RU2526201C2 - Способ лечения артрита - Google Patents
Способ лечения артрита Download PDFInfo
- Publication number
- RU2526201C2 RU2526201C2 RU2012143212/15A RU2012143212A RU2526201C2 RU 2526201 C2 RU2526201 C2 RU 2526201C2 RU 2012143212/15 A RU2012143212/15 A RU 2012143212/15A RU 2012143212 A RU2012143212 A RU 2012143212A RU 2526201 C2 RU2526201 C2 RU 2526201C2
- Authority
- RU
- Russia
- Prior art keywords
- methyl
- amino
- benzoyl
- piperazin
- phenylsulfanyl
- Prior art date
Links
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- 238000000034 method Methods 0.000 title claims description 13
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
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| US98847907P | 2007-11-16 | 2007-11-16 | |
| US60/988,479 | 2007-11-16 |
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| RU2010123796/15A Division RU2472509C2 (ru) | 2007-11-16 | 2008-11-14 | Способ лечения артрита |
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| RU2010123796/15A RU2472509C2 (ru) | 2007-11-16 | 2008-11-14 | Способ лечения артрита |
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| RU2010123796/15A RU2472509C2 (ru) | 2007-11-16 | 2008-11-14 | Способ лечения артрита |
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| DO (1) | DOP2013000169A (enExample) |
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| RU (2) | RU2526201C2 (enExample) |
| WO (1) | WO2009064938A1 (enExample) |
| ZA (1) | ZA201003434B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20100160322A1 (en) | 2008-12-04 | 2010-06-24 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| EP2957558A3 (en) * | 2010-03-25 | 2016-03-02 | AbbVie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| TWI520960B (zh) | 2010-05-26 | 2016-02-11 | 艾伯維有限公司 | 用於治療癌症及免疫及自體免疫疾病之細胞凋亡誘導劑 |
| UA113500C2 (xx) | 2010-10-29 | 2017-02-10 | Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб | |
| MX349533B (es) | 2010-10-29 | 2017-08-02 | Abbvie Inc | Dispersiones solidas que contienen un agente inductor de apoptosis. |
| RU2628560C2 (ru) | 2010-11-23 | 2017-08-18 | Эббви Инк. | Соли и кристаллические формы индуцирующего апоптоз агента |
| AR083946A1 (es) | 2010-11-23 | 2013-04-10 | Abbott Lab | Metodos de tratamiento con inhibidores selectivos de bcl-2 |
| US20140275082A1 (en) | 2013-03-14 | 2014-09-18 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| ES2948287T3 (es) | 2017-08-23 | 2023-09-07 | Guangzhou Lupeng Pharmaceutical Company Ltd | Derivados heterocíclicos condensados como inhibidores de Bcl-2 para el tratamiento de enfermedades neoplásicas |
| US12220419B2 (en) | 2018-08-22 | 2025-02-11 | Newave Pharmaceutical Inc. | BCL-2 inhibitors |
| US20220073513A1 (en) | 2018-12-29 | 2022-03-10 | Newave Pharmaceutical Inc. | 1h-pyrrolo[2,3-b]pyridine derivatives and related compounds as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases |
| US20220372042A1 (en) | 2019-10-03 | 2022-11-24 | Newave Pharmaceutical Inc. | Condensed heterocycles as bcl-2 inhibitors |
| PH12022551091A1 (en) | 2019-11-05 | 2024-06-24 | Abbvie Deutschland | Dosing regimens for use in treating myelofibrosis and mpn-related disorders with navitoclax |
| WO2021133817A1 (en) | 2019-12-27 | 2021-07-01 | Guangzhou Lupeng Pharmaceutical Company Ltd. | 1h-pyrrolo[2,3-b]pyridine derivatives as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases |
| CA3173041A1 (en) | 2020-02-24 | 2021-09-02 | Guangzhou Lupeng Pharmaceutical Company Ltd. | Hot melt extruded solid dispersions containing a bcl2 inhibitor |
| WO2022140224A1 (en) | 2020-12-22 | 2022-06-30 | Newave Pharmaceutical Inc. | 1h-pyrrolo[2,3-b]pyridine derivatives as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases |
Citations (3)
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| RU2112772C1 (ru) * | 1992-01-08 | 1998-06-10 | Руссель-Юклаф | Производные 2-циано-3-гидроксиенамидов, способы их получения, фармацевтическая композиция на их основе |
| US5965745A (en) * | 1995-10-10 | 1999-10-12 | Pfizer Inc | Indole carbamates as leukotriene antagonists |
| RU2264389C2 (ru) * | 2000-10-20 | 2005-11-20 | Эйсай Ко., Лтд. | Азотсодержащие ароматические производные, их применение, лекарственное средство на их основе и способ лечения |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003528080A (ja) * | 2000-03-21 | 2003-09-24 | ザ プロクター アンド ギャンブル カンパニー | 複素環式側鎖を含有するｎ−置換型メタロプロテアーゼ阻害物質 |
| GB0217431D0 (en) * | 2002-07-27 | 2002-09-04 | Astrazeneca Ab | Novel compounds |
| KR101149379B1 (ko) * | 2003-07-28 | 2012-06-28 | 얀센 파마슈티카 엔.브이. | 벤즈이미다졸, 벤즈티아졸 및 벤즈옥사졸 유도체 및ｌｔａ4 ｈ 조정자로서의 그의 용도 |
| CA2536870C (en) * | 2003-09-03 | 2009-10-27 | Pfizer Inc. | Phenyl or pyridyl amide compounds as prostaglandin e2 antagonists |
| WO2005049593A2 (en) * | 2003-11-13 | 2005-06-02 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
| ES2257929B1 (es) * | 2004-07-16 | 2007-05-01 | Laboratorios Del Dr. Esteve, S.A. | Derivados de pirazolina, procedimiento para su obtencion y utilizacion de los mismos como agentes terapeuticos. |
| DK1888550T3 (da) * | 2005-05-12 | 2014-09-29 | Abbvie Bahamas Ltd | Apoptosepromotorer |
| US20060276464A1 (en) * | 2005-05-13 | 2006-12-07 | Wyeth | Diarylsulfone sulfonamides and use thereof |
| US20080182845A1 (en) * | 2006-11-16 | 2008-07-31 | Abbott Laboratories | Method of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection |
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2008
- 2008-11-14 WO PCT/US2008/083478 patent/WO2009064938A1/en not_active Ceased
- 2008-11-14 US US12/270,987 patent/US20090176785A1/en not_active Abandoned
- 2008-11-14 RU RU2012143212/15A patent/RU2526201C2/ru not_active IP Right Cessation
- 2008-11-14 JP JP2010534194A patent/JP5450434B2/ja not_active Expired - Fee Related
- 2008-11-14 KR KR1020107013163A patent/KR101585848B1/ko not_active Expired - Fee Related
- 2008-11-14 NZ NZ601350A patent/NZ601350A/xx not_active IP Right Cessation
- 2008-11-14 AU AU2008322595A patent/AU2008322595B2/en not_active Ceased
- 2008-11-14 EP EP08850262A patent/EP2231159A1/en not_active Withdrawn
- 2008-11-14 CA CA2705294A patent/CA2705294C/en not_active Expired - Fee Related
- 2008-11-14 RU RU2010123796/15A patent/RU2472509C2/ru not_active IP Right Cessation
- 2008-11-14 CN CN2008801242231A patent/CN101969951B/zh not_active Expired - Fee Related
- 2008-11-14 NZ NZ585085A patent/NZ585085A/xx not_active IP Right Cessation
- 2008-11-14 MX MX2010005395A patent/MX2010005395A/es active IP Right Grant
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2010
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- 2010-05-14 ZA ZA2010/03434A patent/ZA201003434B/en unknown
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- 2013-11-11 JP JP2013232754A patent/JP5667684B2/ja not_active Expired - Fee Related
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2015
- 2015-12-17 US US14/972,429 patent/US20160101109A1/en not_active Abandoned
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| RU2112772C1 (ru) * | 1992-01-08 | 1998-06-10 | Руссель-Юклаф | Производные 2-циано-3-гидроксиенамидов, способы их получения, фармацевтическая композиция на их основе |
| US5965745A (en) * | 1995-10-10 | 1999-10-12 | Pfizer Inc | Indole carbamates as leukotriene antagonists |
| RU2264389C2 (ru) * | 2000-10-20 | 2005-11-20 | Эйсай Ко., Лтд. | Азотсодержащие ароматические производные, их применение, лекарственное средство на их основе и способ лечения |
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| MX2010005395A (es) | 2010-06-02 |
| EP2231159A1 (en) | 2010-09-29 |
| CN101969951B (zh) | 2012-10-31 |
| AU2008322595B2 (en) | 2014-01-30 |
| RU2012143212A (ru) | 2014-04-20 |
| IL227641A0 (en) | 2013-09-30 |
| JP5667684B2 (ja) | 2015-02-12 |
| WO2009064938A9 (en) | 2009-08-06 |
| DOP2013000169A (es) | 2013-12-15 |
| JP2014065716A (ja) | 2014-04-17 |
| KR101585848B1 (ko) | 2016-01-15 |
| JP2011503199A (ja) | 2011-01-27 |
| US20160101109A1 (en) | 2016-04-14 |
| NZ601350A (en) | 2013-08-30 |
| NZ585085A (en) | 2012-08-31 |
| AU2008322595A1 (en) | 2009-05-22 |
| CA2705294A1 (en) | 2009-05-22 |
| ZA201003434B (en) | 2011-10-26 |
| IL205501A (en) | 2013-08-29 |
| US20090176785A1 (en) | 2009-07-09 |
| KR20100099172A (ko) | 2010-09-10 |
| RU2472509C2 (ru) | 2013-01-20 |
| JP5450434B2 (ja) | 2014-03-26 |
| WO2009064938A1 (en) | 2009-05-22 |
| CN101969951A (zh) | 2011-02-09 |
| IL205501A0 (en) | 2010-12-30 |
| RU2010123796A (ru) | 2011-12-27 |
| CA2705294C (en) | 2016-05-17 |
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