RU2482877C2 - Композиции и способы для лечения опухоли - Google Patents

Композиции и способы для лечения опухоли Download PDF

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Publication number
RU2482877C2
RU2482877C2 RU2009126588/15A RU2009126588A RU2482877C2 RU 2482877 C2 RU2482877 C2 RU 2482877C2 RU 2009126588/15 A RU2009126588/15 A RU 2009126588/15A RU 2009126588 A RU2009126588 A RU 2009126588A RU 2482877 C2 RU2482877 C2 RU 2482877C2
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RU
Russia
Prior art keywords
thalidomide
melphalan
antibody
bortezomib
patient
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RU2009126588/15A
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English (en)
Russian (ru)
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RU2009126588A (ru
Inventor
Роберт Д. МАСС
Грегори Д. ПЛАУМАН
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Дженентек, Инк.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2009126588/15A 2006-12-11 2007-05-04 Композиции и способы для лечения опухоли RU2482877C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87446006P 2006-12-11 2006-12-11
US60/874,460 2006-12-11
PCT/US2007/068300 WO2008073509A2 (en) 2006-12-11 2007-05-04 Compositions and methods for treating a neoplasm

Publications (2)

Publication Number Publication Date
RU2009126588A RU2009126588A (ru) 2011-01-20
RU2482877C2 true RU2482877C2 (ru) 2013-05-27

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Application Number Title Priority Date Filing Date
RU2009126588/15A RU2482877C2 (ru) 2006-12-11 2007-05-04 Композиции и способы для лечения опухоли

Country Status (17)

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US (1) US20100086544A1 (enExample)
EP (1) EP2099489B1 (enExample)
JP (1) JP2010512407A (enExample)
KR (1) KR101320198B1 (enExample)
CN (1) CN101547705B (enExample)
AU (1) AU2007333565A1 (enExample)
BR (1) BRPI0717688A2 (enExample)
CA (1) CA2670707A1 (enExample)
DK (1) DK2099489T3 (enExample)
IL (1) IL198852A (enExample)
MX (1) MX2009006202A (enExample)
NZ (1) NZ577058A (enExample)
RU (1) RU2482877C2 (enExample)
SG (1) SG177891A1 (enExample)
SI (1) SI2099489T1 (enExample)
WO (1) WO2008073509A2 (enExample)
ZA (1) ZA200903489B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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RU2836995C1 (ru) * 2024-04-18 2025-03-25 Федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ лечения пациентов с множественной миеломой, осложненной двойной рефрактерностью, с помощью адоптивной иммунотерапии на основе натуральных киллеров

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US7750124B2 (en) 2006-09-29 2010-07-06 Oncomed Pharmaceuticals, Inc. Anti-human DLL4 antibodies and compositions
EP3485908B1 (en) 2009-10-16 2021-08-18 Mereo BioPharma 5, Inc. Therapeutic combination and use of dll4 antagonist antibodies and anti-hypertensive agents
US8551479B2 (en) 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
EP2655334B1 (en) 2010-12-22 2018-10-03 Eutropics Pharmaceuticals, Inc. Compositions and methods useful for treating diseases
HRP20190044T1 (hr) 2011-09-23 2019-02-22 Oncomed Pharmaceuticals, Inc. Agensi koji vežu vegf/dll4 i njihove uporabe
CN104244934A (zh) * 2012-03-14 2014-12-24 印第安纳大学研究及科技有限公司 用于治疗白血病的化合物和方法
AU2013337811A1 (en) 2012-10-31 2015-05-14 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a DLL4 antagonist
GB201409471D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
MX382902B (es) 2014-10-31 2025-03-13 Oncomed Pharm Inc Inhibidor de la vía noth en combinación con un agente inmunoterapéutico para usarse en el tratamiento de cáncer.
FI3328843T3 (fi) 2015-07-27 2023-01-31 1,3,4-oksadiatsolisulfonamidijohdannaisyhdisteitä histonideasetylaasi-6:n inhibiittoreina ja samaa käsittävä farmaseuttinen koostumus
CN107980040B (zh) 2015-07-27 2021-11-26 株式会社钟根堂 作为组蛋白去乙酰酶6抑制剂的1,3,4-噁二唑磺酰胺衍生物及含其的医药组合物
HRP20201304T1 (hr) 2015-07-27 2020-11-27 Chong Kun Dang Pharmaceutical Corp. Spoj derivata 1,3,4-oksadiazol-amida koji služi kao inhibitor histonske deacetilaze 6 i farmaceutski pripravak koji sadrži taj spoj
DK3331864T3 (da) 2015-08-04 2021-12-13 Chong Kun Dang Pharmaceutical Corp 1,3,4-Oxadiazolderivat-forbindelser som histon-deacetylase-6-hæmmer, og den farmaceutiske sammensætning omfattende disse
WO2017053705A1 (en) 2015-09-23 2017-03-30 Oncomed Pharmaceuticals, Inc. Methods and compositions for treatment of cancer
MY196174A (en) 2015-10-12 2023-03-20 Chong Kun Dang Pharmaceutical Corp Oxadiazole Amine Derivative Compounds as Histone Deacetylase 6 Inhibitor, and the Pharmaceutical Composition Comprising the Same
GB201709406D0 (en) 2017-06-13 2017-07-26 Euro-Cletique S A Compounds for treating TNBC
US11524053B2 (en) 2018-01-26 2022-12-13 The Regents Of The University Of California Methods and compositions for treatment of angiogenic disorders using anti-VEGF agents
KR102316234B1 (ko) 2018-07-26 2021-10-22 주식회사 종근당 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물
CN113874369B (zh) 2019-05-31 2024-08-27 株式会社钟根堂 作为组蛋白脱乙酰酶6抑制剂的1,3,4-噁二唑高邻苯二甲酰亚胺衍生化合物及包含其的药物组合物
IL293131A (en) 2019-11-25 2022-07-01 Univ California Long-acting vegf inhibitors for intraocular neovascularization

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RU2197477C2 (ru) * 1997-12-05 2003-01-27 АСТРАЗЕНЕКА Ю Кей ЛИМИТЕД Производные адамантана, способ их получения, фармацевтическая композиция на их основе, способ ее получения и способ воздействия на иммуносупрессию
WO2004103274A2 (en) * 2003-05-15 2004-12-02 Celgene Corporation Methods and compositions using immunomodulatory compounds for treatment and management of cancers and other diseases

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DE59906030D1 (de) * 1998-09-25 2003-07-24 Boehringer Ingelheim Pharma Neue substituierte indolinone mit einer inhibierenden wirkung auf verschiedene kinasen und cyclin/cdk-komplexe
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RU2197477C2 (ru) * 1997-12-05 2003-01-27 АСТРАЗЕНЕКА Ю Кей ЛИМИТЕД Производные адамантана, способ их получения, фармацевтическая композиция на их основе, способ ее получения и способ воздействия на иммуносупрессию
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HERBST RS et al. Phase I/II trial evaluating the anti-vascular endothclial growth factor monoclonal antibody bevacizumab in combination with the HER-l/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer //J Clin Oncol. 2005 Apr 10; 23(11):2544-55. *
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HIDESHIMA T et al. p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells // Oncogene. 2004 Nov 18; 23(54): 8766-76. HERBST RS et al. Phase I/II trial evaluating the anti-vascular endothclial growth factor monoclonal antibody bevacizumab in combination with the HER-l/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer //J Clin Oncol. 2005 Apr 10; 23(11):2544-55. BERENSON JR et al. Phase I/II trial assessing bortezomib and melphalan combination therapy for the treatment of patients with relapsed or refractory multiple myeloma // J Clin Oncol. 2006 Feb 20; 24(6):937-44. ZANGARI M et al. Phase II study of SU5416, a small molecule vascular endothelial growth factor tyrosine kinase receptor inhibitor, in patients with refractory multiple myeloma // Clin Cancer Res. 2004 Jan 1; 10 (1 Pt 1):88-95. *
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2836995C1 (ru) * 2024-04-18 2025-03-25 Федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ лечения пациентов с множественной миеломой, осложненной двойной рефрактерностью, с помощью адоптивной иммунотерапии на основе натуральных киллеров

Also Published As

Publication number Publication date
AU2007333565A1 (en) 2008-06-19
CN101547705A (zh) 2009-09-30
KR101320198B1 (ko) 2013-10-30
US20100086544A1 (en) 2010-04-08
WO2008073509A3 (en) 2009-01-08
ZA200903489B (en) 2010-08-25
RU2009126588A (ru) 2011-01-20
NZ577058A (en) 2012-04-27
CA2670707A1 (en) 2008-06-19
IL198852A0 (en) 2011-08-01
EP2099489A2 (en) 2009-09-16
HK1131064A1 (en) 2010-01-15
SG177891A1 (en) 2012-02-28
KR20090087908A (ko) 2009-08-18
SI2099489T1 (sl) 2014-09-30
IL198852A (en) 2013-06-27
DK2099489T3 (da) 2014-08-18
EP2099489B1 (en) 2014-05-21
MX2009006202A (es) 2009-06-22
JP2010512407A (ja) 2010-04-22
BRPI0717688A2 (pt) 2013-01-22
WO2008073509A2 (en) 2008-06-19
CN101547705B (zh) 2013-06-12

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Effective date: 20200505