RU2559532C2 - Антагонисты рецептора и лигандов alk1 и их применение - Google Patents
Антагонисты рецептора и лигандов alk1 и их применение Download PDFInfo
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- RU2559532C2 RU2559532C2 RU2009120695/10A RU2009120695A RU2559532C2 RU 2559532 C2 RU2559532 C2 RU 2559532C2 RU 2009120695/10 A RU2009120695/10 A RU 2009120695/10A RU 2009120695 A RU2009120695 A RU 2009120695A RU 2559532 C2 RU2559532 C2 RU 2559532C2
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- alk1
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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| US10059756B2 (en) | 2006-11-02 | 2018-08-28 | Acceleron Pharma Inc. | Compositions comprising ALK1-ECD protein |
| US8642031B2 (en) | 2006-11-02 | 2014-02-04 | Acceleron Pharma, Inc. | Antagonists of BMP9, BMP10, ALK1 and other ALK1 ligands, and uses thereof |
| BRPI0717964A2 (pt) * | 2006-11-02 | 2013-12-17 | Acceleron Pharma Inc | Receptor e antagonistas de ligante da alk1 e usos dos mesmos. |
| CN101918022A (zh) * | 2007-11-09 | 2010-12-15 | 健泰科生物技术公司 | 激活蛋白受体样激酶-1组合物及使用方法 |
| US7855564B2 (en) * | 2008-02-14 | 2010-12-21 | Delaware Capital Formation, Inc. | Acoustic wave device physical parameter sensor |
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| WO2011056494A1 (en) * | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Activin receptor-like kinase-1 antagonist and vegfr3 antagonist combinations |
| US9932386B2 (en) | 2011-04-20 | 2018-04-03 | Acceleron Pharma, Inc. | Endoglin polypeptides and uses thereof |
| KR101421171B1 (ko) * | 2011-08-31 | 2014-07-22 | 재단법인 제이씨비 공동생물과학연구소 | 인간 골형성 단백질 수용체 1ａ의 세포외 도메인을 유효성분으로 포함하는 피부 상태 개선용 조성물 |
| RU2633638C2 (ru) * | 2012-02-02 | 2017-10-16 | Акселерон Фарма Инк. | Антагонисты alk1 и их применение в лечении почечно-клеточной карциномы |
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| EP3122381A4 (en) * | 2014-03-28 | 2017-11-08 | Acceleron Pharma, Inc. | Use of activin receptor-like kinase 1 (alk-1) antagonists in the treatment of cancer |
| GB201412290D0 (en) | 2014-07-10 | 2014-08-27 | Cambridge Entpr Ltd | Novel use |
| JP2016036322A (ja) * | 2014-08-11 | 2016-03-22 | 日本化薬株式会社 | 血管新生因子と結合するキメラタンパク質 |
| AU2016246602B2 (en) | 2015-04-06 | 2020-11-19 | Acceleron Pharma Inc. | Single-arm type I and type II receptor fusion proteins and uses thereof |
| MA41916A (fr) * | 2015-04-06 | 2021-04-14 | Acceleron Pharma Inc | Hétéromultimères de récepteur de type i et de type ii de la superfamille de tgf-bêta et leurs utilisations |
| EA201792561A1 (ru) | 2015-06-05 | 2018-04-30 | Новартис Аг | Антитела, нацеленные на морфогенетический белок кости 9 (bmp9), и способы их применения |
| CN105254764A (zh) * | 2015-08-27 | 2016-01-20 | 上海康岱生物医药技术有限公司 | ACVR1-Fc融合蛋白及其制法和用途 |
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- 2007-11-02 DK DK07861684.4T patent/DK2087001T3/en active
- 2007-11-02 RU RU2009120695/10A patent/RU2559532C2/ru active
- 2007-11-02 CN CN200780044656A patent/CN101652387A/zh active Pending
- 2007-11-02 EP EP16189344.1A patent/EP3181580A1/en not_active Withdrawn
- 2007-11-02 US US11/982,738 patent/US8455428B2/en active Active
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- 2007-11-02 CA CA2668411A patent/CA2668411C/en not_active Expired - Fee Related
- 2007-11-02 JP JP2009535341A patent/JP2010508816A/ja not_active Withdrawn
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2013
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- 2013-07-08 JP JP2013142324A patent/JP2013199496A/ja not_active Withdrawn
- 2013-07-22 RU RU2013134324/10A patent/RU2013134324A/ru not_active Application Discontinuation
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2015
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2017
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2018
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- 2020-06-24 JP JP2020108938A patent/JP2020150955A/ja active Pending
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2021
- 2021-12-09 US US17/546,983 patent/US12144860B2/en active Active
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