RU2525617C2 - Способ модулирования биологических функций, ассоциированных с процессом старения пожилого или старого животного-компаньона. - Google Patents
Способ модулирования биологических функций, ассоциированных с процессом старения пожилого или старого животного-компаньона. Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/06—Antihyperlipidemics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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Landscapes
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- Chemical & Material Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Zoology (AREA)
- Animal Husbandry (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
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- Birds (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- Biochemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| Application Number | Priority Date | Filing Date | Title |
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| US8218308P | 2008-07-18 | 2008-07-18 | |
| US61/082,183 | 2008-07-18 | ||
| PCT/US2009/051155 WO2010009468A1 (en) | 2008-07-18 | 2009-07-20 | Method for enhancing the quality of life of a senior animal |
Publications (2)
| Publication Number | Publication Date |
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| RU2011105794A RU2011105794A (ru) | 2012-08-27 |
| RU2525617C2 true RU2525617C2 (ru) | 2014-08-20 |
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| RU2011105794/10A RU2525617C2 (ru) | 2008-07-18 | 2009-07-20 | Способ модулирования биологических функций, ассоциированных с процессом старения пожилого или старого животного-компаньона. |
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| Country | Link |
|---|---|
| US (1) | US20110189303A1 (enExample) |
| EP (1) | EP2320752A1 (enExample) |
| JP (2) | JP2011528556A (enExample) |
| CN (1) | CN102170792A (enExample) |
| AU (1) | AU2009270712B2 (enExample) |
| BR (1) | BRPI0915974A2 (enExample) |
| CA (1) | CA2731088C (enExample) |
| RU (1) | RU2525617C2 (enExample) |
| WO (1) | WO2010009468A1 (enExample) |
| ZA (1) | ZA201101281B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8252742B2 (en) * | 2004-12-30 | 2012-08-28 | Hill's Pet Nutrition, Inc. | Methods for enhancing the quality of life of a senior animal |
| EP2653161B1 (en) * | 2008-12-30 | 2015-10-07 | Hill's Pet Nutrition, Inc. | Use of lipoic acid for maintaining or increasing bone mineral density in companion animals |
| JP2013532128A (ja) * | 2010-05-12 | 2013-08-15 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 愛玩動物の炎症を抑制および予防し、炎症状態を緩和する方法 |
| US20130059028A1 (en) * | 2011-09-01 | 2013-03-07 | Julie Marie Foy | Compositions and Methods for Providing a Life-Stage-Appropriate Animal Diet |
| CA2859149A1 (en) | 2011-12-19 | 2013-06-27 | Hill's Pet Nutrition, Inc. | Compositions and methods for diagnosing and treating hyperthyroidism in companion animals |
| EP3016523B1 (en) * | 2013-07-01 | 2020-09-02 | Washington University | Human diet equivalent animal feed |
| EP2898769A1 (en) * | 2014-01-23 | 2015-07-29 | Beefeaters Holding Company, Inc. | Dental care product for pets |
| JP6848962B2 (ja) * | 2016-03-16 | 2021-03-24 | 味の素株式会社 | 行動体力向上剤 |
| EP3466428A1 (de) * | 2017-10-09 | 2019-04-10 | Phytobiotics Futterzusatzstoffe GmbH | Tiernahrung mit febrifugin zur leistungssteigerung |
Citations (1)
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| EP1350435A2 (en) * | 2002-04-05 | 2003-10-08 | Societe Des Produits Nestle S.A. | Compositions and methods for promoting lipid assimilation in pets |
Family Cites Families (53)
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|---|---|---|---|---|
| US1149710A (en) * | 1913-11-28 | 1915-08-10 | Michael Beck | Heavy-oil carbureter for explosive-engines. |
| US2988045A (en) * | 1959-12-28 | 1961-06-13 | Stanton E Fisher | Animal toy |
| US3104648A (en) * | 1962-02-26 | 1963-09-24 | Stanton E Fisher | Animal toy |
| US3202514A (en) * | 1963-07-15 | 1965-08-24 | Gen Foods Corp | Animal food and method of making the same |
| US3441001A (en) * | 1967-05-19 | 1969-04-29 | Ring Sidney B | Corrugated animal toy |
| US3871334A (en) * | 1973-12-03 | 1975-03-18 | Herbert R Axelrod | Pet toy |
| JPS56106593A (en) * | 1980-01-24 | 1981-08-24 | Dainippon Pharmaceut Co Ltd | Alkali protease m3 |
| US5004624A (en) * | 1983-03-14 | 1991-04-02 | Star-Kist Foods, Inc. | Semi-moist pet food having free gravy and process for preparation thereof |
| US4513014A (en) * | 1983-10-11 | 1985-04-23 | Edwards Philip L | Chewable toy for animal |
| US4557219A (en) * | 1983-10-11 | 1985-12-10 | Edwards Philip L | Chewable toy for animal |
| US4674444A (en) * | 1985-07-01 | 1987-06-23 | Axelrod Herbert R | Chewing toy for dogs and preparation thereof |
| US4771733A (en) * | 1986-09-17 | 1988-09-20 | Axelrod Herbert R | Chewable object having flavor or odor extract incorporated therein |
| US4997672A (en) * | 1987-03-10 | 1991-03-05 | Virginia Commonwealth University | Salt taste enhancer |
| US4997671A (en) * | 1988-09-09 | 1991-03-05 | Nabisco Brands, Inc. | Chewy dog snacks |
| US4928632A (en) * | 1988-09-13 | 1990-05-29 | Gordon Richard A | Cat toy |
| US5114704A (en) * | 1989-05-30 | 1992-05-19 | Nabisco Brands, Inc. | Raw hide having a coating containing an inorganic pyrophosphate |
| JPH05339154A (ja) * | 1992-06-03 | 1993-12-21 | Sagami Chem Res Center | 肝機能改善剤 |
| US5419283A (en) * | 1992-04-08 | 1995-05-30 | Ciuffo Gatto S.R.L. | Animal chew toy of starch material and degradable ethylene copolymer |
| US5532010A (en) * | 1993-05-28 | 1996-07-02 | Nabisco, Inc. | Coated canine biscuits and preparation process |
| US5339771A (en) * | 1993-09-15 | 1994-08-23 | Axelrod Herbert R | Animal chew toy containing animal meal |
| JPH10248424A (ja) * | 1997-03-05 | 1998-09-22 | Sakai Pet Sangyo:Kk | 愛玩動物用飼育装置及びそれに使用する飼育用部材 |
| NZ527924A (en) * | 1999-01-29 | 2005-01-28 | Mars Uk Ltd | Antioxidant compositions and methods for companion animals |
| MY134881A (en) * | 1999-09-09 | 2007-12-31 | Nestle Sa | Improving condition of elderly pets |
| JP2001169731A (ja) * | 1999-12-17 | 2001-06-26 | Showa Denko Kk | 動物体の脂質代謝改善剤 |
| US6379727B1 (en) * | 1999-12-29 | 2002-04-30 | John F. Addy | Flavoring system for pet foods |
| CA2399319A1 (en) * | 2000-01-25 | 2001-08-16 | Nathan D. Hamilton | Nutritional supplements for aged pets |
| US20020115710A1 (en) * | 2000-10-31 | 2002-08-22 | Zicker Steven Curtis | Composition and method |
| JP2004519241A (ja) * | 2001-03-09 | 2004-07-02 | ソシエテ デ プロデユイ ネツスル ソシエテ アノニム | 高齢化に伴う生理的障害を改善し寿命を延ばす組成物 |
| JPWO2002102364A1 (ja) * | 2001-06-18 | 2004-09-30 | 山田 幸子 | PPARγ作動性医薬組成物 |
| JP4421295B2 (ja) * | 2001-10-18 | 2010-02-24 | カウンシル・オブ・サイエンティフィック・アンド・インダストリアル・リサーチ | ω3PUFAを有するコレステロール低下性構造脂質 |
| US20040087490A1 (en) * | 2002-09-20 | 2004-05-06 | Troup John P. | Nutritional compositions |
| US8841344B2 (en) * | 2002-10-03 | 2014-09-23 | Hill's Pet Nutrition, Inc. | Method of using omega-3 fatty acids |
| WO2005006877A1 (en) * | 2003-07-03 | 2005-01-27 | Hill's Pet Nutrition, Inc. | Compositions and methods for decreasing age-related deterioration in metal activities in companion animals |
| EP3235384B1 (en) * | 2003-11-25 | 2019-08-28 | Virginia Tech Intellectual Properties, Inc. | Composition for animal consumption |
| US20050266051A1 (en) * | 2004-05-27 | 2005-12-01 | The Procter & Gamble Company | Pet food compositions and methods |
| JP4702678B2 (ja) * | 2004-06-07 | 2011-06-15 | 環境創研株式会社 | 競走馬用飼料添加材 |
| GB0413730D0 (en) * | 2004-06-18 | 2004-07-21 | Tillotts Pharma Ag | A pharmaceutical composition and its use |
| US20060002985A1 (en) * | 2004-07-02 | 2006-01-05 | Zicker Steven C | Compositions and methods for decreasing age-related deterioration in mental activities in companion animals |
| JP4317801B2 (ja) * | 2004-08-10 | 2009-08-19 | 学校法人武庫川学院 | 脂質代謝改善用の食品組成物およびこれを含有する食品 |
| EP1794316B1 (en) * | 2004-08-30 | 2018-10-03 | Hill's Pet Nutrition, Inc. | Genome-based diet design |
| RU2433819C2 (ru) * | 2004-11-09 | 2011-11-20 | Хилл'С Пет Ньютришн, Инк. | Применение антиоксидантов для модуляции генов |
| JP5785355B2 (ja) * | 2004-11-24 | 2015-09-30 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 動物における生体異物物質の肝臓クリアランスを改良する方法 |
| CN102907561A (zh) * | 2004-12-30 | 2013-02-06 | 希尔氏宠物营养品公司 | 提高老年动物的生活质量的方法 |
| US20060211763A1 (en) * | 2005-03-08 | 2006-09-21 | Abdel Fawzy | Treatment with Statin and Omega-3 Fatty Acids and a Combination Product Thereof |
| BRPI0612841A2 (pt) * | 2005-06-29 | 2012-10-09 | Hills Pet Nutrition Inc | composição, métodos para prevenir ou tratar doença inflamatória e para produzir uma composição de ração, kit, meio para comunicar informação ou instruções, e, método para inibir ou prevenir liberação de mediadores pró-inflamatórios |
| JP5590758B2 (ja) * | 2005-08-03 | 2014-09-17 | 太陽化学株式会社 | マーカータンパク質量調節用組成物 |
| EP1951067B1 (en) * | 2005-11-10 | 2017-07-26 | Hill's Pet Nutrition, Inc. | Compositions and methods for improving skin health and pelage quality |
| DE602006008985D1 (de) * | 2005-12-16 | 2009-10-15 | Nutricia Nv | Zusammensetzung enthaltend oligosaccharide als lösliche ballaststoffe zur verwendung gegen muskelschwund |
| US20070231371A1 (en) * | 2006-02-01 | 2007-10-04 | Nestec, S. A. | Nutritional system and methods for increasing longevity |
| JP2009528028A (ja) * | 2006-02-24 | 2009-08-06 | ディーエスエム アイピー アセッツ ビー.ブイ. | 哺乳類における健康状態を促進するためのレスベラトロールおよびその誘導体の使用 |
| US8067152B2 (en) * | 2006-02-27 | 2011-11-29 | The Fred Hutchinson Cancer Research Center | Liver cancer biomarkers |
| CA2660291C (en) * | 2006-08-09 | 2011-11-22 | The Iams Company | Methods of improving bone health and muscle health |
| CN101909632A (zh) * | 2008-01-04 | 2010-12-08 | 雀巢产品技术援助有限公司 | 包含不饱和脂肪酸和一氧化氮释放化合物的组合物及其用于增强认知和相关功能的用途 |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1350435A2 (en) * | 2002-04-05 | 2003-10-08 | Societe Des Produits Nestle S.A. | Compositions and methods for promoting lipid assimilation in pets |
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| US20110189303A1 (en) | 2011-08-04 |
| ZA201101281B (en) | 2014-07-30 |
| CA2731088A1 (en) | 2010-01-21 |
| EP2320752A1 (en) | 2011-05-18 |
| JP2011528556A (ja) | 2011-11-24 |
| CA2731088C (en) | 2015-09-22 |
| AU2009270712A1 (en) | 2010-01-21 |
| AU2009270712B2 (en) | 2013-02-21 |
| RU2011105794A (ru) | 2012-08-27 |
| CN102170792A (zh) | 2011-08-31 |
| BRPI0915974A2 (pt) | 2017-05-30 |
| JP2015091246A (ja) | 2015-05-14 |
| WO2010009468A1 (en) | 2010-01-21 |
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