RU2465328C2 - Мутации в генах oas1 - Google Patents
Мутации в генах oas1 Download PDFInfo
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- RU2465328C2 RU2465328C2 RU2007144986/10A RU2007144986A RU2465328C2 RU 2465328 C2 RU2465328 C2 RU 2465328C2 RU 2007144986/10 A RU2007144986/10 A RU 2007144986/10A RU 2007144986 A RU2007144986 A RU 2007144986A RU 2465328 C2 RU2465328 C2 RU 2465328C2
- Authority
- RU
- Russia
- Prior art keywords
- leu
- lys
- arg
- gly
- gln
- Prior art date
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| CN103536900B (zh) * | 2012-07-16 | 2017-06-16 | 江苏豪森药业集团有限公司 | 含有促红细胞生成素模拟肽的药物组合物 |
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| CN106483282B (zh) * | 2016-09-29 | 2018-08-31 | 北京世纪沃德生物科技有限公司 | 一种抗原稳定剂及其制备方法与应用 |
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| US5404871A (en) | 1991-03-05 | 1995-04-11 | Aradigm | Delivery of aerosol medications for inspiration |
| US6565841B1 (en) | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| NZ244306A (en) | 1991-09-30 | 1995-07-26 | Boehringer Ingelheim Int | Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| US5565552A (en) | 1992-01-21 | 1996-10-15 | Pharmacyclics, Inc. | Method of expanded porphyrin-oligonucleotide conjugate synthesis |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| US5266459A (en) * | 1992-02-24 | 1993-11-30 | The Scripps Research Institute | Gaucher's disease: detection of a new mutation in intron 2 of the glucocerebrosidase gene |
| DE4208916A1 (de) | 1992-03-20 | 1993-09-23 | Akzo Nv | Polyesterfaser und verfahren zu deren herstellung |
| IL105914A0 (en) | 1992-06-04 | 1993-10-20 | Univ California | Methods and compositions for in vivo gene therapy |
| US5785049A (en) | 1994-09-21 | 1998-07-28 | Inhale Therapeutic Systems | Method and apparatus for dispersion of dry powder medicaments |
| US5574142A (en) | 1992-12-15 | 1996-11-12 | Microprobe Corporation | Peptide linkers for improved oligonucleotide delivery |
| US5934272A (en) | 1993-01-29 | 1999-08-10 | Aradigm Corporation | Device and method of creating aerosolized mist of respiratory drug |
| US5558085A (en) | 1993-01-29 | 1996-09-24 | Aradigm Corporation | Intrapulmonary delivery of peptide drugs |
| US5915378A (en) | 1993-01-29 | 1999-06-29 | Aradigm Corporation | Creating an aerosolized formulation of insulin |
| WO1995022245A1 (en) | 1994-02-18 | 1995-08-24 | Cleveland Clinic Foundation | Antiviral transgenic plants, vectors, cells and methods |
| US5861300A (en) | 1993-03-08 | 1999-01-19 | The Cleveland Clinic Foundation | Antiviral transgenic plants, vectors, cells and methods |
| US5426039A (en) | 1993-09-08 | 1995-06-20 | Bio-Rad Laboratories, Inc. | Direct molecular cloning of primer extended DNA containing an alkane diol |
| US5597709A (en) * | 1994-01-27 | 1997-01-28 | Human Genome Sciences, Inc. | Human growth hormone splice variants hGHV-2(88) and hGHV-3(53) |
| JPH10501519A (ja) | 1994-03-07 | 1998-02-10 | インヘイル・セラピューティック・システムズ | インシュリンを肺に送給できる方法および組成物 |
| US5597696A (en) | 1994-07-18 | 1997-01-28 | Becton Dickinson And Company | Covalent cyanine dye oligonucleotide conjugates |
| US5522385A (en) | 1994-09-27 | 1996-06-04 | Aradigm Corporation | Dynamic particle size control for aerosolized drug delivery |
| US5514758A (en) | 1994-09-30 | 1996-05-07 | The Goodyear Tire & Rubber Company | Process for making latex for high performance masking tape |
| US5780014A (en) | 1995-04-14 | 1998-07-14 | Inhale Therapeutic Systems | Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin |
| US5480640A (en) | 1995-05-02 | 1996-01-02 | Schering Corporation | Alpha interferon for treating prostate cancer |
| US5654007A (en) | 1995-06-07 | 1997-08-05 | Inhale Therapeutic Systems | Methods and system for processing dispersible fine powders |
| US5840565A (en) * | 1995-08-22 | 1998-11-24 | The Regents Of The University Of California | Methods for enhancing the production of viral vaccines in PKR-deficient cell culture |
| US6001336A (en) | 1996-12-31 | 1999-12-14 | Inhale Therapeutic Systems | Processes for spray drying aqueous suspensions of hydrophobic drugs and compositions thereof |
| US5765887A (en) | 1997-01-07 | 1998-06-16 | P Ii Inc | Apparatus and method for searching pockets and crevices |
| US5993738A (en) | 1997-05-13 | 1999-11-30 | Universal Air Technology | Electrostatic photocatalytic air disinfection |
| US5855564A (en) | 1997-08-20 | 1999-01-05 | Aradigm Corporation | Aerosol extrusion mechanism |
| AU9131698A (en) | 1997-09-08 | 1999-03-29 | Princeton University | Human genes regulated by human cytomegalovirus and interferon |
| FR2770300B1 (fr) | 1997-10-27 | 1999-12-31 | Vincent Patrice Chritin | Dispositif pour la mesure de la vitesse d'un fluide et pour la mesure des flux de particules solides ou liquides dans les fluides ou le vide |
| WO1999050437A1 (en) * | 1998-03-30 | 1999-10-07 | Esa, Inc. | Methodology for predicting and/or diagnosing disease |
| US5958773A (en) | 1998-12-17 | 1999-09-28 | Isis Pharmaceuticals Inc. | Antisense modulation of AKT-1 expression |
| US20010034023A1 (en) * | 1999-04-26 | 2001-10-25 | Stanton Vincent P. | Gene sequence variations with utility in determining the treatment of disease, in genes relating to drug processing |
| US20030165921A1 (en) * | 2000-02-03 | 2003-09-04 | Tang Y. Tom | Novel nucleic acids and polypeptides |
| WO2001066689A2 (en) | 2000-03-07 | 2001-09-13 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| JP2004502406A (ja) * | 2000-03-09 | 2004-01-29 | カイロン コーポレイション | ヒト遺伝子およびヒト遺伝子発現産物 |
| US20020110815A1 (en) | 2000-04-14 | 2002-08-15 | James Lillie | Novel genes, compositions and methods for the identification, assessment, prevention, and therapy of human cancers |
| FR2823224B1 (fr) | 2001-04-04 | 2003-10-31 | Pasteur Institut | Utilisation de genes oas impliques dans la sensibilite/resistance a l'infection par les flaviviridae pour le criblage de molecules antivirales |
| DE10122206A1 (de) | 2001-05-08 | 2002-11-28 | Switch Biotech Ag | Verwendung von Polypeptiden oder diese kodierende NukleInsäuren einer 2'-5'- Oligoadenylate Synthetase und/oder RNAseL zur Diagnose, Prävention oder Behandlung von Hauterkrankungen oder Wundheilung sowie ihre Verwendung zur Identifizierung von pharmakologisch aktiven Substanzen |
| AU2002341207A1 (en) | 2001-05-08 | 2002-11-18 | Switch Biotech Ag | Use of 2'-5'-oligoadenylate synthetase and/or rnasel or nucleic acids encoding them for diagnosis, prophylaxis or treatment of wound healing |
| US6818420B2 (en) * | 2002-02-27 | 2004-11-16 | Biosource International, Inc. | Methods of using FET labeled oligonucleotides that include a 3′-5′ exonuclease resistant quencher domain and compositions for practicing the same |
| GB0208928D0 (en) | 2002-04-19 | 2002-05-29 | Imp College Innovations Ltd | Methods |
| WO2003092618A2 (en) * | 2002-04-30 | 2003-11-13 | University Of South Florida | Materials and methods for prevention and treatment of rna viral diseases |
| AU2003299505A1 (en) * | 2002-05-17 | 2004-06-03 | Baylor College Of Medicine | Identification of oligoadenylate synthetase-like genes |
| WO2004000998A2 (en) | 2002-06-19 | 2003-12-31 | Georgia State University Research Foundation, Inc. | Compositions and methods for viral resistance genes |
| EP1689888A2 (en) | 2003-10-23 | 2006-08-16 | Illumigen Biosciences Inc. | Detection of mutations in a gene associated with resistance to viral infection, oas1 |
| NZ580169A (en) | 2003-10-23 | 2011-04-29 | Illumigen Biosciences Inc | Detection of mutations in a gene associated with resistance to viral infection, OAS1 (SEQ ID NO:48) |
| UA95446C2 (ru) | 2005-05-04 | 2011-08-10 | Іллюміджен Байосайєнсіз, Інк. | Мутаци в генах oas1 |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2108386C1 (ru) * | 1990-02-03 | 1998-04-10 | Макс-Планк-Гезельшафт Цур Фердерунг дер Виссеншафтен е.ф. | Рекомбинантный гранулоцит-колониестимулирующий фактор (g - csf) без дополнительного остатка метионина на n-конце |
Non-Patent Citations (1)
| Title |
|---|
| HAMANO ET AL.: «Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnames population» Biochemical and biophysical research communications, academic press inc. Orlando, FL, US; vol.329, n.4, 22.04.2005. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2796522C1 (ru) * | 2022-12-28 | 2023-05-25 | федеральное государственное автономное образовательное учреждение высшего образования "Санкт-Петербургский политехнический университет Петра Великого" (ФГАОУ ВО "СПбПУ") | Тест-система для количественной диагностики мРНК генов OAS1a/g, IL-6, IRF-7, IFNA, IFNB, IFNL мыши методом ПЦР в режиме реального времени |
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