RU2556375C1 - Белок, обладающий активностью в отношении стимуляции элонгации цепей жирных кислот, кодирующий его ген и их применение - Google Patents

Белок, обладающий активностью в отношении стимуляции элонгации цепей жирных кислот, кодирующий его ген и их применение Download PDF

Info

Publication number
RU2556375C1
RU2556375C1 RU2014107735/10A RU2014107735A RU2556375C1 RU 2556375 C1 RU2556375 C1 RU 2556375C1 RU 2014107735/10 A RU2014107735/10 A RU 2014107735/10A RU 2014107735 A RU2014107735 A RU 2014107735A RU 2556375 C1 RU2556375 C1 RU 2556375C1
Authority
RU
Russia
Prior art keywords
amino acid
protein
fatty acids
polynucleotide
seq
Prior art date
Application number
RU2014107735/10A
Other languages
English (en)
Russian (ru)
Inventor
Миса ОТИАИ
Original Assignee
Сантори Холдингз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сантори Холдингз Лимитед filed Critical Сантори Холдингз Лимитед
Application granted granted Critical
Publication of RU2556375C1 publication Critical patent/RU2556375C1/ru

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115Fatty acids or derivatives thereof; Fats or oils
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/13Nucleic acids or derivatives thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/18Peptides; Protein hydrolysates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/1029Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436Fatty acid esters
    • C12P7/6445Glycerides
    • C12P7/6463Glycerides obtained from glyceride producing microorganisms, e.g. single cell oil

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cosmetics (AREA)
RU2014107735/10A 2011-08-04 2012-08-03 Белок, обладающий активностью в отношении стимуляции элонгации цепей жирных кислот, кодирующий его ген и их применение RU2556375C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011171044 2011-08-04
JP2011-171044 2011-08-04
PCT/JP2012/069792 WO2013018879A1 (ja) 2011-08-04 2012-08-03 脂肪酸鎖長延長促進活性を有するタンパク質、これをコードする遺伝子及びその用途

Publications (1)

Publication Number Publication Date
RU2556375C1 true RU2556375C1 (ru) 2015-07-10

Family

ID=47629393

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2014107735/10A RU2556375C1 (ru) 2011-08-04 2012-08-03 Белок, обладающий активностью в отношении стимуляции элонгации цепей жирных кислот, кодирующий его ген и их применение

Country Status (11)

Country Link
US (1) US8980591B2 (ja)
EP (1) EP2740797B1 (ja)
JP (1) JP5632085B2 (ja)
KR (1) KR101437308B1 (ja)
CN (1) CN103717736B (ja)
AU (1) AU2012290942B2 (ja)
BR (1) BR112014002418A2 (ja)
CA (2) CA2853849C (ja)
DK (1) DK2740797T3 (ja)
RU (1) RU2556375C1 (ja)
WO (1) WO2013018879A1 (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2015DN01858A (ja) * 2012-08-10 2015-05-29 Opx Biotechnologies Inc
US20150057465A1 (en) 2013-03-15 2015-02-26 Opx Biotechnologies, Inc. Control of growth-induction-production phases
JP6603658B2 (ja) 2013-07-19 2019-11-06 カーギル インコーポレイテッド 脂肪酸及び脂肪酸誘導体の製造のための微生物及び方法
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
JP6778207B2 (ja) * 2015-10-30 2020-10-28 サントリーホールディングス株式会社 Aobgl3ホモログを用いたステビオール配糖体およびステビオールの製造方法
CN110494566A (zh) 2017-02-02 2019-11-22 嘉吉公司 产生c6-c10脂肪酸衍生物的经遗传修饰的细胞

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070270494A1 (en) * 2006-03-15 2007-11-22 Martek Biosciences Corporation Polyunsaturated fatty acid production in heterologous organisms using pufa polyketide synthase systems
RU2008149700A (ru) * 2006-05-17 2010-06-27 Е.И.Дюпон де Немур энд Компани (US) Дельта-5-десатураза и ее применение для получения полиненасыщенных жирных кислот
WO2010147138A1 (ja) * 2009-06-18 2010-12-23 サントリーホールディングス株式会社 脂肪酸鎖長延長酵素をコードする遺伝子およびその用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030163845A1 (en) * 1998-09-02 2003-08-28 Pradip Mukerji Elongase genes and uses thereof
KR101194236B1 (ko) * 2004-03-01 2012-10-29 산토리 홀딩스 가부시키가이샤 장쇄 고도 불포화 지방산을 구성요소로서 포함하는 인지질 및 그 이용
JP4481702B2 (ja) 2004-03-31 2010-06-16 サントリーホールディングス株式会社 脂質生産菌の育種方法およびその利用
US7470532B2 (en) * 2005-10-19 2008-12-30 E.I. Du Pont De Nemours And Company Mortierella alpina C16/18 fatty acid elongase
CN107858204B (zh) * 2008-11-18 2021-10-29 联邦科学技术研究组织 产生ω-3脂肪酸的酶和方法
RU2514655C2 (ru) 2009-12-21 2014-04-27 Сантори Холдингз Лимитед Гены диацилглицерол-ацилтрансферазы и их использование

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070270494A1 (en) * 2006-03-15 2007-11-22 Martek Biosciences Corporation Polyunsaturated fatty acid production in heterologous organisms using pufa polyketide synthase systems
RU2008149700A (ru) * 2006-05-17 2010-06-27 Е.И.Дюпон де Немур энд Компани (US) Дельта-5-десатураза и ее применение для получения полиненасыщенных жирных кислот
WO2010147138A1 (ja) * 2009-06-18 2010-12-23 サントリーホールディングス株式会社 脂肪酸鎖長延長酵素をコードする遺伝子およびその用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PARKER-BARNES J.M. ET AL. Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids // Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8284-9. МАРРИ Р. И ДР. Биохимия человека. Том 1. М.: "МИР", 1993, с. 34 *

Also Published As

Publication number Publication date
JPWO2013018879A1 (ja) 2015-03-05
AU2012290942A1 (en) 2014-02-20
CN103717736B (zh) 2015-11-25
US20140242648A1 (en) 2014-08-28
WO2013018879A1 (ja) 2013-02-07
CA2853849C (en) 2015-10-13
KR20140041483A (ko) 2014-04-04
US8980591B2 (en) 2015-03-17
CA2853849A1 (en) 2013-02-07
EP2740797A1 (en) 2014-06-11
CA2843552A1 (en) 2013-02-07
CN103717736A (zh) 2014-04-09
AU2012290942B2 (en) 2014-09-25
JP5632085B2 (ja) 2014-11-26
EP2740797B1 (en) 2016-12-14
EP2740797A4 (en) 2015-09-30
BR112014002418A2 (pt) 2017-03-14
KR101437308B1 (ko) 2014-09-03
DK2740797T3 (da) 2017-02-20

Similar Documents

Publication Publication Date Title
RU2514655C2 (ru) Гены диацилглицерол-ацилтрансферазы и их использование
RU2556375C1 (ru) Белок, обладающий активностью в отношении стимуляции элонгации цепей жирных кислот, кодирующий его ген и их применение
US9828596B2 (en) Polynucleotide encoding acyl-CoA synthetase homolog and use thereof
RU2444572C2 (ru) Синтетаза жирных кислот, кодирующий ее полинуклеотид и их применение
RU2499835C1 (ru) Глицерол-3-фосфатацилтрансфераза
AU2014202244B2 (en) Polynucleotide encoding acyl-coa synthetase homolog and use thereof