RU2547596C2 - Полиспецифические антитела - Google Patents
Полиспецифические антитела Download PDFInfo
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- RU2547596C2 RU2547596C2 RU2011112324/10A RU2011112324A RU2547596C2 RU 2547596 C2 RU2547596 C2 RU 2547596C2 RU 2011112324/10 A RU2011112324/10 A RU 2011112324/10A RU 2011112324 A RU2011112324 A RU 2011112324A RU 2547596 C2 RU2547596 C2 RU 2547596C2
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| US20050106667A1 (en) * | 2003-08-01 | 2005-05-19 | Genentech, Inc | Binding polypeptides with restricted diversity sequences |
| US7758859B2 (en) * | 2003-08-01 | 2010-07-20 | Genentech, Inc. | Anti-VEGF antibodies |
| EP2059533B1 (en) | 2006-08-30 | 2012-11-14 | Genentech, Inc. | Multispecific antibodies |
| ES2628108T3 (es) | 2008-09-03 | 2017-08-01 | F. Hoffmann-La Roche Ag | Anticuerpos multiespecíficos |
| US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
| CN103153339B (zh) | 2010-05-27 | 2021-05-04 | 根马布股份公司 | 针对her2表位的单克隆抗体 |
| CN107253992B (zh) | 2010-05-27 | 2022-03-11 | 根马布股份公司 | 针对her2的单克隆抗体 |
| US20130323259A1 (en) * | 2011-01-17 | 2013-12-05 | Novo Nordisk A/S | Il-21 ligands |
| US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
| WO2012143524A2 (en) | 2011-04-20 | 2012-10-26 | Genmab A/S | Bispecific antibodies against her2 and cd3 |
| CA2845179A1 (en) | 2011-08-31 | 2013-03-07 | Genentech, Inc. | Diagnostic markers |
| KR101453516B1 (ko) | 2011-09-20 | 2014-10-24 | 가톨릭대학교 산학협력단 | 항-ｖｅｇｆ 항체를 포함하는 자가면역질환 예방 및 치료용 조성물 |
| JP2014531213A (ja) | 2011-09-30 | 2014-11-27 | ジェネンテック， インコーポレイテッド | 上皮又は間葉の表現型の診断用メチル化マーカー、及び腫瘍又は腫瘍細胞におけるｅｇｆｒキナーゼ阻害薬に対する応答 |
| WO2013187495A1 (ja) | 2012-06-14 | 2013-12-19 | 中外製薬株式会社 | 改変されたFc領域を含む抗原結合分子 |
| RS57704B1 (sr) | 2012-07-13 | 2018-12-31 | Roche Glycart Ag | Bispecifična anti-vegf/anti-ang-2 antitela i njihova primena u lečenju vaskularnih bolesti oka |
| EP2961409A1 (en) * | 2013-02-26 | 2016-01-06 | Senex Biotechnology, Inc. | Inhibitors of cdk8/19 for use in treating estrogen receptor positive breast cancer |
| KR102551410B1 (ko) * | 2013-11-11 | 2023-07-04 | 추가이 세이야쿠 가부시키가이샤 | 개변된 항체 가변영역을 포함하는 항원 결합 분자 |
| JP2015097496A (ja) * | 2013-11-19 | 2015-05-28 | 国立大学法人 東京大学 | Ｒｏｂｏ１に対する親和性を向上させた抗体及び高親和性抗体の分子設計方法 |
| WO2015119841A1 (en) * | 2014-02-05 | 2015-08-13 | Merck Sharp & Dohme Corp. | Role of il-23 and pd-1 in autoreactive immune response |
| GB201411420D0 (en) * | 2014-06-26 | 2014-08-13 | Ucb Biopharma Sprl | Antibody constructs |
| CA2955984A1 (en) | 2014-07-22 | 2016-01-28 | The University Of Notre Dame Du Lac | Molecular constructs and uses thereof |
| JP6897952B2 (ja) * | 2014-09-16 | 2021-07-07 | 国立大学法人東京海洋大学 | 濃縮された生着能をもつ未分化生殖細胞を用いた生殖細胞系列への分化誘導方法 |
| KR102390359B1 (ko) | 2014-09-29 | 2022-04-22 | 삼성전자주식회사 | 폴리펩타이드, 이를 포함하는 항 VEGF 항체 및 항 c-Met/항 VEGF 이중 특이 항체 |
| US11154615B2 (en) | 2014-11-11 | 2021-10-26 | Chugai Seiyaku Kabushiki Kaisha | Library of antigen-binding molecules including modified antibody variable region |
| JP6622396B2 (ja) | 2015-08-26 | 2019-12-18 | バイソン セラピュイティクス インコーポレイテッド | 多重特異性抗体プラットフォームおよびその関連方法 |
| JP6959912B2 (ja) | 2015-09-23 | 2021-11-05 | ジェネンテック， インコーポレイテッド | 抗ｖｅｇｆ抗体の最適化変異体 |
| GB201521447D0 (en) * | 2015-12-04 | 2016-01-20 | Ucb Biopharma Sprl | De novo antibody design |
| US20170218092A1 (en) * | 2016-01-28 | 2017-08-03 | Janssen Biotech, Inc. | Bispecific Anti-TNF-Alpha/IL17A Antibodies and Anti-TNF-Alpha Antibodies and Methods of Their Use |
| EP3634999A1 (en) * | 2017-06-07 | 2020-04-15 | Philogen S.p.A. | Vascular endothelial growth factor/anti-fibronectin antibody fusion proteins |
| CN107602702A (zh) * | 2017-09-22 | 2018-01-19 | 生标（上海）医疗器械科技有限公司 | 一种同时靶向人p185和血管内皮生长因子的抗体及其应用 |
| JP7357616B2 (ja) | 2017-12-05 | 2023-10-06 | 中外製薬株式会社 | Ｃｄ３およびｃｄ１３７に結合する改変された抗体可変領域を含む抗原結合分子 |
| JP7504027B2 (ja) | 2018-08-03 | 2024-06-21 | 中外製薬株式会社 | 互いに連結された２つの抗原結合ドメインを含む抗原結合分子 |
| CN110850068B (zh) * | 2018-08-21 | 2023-08-15 | 上海恒润达生生物科技股份有限公司 | 一种嵌合抗原受体亲和力检测方法 |
| EP3947469A4 (en) | 2019-04-02 | 2022-12-14 | National Research Council of Canada | ANTIBODY VARIANTS WITH PH DEPENDENT ANTIGEN BINDING FOR SELECTIVE TARGETING OF SOLID TUMORS |
| AR121695A1 (es) | 2020-03-31 | 2022-06-29 | Chugai Pharmaceutical Co Ltd | Moléculas de unión al antígeno multiespecíficas dirigidas a dll3 y sus usos |
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| ES2628108T3 (es) | 2008-09-03 | 2017-08-01 | F. Hoffmann-La Roche Ag | Anticuerpos multiespecíficos |
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- 2009-09-01 CN CN200980134512.4A patent/CN102143977B/zh not_active Expired - Fee Related
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002355074A (ja) * | 2001-01-24 | 2002-12-10 | Univ Tsukuba | 腸管出血性病原性大腸菌ｏ１５７：ｈ７に特異的な核酸分子およびポリペプチド並びにこれらの使用方法 |
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| РОЙТ А. и др., Иммунология, Москва, "Мир", 2000, 592 с * |
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| ZA201101970B (en) | 2012-05-30 |
| SG193851A1 (en) | 2013-10-30 |
| PE20110593A1 (es) | 2011-09-10 |
| PE20150222A1 (es) | 2015-03-02 |
| US9522960B2 (en) | 2016-12-20 |
| US20110142852A1 (en) | 2011-06-16 |
| TWI487712B (zh) | 2015-06-11 |
| KR20110081812A (ko) | 2011-07-14 |
| CA2734905A1 (en) | 2010-03-11 |
| MX353984B (es) | 2017-11-27 |
| JP5796831B2 (ja) | 2015-10-21 |
| US9017686B2 (en) | 2015-04-28 |
| WO2010027981A1 (en) | 2010-03-11 |
| PH12013502230A1 (en) | 2016-01-25 |
| US20100322946A1 (en) | 2010-12-23 |
| EP2324061B1 (en) | 2017-04-12 |
| EP2324061A1 (en) | 2011-05-25 |
| BRPI0918648A2 (pt) | 2019-09-03 |
| CN102143977A (zh) | 2011-08-03 |
| JP2012501648A (ja) | 2012-01-26 |
| CN102143977B (zh) | 2014-08-06 |
| AU2009288167B2 (en) | 2015-10-22 |
| KR101705911B1 (ko) | 2017-02-10 |
| IL211349A0 (en) | 2011-05-31 |
| MX2011002389A (es) | 2011-05-23 |
| US8193321B2 (en) | 2012-06-05 |
| US20150315290A1 (en) | 2015-11-05 |
| RU2011112324A (ru) | 2012-10-10 |
| AR073538A1 (es) | 2010-11-17 |
| ES2628108T3 (es) | 2017-08-01 |
| AU2009288167A1 (en) | 2010-03-11 |
| TW201011047A (en) | 2010-03-16 |
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