RU2355388C2 - Method of treating psoroptosis in sheep and preparation for its realisation - Google Patents

Abstract

FIELD: medicine, veterinary.

SUBSTANCE: claimed is preparation for treating psoroptosis in sheep, based on creolin - 50 wt %, sulphur - 4 wt %, tetramethylthiuram disulphide - 1 wt %, vegetable oil - 45 wt %. Mixing preliminarily heated at 95-100°C sulphur, tetramethylthiuram disulphide and vegetable oil, cooling and mixing with equal in weight amount of creolin. Claimed is method of treating psoroptosis in sheep, including application of said medication in form of 0.1% emulsion in water by single or double bathing of animals.

EFFECT: stable medicinal effect, medication does not have toxic activity.

2 cl

Description

The invention relates to veterinary medicine, specifically to methods for treating sheep psoroptosis and preparations for its implementation.

There is a method of treating sheep psoroptosis using organophosphorus preparations (eg, neocidol) [1].

A known method of treating sheep psoroptosis using synthetic pyrethroids (e.g. permethrin, deltamethrin).

A known method of treating sheep psoroptosis using creolin obtained from oil, the active principle of which are sulfur compounds found in oils of various fields [2].

However, the content of sulfur preparations and their effectiveness varies in different oils, which does not allow to achieve a permanent therapeutic effect in sheep psoroptosis and makes it necessary to introduce active substances of other classes into the composition of creolin preparations.

The aim of the invention is to develop a method for the treatment of sheep psoroptosis using a creolin-containing preparation in which organic sulfur derivatives are added.

This goal is achieved by the fact that sulfur-containing organic substances are added to the creole as an active substance, and inorganic sulfur, tetramethylthiuram disulfide and vegetable oils processed according to the following method are used to obtain these substances: a mixture of 90 g of vegetable oil, 8 g of sulfur, 2 g of tetramethylthiuram disulfide (TMTD) is heated in a water bath at 95-100 ° C, with stirring for 1 hour. During this time, the dissolution of sulfur and TMTD occurs, with the subsequent cooling of the precipitate is not formed. During heat treatment, a chemical reaction occurs with the participation of sulfur, TMTD and double bonds present in the residues of fatty acids of any vegetable oil, with the formation of substances of the following structure:

,

,

,

,

where n = 1, 2, 3, a R are fragments of fatty acids found in vegetable oil.

The resulting homogeneous mass is mixed with creolin in a ratio of 1: 1 by weight and used as an active substance in the treatment of sheep psoroptosis.

The drug can be stored for 3 years (observation period) without the formation of a precipitate of sulfur, which indicates its complete chemical binding to organic matter.

For the treatment of sheep with psoroptosis, a 0.1% emulsion of the drug in water is used.

So, in one of the experiments, in a herd of 16 sheep, four sheep showed signs of scabies. Microscopic examination of skin scrapings from places of “faces” revealed Psoroptes ovis scabies mites.

Sick animals were treated with 0.1% emulsion of the drug (conventional name "Akarizol") in water by bathing at a water temperature in the bath tub + 25 ° C and exposure for at least 1 minute. On the second and subsequent days, physiological deviations and changes in behavioral reactions in sheep were not found. Itching and scratching stopped during the first days after treatment. In order to prevent the spread of scabies, all animal groups were treated in a similar way. After that, animals were monitored for 1 year. For the entire period of observation of relapse of the disease is not detected. During this period, 9 ewes lulled (3 of them twins), bringing healthy offspring.

Thus, the tested preparation "Akarizol" has a pronounced anti-scabrous effect, does not have a toxic and embryotoxic effect at a concentration of 0.1% of ADV.

Information sources

1. V. G. Zharov, V. I. Remez, “Bulletin of Veterinary Medicine”, 5 (3), 1997, p. 81, “The use of organophosphorus compounds (neocidol) for the treatment of sheep psoroptosis”.

2. RF patent 2074722 C1, 1997.

Claims (2)

1. A drug for the treatment of sheep psoroptosis, characterized in that it is obtained on the basis of creolin - 50 wt.%, Sulfur - 4 wt.%, Tetramethylthiuram disulfide - 1 wt.%, Vegetable oil - 45 wt.% When mixing pre-warmed at a temperature 95-100 ° C sulfur, tetramethylthiuram disulfide and vegetable oil, taken in the above amounts, cooling and mixing with an equal weight amount of creolin. 2. A method of treating sheep psoroptosis, characterized in that the preparation according to claim 1 is used in the form of a 0.1% emulsion in water by once or twice bathing sheep in it.