RU2553379C2 - ОПРЕДЕЛЕНИЕ ЧУВСТВИТЕЛЬНОСТИ КЛЕТОК К ОБРАБОТКЕ ИНГИБИТОРОМ B-Raf ПУТЕМ ДЕТЕКЦИИ МУТАЦИИ K-ras И УРОВНЕЙ ЭКСПРЕССИИ RTK - Google Patents

ОПРЕДЕЛЕНИЕ ЧУВСТВИТЕЛЬНОСТИ КЛЕТОК К ОБРАБОТКЕ ИНГИБИТОРОМ B-Raf ПУТЕМ ДЕТЕКЦИИ МУТАЦИИ K-ras И УРОВНЕЙ ЭКСПРЕССИИ RTK Download PDF

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RU2553379C2
RU2553379C2 RU2012111231/15A RU2012111231A RU2553379C2 RU 2553379 C2 RU2553379 C2 RU 2553379C2 RU 2012111231/15 A RU2012111231/15 A RU 2012111231/15A RU 2012111231 A RU2012111231 A RU 2012111231A RU 2553379 C2 RU2553379 C2 RU 2553379C2
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ras
raf
mutant
inhibitor
cancer
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RU2012111231/15A
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Russian (ru)
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RU2012111231A (ru
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Джорджия ХАТЗИВАССИЛИУ
Шива МАЛЕК
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Дженентек, Инк.
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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RU2012111231/15A 2009-08-24 2010-08-24 ОПРЕДЕЛЕНИЕ ЧУВСТВИТЕЛЬНОСТИ КЛЕТОК К ОБРАБОТКЕ ИНГИБИТОРОМ B-Raf ПУТЕМ ДЕТЕКЦИИ МУТАЦИИ K-ras И УРОВНЕЙ ЭКСПРЕССИИ RTK RU2553379C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US23646609P 2009-08-24 2009-08-24
US61/236,466 2009-08-24
US30114910P 2010-02-03 2010-02-03
US61/301,149 2010-02-03
PCT/US2010/046520 WO2011028540A1 (en) 2009-08-24 2010-08-24 Determining sensitivity of cells to b-raf inhibitor treatment by detecting kras mutation and rtk expression levels

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RU2015104058/15A Division RU2015104058A (ru) 2009-08-24 2010-08-24 ОПРЕДЕЛЕНИЕ ЧУВСТВИТЕЛЬНОСТИ КЛЕТОК К ОБРАБОТКЕ ИНГИБИТОРОМ B-Raf ПУТЕМ ДЕТЕКЦИИ МУТАЦИИ KRAS И УРОВНЕЙ ЭКСПРЕССИИ RTK

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RU2012111231A RU2012111231A (ru) 2013-10-10
RU2553379C2 true RU2553379C2 (ru) 2015-06-10

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RU2012111231/15A RU2553379C2 (ru) 2009-08-24 2010-08-24 ОПРЕДЕЛЕНИЕ ЧУВСТВИТЕЛЬНОСТИ КЛЕТОК К ОБРАБОТКЕ ИНГИБИТОРОМ B-Raf ПУТЕМ ДЕТЕКЦИИ МУТАЦИИ K-ras И УРОВНЕЙ ЭКСПРЕССИИ RTK
RU2015104058/15A RU2015104058A (ru) 2009-08-24 2010-08-24 ОПРЕДЕЛЕНИЕ ЧУВСТВИТЕЛЬНОСТИ КЛЕТОК К ОБРАБОТКЕ ИНГИБИТОРОМ B-Raf ПУТЕМ ДЕТЕКЦИИ МУТАЦИИ KRAS И УРОВНЕЙ ЭКСПРЕССИИ RTK

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US (2) US20120214828A1 (enExample)
EP (1) EP2470898A4 (enExample)
JP (1) JP2013502236A (enExample)
KR (1) KR20120050493A (enExample)
CN (1) CN102859355B (enExample)
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RU2012111231A (ru) 2013-10-10
BR112012003926A2 (pt) 2020-08-11
CN102859355B (zh) 2015-10-07
US20120214828A1 (en) 2012-08-23
RU2015104058A (ru) 2015-06-10
JP2013502236A (ja) 2013-01-24
MY165154A (en) 2018-02-28
AU2010289794B2 (en) 2014-10-02
EP2470898A4 (en) 2013-03-13
SG10201402917XA (en) 2014-08-28
KR20120050493A (ko) 2012-05-18
IN2012DN01403A (enExample) 2015-06-05
MX2012002292A (es) 2012-03-19
WO2011028540A1 (en) 2011-03-10
AU2010289794A1 (en) 2012-04-05
EP2470898A1 (en) 2012-07-04
SG178866A1 (en) 2012-04-27
CA2771369A1 (en) 2011-03-10
IL235398A0 (en) 2014-12-31
CN102859355A (zh) 2013-01-02
HK1175248A1 (zh) 2013-06-28
MX338856B (es) 2016-05-03

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