RU2491953C2 - Соединения для лечения амилоидозов - Google Patents

Соединения для лечения амилоидозов Download PDF

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Publication number
RU2491953C2
RU2491953C2 RU2011100125/15A RU2011100125A RU2491953C2 RU 2491953 C2 RU2491953 C2 RU 2491953C2 RU 2011100125/15 A RU2011100125/15 A RU 2011100125/15A RU 2011100125 A RU2011100125 A RU 2011100125A RU 2491953 C2 RU2491953 C2 RU 2491953C2
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RU
Russia
Prior art keywords
compound
amino acid
peptide
use according
disease
Prior art date
Application number
RU2011100125/15A
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English (en)
Russian (ru)
Other versions
RU2011100125A (ru
Inventor
Маркус МАНДЛЕР
Радмилла САНТИК
Харальд ВЕНИНГЕР
Эдит КОПИНИТС
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Аффирис Аг
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Publication date
Application filed by Аффирис Аг filed Critical Аффирис Аг
Publication of RU2011100125A publication Critical patent/RU2011100125A/ru
Application granted granted Critical
Publication of RU2491953C2 publication Critical patent/RU2491953C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
RU2011100125/15A 2008-06-12 2009-06-12 Соединения для лечения амилоидозов RU2491953C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AT0095208A AT506820B1 (de) 2008-06-12 2008-06-12 Vakzine gegen alzheimer-krankheit
ATA952/2008 2008-06-12
PCT/AT2009/000235 WO2009149485A2 (en) 2008-06-12 2009-06-12 Compounds for treating amyloidoses

Publications (2)

Publication Number Publication Date
RU2011100125A RU2011100125A (ru) 2012-07-20
RU2491953C2 true RU2491953C2 (ru) 2013-09-10

Family

ID=41401983

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2011100125/15A RU2491953C2 (ru) 2008-06-12 2009-06-12 Соединения для лечения амилоидозов

Country Status (14)

Country Link
US (1) US8409581B2 (https=)
EP (1) EP2310033B1 (https=)
JP (3) JP2011522840A (https=)
KR (1) KR20110036039A (https=)
CN (1) CN102123728B (https=)
AT (2) AT506820B1 (https=)
AU (1) AU2009257168B2 (https=)
BR (1) BRPI0915136A2 (https=)
CA (1) CA2723967A1 (https=)
ES (1) ES2392789T3 (https=)
IL (1) IL209894A (https=)
MX (1) MX2010013657A (https=)
RU (1) RU2491953C2 (https=)
WO (1) WO2009149485A2 (https=)

Families Citing this family (20)

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US20120328605A1 (en) * 2010-10-27 2012-12-27 Daniel Larocque Compositions and uses
CA2828433C (en) 2011-03-16 2020-08-04 Probiodrug Ag Diagnostic antibody assay
GB201113570D0 (en) 2011-08-05 2011-09-21 Glaxosmithkline Biolog Sa Vaccine
PT2579042E (pt) 2011-10-04 2014-09-09 Affiris Ag Método para detecção de anticorpos específicos para a numa amostra biológica.
EP2659908A1 (en) 2012-05-01 2013-11-06 Affiris AG Compositions
US9102752B2 (en) * 2013-03-15 2015-08-11 United Biomedical, Inc. Peptide vaccine for prevention and immunotherapy of dementia of the Alzheimer's type
EP2787347A1 (en) 2013-04-03 2014-10-08 Affiris AG Method for detecting Aß-specific antibodies in a biological sample
WO2015165961A1 (en) 2014-04-29 2015-11-05 Affiris Ag Treatment and prevention of alzheimer's disease (ad)
KR102460465B1 (ko) * 2014-04-29 2022-10-27 어드밴티지 테라퓨틱스, 인코포레이티드 알츠하이머병（ａｄ）의 치료 및 예방
FI3137094T3 (fi) 2014-04-29 2023-03-20 Advantage Therapeutics Inc Alzheimerin taudin (ad) hoitaminen ja ehkäiseminen
EP3374381A4 (en) 2015-11-09 2019-05-15 The University Of British Columbia EPITOPES IN THE AMYLOID-BETA MEDIUM REGION AND CONFORMITY-SELECTIVE ANTIBODIES THEREOF
KR102776187B1 (ko) 2015-11-09 2025-03-07 더 유니버시티 오브 브리티쉬 콜롬비아 아밀로이드 베타에서의 n-말단 에피토프 및 이에 형태적으로-선택적인 항체
AU2016353553B2 (en) 2015-11-09 2022-01-20 The University Of British Columbia Amyloid beta epitopes and antibodies thereto
CN109476729A (zh) 2016-07-18 2019-03-15 英属哥伦比亚大学 淀粉样蛋白β的抗体
US20180125920A1 (en) 2016-11-09 2018-05-10 The University Of British Columbia Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions
ES2984844T3 (es) 2017-07-18 2024-10-31 Univ British Columbia Anticuerpos contra beta amiloide
US12286469B2 (en) 2017-07-18 2025-04-29 The University Of British Columbia Humanized antibodies binding to amyloid-beta (A-beta)
RU2679080C1 (ru) * 2018-04-17 2019-02-05 Александр Олегович Морозов Пептид и способ лечения болезни альцгеймера
WO2023159970A1 (zh) * 2022-02-28 2023-08-31 安域生物科技杭州有限公司 基于β-淀粉样蛋白修饰的抗原多肽及其应用
EP4486389A1 (en) 2022-02-28 2025-01-08 Tridem Bioscience GmbH & Co KG A conjugate comprising at least a beta-glucan

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1172377A1 (en) * 1994-10-25 2002-01-16 The President And Fellows Of Harvard College Compounds and methods for inhibiting amyloid Beta-protein filament formation and neurotoxicity
WO2004062556A2 (en) * 2003-01-14 2004-07-29 Frank Mattner Methods for preventing and treating alzheimer’s disease (ad)
US20040265308A1 (en) * 1997-12-02 2004-12-30 Neuralab Limited Prevention and treatment of amyloidogenic disease
US6861057B2 (en) * 1998-05-08 2005-03-01 Gemvax As Immunogenic β-amyloid peptide
EP1075270B1 (en) * 1998-04-06 2005-06-15 Advanced Immunit, Inc. Short peptide for treatment of neurological degenerative diseases
RU2004107695A (ru) * 1998-05-21 2005-08-27 Юниверситити Оф Теннесси Рисерч Фаундэушн (Us) Способы удаления амилоида с помощью анти-амилоидных антител

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7504490B1 (en) * 1998-10-16 2009-03-17 Oscient Pharmaceuticals Corporation Nucleic acid and amino acid sequences relating to Apergillus fumigatus for diagnostics and therapeutics
US20040067535A1 (en) * 2002-10-03 2004-04-08 Life Sciences Development Corp. Alzheimer's disease linked genes
CN1753662A (zh) * 2002-12-24 2006-03-29 神经化学（国际）有限公司 用于治疗β－淀粉状蛋白相关疾病的治疗制剂
EP1440981A3 (en) * 2003-01-21 2005-11-23 Research Association for Biotechnology Full-length human cdna
US7358331B2 (en) * 2003-05-19 2008-04-15 Elan Pharmaceuticals, Inc. Truncated fragments of alpha-synuclein in Lewy body disease
AT413946B (de) * 2004-07-13 2006-07-15 Mattner Frank Dr Impfstoff gegen die alzheimer-krankheit
AT500483B1 (de) * 2004-07-13 2006-01-15 Mattner Frank Dr Set zur vorbeugung oder behandlung der alzheimer'schen erkrankung
CA2790433A1 (en) * 2004-10-25 2006-05-26 Northwestern University Anti-addl antibodies and uses thereof
WO2006136906A2 (en) * 2005-06-17 2006-12-28 Epfl Ecole Polytechnique Fédérale De Lausanne Switch-peptides as tool for the study of fibrillogenesis
EP1959996A2 (en) * 2005-12-12 2008-08-27 AC Immune S.A. Monoclonal antibody
JP5097695B2 (ja) * 2006-02-22 2012-12-12 株式会社林原 抗アミロイドβペプチド抗体産生誘導用のペプチドワクチン

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1172377A1 (en) * 1994-10-25 2002-01-16 The President And Fellows Of Harvard College Compounds and methods for inhibiting amyloid Beta-protein filament formation and neurotoxicity
US20040265308A1 (en) * 1997-12-02 2004-12-30 Neuralab Limited Prevention and treatment of amyloidogenic disease
EP1075270B1 (en) * 1998-04-06 2005-06-15 Advanced Immunit, Inc. Short peptide for treatment of neurological degenerative diseases
US6861057B2 (en) * 1998-05-08 2005-03-01 Gemvax As Immunogenic β-amyloid peptide
RU2004107695A (ru) * 1998-05-21 2005-08-27 Юниверситити Оф Теннесси Рисерч Фаундэушн (Us) Способы удаления амилоида с помощью анти-амилоидных антител
WO2004062556A2 (en) * 2003-01-14 2004-07-29 Frank Mattner Methods for preventing and treating alzheimer’s disease (ad)

Also Published As

Publication number Publication date
CN102123728B (zh) 2017-05-31
JP5984867B2 (ja) 2016-09-06
AT509611A1 (de) 2011-10-15
US20110171243A1 (en) 2011-07-14
CN102123728A (zh) 2011-07-13
JP2015110588A (ja) 2015-06-18
EP2310033A2 (en) 2011-04-20
IL209894A0 (en) 2011-02-28
IL209894A (en) 2015-08-31
EP2310033B1 (en) 2012-09-05
AU2009257168A1 (en) 2009-12-17
AT506820A1 (de) 2009-12-15
RU2011100125A (ru) 2012-07-20
WO2009149485A2 (en) 2009-12-17
KR20110036039A (ko) 2011-04-06
JP2014139227A (ja) 2014-07-31
AT506820B1 (de) 2011-07-15
MX2010013657A (es) 2011-04-11
BRPI0915136A2 (pt) 2019-09-24
US8409581B2 (en) 2013-04-02
WO2009149485A3 (en) 2010-06-10
ES2392789T3 (es) 2012-12-13
CA2723967A1 (en) 2009-12-17
AT509611B1 (de) 2012-04-15
JP5989074B2 (ja) 2016-09-07
JP2011522840A (ja) 2011-08-04
AU2009257168B2 (en) 2015-01-22

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Effective date: 20160613