RU2480199C2 - Method of obtaining medicinal ointment for animals - Google Patents

Abstract

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of veterinary medicine, namely to veterinary pharmacology. Method of obtaining medicinal ointment for animals, includes manufacturing ointment base, consisting of mixture of colophony, wax, vegetable oil and addition of active substances in form of precipitated sulphur, boric acid, 2-3% benzyl alcohol is introduced into ointment base brought to complete dissolution at t- 65-76°C with further addition of 3-4% citric acid with following mixing of components by homogenisation at t -40-50°C and filtration.

EFFECT: reduction of treatment terms is ensured.

1 ex

Description

The invention relates to the field of veterinary medicine, in particular veterinary pharmacology with toxicology, and can be used in veterinary practice for the treatment of chronic eczema, dermatitis, trichophytosis and other animal skin diseases.

For the treatment of the above diseases, drugs are known, in particular, Yam ointment, consisting of sulfur, salicylic acid, tar, lysol, zinc oxide, turpentine, lanolin and petrolatum.

However, treatment with such a therapeutic ointment is ineffective and requires a second course.

The closest analogue is a therapeutic ointment for animals, consisting of tartaric acid, chilled sulfur, boric acid, wax, rosin, vegetable oil (patent No. 2261086, published September 27, 2005).

The main disadvantages are as follows:

- shallow penetration of the drug into the skin tissues of the animal’s body, which affects the timing of treatment of animals,

- the medicinal product has a specific smell, which negatively affects the behavior of animals,

- the shelf life of the drug is short.

The technical result of the method for producing the drug is to increase the effectiveness of the healing properties of the ointment.

The technical solution of the claimed object is that to the well-known therapeutic ointment for animals, benzyl alcohol (fragrance, odor fixative and solvent) is additionally added in an amount of 2-3% of the total mass, which improves the uniformity of the ointment and contributes to a deep penetrating effect in the body tissue animals. Citric acid (3-4%) is also added as an active substance, which plays an important role in the metabolism (tricarboxylic acid cycle) of animal organisms. Citric acid salts, called citrates, are used to prevent blood clotting.

The method of obtaining a therapeutic agent for animals is carried out in two stages:

1) an ointment base is made with the introduction of benzyl alcohol,

2) certain active ingredients are added, including citric acid.

An ointment base is prepared, consisting of rosin, vegetable oil wax. Rosin and wax are crushed, placed in an enameled (porcelain, glass) container, vegetable (corn, sunflower) oil is added, the container is covered with a lid and insisted for 24-48 hours at room temperature. Then the container with the ointment base is immersed in a water bath at t - 65-75 ° C, stirring occasionally during heating until the rosin and wax are completely dissolved and a viscous homogeneous mixture is formed. Turning off the heat source, the resulting substance is left to ripen for 24 hours. Then add benzyl alcohol in an amount of 2-3% of the total mass. Thus, an ointment base is obtained. The declared ointment base at the appropriate temperature conditions (t - 10-25 ° C) can be stored for 3-4 years.

At the next stage of the method for producing a therapeutic agent, precipitated sulfur, boric acid, citric acid 3-4% of the total mass are added to the ointment base (manufacturing technology at this stage does not require sequence), the components are mixed and homogenized at t - 40-50 ° C. Then filtration and removal of undissolved particles is carried out, left to ripen for 2-3 days.

The result is a combined preparation consisting of an ointment base with the addition of active substances in the following ratio (%):

The specified drug is used externally for dermatitis and eczema of various etiologies, infectious and invasive diseases (trichophytosis, mycosporea, seborrhea and other skin diseases) in animals and humans.

Example. To establish the effectiveness of the treatment of the claimed therapeutic agent, experiments were conducted on calves suffering from trichophytosis. After removal of the affected skin areas by scraping to blood, this body area was washed with a 3% hydrogen peroxide solution, then the scraping site was burned with a 5% iodine alcohol solution (once per treatment course) and the test ointment was rubbed onto and around the affected skin area . Twelve days later, a complete clinical examination of the experimental calves was carried out, the number of recovered animals was 100%.

The result of the experiment indicates that the proposed ointment is therapeutically justified for the treatment of calves and carnivores.

The proposed ointment, due to the ratio of the listed therapeutic components, has antimicrobial, antiparasitic, absorbable, anti-inflammatory, itching, wound healing properties.

Claims (1)

A method of obtaining a therapeutic ointment for animals, including the manufacture of an ointment base consisting of a mixture of rosin, wax, vegetable oil with the addition of active substances in the form of precipitated sulfur, boric acid, characterized in that the ointment base, brought to complete dissolution at t - 65- 76 ° C, 2-3% benzyl alcohol is introduced, then 3-4% citric acid is added, followed by mixing of the components, homogenization at t - 40-50 ° C and filtration.