11
EP3027622B8 (de) 2019-06-12
AU2014298257B2 (en) 2016-11-10
CN110172063A (zh) 2019-08-27
CN105452253A (zh) 2016-03-30
US20150329553A1 (en) 2015-11-19
WO2015015146A1 (en) 2015-02-05
GB201401922D0 (en) 2014-03-19
EP3027622A1 (de) 2016-06-08
CA2919602C (en) 2018-03-13
GB2517000B (en) 2018-05-09
CA2919602A1 (en) 2015-02-05
US9120800B2 (en) 2015-09-01

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