RU2475266C2 - Оптические агенты визуализации - Google Patents

Оптические агенты визуализации Download PDF

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Publication number
RU2475266C2
RU2475266C2 RU2009140478/15A RU2009140478A RU2475266C2 RU 2475266 C2 RU2475266 C2 RU 2475266C2 RU 2009140478/15 A RU2009140478/15 A RU 2009140478/15A RU 2009140478 A RU2009140478 A RU 2009140478A RU 2475266 C2 RU2475266 C2 RU 2475266C2
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RU
Russia
Prior art keywords
group
tmv
formula
tissue
peptide
Prior art date
Application number
RU2009140478/15A
Other languages
English (en)
Russian (ru)
Other versions
RU2009140478A (ru
Inventor
Алан КАТБЕРТСОН
Эдвин Вильгельм ЙОХАННЕСЕН
Майкл Эдвард КУПЕР
Original Assignee
ДжиИ Хелткер АС
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0709441A external-priority patent/GB0709441D0/en
Priority claimed from GB0715682A external-priority patent/GB0715682D0/en
Priority claimed from GB0716175A external-priority patent/GB0716175D0/en
Application filed by ДжиИ Хелткер АС filed Critical ДжиИ Хелткер АС
Priority claimed from PCT/GB2008/001693 external-priority patent/WO2008139206A2/en
Publication of RU2009140478A publication Critical patent/RU2009140478A/ru
Application granted granted Critical
Publication of RU2475266C2 publication Critical patent/RU2475266C2/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/005Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056Peptides, proteins, polyamino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4842Monitoring progression or stage of a disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032Methine dyes, e.g. cyanine dyes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Solid State Image Pick-Up Elements (AREA)
RU2009140478/15A 2007-05-16 2008-05-16 Оптические агенты визуализации RU2475266C2 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0709441.0 2007-05-16
GB0709441A GB0709441D0 (en) 2007-05-16 2007-05-16 Peptide imaging agents
GB0715682A GB0715682D0 (en) 2007-08-13 2007-08-13 Peptide imaging agents
GB0715682.1 2007-08-13
GB0716175.5 2007-08-20
GB0716175A GB0716175D0 (en) 2007-08-20 2007-08-20 Optical imaging agents
PCT/GB2008/001693 WO2008139206A2 (en) 2007-05-16 2008-05-16 Optical imaging agents

Publications (2)

Publication Number Publication Date
RU2009140478A RU2009140478A (ru) 2011-06-27
RU2475266C2 true RU2475266C2 (ru) 2013-02-20

Family

ID=39743846

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2009140478/15A RU2475266C2 (ru) 2007-05-16 2008-05-16 Оптические агенты визуализации
RU2009140475/10A RU2473361C9 (ru) 2007-05-16 2008-05-16 Меченые пептиды, связывающие фактор роста гепатоцитов (hgf), для визуализации

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2009140475/10A RU2473361C9 (ru) 2007-05-16 2008-05-16 Меченые пептиды, связывающие фактор роста гепатоцитов (hgf), для визуализации

Country Status (17)

Country Link
US (1) US8529874B2 (enExample)
EP (1) EP2146749B1 (enExample)
JP (1) JP2010526859A (enExample)
KR (2) KR101578225B1 (enExample)
CN (1) CN101848734B (enExample)
AT (1) ATE551073T1 (enExample)
AU (1) AU2008249821B2 (enExample)
BR (1) BRPI0811210B1 (enExample)
CA (1) CA2685553C (enExample)
ES (1) ES2385066T3 (enExample)
IL (1) IL201778A0 (enExample)
MX (1) MX2009012386A (enExample)
NZ (1) NZ581160A (enExample)
PL (1) PL2146749T3 (enExample)
RU (2) RU2475266C2 (enExample)
WO (1) WO2008139207A2 (enExample)
ZA (1) ZA200908016B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2795062C2 (ru) * 2018-03-02 2023-04-28 Лайф Текнолоджис Корпорейшн Новые комбинации гасителя и репортерного красителя

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0811588A2 (pt) * 2007-05-16 2014-10-21 Ge Healthcare As Agente de formação de imagem, composição farmacêutica, kit para a preparação da mesma, conjugado, corante de cianina, e, métodos de formação de imagem óptica in vivo do corpo de um mamífero e de detecção, avaliação do estágio, diagnóstico, monitoração da progressão da doença ou monitoração do tratamento de um estado de doença do corpo de um mamífero
GB0718967D0 (en) * 2007-09-28 2007-11-07 Ge Healthcare Ltd Peptide imaging agents
GB0918321D0 (en) 2009-10-20 2009-12-02 Ge Healthcare As Cyclic peptide synthesis
GB201010878D0 (en) 2010-06-29 2010-08-11 Ge Healthcare As Dye compositiion and dye syntheses
WO2012001063A1 (en) * 2010-06-29 2012-01-05 Ge Healthcare As Dye compositions and dye syntheses
GB201013808D0 (en) 2010-08-18 2010-09-29 Ge Healthcare Ltd Peptide radiotracer compositions
WO2012048063A2 (en) * 2010-10-06 2012-04-12 Emd Millipore Corporation Cyanine compounds, conjugates and method of use
CA2828810A1 (en) 2011-03-01 2012-09-07 Ge Healthcare Limited Radiolabelled octreotate analogues as pet tracers
GB201103696D0 (en) 2011-03-04 2011-04-20 Ge Healthcare Ltd Technetium labelled peptides
DE102011118029A1 (de) * 2011-06-20 2012-12-20 Universität Leipzig Modifizierte antibiotische Peptide mit variabler systemischer Freisetzung
GB201116733D0 (en) 2011-09-28 2011-11-09 Ge Healthcare As Peptide margin imaging agents
GB201116862D0 (en) 2011-09-30 2011-11-09 Ge Healthcare As Infusion imaging method
GB201121914D0 (en) * 2011-12-20 2012-02-01 Ge Healthcare Ltd Method for patient selection
US10046068B2 (en) * 2013-03-15 2018-08-14 Arizona Board Of Regents On Behalf Of Arizona State University Saccharide conjugates
GB201314936D0 (en) 2013-08-21 2013-10-02 Ge Healthcare Ltd Radiolabelling method
GB201322456D0 (en) 2013-12-18 2014-02-05 Ge Healthcare Ltd Radiotracer compositions and methods
CN105111773B (zh) * 2015-08-19 2017-06-27 大连理工大学 一类氨基菁类荧光染料及其制备方法和应用
GB201804835D0 (en) * 2018-03-26 2018-05-09 Ge Healthcare As Formulation and method of preparation
CN112129736B (zh) * 2020-09-22 2022-08-02 四川大学华西医院 粘蛋白和循环肿瘤细胞的均相可视化/荧光poct检测方法
EP4352167A1 (en) * 2021-06-07 2024-04-17 SurgVision GmbH Stable liquid phantom for near-infrared fluorescence verification
TW202404643A (zh) 2022-04-20 2024-02-01 大陸商同宜醫藥(蘇州)有限公司 化合物及用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004075032A2 (en) * 2003-02-19 2004-09-02 Sicel Technologies Inc. In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes
WO2005044923A1 (en) * 2003-10-31 2005-05-19 Ge Healthcare Limited Cyanine dye labelling reagents
WO2006073314A1 (en) * 2005-01-06 2006-07-13 Ge Healthcare As Optical imaging
WO2006078914A1 (en) * 2005-01-21 2006-07-27 Washington University In St. Louis Compounds having rd targeting motifs

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
EP2258776A1 (en) * 2002-05-10 2010-12-08 Carnegie Mellon University Fluorescent cyanine dyes containing functional groups
GB0223249D0 (en) * 2002-10-08 2002-11-13 Amersham Plc Improved imaging agents
PT2949658T (pt) * 2003-03-03 2018-10-18 Bracco Suisse Sa Péptidos que ligam especificamente o recetor de hgf (cmet) e utilizações dos mesmos
NO20034350D0 (no) * 2003-09-29 2003-09-29 Amersham Health As Optisk avbilding av kolorektal kreft
US7785566B2 (en) 2003-11-06 2010-08-31 Ge Healthcare, Inc. Pharmaceutical compounds
NO20035682D0 (no) 2003-12-18 2003-12-18 Amersham Health As Optisk avbildning av ösofagkreft og Barretts ösofag
GB0502277D0 (en) 2005-02-04 2005-03-09 Amersham Plc Novel imaging agents
EP1877428B1 (en) * 2005-04-22 2011-03-16 University of Washington Cyanine- chlorotoxin conjugate and method for intra-operative visualization of cancer
NO20053354D0 (no) 2005-07-11 2005-07-11 Amersham Health As Optical imaging contrast agent.

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
WO2004075032A2 (en) * 2003-02-19 2004-09-02 Sicel Technologies Inc. In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes
WO2005044923A1 (en) * 2003-10-31 2005-05-19 Ge Healthcare Limited Cyanine dye labelling reagents
WO2006073314A1 (en) * 2005-01-06 2006-07-13 Ge Healthcare As Optical imaging
WO2006078914A1 (en) * 2005-01-21 2006-07-27 Washington University In St. Louis Compounds having rd targeting motifs

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Daniel J Hawrysz, Eva M Sevick-Muraca. Developments Toward Diagnostic Breast Cancer Imaging Using Near-Infrared Optical Measurements and Fluorescent Contrast Agents // Neoplasia, Vol.2, No. 5, p.388-417, 2000. *
Daniel J Hawrysz, Eva M Sevick-Muraca. Developments Toward Diagnostic Breast Cancer Imaging Using Near-Infrared Optical Measurements and Fluorescent Contrast Agents // Neoplasia, Vol.2, No. 5, p.388-417, 2000. Муравьев И.А. Технология лекарств. Изд. 3-е, в 2-х т. Т.2. - М.: Медицина, 1980, 704 с. Tuan Vo-Dinh. Biomedical Photonics Handbook. CRC Press LLC, 2003. *
Муравьев И.А. Технология лекарств. Изд. 3-е, в 2-х т. Т.2. - М.: Медицина, 1980, 704 с. Tuan Vo-Dinh. Biomedical Photonics Handbook. CRC Press LLC, 2003. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2795062C2 (ru) * 2018-03-02 2023-04-28 Лайф Текнолоджис Корпорейшн Новые комбинации гасителя и репортерного красителя

Also Published As

Publication number Publication date
CA2685553C (en) 2017-03-28
WO2008139207A3 (en) 2009-02-26
BRPI0811210A2 (pt) 2014-11-11
KR20150017387A (ko) 2015-02-16
KR101578225B1 (ko) 2015-12-17
EP2146749A2 (en) 2010-01-27
US8529874B2 (en) 2013-09-10
CA2685553A1 (en) 2008-11-20
RU2009140475A (ru) 2011-06-27
WO2008139207A2 (en) 2008-11-20
BRPI0811210B1 (pt) 2021-11-09
NZ581160A (en) 2012-05-25
AU2008249821A1 (en) 2008-11-20
ZA200908016B (en) 2012-04-25
CN101848734B (zh) 2013-08-28
KR20100016543A (ko) 2010-02-12
RU2473361C9 (ru) 2013-06-20
MX2009012386A (es) 2009-12-03
ATE551073T1 (de) 2012-04-15
AU2008249821B2 (en) 2013-08-22
PL2146749T3 (pl) 2012-09-28
CN101848734A (zh) 2010-09-29
US20100150843A1 (en) 2010-06-17
RU2009140478A (ru) 2011-06-27
RU2473361C2 (ru) 2013-01-27
EP2146749B1 (en) 2012-03-28
IL201778A0 (en) 2010-06-16
ES2385066T3 (es) 2012-07-17
JP2010526859A (ja) 2010-08-05

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Effective date: 20140517