RU2593709C2 - Биологические материалы и их применение - Google Patents

Биологические материалы и их применение Download PDF

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Publication number
RU2593709C2
RU2593709C2 RU2013105769/10A RU2013105769A RU2593709C2 RU 2593709 C2 RU2593709 C2 RU 2593709C2 RU 2013105769/10 A RU2013105769/10 A RU 2013105769/10A RU 2013105769 A RU2013105769 A RU 2013105769A RU 2593709 C2 RU2593709 C2 RU 2593709C2
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RU
Russia
Prior art keywords
antibody
mcg
fragment
cancer
antigen binding
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RU2013105769/10A
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English (en)
Russian (ru)
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RU2013105769A (ru
Inventor
Маркус ХАНССОН
Бйорн ФРЕНДЕУС
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Биоинвент Интернэшнл Аб
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2013105769/10A 2010-07-13 2011-07-13 Биологические материалы и их применение RU2593709C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1011771.1 2010-07-13
GBGB1011771.1A GB201011771D0 (en) 2010-07-13 2010-07-13 Biological material and particular uses thereof
PCT/EP2011/061983 WO2012007516A1 (en) 2010-07-13 2011-07-13 Use of antibodies against icam-1 in the treatment of patients with relapsed cancer

Publications (2)

Publication Number Publication Date
RU2013105769A RU2013105769A (ru) 2014-08-20
RU2593709C2 true RU2593709C2 (ru) 2016-08-10

Family

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Application Number Title Priority Date Filing Date
RU2013105769/10A RU2593709C2 (ru) 2010-07-13 2011-07-13 Биологические материалы и их применение

Country Status (10)

Country Link
US (2) US20130189260A1 (enExample)
EP (1) EP2593481A1 (enExample)
JP (2) JP5992406B2 (enExample)
KR (1) KR20130100977A (enExample)
CN (1) CN103003308B (enExample)
AU (1) AU2011278350B2 (enExample)
CA (1) CA2805200A1 (enExample)
GB (1) GB201011771D0 (enExample)
RU (1) RU2593709C2 (enExample)
WO (1) WO2012007516A1 (enExample)

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GB0525214D0 (en) 2005-12-12 2006-01-18 Bioinvent Int Ab Biological materials and uses thereof
GB2495113A (en) * 2011-09-29 2013-04-03 Bioinvent Int Ab Anti-ICAM-1 antibody for treating multiple-myeloma-related disorders
CN104936618A (zh) 2012-11-29 2015-09-23 拜尔健康护理有限责任公司 针对活化蛋白c的人源化单克隆抗体及其用途
MX2015006424A (es) * 2012-11-29 2015-08-14 Bayer Healthcare Llc Anticuerpos monoclonales contra una proteina activada c (apc).
GB201300346D0 (en) * 2013-01-09 2013-02-20 Biolnvent Internat Ab BiologIcal materials and uses thereof
US20170173005A1 (en) 2014-03-27 2017-06-22 Research Foundation Of The City University Of New York Method for detecting or treating triple negative breast cancer
KR101674874B1 (ko) 2014-10-21 2016-11-22 한국원자력의학원 항암제 내성 예측용 바이오마커로서의 ｉｃａｍ－３ 및 이의 용도
US9795624B2 (en) 2015-05-04 2017-10-24 Research Foundation Of The City University Of New York Cationic polymers as co-drugs for chemotherapeutic agents
US11077187B2 (en) 2015-11-17 2021-08-03 Oklahoma Medical Research Foundation Epitope of optimized humanized monoclonal antibodies against activated protein C and uses thereof
CA3224535C (en) * 2016-01-12 2026-03-17 University Of Southern California A diet package for a fasting mimicking and enhancing diet
KR20180136551A (ko) 2016-05-11 2018-12-24 유니버시티 오브 써던 캘리포니아 위장 자가면역/염증 질환을 위한 면역조절 치료로서의 단식 모방 식이(fmd)
US11284640B2 (en) 2017-02-14 2022-03-29 University Of Southern California Fasting mimicking diet
US11260132B2 (en) 2017-03-16 2022-03-01 Children's Medical Center Corporation Engineered liposomes as cancer-targeted therapeutics
CN109949256B (zh) * 2019-01-14 2023-04-07 昆明理工大学 一种基于傅里叶变换的天文图像融合方法
SG11202108274SA (en) 2019-02-06 2021-08-30 Venthera Inc Topical phosphoinositide 3-kinase inhibitors
JP2023535280A (ja) * 2020-07-20 2023-08-17 エフエヌシーティー バイオテック、インコーポレイテッド 大腸癌転移阻害剤をスクリーニングする方法
EP4192431A1 (en) * 2020-08-04 2023-06-14 Venthera, Inc. Formulations of phosphoinositide 3-kinase inhibitors
KR20230107115A (ko) 2022-01-07 2023-07-14 서울대학교병원 항-icam-1 항체의 단기요법을 이용한 간이식 거부반응의 억제방법
CN121399157A (zh) 2023-06-12 2026-01-23 美国安进公司 淋巴毒素β受体激动剂结合蛋白
KR20250179879A (ko) 2024-06-24 2025-12-31 서울대학교병원 항-icam-1 항체를 유효성분으로 포함하는 비알콜성 지방간 또는 비알콜성 지방간염 치료용 약학적 조성물
WO2026082770A1 (en) * 2024-10-16 2026-04-23 Bioinvent International Ab Antibodies against domain 4 of icam-1 and uses thereof

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RU2090615C1 (ru) * 1987-05-04 1997-09-20 Дана Фарбер Кензер Инститют Моноклональное антитело r6-5-d6, взаимодействующее с производным гликопротеина клеточной адгезии 1сам-1
WO2007068485A2 (en) * 2005-12-12 2007-06-21 Bioinvent International Ab Biological materials and uses thereof

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US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5643872A (en) 1989-10-23 1997-07-01 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US6008058A (en) 1993-06-18 1999-12-28 University Of Louisville Cyclic peptide mixtures via side chain or backbone attachment and solid phase synthesis
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GB0903151D0 (en) * 2009-02-25 2009-04-08 Bioinvent Int Ab Antibody uses and methods

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RU2090615C1 (ru) * 1987-05-04 1997-09-20 Дана Фарбер Кензер Инститют Моноклональное антитело r6-5-d6, взаимодействующее с производным гликопротеина клеточной адгезии 1сам-1
WO2007068485A2 (en) * 2005-12-12 2007-06-21 Bioinvent International Ab Biological materials and uses thereof

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VEITONMAKI N.E. et al., В599 Apoptosis-inducing ICAM-1 antibody BI-505 is a potent inhibitor of multiple myeloma, Clinical Lymphoma and Myeloma, февраль 2009, т.9, стр.S157. LACY MARTHA Q. et al., Phase I, pharmacokinetic and pharmacodynamic study of the anti-insulinlike growth factor type 1 Receptor monoclonal antibody CP-751,871 in patients with multiple myeloma, JOURNAL OF CLINICAL ONCOLOGY, 2008, vol.26, no.19, pp.3196-3203. RICHARDSON P. et al, Thalidomide for patiens with relapsed multiple myeloma after high-dose chemotherapy and stem cell transplantation: results of an open-label multicenter phase 2 study of efficacy, toxicity, and biological activity, Mayo Clinic Proceedings, 2004, vol.79, Issue 7, pp.875-882. *

Also Published As

Publication number Publication date
JP2013539454A (ja) 2013-10-24
AU2011278350B2 (en) 2014-03-20
KR20130100977A (ko) 2013-09-12
CN103003308A (zh) 2013-03-27
WO2012007516A1 (en) 2012-01-19
JP2016175906A (ja) 2016-10-06
CA2805200A1 (en) 2012-01-19
AU2011278350A1 (en) 2013-01-10
US20130189260A1 (en) 2013-07-25
GB201011771D0 (en) 2010-08-25
JP5992406B2 (ja) 2016-09-14
US20160280788A1 (en) 2016-09-29
RU2013105769A (ru) 2014-08-20
EP2593481A1 (en) 2013-05-22
CN103003308B (zh) 2016-08-10

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Effective date: 20180714