RU2521358C2 - Производные циклоспорина для лечения глазных и кожных заболеваний и состояний - Google Patents

Производные циклоспорина для лечения глазных и кожных заболеваний и состояний Download PDF

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Publication number
RU2521358C2
RU2521358C2 RU2011104584/15A RU2011104584A RU2521358C2 RU 2521358 C2 RU2521358 C2 RU 2521358C2 RU 2011104584/15 A RU2011104584/15 A RU 2011104584/15A RU 2011104584 A RU2011104584 A RU 2011104584A RU 2521358 C2 RU2521358 C2 RU 2521358C2
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Russia
Prior art keywords
cyclosporin
group
alkyl
derivatives
eye
Prior art date
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RU2011104584/15A
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English (en)
Russian (ru)
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RU2011104584A (ru
Inventor
Майкл Е. ГАРСТ
Original Assignee
Аллерган, Инк.
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Application filed by Аллерган, Инк. filed Critical Аллерган, Инк.
Publication of RU2011104584A publication Critical patent/RU2011104584A/ru
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Publication of RU2521358C2 publication Critical patent/RU2521358C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2011104584/15A 2008-07-10 2009-07-09 Производные циклоспорина для лечения глазных и кожных заболеваний и состояний RU2521358C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13451008P 2008-07-10 2008-07-10
US61/134,510 2008-07-10
PCT/US2009/050038 WO2010006117A2 (en) 2008-07-10 2009-07-09 Cyclosporin derivatives for treating ocular and dermal diseases and conditions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2014101057/15A Division RU2014101057A (ru) 2008-07-10 2014-01-15 Производные циклоспорина для лечения глазных и кожных заболеваний и состояний

Publications (2)

Publication Number Publication Date
RU2011104584A RU2011104584A (ru) 2012-08-20
RU2521358C2 true RU2521358C2 (ru) 2014-06-27

Family

ID=41404608

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2011104584/15A RU2521358C2 (ru) 2008-07-10 2009-07-09 Производные циклоспорина для лечения глазных и кожных заболеваний и состояний
RU2014101057/15A RU2014101057A (ru) 2008-07-10 2014-01-15 Производные циклоспорина для лечения глазных и кожных заболеваний и состояний

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2014101057/15A RU2014101057A (ru) 2008-07-10 2014-01-15 Производные циклоспорина для лечения глазных и кожных заболеваний и состояний

Country Status (10)

Country Link
US (2) US8716238B2 (https=)
EP (1) EP2313157A2 (https=)
JP (1) JP5661035B2 (https=)
KR (1) KR20110031973A (https=)
CN (1) CN102149402B (https=)
AU (1) AU2009268549B2 (https=)
BR (1) BRPI0915552A2 (https=)
CA (1) CA2730108A1 (https=)
RU (2) RU2521358C2 (https=)
WO (1) WO2010006117A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9714271B2 (en) 2010-12-15 2017-07-25 Contravir Pharmaceuticals, Inc. Cyclosporine analogue molecules modified at amino acid 1 and 3

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110031973A (ko) * 2008-07-10 2011-03-29 알러간, 인코포레이티드 눈 및 피부의 질환 및 상태를 치료하기 위한 사이클로스포린 유도체
WO2010138422A1 (en) * 2009-05-27 2010-12-02 Allergan, Inc. Cyclosporin derivatives for enhancing the growth of hair
WO2010138423A1 (en) * 2009-05-27 2010-12-02 Allergan, Inc. Cyclosporin derivatives for treating inflammatory diseases and conditions
MX2013004062A (es) 2010-10-12 2013-07-22 Allergan Inc Analogos de ciclosporina.
BR112013008864A2 (pt) 2010-10-12 2016-06-28 Allergan Inc análogos d ciclosporina
RU2630970C2 (ru) * 2011-11-15 2017-09-15 Аллерган, Инк. Автоклавируемые взвеси циклоспорина а формы 2
JP2015519368A (ja) 2012-06-01 2015-07-09 アラーガン インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ シクロスポリンａ類似体
WO2014138425A1 (en) 2013-03-08 2014-09-12 Allergan, Inc. Cyclosporine a-steroid conjugates
US9463201B2 (en) 2014-10-19 2016-10-11 M.G. Therapeutics Ltd Compositions and methods for the treatment of meibomian gland dysfunction
US9914755B2 (en) 2015-01-08 2018-03-13 Allergan, Inc. Cyclosporin derivatives wherein the MeBmt sidechain has been cyclized
ES3007759T3 (en) 2015-09-28 2025-03-20 Azura Ophthalmics Ltd Thiol and disulfide-containing agents for increasing meibomian gland lipid secretion
CN114469991A (zh) 2016-04-14 2022-05-13 阿祖拉眼科有限公司 用于治疗睑板腺功能障碍的二硫化硒组合物
CA3166357A1 (en) 2020-01-10 2021-07-15 Azura Ophthalmics Ltd. Instructions for composition and sensitivity

Family Cites Families (10)

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US4649047A (en) 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
US5474979A (en) 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
FR2757520B1 (fr) 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent
FR2757522B1 (fr) 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757521B1 (fr) 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
PT1086124E (pt) 1998-06-12 2004-04-30 Chem Ag C Ciclosporinas novas
US6254860B1 (en) * 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
US6806279B2 (en) 2001-12-17 2004-10-19 Sunesis Pharmaceuticals, Inc. Small-molecule inhibitors of interleukin-2
KR20030065831A (ko) * 2002-02-01 2003-08-09 주식회사 태평양 사이클로스포린을 함유한 지속 방출형 약학적 조성물
KR20110031973A (ko) * 2008-07-10 2011-03-29 알러간, 인코포레이티드 눈 및 피부의 질환 및 상태를 치료하기 위한 사이클로스포린 유도체

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ДАЙСОН Г., МЕЙ П. «Химия синтетических лекарственных веществ», пер. с англ. М.:–«Мир», 1964 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9714271B2 (en) 2010-12-15 2017-07-25 Contravir Pharmaceuticals, Inc. Cyclosporine analogue molecules modified at amino acid 1 and 3
RU2630690C2 (ru) * 2010-12-15 2017-09-12 КонтраВир Фармасьютикалз, Инк. МОЛЕКУЛЫ АНАЛОГОВ ЦИКЛОСПОРИНА, МОДИФИЦИРОВАННЫЕ ПО 1 и 3 АМИНОКИСЛОТЕ
RU2630690C9 (ru) * 2010-12-15 2017-12-28 КонтраВир Фармасьютикалз, Инк. МОЛЕКУЛЫ АНАЛОГОВ ЦИКЛОСПОРИНА, МОДИФИЦИРОВАННЫЕ ПО 1 и 3 АМИНОКИСЛОТЕ

Also Published As

Publication number Publication date
AU2009268549A1 (en) 2010-01-14
CN102149402B (zh) 2014-07-09
CA2730108A1 (en) 2010-01-14
AU2009268549B2 (en) 2015-07-16
WO2010006117A3 (en) 2010-03-04
RU2011104584A (ru) 2012-08-20
BRPI0915552A2 (pt) 2017-06-20
US20100009953A1 (en) 2010-01-14
KR20110031973A (ko) 2011-03-29
RU2014101057A (ru) 2015-07-20
CN102149402A (zh) 2011-08-10
WO2010006117A2 (en) 2010-01-14
US20140200185A1 (en) 2014-07-17
JP2011527694A (ja) 2011-11-04
JP5661035B2 (ja) 2015-01-28
EP2313157A2 (en) 2011-04-27
US8716238B2 (en) 2014-05-06

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20150710