CN101730701B - 用于癌症治疗的水合的喜树碱酯晶体 - Google Patents

用于癌症治疗的水合的喜树碱酯晶体 Download PDF

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Publication number
CN101730701B
CN101730701B CN200880013536XA CN200880013536A CN101730701B CN 101730701 B CN101730701 B CN 101730701B CN 200880013536X A CN200880013536X A CN 200880013536XA CN 200880013536 A CN200880013536 A CN 200880013536A CN 101730701 B CN101730701 B CN 101730701B
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CN
China
Prior art keywords
cancer
camptothecin
camptothecine
purposes
compound
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Expired - Fee Related
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CN200880013536XA
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English (en)
Chinese (zh)
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CN101730701A (zh
Inventor
曹志松
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
B Giovanni Pull
Cao Zhisong
Stryn Research Foundation
Cao Pharmaceuticals Inc
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Stehlin Foundation for Cancer Research
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Publication of CN101730701A publication Critical patent/CN101730701A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200880013536XA 2007-10-25 2008-10-24 用于癌症治疗的水合的喜树碱酯晶体 Expired - Fee Related CN101730701B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/923,727 US7572803B2 (en) 2007-10-25 2007-10-25 Hydrated crystalline esters of camptothecin
US11/923,727 2007-10-25
PCT/US2008/081047 WO2009055633A1 (en) 2007-10-25 2008-10-24 Hydrated crystalline esters of camptothecin for the treatment of cancer

Publications (2)

Publication Number Publication Date
CN101730701A CN101730701A (zh) 2010-06-09
CN101730701B true CN101730701B (zh) 2013-05-29

Family

ID=40229972

Family Applications (1)

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CN200880013536XA Expired - Fee Related CN101730701B (zh) 2007-10-25 2008-10-24 用于癌症治疗的水合的喜树碱酯晶体

Country Status (11)

Country Link
US (1) US7572803B2 (enExample)
EP (1) EP2205605B1 (enExample)
JP (1) JP5487111B2 (enExample)
KR (1) KR20100082358A (enExample)
CN (1) CN101730701B (enExample)
BR (1) BRPI0816584A2 (enExample)
CA (1) CA2703054C (enExample)
ES (1) ES2396222T3 (enExample)
MX (1) MX2010004332A (enExample)
RU (1) RU2483071C2 (enExample)
WO (1) WO2009055633A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130121921A1 (en) 2011-11-11 2013-05-16 The Christus Stehlin Foundation For Cancer Research Rodent Therapeutic Model And Methods
US9387257B2 (en) * 2014-01-17 2016-07-12 Academia Sinica Lung cancer specific peptides for targeted drug delivery and molecular imaging
US9675609B2 (en) 2015-11-11 2017-06-13 Cao Pharmaceuticals Inc. Nano- and micro-sized particles of 20-camptothecin or derivative thereof and pharmaceutical compositions containing same, and treatment of cancers therewith
US20220395497A1 (en) * 2019-11-20 2022-12-15 Vivacitas Oncology, Inc. Cancer Treatment Using Camptothecin Derivatives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010031761A1 (en) * 1996-01-30 2001-10-18 Zhisong Cao Derivatives of camptothecin and methods of treating cancer using these derivatives

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
US5527913A (en) * 1993-02-25 1996-06-18 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
US5352789A (en) * 1993-02-25 1994-10-04 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
US6407118B1 (en) * 1996-01-30 2002-06-18 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US5922877A (en) * 1997-08-05 1999-07-13 The Stehlin Foundation For Cancer Research Methods of preparing and purifying 9-nitro-20-camptothecin
USRE38408E1 (en) * 1997-08-05 2004-01-27 The Stehlin Foundation For Cancer Research Methods of preparing and purifying 9-nitro-20-camptothecin
US6228855B1 (en) * 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
US6352996B1 (en) * 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6699875B2 (en) * 2002-05-06 2004-03-02 The Stehlin Foundation For Cancer Research Cascade esters of camptothecins and methods of treating cancer using these compounds
US6703399B2 (en) * 2002-05-06 2004-03-09 The Stehlin Foundation For Cancer Research Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds
KR101095382B1 (ko) * 2003-02-25 2011-12-16 가부시키가이샤 야쿠르트 혼샤 이리노테칸 염산염의 결정다형의 제조방법
TWI333492B (en) * 2003-11-12 2010-11-21 Smithkline Beecham Cork Ltd Crystalline topotecan hydrochloride product and preparation thereof
WO2007035709A2 (en) * 2005-09-20 2007-03-29 Scinopharm Singapore Pte, Ltd. Novel crystal forms of irinotecan hydrochloride

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010031761A1 (en) * 1996-01-30 2001-10-18 Zhisong Cao Derivatives of camptothecin and methods of treating cancer using these derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Zhisong Cao,et al..Alkyl Esters of Camptothecin and 9-Nitrocamptothecin: Synthesis, in Vitro Pharmacokinetics, Toxicity, and Antitumor Activity.《J. Med. Chem.》.1998,第41卷(第1期),31-37. *
ZhisongCao et al..Alkyl Esters of Camptothecin and 9-Nitrocamptothecin: Synthesis

Also Published As

Publication number Publication date
ES2396222T3 (es) 2013-02-20
US20090111845A1 (en) 2009-04-30
CA2703054C (en) 2017-08-22
RU2483071C2 (ru) 2013-05-27
RU2010120810A (ru) 2011-11-27
BRPI0816584A2 (pt) 2015-03-03
CN101730701A (zh) 2010-06-09
KR20100082358A (ko) 2010-07-16
MX2010004332A (es) 2010-05-20
EP2205605A1 (en) 2010-07-14
CA2703054A1 (en) 2009-04-30
JP5487111B2 (ja) 2014-05-07
JP2011500841A (ja) 2011-01-06
WO2009055633A1 (en) 2009-04-30
EP2205605B1 (en) 2012-11-21
US7572803B2 (en) 2009-08-11

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C41 Transfer of patent application or patent right or utility model
C56 Change in the name or address of the patentee
CP01 Change in the name or title of a patent holder

Address after: Texas, USA

Patentee after: Stryn Research Foundation

Address before: Texas, USA

Patentee before: THE CHRISTUS STEHLIN FOUNDATION FOR CANCER RESEARCH

TR01 Transfer of patent right

Effective date of registration: 20160129

Address after: Texas, USA

Patentee after: CAO PHARMACEUTICALS Inc.

Address before: Texas, USA

Patentee before: Cao Zhisong

Patentee before: B Giovanni pull

Effective date of registration: 20160129

Address after: Texas, USA

Patentee after: Cao Zhisong

Patentee after: B Giovanni pull

Address before: Texas, USA

Patentee before: Stryn Research Foundation

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20130529

CF01 Termination of patent right due to non-payment of annual fee