RU2616500C2 - Композиция пазопаниба - Google Patents

Композиция пазопаниба Download PDF

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Publication number
RU2616500C2
RU2616500C2 RU2014115289A RU2014115289A RU2616500C2 RU 2616500 C2 RU2616500 C2 RU 2616500C2 RU 2014115289 A RU2014115289 A RU 2014115289A RU 2014115289 A RU2014115289 A RU 2014115289A RU 2616500 C2 RU2616500 C2 RU 2616500C2
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RU
Russia
Prior art keywords
composition
indazol
pyrimidinyl
methylamino
dimethyl
Prior art date
Application number
RU2014115289A
Other languages
English (en)
Russian (ru)
Other versions
RU2014115289A (ru
Inventor
Огастус Кэмпбелл ГОССЕТТ
Хелен РИЧАРДСОН
Питер А. УИЛЛЬЯМС
Original Assignee
Новартис Аг
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Application filed by Новартис Аг filed Critical Новартис Аг
Publication of RU2014115289A publication Critical patent/RU2014115289A/ru
Application granted granted Critical
Publication of RU2616500C2 publication Critical patent/RU2616500C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2014115289A 2011-10-31 2012-10-16 Композиция пазопаниба RU2616500C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161553454P 2011-10-31 2011-10-31
US61/553,454 2011-10-31
PCT/US2012/060361 WO2013066616A1 (en) 2011-10-31 2012-10-16 Pazopanib formulation

Publications (2)

Publication Number Publication Date
RU2014115289A RU2014115289A (ru) 2015-12-10
RU2616500C2 true RU2616500C2 (ru) 2017-04-17

Family

ID=48192602

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2014115289A RU2616500C2 (ru) 2011-10-31 2012-10-16 Композиция пазопаниба

Country Status (12)

Country Link
US (3) US9278099B2 (OSRAM)
EP (1) EP2773204A4 (OSRAM)
JP (2) JP6200893B2 (OSRAM)
KR (1) KR101993436B1 (OSRAM)
CN (1) CN104254249B (OSRAM)
AU (1) AU2012332952B2 (OSRAM)
BR (1) BR112014010551A2 (OSRAM)
CA (1) CA2852912A1 (OSRAM)
HK (1) HK1201685A1 (OSRAM)
IN (1) IN2014CN02850A (OSRAM)
RU (1) RU2616500C2 (OSRAM)
WO (1) WO2013066616A1 (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA201502073B (en) * 2014-03-28 2016-03-30 Cipla Ltd Pharmaceutical composition
CN110753546B (zh) 2017-04-17 2023-11-10 耶鲁大学 治疗或预防急性肺损伤的化合物、组合物和方法
WO2019053500A1 (en) 2018-04-17 2019-03-21 Alvogen Malta Operations (Row) Ltd PHARMACEUTICAL COMPOSITION OF SOLID DOSAGE FORM CONTAINING PAZOPANIB AND PROCESS FOR PREPARING THE SAME
MX395463B (es) 2018-04-24 2025-03-25 Shionogi & Co Forma de dosificacion solida que tiene excelente estabilidad
AU2019259686B2 (en) 2018-04-24 2023-05-25 Shionogi & Co., Ltd. Solid formulation having excellent stability

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2241460C2 (ru) * 2001-11-23 2004-12-10 Глэксо Груп Лимитед Фармацевтическая композиция цефуроксим аксетила с маскированным горьким вкусом
RU2003130115A (ru) * 2003-10-14 2005-04-10 Федеральное государственное унитарное предпри тие "Всероссийкий научный центр по безопасности биологически активных веществ"(ФГУП "ВНЦ БАВ") (RU) Стабильная фармацевтическая суспензия азитромицина и способ ее получения
US20090005406A1 (en) * 2005-11-29 2009-01-01 Smithkline Beecham Corporation Cancer Treatment Method
RU2381223C2 (ru) * 2004-08-16 2010-02-10 Тереванс, Инк. Кристаллическая форма бифенильного соединения

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
CH675537A5 (OSRAM) * 1988-03-25 1990-10-15 Ciba Geigy Ag
EP0373103B1 (de) * 1988-11-10 1993-03-31 Ciba-Geigy Ag Flüssige orale Formulierung
DK1343782T3 (da) * 2000-12-21 2009-08-24 Smithkline Beecham Corp Pyrimidinaminer som angiogenesemodulatorer
TW200740820A (en) * 2005-07-05 2007-11-01 Takeda Pharmaceuticals Co Fused heterocyclic derivatives and use thereof
JP5180834B2 (ja) 2005-11-29 2013-04-10 スミスクライン ビーチャム コーポレーション 治療方法
AR059066A1 (es) 2006-01-27 2008-03-12 Amgen Inc Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf)
KR20100087002A (ko) * 2007-11-12 2010-08-02 노파르티스 아게 발사르탄을 포함하는 액체 조성물
CL2008000374A1 (es) * 2008-02-05 2008-04-04 Igloo Zone Chile S A Composicion farmaceutica que comprende un polvo para suspension oral de tacrolimus o una de sus sales, hidratos o solvatos y excipientes farmaceuticamente aceptables; procedimiento de preparacion de dicha composicion farmaceutica; y uso para la preve
JP2011516607A (ja) * 2008-04-15 2011-05-26 サーコード コーポレイション 胃腸系へのｌｆａ−１アンタゴニストの送達
WO2010037095A2 (en) * 2008-09-29 2010-04-01 Nometics Agents and methods for the treatment of cancer
US20100291025A1 (en) * 2009-04-13 2010-11-18 Auspex Pharmaceuticals, Inc. Indazole inhibitors of tyrosine kinase
EP2298321A1 (en) * 2009-08-26 2011-03-23 Nordic Pharma Novel pharmaceutical compositions for treating IBD
US8501811B2 (en) * 2010-06-17 2013-08-06 Washington University TASPASE1 inhibitors and their uses

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2241460C2 (ru) * 2001-11-23 2004-12-10 Глэксо Груп Лимитед Фармацевтическая композиция цефуроксим аксетила с маскированным горьким вкусом
RU2003130115A (ru) * 2003-10-14 2005-04-10 Федеральное государственное унитарное предпри тие "Всероссийкий научный центр по безопасности биологически активных веществ"(ФГУП "ВНЦ БАВ") (RU) Стабильная фармацевтическая суспензия азитромицина и способ ее получения
RU2381223C2 (ru) * 2004-08-16 2010-02-10 Тереванс, Инк. Кристаллическая форма бифенильного соединения
US20090005406A1 (en) * 2005-11-29 2009-01-01 Smithkline Beecham Corporation Cancer Treatment Method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RU 2241460 C2, 12.2004. *

Also Published As

Publication number Publication date
US10080802B2 (en) 2018-09-25
US20160120988A1 (en) 2016-05-05
AU2012332952B2 (en) 2016-05-05
US10596263B2 (en) 2020-03-24
HK1201685A1 (en) 2015-09-11
BR112014010551A2 (pt) 2017-05-02
CN104254249A (zh) 2014-12-31
US20140255505A1 (en) 2014-09-11
JP6200893B2 (ja) 2017-09-20
RU2014115289A (ru) 2015-12-10
CN104254249B (zh) 2017-02-15
KR20140096082A (ko) 2014-08-04
US9278099B2 (en) 2016-03-08
KR101993436B1 (ko) 2019-06-26
CA2852912A1 (en) 2013-05-10
JP2014534215A (ja) 2014-12-18
IN2014CN02850A (OSRAM) 2015-07-03
AU2012332952A1 (en) 2014-05-15
EP2773204A4 (en) 2015-05-27
EP2773204A1 (en) 2014-09-10
US20180360971A1 (en) 2018-12-20
WO2013066616A1 (en) 2013-05-10
JP6423484B2 (ja) 2018-11-14
JP2017197542A (ja) 2017-11-02

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