RU2496515C2 - Введение в дыхательные пути активированного белка с при воспалительных состояниях, поражающих дыхательные пути - Google Patents
Введение в дыхательные пути активированного белка с при воспалительных состояниях, поражающих дыхательные пути Download PDFInfo
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- RU2496515C2 RU2496515C2 RU2008102656/15A RU2008102656A RU2496515C2 RU 2496515 C2 RU2496515 C2 RU 2496515C2 RU 2008102656/15 A RU2008102656/15 A RU 2008102656/15A RU 2008102656 A RU2008102656 A RU 2008102656A RU 2496515 C2 RU2496515 C2 RU 2496515C2
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Classifications
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- A61K38/55—Protease inhibitors
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4866—Protein C (3.4.21.69)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/0012—Galenical forms characterised by the site of application
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- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
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- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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- A—HUMAN NECESSITIES
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
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- A61P11/16—Central respiratory analeptics
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- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Otolaryngology (AREA)
- Zoology (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69396805P | 2005-06-24 | 2005-06-24 | |
| US60/693,968 | 2005-06-24 | ||
| PCT/IB2006/002773 WO2007012976A2 (en) | 2005-06-24 | 2006-06-23 | Airway administration of activated protein c in inflammatory conditions affecting the respiratory tract |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2008102656A RU2008102656A (ru) | 2009-07-27 |
| RU2496515C2 true RU2496515C2 (ru) | 2013-10-27 |
Family
ID=37570814
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008102656/15A RU2496515C2 (ru) | 2005-06-24 | 2006-06-23 | Введение в дыхательные пути активированного белка с при воспалительных состояниях, поражающих дыхательные пути |
| RU2008102655/15A RU2496516C2 (ru) | 2005-06-24 | 2006-06-23 | Введение в дыхательные пути ингибитора тканевого фактора при воспалительных состояниях, поражающих дыхательные пути |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008102655/15A RU2496516C2 (ru) | 2005-06-24 | 2006-06-23 | Введение в дыхательные пути ингибитора тканевого фактора при воспалительных состояниях, поражающих дыхательные пути |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8088728B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP1898945B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP2008543926A (cg-RX-API-DMAC7.html) |
| KR (2) | KR20080071116A (cg-RX-API-DMAC7.html) |
| CN (2) | CN101262880A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2006273696B2 (cg-RX-API-DMAC7.html) |
| BR (2) | BRPI0613137A2 (cg-RX-API-DMAC7.html) |
| CA (2) | CA2612597C (cg-RX-API-DMAC7.html) |
| DK (3) | DK1896059T3 (cg-RX-API-DMAC7.html) |
| IL (2) | IL188221A0 (cg-RX-API-DMAC7.html) |
| NO (2) | NO20080434L (cg-RX-API-DMAC7.html) |
| RU (2) | RU2496515C2 (cg-RX-API-DMAC7.html) |
| WO (3) | WO2007012976A2 (cg-RX-API-DMAC7.html) |
| ZA (2) | ZA200800251B (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010512350A (ja) * | 2006-12-11 | 2010-04-22 | ダラグレキュル・アンパルトセルスカブ | ホスホマイシンの肺投与により細菌感染を伴う嚢胞性線維症または肺炎を処置するための方法 |
| JP6273272B2 (ja) | 2012-07-04 | 2018-01-31 | ジージー バイオテック エルエルシー | 炎症性皮膚障害の治療 |
| ES2890623T3 (es) | 2014-04-16 | 2022-01-20 | Zz Biotech Llc | Uso del análogo de APC para curar heridas |
| DK3137102T3 (da) | 2014-04-16 | 2021-10-11 | Zz Biotech Llc | Apc til anvendelse til behandling af unormal kutan ardannelse |
| CA3036553A1 (en) * | 2016-09-13 | 2018-03-22 | Prothera Biologics, Inc. | Methods for treating pulmonary disease using inter-alpha inhibitor proteins |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0946715A1 (en) * | 1996-11-08 | 1999-10-06 | Oklahoma Medical Research Foundation | Modified protein c and methods of use thereof |
| WO2001057193A2 (en) * | 2000-02-02 | 2001-08-09 | Eli Lilly And Company | Protein c derivatives |
| EP1273305A1 (de) * | 2001-07-06 | 2003-01-08 | Aventis Behring GmbH | Arzneizubereitung zur Inhalation von Antithrombin bei entzündlichen Lungenerkrankungen und ARDS |
| RU2253450C2 (ru) * | 2000-02-01 | 2005-06-10 | Исихара Сангио Кайся, Лтд. | Средство для лечения или профилактики легочной недостаточности, содержащее производное диаминотрифторметилпиридина |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) * | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4775624A (en) * | 1985-02-08 | 1988-10-04 | Eli Lilly And Company | Vectors and compounds for expression of human protein C |
| GR860984B (en) * | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
| US4837028A (en) * | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US4966852A (en) * | 1987-07-23 | 1990-10-30 | Monsanto Company | DNA clone of human tissue factor inhibitor |
| US5106833A (en) * | 1987-07-23 | 1992-04-21 | Washington University | Coagulation inhibitors |
| US4992373A (en) * | 1987-12-04 | 1991-02-12 | Eli Lilly And Company | Vectors and compounds for direct expression of activated human protein C |
| US6013619A (en) * | 1988-01-06 | 2000-01-11 | The Scripps Research Institute | Pulmonary surfactants and therapeutic uses, including pulmonary lavage |
| US4981952A (en) * | 1988-10-04 | 1991-01-01 | Eli Lilly And Company | Method for the purification of vitamin K-dependent proteins |
| US5378614A (en) * | 1989-08-18 | 1995-01-03 | Novo Nordisk A/S | Vector and method for making tissue factor pathway inhibitor (TFPI) analogues in yeast |
| DK408089D0 (da) * | 1989-08-18 | 1989-08-18 | Novo Nordisk As | Proteiner |
| SE9200541D0 (sv) * | 1992-02-24 | 1992-02-24 | Kabi Pharmacia Ab | New usee of omega-3-fatty acids |
| US5212091A (en) * | 1992-03-02 | 1993-05-18 | Monsanto Company | Method of producing tissue factor pathway inhibitor |
| US6497877B1 (en) * | 1997-01-29 | 2002-12-24 | University Technology Corporation | Plasminogen activator as an anti-inflammatory agent |
| HUP0001237A3 (en) * | 1997-10-20 | 2002-01-28 | Lilly Co Eli | Methods for treating vascular disorders |
| US6049577A (en) * | 1998-05-28 | 2000-04-11 | Glenayre Electronics, Inc. | Header synchronization detector |
| AR023819A1 (es) * | 1999-05-03 | 2002-09-04 | Astrazeneca Ab | FORMULACIoN FARMACEUTICA, KIT DE PARTES Y UTILIZACION DE DICHA FORMULACION |
| WO2001058935A2 (en) * | 2000-02-11 | 2001-08-16 | Maxygen Aps | FACTOR VII OR VIIa-LIKE MOLECULES |
| US6933367B2 (en) * | 2000-10-18 | 2005-08-23 | Maxygen Aps | Protein C or activated protein C-like molecules |
| IL158615A0 (en) * | 2001-05-02 | 2004-05-12 | Novo Nordisk As | Modified factor vii in treatment of acute lung injury or acute respiratory distress syndrome |
| BR0213293A (pt) * | 2001-10-15 | 2004-12-21 | Chiron Corp | Uso de tfpi ou de um análogo de tfpi no tratamento de septicemia |
| KR100674315B1 (ko) * | 2002-02-08 | 2007-01-24 | 에스케이 주식회사 | 가열로 튜브 세척제 및 세척방법 |
| NZ536796A (en) * | 2002-04-25 | 2007-03-30 | Scripps Research Inst | Treatment and prevention of pulmonary conditions comprising at least one lung surfactant polypeptide and at least one protease inhibitor, lipase inhibitor or an anti-oxidant |
| ES2321297T3 (es) * | 2003-01-08 | 2009-06-04 | Novartis Vaccines And Diagnostics, Inc. | Composiciones acuosas estabilizadas que comprenden inhibidor de la via del factor tisular (ivft) o variante del inhibidor de la via del factor tisular. |
| EP1609471A1 (en) * | 2003-03-31 | 2005-12-28 | Kyowa Hakko Kogyo Co., Ltd. | Remedy and/or preventive for lung diseases |
| WO2005042011A1 (en) * | 2003-11-04 | 2005-05-12 | Novo Nordisk A/S | Pharmaceutical composition comprising a protein c polypeptide and a blood glucose regulator |
| MX2007002903A (es) * | 2004-09-10 | 2007-07-11 | Pharmaorigin Aps | Metodos para el tratamiento de hemoptisis o hemorragias traqueales, bronquiales o alveolares, locales. |
| CA2582353A1 (en) | 2004-10-06 | 2006-04-20 | University Of Rochester | Treatment of pulmonary hypertension using an agent that inhibits a tissue factor pathway |
-
2006
- 2006-06-23 ZA ZA200800251A patent/ZA200800251B/xx unknown
- 2006-06-23 WO PCT/IB2006/002773 patent/WO2007012976A2/en not_active Ceased
- 2006-06-23 US US11/993,253 patent/US8088728B2/en not_active Expired - Fee Related
- 2006-06-23 CN CNA2006800310726A patent/CN101262880A/zh active Pending
- 2006-06-23 WO PCT/IB2006/002602 patent/WO2006136962A2/en not_active Ceased
- 2006-06-23 EP EP06795540A patent/EP1898945B1/en not_active Expired - Lifetime
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- 2006-06-23 DK DK06795527.8T patent/DK1896059T3/da active
- 2006-06-23 DK DK06808954.9T patent/DK1906994T3/da active
- 2006-06-23 AU AU2006273696A patent/AU2006273696B2/en not_active Ceased
- 2006-06-23 EP EP06808954.9A patent/EP1906994B1/en not_active Expired - Lifetime
- 2006-06-23 BR BRPI0613137-9A patent/BRPI0613137A2/pt not_active Application Discontinuation
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2007
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0946715A1 (en) * | 1996-11-08 | 1999-10-06 | Oklahoma Medical Research Foundation | Modified protein c and methods of use thereof |
| RU2253450C2 (ru) * | 2000-02-01 | 2005-06-10 | Исихара Сангио Кайся, Лтд. | Средство для лечения или профилактики легочной недостаточности, содержащее производное диаминотрифторметилпиридина |
| WO2001057193A2 (en) * | 2000-02-02 | 2001-08-09 | Eli Lilly And Company | Protein c derivatives |
| EP1273305A1 (de) * | 2001-07-06 | 2003-01-08 | Aventis Behring GmbH | Arzneizubereitung zur Inhalation von Antithrombin bei entzündlichen Lungenerkrankungen und ARDS |
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| Title |
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| Idell S et. al. Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome// J Clin Invest. - 1989 Aug; 84(2):695-705. * |
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