RU2483071C2 - Гидратированные кристаллические сложные эфиры камптотецина для лечения рака - Google Patents

Гидратированные кристаллические сложные эфиры камптотецина для лечения рака Download PDF

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Publication number
RU2483071C2
RU2483071C2 RU2010120810/04A RU2010120810A RU2483071C2 RU 2483071 C2 RU2483071 C2 RU 2483071C2 RU 2010120810/04 A RU2010120810/04 A RU 2010120810/04A RU 2010120810 A RU2010120810 A RU 2010120810A RU 2483071 C2 RU2483071 C2 RU 2483071C2
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Russia
Prior art keywords
cancer
camptothecin
crystalline
hydrate
crystalline camptothecin
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RU2010120810/04A
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English (en)
Russian (ru)
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RU2010120810A (ru
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Чжисун ЦАО
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Дзе Кристус Стелин Фаундейшн Фор Кэнсер Рисерч
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RU2010120810/04A 2007-10-25 2008-10-24 Гидратированные кристаллические сложные эфиры камптотецина для лечения рака RU2483071C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/923,727 US7572803B2 (en) 2007-10-25 2007-10-25 Hydrated crystalline esters of camptothecin
US11/923,727 2007-10-25
PCT/US2008/081047 WO2009055633A1 (en) 2007-10-25 2008-10-24 Hydrated crystalline esters of camptothecin for the treatment of cancer

Publications (2)

Publication Number Publication Date
RU2010120810A RU2010120810A (ru) 2011-11-27
RU2483071C2 true RU2483071C2 (ru) 2013-05-27

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RU2010120810/04A RU2483071C2 (ru) 2007-10-25 2008-10-24 Гидратированные кристаллические сложные эфиры камптотецина для лечения рака

Country Status (11)

Country Link
US (1) US7572803B2 (enExample)
EP (1) EP2205605B1 (enExample)
JP (1) JP5487111B2 (enExample)
KR (1) KR20100082358A (enExample)
CN (1) CN101730701B (enExample)
BR (1) BRPI0816584A2 (enExample)
CA (1) CA2703054C (enExample)
ES (1) ES2396222T3 (enExample)
MX (1) MX2010004332A (enExample)
RU (1) RU2483071C2 (enExample)
WO (1) WO2009055633A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130121921A1 (en) 2011-11-11 2013-05-16 The Christus Stehlin Foundation For Cancer Research Rodent Therapeutic Model And Methods
US9387257B2 (en) * 2014-01-17 2016-07-12 Academia Sinica Lung cancer specific peptides for targeted drug delivery and molecular imaging
US9675609B2 (en) 2015-11-11 2017-06-13 Cao Pharmaceuticals Inc. Nano- and micro-sized particles of 20-camptothecin or derivative thereof and pharmaceutical compositions containing same, and treatment of cancers therewith
US20220395497A1 (en) * 2019-11-20 2022-12-15 Vivacitas Oncology, Inc. Cancer Treatment Using Camptothecin Derivatives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010031761A1 (en) * 1996-01-30 2001-10-18 Zhisong Cao Derivatives of camptothecin and methods of treating cancer using these derivatives

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
US5527913A (en) * 1993-02-25 1996-06-18 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
US5352789A (en) * 1993-02-25 1994-10-04 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
US6407118B1 (en) * 1996-01-30 2002-06-18 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US5922877A (en) * 1997-08-05 1999-07-13 The Stehlin Foundation For Cancer Research Methods of preparing and purifying 9-nitro-20-camptothecin
USRE38408E1 (en) * 1997-08-05 2004-01-27 The Stehlin Foundation For Cancer Research Methods of preparing and purifying 9-nitro-20-camptothecin
US6228855B1 (en) * 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
US6352996B1 (en) * 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6699875B2 (en) * 2002-05-06 2004-03-02 The Stehlin Foundation For Cancer Research Cascade esters of camptothecins and methods of treating cancer using these compounds
US6703399B2 (en) * 2002-05-06 2004-03-09 The Stehlin Foundation For Cancer Research Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds
KR101095382B1 (ko) * 2003-02-25 2011-12-16 가부시키가이샤 야쿠르트 혼샤 이리노테칸 염산염의 결정다형의 제조방법
TWI333492B (en) * 2003-11-12 2010-11-21 Smithkline Beecham Cork Ltd Crystalline topotecan hydrochloride product and preparation thereof
WO2007035709A2 (en) * 2005-09-20 2007-03-29 Scinopharm Singapore Pte, Ltd. Novel crystal forms of irinotecan hydrochloride

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010031761A1 (en) * 1996-01-30 2001-10-18 Zhisong Cao Derivatives of camptothecin and methods of treating cancer using these derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
САО Z ЕТ AL: "Alkyl esters of camptothecin and 9-nitrocamptothecin: Synthesis, in vitro pharmcokinetics, toxicity, and antitumor activity" JOURNAL OF MEDICINAL CHEMISTRY, US AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol.41, no.1, 1998 p.31-37. *

Also Published As

Publication number Publication date
CN101730701B (zh) 2013-05-29
ES2396222T3 (es) 2013-02-20
US20090111845A1 (en) 2009-04-30
CA2703054C (en) 2017-08-22
RU2010120810A (ru) 2011-11-27
BRPI0816584A2 (pt) 2015-03-03
CN101730701A (zh) 2010-06-09
KR20100082358A (ko) 2010-07-16
MX2010004332A (es) 2010-05-20
EP2205605A1 (en) 2010-07-14
CA2703054A1 (en) 2009-04-30
JP5487111B2 (ja) 2014-05-07
JP2011500841A (ja) 2011-01-06
WO2009055633A1 (en) 2009-04-30
EP2205605B1 (en) 2012-11-21
US7572803B2 (en) 2009-08-11

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Effective date: 20160216

MM4A The patent is invalid due to non-payment of fees

Effective date: 20181025